Reference/UniProt P49185
type: UnificationXref
id: P49185
db: UniProt

Toll-Like Receptor Pathway 2
type: Pathway
pathway order: PathwayInteraction/2719
pathway order: PathwayInteraction/2717
pathway order: PathwayInteraction/2718
pathway order: PathwayInteraction/2715
pathway order: PathwayInteraction/2716
pathway order: PathwayInteraction/2713
pathway order: PathwayInteraction/2714
pathway order: PathwayInteraction/2711
pathway order: PathwayInteraction/2733
pathway order: PathwayInteraction/2712
pathway order: PathwayInteraction/2731
pathway order: PathwayInteraction/2710
pathway order: PathwayInteraction/2732
pathway order: PathwayInteraction/2730
pathway order: PathwayEnzymeReaction/2120938
pathway order: PathwayInteraction/2708
pathway order: PathwayInteraction/2709
pathway order: PathwayInteraction/2706
pathway order: PathwayInteraction/2728
pathway order: PathwayInteraction/2707
pathway order: PathwayInteraction/2729
pathway order: PathwayInteraction/2704
pathway order: PathwayInteraction/2726
pathway order: PathwayInteraction/2705
pathway order: PathwayInteraction/2727
pathway order: PathwayInteraction/2702
pathway order: PathwayInteraction/2724
pathway order: PathwayInteraction/2703
pathway order: PathwayInteraction/2725
pathway order: PathwayInteraction/2722
pathway order: PathwayInteraction/2723
pathway order: PathwayInteraction/2720
pathway order: PathwayInteraction/2721
pathway component: Interaction2730
pathway component: Interaction2731
pathway component: Reaction179123
pathway component: Interaction2714
pathway component: Interaction2715
pathway component: Interaction2716
pathway component: Interaction2717
pathway component: Interaction2710
pathway component: Interaction2732
pathway component: Interaction2711
pathway component: Interaction2733
pathway component: Interaction2712
pathway component: Interaction2713
pathway component: Interaction2718
pathway component: Interaction2719
pathway component: Interaction2720
pathway component: Interaction2703
pathway component: Interaction2725
pathway component: Interaction2704
pathway component: Interaction2726
pathway component: Interaction2705
pathway component: Interaction2727
pathway component: Interaction2706
pathway component: Interaction2728
pathway component: Interaction2721
pathway component: Interaction2722
pathway component: Interaction2723
pathway component: Interaction2702
pathway component: Interaction2724
pathway component: Interaction2707
pathway component: Interaction2729
pathway component: Interaction2708
pathway component: Interaction2709
xref: Reference/PathWhiz PW122224
xref: Reference/SMPDB SMP0120961
organism: Rattus norvegicus

Monocyte differentiation antigen CD14
type: Protein
cellular location: Cytoplasm
entity reference: Monocyte differentiation antigen CD14

Reference/UniProt Q7TQN4
type: UnificationXref
id: Q7TQN4
db: UniProt

RCG59826
type: Protein
cellular location: Cytoplasm
entity reference: RCG59826

Toll-like receptor 4
type: Protein
cellular location: Cytoplasm
entity reference: Toll-like receptor 4

TNF receptor-associated factor 6
type: ProteinReference
xref: Reference/UniProt B5DF45
organism: Rattus norvegicus

direct_interaction
type: InteractionVocabulary

Mitogen-activated protein kinase kinase kinase 7
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 7

NF-kappa-B inhibitor alpha
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B inhibitor alpha

Protein/22099 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: RCG22794, isoform CRA_a
stoichiometric coefficient: 1.0

NF-kappa-B essential modulator
type: Protein
cellular location: Cytoplasm
entity reference: NF-kappa-B essential modulator

Reference/ChEBI CHEBI 59309
type: UnificationXref
id: CHEBI:59309
db: ChEBI

TNF receptor-associated factor 6
type: Protein
cellular location: Cytoplasm
entity reference: TNF receptor-associated factor 6

