Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha

Inhibitor of nuclear factor kappa-B kinase
type: Complex
cellular location: Cytoplasm
component: Inhibitor of nuclear factor kappa-B kinase subunit alpha
component: Inhibitor of nuclear factor kappa-B kinase subunit beta
component: NF-kappa-B essential modulator

NF-kappa-B essential modulator
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B essential modulator

direct_interaction
type: InteractionVocabulary

TLR2,6
type: Complex
cellular location: Cytoplasm
component: Toll-like receptor 2
component: Toll-like receptor 6

Toll-like receptor 4
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 4

Reference/UniProt Q9D5P5
type: UnificationXref
id: Q9D5P5
db: UniProt

Reference/ChEBI CHEBI 59309
type: UnificationXref
id: CHEBI:59309
db: ChEBI

Toll-like receptor 8
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 8

Monocyte differentiation antigen CD14
type: Protein
entity reference: Monocyte differentiation antigen CD14

Reference/TAXONOMY 10090
type: UnificationXref
id: 10090
db: TAXONOMY

Toll-like receptor 7
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 7

Dual specificity mitogen-activated protein kinase kinase 4
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 4

Mitogen-activated protein kinase 10
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 10

Toll-like receptor 5
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 5

NF-kappa-B essential modulator
type: ProteinReference
xref: Reference/UniProt Q924H4
organism: Mus musculus

Reference/UniProt Q9D2X3
type: UnificationXref
id: Q9D2X3
db: UniProt

CpG-DNA
type: DnaReference
organism: Mus musculus

Double-Stranded RNA
type: DnaReference
organism: Mus musculus

Liproproteins
type: ProteinReference
organism: Mus musculus

ProteinComplex/11178 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NFKBIA, NFKB1, RELA complex
stoichiometric coefficient: 1.0

Toll-like receptor 4 (Mus musculus)_Lymphocyte antigen 96 (Mus musculus)
type: Complex
component stoichiometry: Protein/21291 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/22183 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Toll-like receptor 4
component: Lymphocyte antigen 96

LPS core
type: SmallMolecule
cellular location: Cell Membrane
entity reference: LPS core

Imiquimod
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0014862
xref: Reference/ChEBI CHEBI 36704
xref: Reference/ChemSpider 51809
xref: Reference/PubChem-compound 57469
xref: Reference/CAS 99011-02-6
chemical formula: C14H16N4
molecular weight: 240.1375
structure: ChemicalStructure/PW C009198

NFKBIA, NFKB1, RELA complex
type: Complex
cellular location: Cytoplasm
component: Nuclear factor NF-kappa-B p105 subunit
component: Transcription factor p65
component: NF-kappa-B inhibitor alpha

Mus musculus
type: BioSource
xref: Reference/TAXONOMY 10090

Imiquimod
type: SmallMolecule
entity reference: Imiquimod

Reference/UniProt Q8C712
type: UnificationXref
id: Q8C712
db: UniProt

NF-kappa-B inhibitor alpha
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B inhibitor alpha

Reference/UniProt Q9JLF7
type: UnificationXref
id: Q9JLF7
db: UniProt

Protein/22097 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll/interleukin-1 receptor domain-containing adapter protein
stoichiometric coefficient: 1.0

Reference/BioCyc CPD0-2271
type: UnificationXref
id: CPD0-2271
db: BioCyc

Toll-interacting protein
type: ProteinReference
xref: Reference/UniProt Q9D5P5
organism: Mus musculus

Mitogen-activated protein kinase 10
type: ProteinReference
xref: Reference/UniProt Q9R0U6
organism: Mus musculus

Reference/KEGG Compound c0338
type: UnificationXref
id: c0338
db: KEGG Compound

Monocyte differentiation antigen CD14
type: ProteinReference
xref: Reference/UniProt P10810
organism: Mus musculus

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Lymphocyte antigen 96
type: ProteinReference
xref: Reference/UniProt Q9JHF9
organism: Mus musculus

NFKB1,RELA complex
type: Complex
cellular location: Cytoplasm
component: Nuclear factor NF-kappa-B p105 subunit
component: Transcription factor p65

