Piroxicam is a nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects. Piroxicam will be transported via Solute carrier family 22 member 6, Solute carrier family 22 member 8, Solute carrier family 22 member 11 and Solute carrier organic anion transporter family member 2B1 into cell. After get into cell, piroxicam will inhibit the Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1's function; so that Prostaglandin G2 couldn't be transferred into Prostaglandin H2.
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Piroxicam Action Pathway Xuan References
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