Toll-like receptor 4
type: Protein
cellular location: Cell Membrane
entity reference: Toll-like receptor 4

MD2
type: Protein
cellular location: Cell Membrane
entity reference: MD2

Monocyte differentiation antigen CD14
type: Protein
entity reference: Monocyte differentiation antigen CD14

NF-kappa-B essential modulator
type: ProteinReference
xref: Reference/UniProt Q6TMG5
organism: Rattus norvegicus

Reaction179123
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/11426 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/11427 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/19512 Cytoplasm/Stoichiometry/1.0
right: NF-kappa-B inhibitor alpha
right: NFKB1,RELA complex
spontaneous: false
left: NFKBIA, NFKB1, RELA complex
name: NFKBIA, NFKB1, RELA complex → NFKB1,RELA complex + NFKBIA with phosphate
conversion direction: LEFT_TO_RIGHT

ProteinComplex/11427 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NFKB1,RELA complex
stoichiometric coefficient: 1.0

CpG-DNA
type: DnaReference
organism: Rattus norvegicus

Double-Stranded RNA
type: DnaReference
organism: Rattus norvegicus

Protein/21290 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Liproproteins
type: ProteinReference
organism: Rattus norvegicus

MD2
type: Protein
cellular location: Cytoplasm
entity reference: MD2

Protein/22184 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: MD2
stoichiometric coefficient: 1.0

Rattus norvegicus
type: BioSource
xref: Reference/TAXONOMY 10116

LPS core
type: SmallMolecule
cellular location: Cell Membrane
entity reference: LPS core

Imiquimod
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0014862
xref: Reference/ChEBI CHEBI 36704
xref: Reference/ChemSpider 51809
xref: Reference/PubChem-compound 57469
xref: Reference/CAS 99011-02-6
chemical formula: C14H16N4
molecular weight: 240.1375
structure: ChemicalStructure/PW C009198

Imiquimod
type: SmallMolecule
entity reference: Imiquimod

Inhibitor of nuclear factor kappa-B kinase
type: Complex
cellular location: Cytoplasm
component: Inhibitor of nuclear factor kappa-B kinase subunit beta
component: NF-kappa-B essential modulator

Reference/BioCyc CPD0-2271
type: UnificationXref
id: CPD0-2271
db: BioCyc

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: Reference/UniProt Q4KSH7
organism: Rattus norvegicus

MD2
type: ProteinReference
xref: Reference/UniProt Q56DL5
organism: Rattus norvegicus

Toll-interacting protein
type: ProteinReference
xref: Reference/UniProt A2RUW1
organism: Rattus norvegicus

Reference/KEGG Compound c0338
type: UnificationXref
id: c0338
db: KEGG Compound

Mitogen-activated protein kinase 8
type: ProteinReference
xref: Reference/UniProt P49185
organism: Rattus norvegicus

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Monocyte differentiation antigen CD14
type: ProteinReference
xref: Reference/UniProt Q6GT04
organism: Rattus norvegicus

Reference/UniProt Q6GT04
type: UnificationXref
id: Q6GT04
db: UniProt

Reference/HMDB HMDB0014862
type: UnificationXref
id: HMDB0014862
db: HMDB

Toll-interacting protein
type: Protein
cellular location: Cytoplasm
entity reference: Toll-interacting protein

Mitogen-activated protein kinase 14
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 14

Reference/ChemSpider 51809
type: UnificationXref
id: 51809
db: ChemSpider

Reference/PubChem-compound 53481794
type: UnificationXref
id: 53481794
db: PubChem-compound

ChemicalStructure/PW C009198
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)CN1C=NC2=C1C1=CC=CC=C1N=C2N

TAB Complex
type: Complex
cellular location: Cytoplasm
component: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
component: RCG59826

Reference/UniProt P0C8E4
type: UnificationXref
id: P0C8E4
db: UniProt

Toll-like receptor 4
type: Protein
entity reference: Toll-like receptor 4

Liproproteins
type: Protein
cellular location: Cytoplasm
entity reference: Liproproteins

