Reference/ChemSpider 388357
type: UnificationXref
id: 388357
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Farnesyl pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Farnesyl pyrophosphate

Reference/UniProt Q12063
type: UnificationXref
id: Q12063
db: UniProt

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc MEVALONATE
type: UnificationXref
id: MEVALONATE
db: BioCyc

Reference/ChemSpider 388353
type: UnificationXref
id: 388353
db: ChemSpider

2.5.1.-,2.5.1.1, 2.5.1.29, 2.5.1.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000768/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001039/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002145/Stoichiometry/1.0
right: Geranylgeranyl-PP
right: Pyrophosphate
spontaneous: false
EC number: 2.5.1.-,2.5.1.1, 2.5.1.29, 2.5.1.10
left: Farnesyl pyrophosphate
left: Isopentenyl pyrophosphate
name: Farnesyl pyrophosphate + Isopentenyl pyrophosphate → Geranylgeranyl-PP + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 6699-20-3
type: UnificationXref
id: 6699-20-3
db: CAS

2.5.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C007741/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000768/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001039/Stoichiometry/3.0
right: All-trans-hexaprenyl diphosphate
right: Pyrophosphate
spontaneous: false
EC number: 2.5.1.-
left: Farnesyl pyrophosphate
left: Isopentenyl pyrophosphate
name: Farnesyl pyrophosphate + 3 Isopentenyl pyrophosphate → All-trans-hexaprenyl diphosphate + 3 Pyrophosphate
conversion direction: LEFT_TO_RIGHT

2.5.1.87
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170/Stoichiometry/13.0
participant stoichiometry: Compound/PW C044584/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000768/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001039/Stoichiometry/13.0
right: di-trans, poly-cis-polyprenyl diphosphate (C80)
right: Pyrophosphate
spontaneous: false
EC number: 2.5.1.87
left: Farnesyl pyrophosphate
left: Isopentenyl pyrophosphate
name: Farnesyl pyrophosphate + 13 Isopentenyl pyrophosphate → di-trans, poly-cis-polyprenyl diphosphate (C80) + 13 Pyrophosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/PathWhiz PW122261
type: UnificationXref
id: PW122261
db: PathWhiz

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Mevalonic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25351
xref: Reference/PubChem-compound 449
xref: Reference/CAS 150-97-0
xref: Reference/KEGG Compound C00418
xref: Reference/HMDB HMDB0000227
xref: Reference/BioCyc MEVALONATE
xref: Reference/ChemSpider 436
chemical formula: C6H12O4
molecular weight: 148.07356
structure: ChemicalStructure/PW C000152

Reference/UniProt P08524
type: UnificationXref
id: P08524
db: UniProt

Reference/KEGG Compound C00448
type: UnificationXref
id: C00448
db: KEGG Compound

ReactionCatalysis6580
type: Catalysis
controller: 3-ketoacyl-CoA thiolase, peroxisomal
controlled: 2.3.1.9
control type: ACTIVATION

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/ChemSpider 393270
type: UnificationXref
id: 393270
db: ChemSpider

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Protein/11193 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Farnesyl pyrophosphate synthase
stoichiometric coefficient: 2.0

Unknown
type: ProteinReference
organism: Saccharomyces cerevisiae

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Mevalonic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Mevalonic acid

Dimethylallylpyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dimethylallylpyrophosphate

Reference/CAS 1553-55-5
type: UnificationXref
id: 1553-55-5
db: CAS

Isopentenyl-diphosphate Delta-isomerase
type: Protein
cellular location: Peroxisome
entity reference: Isopentenyl-diphosphate Delta-isomerase

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/CAS 358-72-5
type: UnificationXref
id: 358-72-5
db: CAS

Geranylgeranyl pyrophosphate synthase
type: Complex
component stoichiometry: Protein/9969/Stoichiometry/6.0
component: Unknown

Compound/PW C001039/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isopentenyl pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C00332
type: UnificationXref
id: C00332
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

(R)-5-Diphosphomevalonic acid
type: SmallMolecule
cellular location: Peroxisome
entity reference: (R)-5-Diphosphomevalonic acid

Carbon dioxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbon dioxide

ChemicalStructure/PW C007741
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

Reference/BioCyc GERANYLGERANYL-PP
type: UnificationXref
id: GERANYLGERANYL-PP
db: BioCyc

Reference/HMDB HMDB0001090
type: UnificationXref
id: HMDB0001090
db: HMDB

Reference/BioCyc CPD-641
type: UnificationXref
id: CPD-641
db: BioCyc

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/KEGG Compound C00341
type: UnificationXref
id: C00341
db: KEGG Compound

Reference/UniProt P18900
type: UnificationXref
id: P18900
db: UniProt

Reference/ChEBI CHEBI 17211
type: UnificationXref
id: CHEBI:17211
db: ChEBI

Reference/PubChem-compound 445713
type: UnificationXref
id: 445713
db: PubChem-compound

Saccharomyces cerevisiae
type: BioSource
xref: Reference/TAXONOMY 4932

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis6922
type: Catalysis
controller: dehydrodolichyl diphosphate synthase complex
controlled: 2.5.1.87
control type: ACTIVATION

Adenosine triphosphate
type: SmallMolecule
cellular location: Peroxisome
entity reference: Adenosine triphosphate

Reference/SMPDB SMP0120994
type: UnificationXref
id: SMP0120994
db: SMPDB

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Compound/PW C000874 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethylallylpyrophosphate
stoichiometric coefficient: 1.0