Reference/HMDB HMDB0014862
type: UnificationXref
id: HMDB0014862
db: HMDB

MYD88,IRAK (myddosome)
type: Complex
cellular location: Cytoplasm
component: Interleukin-1 receptor-associated kinase 1
component: Myeloid differentiation primary response protein MyD88

Reference/UniProt Q9R1J6
type: UnificationXref
id: Q9R1J6
db: UniProt

TNF receptor-associated factor 6
type: Protein
cellular location: Cytoplasm
entity reference: TNF receptor-associated factor 6

Reference/ChemSpider 51809
type: UnificationXref
id: 51809
db: ChemSpider

Reference/UniProt Q9WTQ4
type: UnificationXref
id: Q9WTQ4
db: UniProt

Lymphocyte antigen 96
type: Protein
cellular location: Cell Membrane
entity reference: Lymphocyte antigen 96

Toll-like receptor 5
type: Protein
entity reference: Toll-like receptor 5

Reference/PubChem-compound 53481794
type: UnificationXref
id: 53481794
db: PubChem-compound

Mitogen-activated protein kinase kinase kinase 7 (Mus musculus)_TAB Complex (Mus musculus)
type: Complex
component stoichiometry: Protein/21069 Cytoplasm/Stoichiometry/1.0
component stoichiometry: ProteinComplex/12227 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: TAB Complex
component: Mitogen-activated protein kinase kinase kinase 7

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
type: Protein
cellular location: Cytoplasm
entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

ChemicalStructure/PW C009198
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)CN1C=NC2=C1C1=CC=CC=C1N=C2N

Toll-like receptor 8
type: Protein
entity reference: Toll-like receptor 8

Interleukin-1 receptor-associated kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Interleukin-1 receptor-associated kinase 1

Reference/UniProt P10810
type: UnificationXref
id: P10810
db: UniProt

Reference/UniProt Q91V53
type: UnificationXref
id: Q91V53
db: UniProt

Liproproteins
type: Protein
cellular location: Cytoplasm
entity reference: Liproproteins

Reaction179047
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11178 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11179 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/19511 Cytoplasm/Stoichiometry/1.0
right: NF-kappa-B inhibitor alpha
right: NFKB1,RELA complex
spontaneous: false
left: NFKBIA, NFKB1, RELA complex
name: NFKBIA, NFKB1, RELA complex → NFKB1,RELA complex + NFKBIA with phosphate
conversion direction: LEFT_TO_RIGHT

Toll-like receptor 9
type: ProteinReference
xref: Reference/UniProt Q99MQ8
organism: Mus musculus

Toll-interacting protein
type: Protein
cellular location: Cytoplasm
entity reference: Toll-interacting protein

Reference/UniProt Q91XI7
type: UnificationXref
id: Q91XI7
db: UniProt

Toll/interleukin-1 receptor domain-containing adapter protein (Mus musculus)_Toll-interacting protein (Mus musculus)
type: Complex
component stoichiometry: Protein/22186 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/22097 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Toll-interacting protein
component: Toll/interleukin-1 receptor domain-containing adapter protein

Mitogen-activated protein kinase kinase kinase 7
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 7

Reference/UniProt Q91ZM4
type: UnificationXref
id: Q91ZM4
db: UniProt

Reference/UniProt Q8R0D1
type: UnificationXref
id: Q8R0D1
db: UniProt

Reference/UniProt Q9DBC4
type: UnificationXref
id: Q9DBC4
db: UniProt

Monocyte differentiation antigen CD14
type: Protein
cellular location: Cytoplasm
entity reference: Monocyte differentiation antigen CD14

Toll-like receptor 4 (Mus musculus)_Lymphocyte antigen 96 (Mus musculus)
type: Complex
component stoichiometry: Protein/22183 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/21291 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Toll-like receptor 4
component: Lymphocyte antigen 96

Transcription factor p65
type: Protein
cellular location: Cytoplasm
entity reference: Transcription factor p65

Unknown
type: Protein
entity reference: Unknown

Monocyte differentiation antigen CD14
type: Protein
cellular location: Cell Membrane
entity reference: Monocyte differentiation antigen CD14