Insulin-like growth factor-binding protein complex acid labile subunit
type: ProteinReference
xref: Reference/UniProt P35859
organism: Rattus norvegicus

Mitogen-activated protein kinase kinase kinase 7 (Rattus norvegicus)_TAB Complex (Rattus norvegicus)
type: Complex
component stoichiometry: ProteinComplex/12663 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21067 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Mitogen-activated protein kinase kinase kinase 7
component: TAB Complex

Mitogen-activated protein kinase 14
type: ProteinReference
xref: Reference/UniProt Q99MG4
organism: Rattus norvegicus

RELA
type: Protein
cellular location: Cytoplasm
entity reference: RELA

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta

Reference/UniProt B5DF45
type: UnificationXref
id: B5DF45
db: UniProt

Monocyte differentiation antigen CD14
type: Protein
cellular location: Cell Membrane
entity reference: Monocyte differentiation antigen CD14

Insulin-like growth factor-binding protein complex acid labile subunit
type: Protein
cellular location: Cytoplasm
entity reference: Insulin-like growth factor-binding protein complex acid labile subunit

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

RCG22794, isoform CRA_a
type: ProteinReference
xref: Reference/UniProt D3ZXA5
organism: Rattus norvegicus

RCG59826
type: ProteinReference
organism: Rattus norvegicus

Protein/21067 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase kinase kinase 7
stoichiometric coefficient: 1.0

Reference/TAXONOMY 10116
type: UnificationXref
id: 10116
db: TAXONOMY

Reference/UniProt P35859
type: UnificationXref
id: P35859
db: UniProt

Reference/UniProt Q56DL5
type: UnificationXref
id: Q56DL5
db: UniProt

Reference/UniProt Q9QY78
type: UnificationXref
id: Q9QY78
db: UniProt

Reference/UniProt B2RYS5
type: UnificationXref
id: B2RYS5
db: UniProt

Reference/UniProt Q99MG4
type: UnificationXref
id: Q99MG4
db: UniProt

Dual specificity mitogen-activated protein kinase kinase 7
type: Protein
cellular location: Cytoplasm
entity reference: Dual specificity mitogen-activated protein kinase kinase 7

RELA
type: ProteinReference
xref: Reference/UniProt Q7TQN4
organism: Rattus norvegicus

Toll-like receptor 4
type: ProteinReference
xref: Reference/UniProt Q9QX05
organism: Rattus norvegicus

Reference/UniProt Q4KSH7
type: UnificationXref
id: Q4KSH7
db: UniProt

Reference/UniProt Q4QQS0
type: UnificationXref
id: Q4QQS0
db: UniProt

Unknown
type: Protein
entity reference: Unknown

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
type: ProteinReference
xref: Reference/UniProt Q5U303
organism: Rattus norvegicus

Mitogen-activated protein kinase kinase kinase 7
type: ProteinReference
xref: Reference/UniProt P0C8E4
organism: Rattus norvegicus

Double-Stranded RNA
type: Dna
entity reference: Double-Stranded RNA

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

CpG-DNA
type: Dna
entity reference: CpG-DNA

Reference/UniProt Q5XIC2
type: UnificationXref
id: Q5XIC2
db: UniProt

Reference/UniProt Q5U303
type: UnificationXref
id: Q5U303
db: UniProt

NFKB1,RELA complex
type: Complex
cellular location: Cytoplasm
component: RELA
component: Nuclear factor NF-kappa-B p105 subunit

Interaction2714
type: MolecularInteraction
interaction type: direct_interaction
name: Toll/interleukin-1 receptor domain-containing adapter protein (Rattus norvegicus) + Toll-interacting protein (Rattus norvegicus) activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll/interleukin-1 receptor domain-containing adapter protein (Rattus norvegicus)_Toll-interacting protein (Rattus norvegicus)

Interaction2715
type: MolecularInteraction
interaction type: direct_interaction
name: CpG-DNA activates Toll-like receptor 9
participant: Insulin-like growth factor-binding protein complex acid labile subunit
participant: CpG-DNA

Interaction2716
type: MolecularInteraction
interaction type: direct_interaction
name: Imiquimod activates Toll-like receptor 7
participant: Toll-like receptor 4
participant: Imiquimod

Interaction2717
type: MolecularInteraction
interaction type: direct_interaction
name: Double-Stranded RNA activates Toll-like receptor 3
participant: Double-Stranded RNA
participant: Insulin-like growth factor-binding protein complex acid labile subunit

Interaction2710
type: MolecularInteraction
interaction type: direct_interaction
name: LPS core activates Toll-like receptor 4 (Rattus norvegicus) + Lymphocyte antigen 96 (Rattus norvegicus)
participant: LPS core
participant: Toll-like receptor 4 (Rattus norvegicus)_Lymphocyte antigen 96 (Rattus norvegicus)

Interaction2711
type: MolecularInteraction
interaction type: direct_interaction
name: LPS core activates Monocyte differentiation antigen CD14
participant: LPS core
participant: Monocyte differentiation antigen CD14

Interaction2712
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates Toll-like receptor 4 (Rattus norvegicus) + Lymphocyte antigen 96 (Rattus norvegicus)
participant: Monocyte differentiation antigen CD14
participant: Toll-like receptor 4 (Rattus norvegicus)_Lymphocyte antigen 96 (Rattus norvegicus)

Interaction2713
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 4 (Rattus norvegicus) + Lymphocyte antigen 96 (Rattus norvegicus) activates Toll/interleukin-1 receptor domain-containing adapter protein (Rattus norvegicus) + Toll-interacting protein (Rattus norvegicus)
participant: Toll/interleukin-1 receptor domain-containing adapter protein (Rattus norvegicus)_Toll-interacting protein (Rattus norvegicus)
participant: Toll-like receptor 4 (Rattus norvegicus)_Lymphocyte antigen 96 (Rattus norvegicus)

Reference/CAS 99011-02-6
type: UnificationXref
id: 99011-02-6
db: CAS

Nuclear factor NF-kappa-B p105 subunit
type: Protein
cellular location: Cytoplasm
entity reference: Nuclear factor NF-kappa-B p105 subunit

Interaction2718
type: MolecularInteraction
interaction type: direct_interaction
name: Flagellin activates Toll-like receptor 5
participant: Toll-like receptor 4
participant: Unknown

Interaction2719
type: MolecularInteraction
interaction type: direct_interaction
name: Double-Stranded RNA activates Toll-like receptor 8
participant: Toll-like receptor 4
participant: Double-Stranded RNA

MYD88,IRAK (myddosome)
type: Complex
cellular location: Cytoplasm
component: Myeloid differentiation primary response protein MyD88
component: Interleukin-1 receptor-associated kinase-like 2

Toll/interleukin-1 receptor domain-containing adapter protein (Rattus norvegicus)_Toll-interacting protein (Rattus norvegicus)
type: Complex
component stoichiometry: Protein/22185 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/22099 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: RCG22794, isoform CRA_a
component: Toll-interacting protein

Reference/PubChem-compound 57469
type: UnificationXref
id: 57469
db: PubChem-compound

Reference/HMDB HMDB0013471
type: UnificationXref
id: HMDB0013471
db: HMDB

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q5XIC2
organism: Rattus norvegicus

Interaction2703
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates TLR2,6
participant: Liproproteins
participant: Toll-like receptor 4

Interaction2704
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates TLR2,6
participant: Monocyte differentiation antigen CD14
participant: Toll-like receptor 4

Interaction2705
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates TLR1,2
participant: Liproproteins
participant: Toll-like receptor 4

Interaction2706
type: MolecularInteraction
interaction type: direct_interaction
name: Monocyte differentiation antigen CD14 activates TLR1,2
participant: Monocyte differentiation antigen CD14
participant: Toll-like receptor 4