Reference/UniProt Q571K4
type: UnificationXref
id: Q571K4
db: UniProt

Toll-like receptor 2
type: ProteinReference
xref: Reference/UniProt Q9DBC4
organism: Mus musculus

Reference/PathWhiz PW122176
type: UnificationXref
id: PW122176
db: PathWhiz

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Toll/interleukin-1 receptor domain-containing adapter protein
type: ProteinReference
xref: Reference/UniProt Q91ZW0
organism: Mus musculus

Toll-like receptor 1
type: ProteinReference
xref: Reference/UniProt Q9EPW5
organism: Mus musculus

TAB Complex
type: Complex
cellular location: Cytoplasm
component: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
component: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
component: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

TLR1,2
type: Complex
cellular location: Cytoplasm
component: Toll-like receptor 2
component: Toll-like receptor 1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
type: Protein
cellular location: Cytoplasm
entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Interaction1961
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates TLR1,2
participant: Monocyte differentiation antigen CD14
participant: TLR1,2

Reference/UniProt Q8BLV2
type: UnificationXref
id: Q8BLV2
db: UniProt

Interaction1960
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates TLR1,2
participant: Liproproteins
participant: TLR1,2

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
type: ProteinReference
xref: Reference/UniProt Q8R0D1
organism: Mus musculus

Interaction1965
type: MolecularInteraction
interaction type: direct_interaction
name: LPS core activates Toll-like receptor 4 (Mus musculus) + Lymphocyte antigen 96 (Mus musculus)
participant: Toll-like receptor 4 (Mus musculus)_Lymphocyte antigen 96 (Mus musculus)
participant: LPS core

Interaction1964
type: MolecularInteraction
interaction type: direct_interaction
name: MYD88,IRAK (myddosome) activates TNF receptor-associated factor 6
participant: MYD88,IRAK (myddosome)
participant: TNF receptor-associated factor 6

Toll-like receptor 8
type: ProteinReference
xref: Reference/UniProt Q91XI7
organism: Mus musculus

Interaction1963
type: MolecularInteraction
interaction type: direct_interaction
name: TLR2,6 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: TLR2,6

Interaction1962
type: MolecularInteraction
interaction type: direct_interaction
name: TLR1,2 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: TLR1,2

Interaction1969
type: MolecularInteraction
interaction type: direct_interaction
name: Toll/interleukin-1 receptor domain-containing adapter protein (Mus musculus) + Toll-interacting protein (Mus musculus) activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll/interleukin-1 receptor domain-containing adapter protein (Mus musculus)_Toll-interacting protein (Mus musculus)

Interaction1968
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 4 (Mus musculus) + Lymphocyte antigen 96 (Mus musculus) activates Toll/interleukin-1 receptor domain-containing adapter protein (Mus musculus) + Toll-interacting protein (Mus musculus)
participant: Toll-like receptor 4 (Mus musculus)_Lymphocyte antigen 96 (Mus musculus)
participant: Toll/interleukin-1 receptor domain-containing adapter protein (Mus musculus)_Toll-interacting protein (Mus musculus)

Interaction1967
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates Toll-like receptor 4 (Mus musculus) + Lymphocyte antigen 96 (Mus musculus)
participant: Toll-like receptor 4 (Mus musculus)_Lymphocyte antigen 96 (Mus musculus)
participant: Monocyte differentiation antigen CD14

Interaction1966
type: MolecularInteraction
interaction type: direct_interaction
name: LPS core activates Monocyte differentiation antigen CD14
participant: Monocyte differentiation antigen CD14
participant: LPS core

Toll-like receptor 5
type: ProteinReference
xref: Reference/UniProt Q9JLF7
organism: Mus musculus

Toll-like receptor 2
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 2

Toll-like receptor 7
type: Protein
entity reference: Toll-like receptor 7

Toll-like receptor 4
type: ProteinReference
xref: Reference/UniProt Q9Z203
organism: Mus musculus

Protein/22183 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lymphocyte antigen 96
stoichiometric coefficient: 1.0

Protein/21291 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

ProteinComplex/11179 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NFKB1,RELA complex
stoichiometric coefficient: 1.0