Double-Stranded RNA
type: Dna
cellular location: Cytoplasm
entity reference: Double-Stranded RNA

Interaction2702
type: MolecularInteraction
interaction type: direct_interaction
name: Liproproteins activates Monocyte differentiation antigen CD14
participant: Monocyte differentiation antigen CD14
participant: Liproproteins

LPS core
type: SmallMolecule
entity reference: LPS core

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q62925
organism: Rattus norvegicus

Interaction2707
type: MolecularInteraction
interaction type: direct_interaction
name: TLR1,2 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 4

LPS core
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 59309
xref: Reference/KEGG Compound c0338
xref: Reference/PubChem-compound 53481794
xref: Reference/HMDB HMDB0013471
xref: Reference/BioCyc CPD0-2271
chemical formula: C175H317N5O101P6
molecular weight: 4290.8247
structure: ChemicalStructure/PW C008388

Interaction2708
type: MolecularInteraction
interaction type: direct_interaction
name: TLR2,6 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 4

Interaction2709
type: MolecularInteraction
interaction type: direct_interaction
name: MYD88,IRAK (myddosome) activates TNF receptor-associated factor 6
participant: MYD88,IRAK (myddosome)
participant: TNF receptor-associated factor 6

Reference/UniProt A2RUW1
type: UnificationXref
id: A2RUW1
db: UniProt

Protein/22185 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-interacting protein
stoichiometric coefficient: 1.0

Toll-like receptor 4 (Rattus norvegicus)_Lymphocyte antigen 96 (Rattus norvegicus)
type: Complex
component stoichiometry: Protein/22184 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/21290 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: MD2
component: Toll-like receptor 4

Toll-like receptor 4 (Rattus norvegicus)_Lymphocyte antigen 96 (Rattus norvegicus)
type: Complex
component stoichiometry: Protein/21290 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/22184 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Toll-like receptor 4
component: MD2

Interleukin-1 receptor-associated kinase-like 2
type: Protein
cellular location: Cytoplasm
entity reference: Interleukin-1 receptor-associated kinase-like 2

Interaction2730
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 7 (Rattus norvegicus) + TAB Complex (Rattus norvegicus) activates Mitogen-activated protein kinase kinase kinase 14
participant: Mitogen-activated protein kinase 14
participant: Mitogen-activated protein kinase kinase kinase 7 (Rattus norvegicus)_TAB Complex (Rattus norvegicus)

Interaction2731
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 14 activates Inhibitor of nuclear factor kappa-B kinase
participant: Inhibitor of nuclear factor kappa-B kinase
participant: Mitogen-activated protein kinase 14

Reference/UniProt Q9QX05
type: UnificationXref
id: Q9QX05
db: UniProt

Reference/UniProt Q62925
type: UnificationXref
id: Q62925
db: UniProt

Interleukin-1 receptor-associated kinase-like 2
type: ProteinReference
xref: Reference/UniProt Q4QQS0
organism: Rattus norvegicus

Reference/PathWhiz PW122224
type: UnificationXref
id: PW122224
db: PathWhiz

Myeloid differentiation primary response protein MyD88
type: ProteinReference
xref: Reference/UniProt Q4QRC0
organism: Rattus norvegicus

Myeloid differentiation primary response protein MyD88
type: Protein
cellular location: Cytoplasm
entity reference: Myeloid differentiation primary response protein MyD88

RCG22794, isoform CRA_a
type: Protein
cellular location: Cytoplasm
entity reference: RCG22794, isoform CRA_a

Interaction2732
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 7 (Rattus norvegicus) + TAB Complex (Rattus norvegicus) activates Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate
participant: Dual specificity mitogen-activated protein kinase kinase 7
participant: Mitogen-activated protein kinase kinase kinase 7 (Rattus norvegicus)_TAB Complex (Rattus norvegicus)

Interaction2733
type: MolecularInteraction
interaction type: direct_interaction
name: Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate activates Mitogen-activated protein kinase 8 without Magnesium
participant: Mitogen-activated protein kinase 8
participant: Dual specificity mitogen-activated protein kinase kinase 7

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

ProteinComplex/11426 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NFKBIA, NFKB1, RELA complex
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 8
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase 8

Interaction2720
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 9 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Insulin-like growth factor-binding protein complex acid labile subunit

Protein/22184 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: MD2
stoichiometric coefficient: 1.0

Interaction2725
type: MolecularInteraction
interaction type: direct_interaction
name: TNF receptor-associated factor 6 activates Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
participant: TNF receptor-associated factor 6
participant: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Interaction2726
type: MolecularInteraction
interaction type: direct_interaction
name: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium
participant: Mitogen-activated protein kinase kinase kinase 1
participant: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Interaction2727
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Inhibitor of nuclear factor kappa-B kinase
participant: Inhibitor of nuclear factor kappa-B kinase
participant: Mitogen-activated protein kinase kinase kinase 1

Interaction2728
type: MolecularInteraction
interaction type: direct_interaction
name: Inhibitor of nuclear factor kappa-B kinase activates NFKBIA, NFKB1, RELA complex
participant: Inhibitor of nuclear factor kappa-B kinase
participant: NFKBIA, NFKB1, RELA complex

Interaction2721
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 3 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Insulin-like growth factor-binding protein complex acid labile subunit

Interaction2722
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 8 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 4

Interaction2723
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 7 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 4

Mitogen-activated protein kinase kinase kinase 1
type: Protein
cellular location: Cytoplasm
entity reference: Mitogen-activated protein kinase kinase kinase 1

Interaction2724
type: MolecularInteraction
interaction type: direct_interaction
name: Toll-like receptor 5 activates MYD88,IRAK (myddosome)
participant: MYD88,IRAK (myddosome)
participant: Toll-like receptor 4

ChemicalStructure/PW C008388
type: ChemicalStructure
structure format: SMILES

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: Reference/UniProt Q9QY78
organism: Rattus norvegicus

Interaction2729
type: MolecularInteraction
interaction type: direct_interaction
name: TNF receptor-associated factor 6 activates Mitogen-activated protein kinase kinase kinase 7 (Rattus norvegicus) + TAB Complex (Rattus norvegicus)
participant: TNF receptor-associated factor 6
participant: Mitogen-activated protein kinase kinase kinase 7 (Rattus norvegicus)_TAB Complex (Rattus norvegicus)

Reference/UniProt D3ZXA5
type: UnificationXref
id: D3ZXA5
db: UniProt

Unknown
type: ProteinReference
organism: Rattus norvegicus

Reference/SMPDB SMP0120961
type: UnificationXref
id: SMP0120961
db: SMPDB

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
type: Protein
cellular location: Cytoplasm
entity reference: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: Reference/UniProt B2RYS5
organism: Rattus norvegicus

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: Reference/UniProt Q63369
organism: Rattus norvegicus

Reference/UniProt Q63369
type: UnificationXref
id: Q63369
db: UniProt

NFKBIA, NFKB1, RELA complex
type: Complex
cellular location: Cytoplasm
component: RELA
component: NF-kappa-B inhibitor alpha
component: Nuclear factor NF-kappa-B p105 subunit

ProteinComplex/12663 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: TAB Complex
stoichiometric coefficient: 1.0

Insulin-like growth factor-binding protein complex acid labile subunit
type: Protein
entity reference: Insulin-like growth factor-binding protein complex acid labile subunit

Reference/ChEBI CHEBI 36704
type: UnificationXref
id: CHEBI:36704
db: ChEBI

Protein/19512 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NF-kappa-B inhibitor alpha
stoichiometric coefficient: 1.0

Protein/21290 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Toll-like receptor 4
stoichiometric coefficient: 1.0

Reference/UniProt Q6TMG5
type: UnificationXref
id: Q6TMG5
db: UniProt

Reference/UniProt Q4QRC0
type: UnificationXref
id: Q4QRC0
db: UniProt