Reference/UniProt Q91ZW0
type: UnificationXref
id: Q91ZW0
db: UniProt

Protein/19511 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NF-kappa-B inhibitor alpha
stoichiometric coefficient: 1.0

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
type: ProteinReference
xref: Reference/UniProt Q571K4
organism: Mus musculus

Toll-like receptor 3
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 3

Interaction1958
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates TLR2,6
participant: Liproproteins
participant: TLR2,6

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: Reference/UniProt Q62073
organism: Mus musculus

Interaction1957
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates Monocyte differentiation antigen CD14
participant: Monocyte differentiation antigen CD14
participant: Liproproteins

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
type: ProteinReference
xref: Reference/UniProt Q99KP4
organism: Mus musculus

Double-Stranded RNA
type: Dna
entity reference: Double-Stranded RNA

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/UniProt Q924H4
type: UnificationXref
id: Q924H4
db: UniProt

Interaction1959
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates TLR2,6
participant: Monocyte differentiation antigen CD14
participant: TLR2,6

CpG-DNA
type: Dna
entity reference: CpG-DNA

Reference/UniProt Q9Z203
type: UnificationXref
id: Q9Z203
db: UniProt

Reference/UniProt Q9R0U6
type: UnificationXref
id: Q9R0U6
db: UniProt

Interaction1983
type: MolecularInteraction
interaction type: direct_interaction
name: Inhibitor of nuclear factor kappa-B kinase activates NFKBIA, NFKB1, RELA complex
participant: Inhibitor of nuclear factor kappa-B kinase
participant: NFKBIA, NFKB1, RELA complex

Reference/UniProt Q6Y3Z6
type: UnificationXref
id: Q6Y3Z6
db: UniProt

Interaction1982
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Inhibitor of nuclear factor kappa-B kinase
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Inhibitor of nuclear factor kappa-B kinase

Interaction1981
type: MolecularInteraction
interaction type: direct_interaction
name: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium
participant: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
participant: Mitogen-activated protein kinase kinase kinase 1

Interaction1980
type: MolecularInteraction
interaction type: direct_interaction
name: TNF receptor-associated factor 6 activates Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
participant: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
participant: TNF receptor-associated factor 6

Interaction1987
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 7 (Mus musculus) + TAB Complex (Mus musculus) activates Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate
participant: Dual specificity mitogen-activated protein kinase kinase 4
participant: Mitogen-activated protein kinase kinase kinase 7 (Mus musculus)_TAB Complex (Mus musculus)

Interaction1986
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 14 activates Inhibitor of nuclear factor kappa-B kinase
participant: Inhibitor of nuclear factor kappa-B kinase
participant: Mitogen-activated protein kinase 14

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Interaction1985
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 7 (Mus musculus) + TAB Complex (Mus musculus) activates Mitogen-activated protein kinase kinase kinase 14
participant: Mitogen-activated protein kinase 14
participant: Mitogen-activated protein kinase kinase kinase 7 (Mus musculus)_TAB Complex (Mus musculus)

Interaction1984
type: MolecularInteraction
interaction type: direct_interaction
name: TNF receptor-associated factor 6 activates Mitogen-activated protein kinase kinase kinase 7 (Mus musculus) + TAB Complex (Mus musculus)
participant: Mitogen-activated protein kinase kinase kinase 7 (Mus musculus)_TAB Complex (Mus musculus)
participant: TNF receptor-associated factor 6

Interaction1988
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate activates Mitogen-activated protein kinase 8 without Magnesium
participant: Dual specificity mitogen-activated protein kinase kinase 4
participant: Mitogen-activated protein kinase 10

Protein/21291 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Reference/CAS 99011-02-6
type: UnificationXref
id: 99011-02-6
db: CAS

Reference/UniProt O35916
type: UnificationXref
id: O35916
db: UniProt

Reference/UniProt Q9R256
type: UnificationXref
id: Q9R256
db: UniProt

ProteinComplex/12227 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: TAB Complex
stoichiometric coefficient: 1.0

Reference/UniProt Q923I1
type: UnificationXref
id: Q923I1
db: UniProt

Toll-like receptor 4
type: Protein
cellular location: Cell Membrane
entity reference: Toll-like receptor 4

Mitogen-activated protein kinase 14
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 14

Reference/PubChem-compound 57469
type: UnificationXref
id: 57469
db: PubChem-compound

TNF receptor-associated factor 6
type: ProteinReference
xref: Reference/UniProt Q8BLV2
organism: Mus musculus

Reference/HMDB HMDB0013471
type: UnificationXref
id: HMDB0013471
db: HMDB

Interaction1972
type: MolecularInteraction
interaction type: direct_interaction
name: Double-Stranded RNA activates Toll-like receptor 3
participant: Toll-like receptor 3
participant: Double-Stranded RNA

Interaction1971
type: MolecularInteraction
interaction type: direct_interaction
name: Imiquimod activates Toll-like receptor 7
participant: Toll-like receptor 7
participant: Imiquimod

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q91V53
organism: Mus musculus

Interaction1970
type: MolecularInteraction
interaction type: direct_interaction
name: CpG-DNA activates Toll-like receptor 9
participant: CpG-DNA
participant: Toll-like receptor 9

Reference/SMPDB SMP0120913
type: UnificationXref
id: SMP0120913
db: SMPDB

Interaction1976
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 3 activates MYD88,IRAK (myddosome)
participant: Toll-like receptor 3
participant: MYD88,IRAK (myddosome)

Interaction1975
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 9 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 9

Interaction1974
type: MolecularInteraction
interaction type: direct_interaction
name: Double-Stranded RNA activates Toll-like receptor 8
participant: Double-Stranded RNA
participant: Toll-like receptor 8

Reference/UniProt Q80ZX5
type: UnificationXref
id: Q80ZX5
db: UniProt

Double-Stranded RNA
type: Dna
cellular location: Cytoplasm
entity reference: Double-Stranded RNA

Interaction1973
type: MolecularInteraction
interaction type: direct_interaction
name: Flagellin activates Toll-like receptor 5
participant: Toll-like receptor 5
participant: Unknown

Interaction1979
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 5 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 5

Interaction1978
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 7 activates MYD88,IRAK (myddosome)
participant: Toll-like receptor 7
participant: MYD88,IRAK (myddosome)

LPS core
type: SmallMolecule
entity reference: LPS core

Toll/interleukin-1 receptor domain-containing adapter protein
type: Protein
cellular location: Cytoplasm
entity reference: Toll/interleukin-1 receptor domain-containing adapter protein

Interaction1977
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 8 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 8

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q9R256
organism: Mus musculus

Reference/UniProt Q9QZ80
type: UnificationXref
id: Q9QZ80
db: UniProt

LPS core
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 59309
xref: Reference/KEGG Compound c0338
xref: Reference/PubChem-compound 53481794
xref: Reference/HMDB HMDB0013471
xref: Reference/BioCyc CPD0-2271
chemical formula: C175H317N5O101P6
molecular weight: 4290.8247
structure: ChemicalStructure/PW C008388

Reference/UniProt Q62073
type: UnificationXref
id: Q62073
db: UniProt

Unknown
type: ProteinReference
organism: Mus musculus

Toll-like receptor 6
type: ProteinReference
xref: Reference/UniProt Q9WTQ4
organism: Mus musculus

Toll-like receptor 1
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 1

Reference/UniProt Q9JHF9
type: UnificationXref
id: Q9JHF9
db: UniProt

Toll-like receptor 3
type: ProteinReference
xref: Reference/UniProt Q91ZM4
organism: Mus musculus

Toll-like receptor 9
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 9

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: Reference/UniProt O35916
organism: Mus musculus

Interleukin-1 receptor-associated kinase 1
type: ProteinReference
xref: Reference/UniProt Q6Y3Z6
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 1

Protein/22183 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lymphocyte antigen 96
stoichiometric coefficient: 1.0

Reference/UniProt P47809
type: UnificationXref
id: P47809
db: UniProt

Toll-Like Receptor Pathway 2
type: Pathway
pathway order: PathwayEnzymeReaction/2119976
pathway order: PathwayInteraction/1969
pathway order: PathwayInteraction/1967
pathway order: PathwayInteraction/1968
pathway order: PathwayInteraction/1965
pathway order: PathwayInteraction/1987
pathway order: PathwayInteraction/1966
pathway order: PathwayInteraction/1988
pathway order: PathwayInteraction/1963
pathway order: PathwayInteraction/1985
pathway order: PathwayInteraction/1964
pathway order: PathwayInteraction/1986
pathway order: PathwayInteraction/1961
pathway order: PathwayInteraction/1983
pathway order: PathwayInteraction/1962
pathway order: PathwayInteraction/1984
pathway order: PathwayInteraction/1981
pathway order: PathwayInteraction/1960
pathway order: PathwayInteraction/1982
pathway order: PathwayInteraction/1980
pathway order: PathwayInteraction/1958
pathway order: PathwayInteraction/1959
pathway order: PathwayInteraction/1978
pathway order: PathwayInteraction/1957
pathway order: PathwayInteraction/1979
pathway order: PathwayInteraction/1976
pathway order: PathwayInteraction/1977
pathway order: PathwayInteraction/1974
pathway order: PathwayInteraction/1975
pathway order: PathwayInteraction/1972
pathway order: PathwayInteraction/1973
pathway order: PathwayInteraction/1970
pathway order: PathwayInteraction/1971
pathway component: Reaction179047
pathway component: Interaction1961
pathway component: Interaction1983
pathway component: Interaction1960
pathway component: Interaction1982
pathway component: Interaction1981
pathway component: Interaction1980
pathway component: Interaction1965
pathway component: Interaction1987
pathway component: Interaction1964
pathway component: Interaction1986
pathway component: Interaction1963
pathway component: Interaction1985
pathway component: Interaction1962
pathway component: Interaction1984
pathway component: Interaction1969
pathway component: Interaction1968
pathway component: Interaction1967
pathway component: Interaction1966
pathway component: Interaction1988
pathway component: Interaction1972
pathway component: Interaction1971
pathway component: Interaction1970
pathway component: Interaction1976
pathway component: Interaction1975
pathway component: Interaction1974
pathway component: Interaction1973
pathway component: Interaction1958
pathway component: Interaction1957
pathway component: Interaction1979
pathway component: Interaction1978
pathway component: Interaction1977
pathway component: Interaction1959
xref: Reference/SMPDB SMP0120913
xref: Reference/PathWhiz PW122176
organism: Mus musculus

Toll-like receptor 6
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 6

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: Reference/UniProt Q9R1J6
organism: Mus musculus

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
type: Protein
cellular location: Cytoplasm
entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Protein/21069 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase kinase kinase 7
stoichiometric coefficient: 1.0

Reference/UniProt Q99KP4
type: UnificationXref
id: Q99KP4
db: UniProt

Myeloid differentiation primary response protein MyD88
type: Protein
cellular location: Cytoplasm
entity reference: Myeloid differentiation primary response protein MyD88

Toll-like receptor 7
type: ProteinReference
xref: Reference/UniProt Q923I1
organism: Mus musculus

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor NF-kappa-B p105 subunit

ChemicalStructure/PW C008388
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q9EPW5
type: UnificationXref
id: Q9EPW5
db: UniProt

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: Reference/UniProt P47809
organism: Mus musculus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: Reference/UniProt Q9QZ80
organism: Mus musculus

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: Reference/UniProt Q9D2X3
organism: Mus musculus

Reference/UniProt Q62025
type: UnificationXref
id: Q62025
db: UniProt

Reference/UniProt Q99MQ8
type: UnificationXref
id: Q99MQ8
db: UniProt

Protein/22186 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-interacting protein
stoichiometric coefficient: 1.0

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: Reference/UniProt Q80ZX5
organism: Mus musculus

Lymphocyte antigen 96
type: Protein
cellular location: Cytoplasm
entity reference: Lymphocyte antigen 96

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: Reference/UniProt Q8C712
organism: Mus musculus

Reference/ChEBI CHEBI 36704
type: UnificationXref
id: CHEBI:36704
db: ChEBI

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta

Transcription factor p65
type: ProteinReference
xref: Reference/UniProt Q62025
organism: Mus musculus

Toll-like receptor 9
type: Protein
entity reference: Toll-like receptor 9