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Acetyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetyl-CoA

Geranylgeranyl pyrophosphate synthase
type: Complex
component stoichiometry: Protein/9969 Cytoplasm/Stoichiometry/6.0
cellular location: Cytoplasm
component: Unknown

ReactionCatalysis6921
type: Catalysis
controller: Hexaprenyl pyrophosphate synthase, mitochondrial
controlled: 2.5.1.-
control type: ACTIVATION

ReactionCatalysis6920
type: Catalysis
controller: Geranylgeranyl pyrophosphate synthase
controlled: 2.5.1.-,2.5.1.1, 2.5.1.29, 2.5.1.10
control type: ACTIVATION

Reference/HMDB HMDB0004486
type: UnificationXref
id: HMDB0004486
db: HMDB

Compound/PW C001039 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isopentenyl pyrophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/PubChem-compound 449
type: UnificationXref
id: 449
db: PubChem-compound

Mevalonic acid-5P
type: SmallMolecule
cellular location: Peroxisome
entity reference: Mevalonic acid-5P

Reference/KEGG Compound C00353
type: UnificationXref
id: C00353
db: KEGG Compound

Isopentenyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00129
xref: Reference/ChemSpider 1158
xref: Reference/PubChem-compound 1195
xref: Reference/CAS 358-71-4
xref: Reference/HMDB HMDB0001347
xref: Reference/ChEBI CHEBI 16584
chemical formula: C5H12O7P2
molecular weight: 246.00583
structure: ChemicalStructure/PW C001039

Reference/KEGG Compound C00356
type: UnificationXref
id: C00356
db: KEGG Compound

Reference/KEGG Compound C00235
type: UnificationXref
id: C00235
db: KEGG Compound

Reference/ChEBI CHEBI 16057
type: UnificationXref
id: CHEBI:16057
db: ChEBI

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

2.3.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001142 Cytoplasm/Stoichiometry/1.0
right: Acetoacetyl-CoA
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.9
left: Acetyl-CoA
name: 2 Acetyl-CoA ↔ Acetoacetyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/UniProt P24521
type: UnificationXref
id: P24521
db: UniProt

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Geranyl-PP
type: SmallMoleculeReference
xref: Reference/BioCyc GERANYL-PP
xref: Reference/CAS 763-10-0
xref: Reference/KEGG Compound C00341
xref: Reference/PubChem-compound 445995
xref: Reference/HMDB HMDB0001285
xref: Reference/ChEBI CHEBI 17211
xref: Reference/ChemSpider 393471
chemical formula: C10H20O7P2
molecular weight: 314.06842
structure: ChemicalStructure/PW C000993

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Protein/9969/Stoichiometry/6.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 6.0

mevalonate kinase
type: ProteinReference
xref: Reference/UniProt P07277
organism: Saccharomyces cerevisiae

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Protein/9969 Cytoplasm/Stoichiometry/6.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 6.0

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00129
type: UnificationXref
id: C00129
db: KEGG Compound

Reference/ChemSpider 1158
type: UnificationXref
id: 1158
db: ChemSpider

3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
type: ProteinReference
xref: Reference/UniProt P12684
organism: Saccharomyces cerevisiae

Compound/PW C001036 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mevalonic acid-5P
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/PubChem-compound 447277
type: UnificationXref
id: 447277
db: PubChem-compound

Reference/UniProt P32377
type: UnificationXref
id: P32377
db: UniProt

Dimethylallylpyrophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-4211
xref: Reference/PubChem-compound 647
xref: Reference/CAS 358-72-5
xref: Reference/ChemSpider 627
xref: Reference/HMDB HMDB0001120
xref: Reference/KEGG Compound C00235
xref: Reference/ChEBI CHEBI 16057
chemical formula: C5H12O7P2
molecular weight: 246.00583
structure: ChemicalStructure/PW C000874

3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
type: ProteinReference
xref: Reference/UniProt P12683
organism: Saccharomyces cerevisiae

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/ChEBI CHEBI 15899
type: UnificationXref
id: CHEBI:15899
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADP

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADPH

Farnesyl pyrophosphate
type: SmallMolecule
entity reference: Farnesyl pyrophosphate

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Geranylgeranyl-PP
type: SmallMolecule
entity reference: Geranylgeranyl-PP

Reference/UniProt P15496
type: UnificationXref
id: P15496
db: UniProt

Geranylgeranyl-PP
type: SmallMoleculeReference
xref: Reference/CAS 6699-20-3
xref: Reference/ChemSpider 394418
xref: Reference/PubChem-compound 447277
xref: Reference/KEGG Compound C00353
xref: Reference/BioCyc GERANYLGERANYL-PP
xref: Reference/ChEBI CHEBI 48861
xref: Reference/HMDB HMDB0004486
chemical formula: C20H36O7P2
molecular weight: 450.19363
structure: ChemicalStructure/PW C002145

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/CAS 150-97-0
type: UnificationXref
id: 150-97-0
db: CAS

Reference/HMDB HMDB0000227
type: UnificationXref
id: HMDB0000227
db: HMDB

Compound/PW C044584/Stoichiometry/1.0
type: Stoichiometry
physical entity: di-trans, poly-cis-polyprenyl diphosphate (C80)
stoichiometric coefficient: 1.0

Compound/PW C000768/Stoichiometry/1.0
type: Stoichiometry
physical entity: Farnesyl pyrophosphate
stoichiometric coefficient: 1.0

Geranyl-PP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Geranyl-PP

Reference/ChEBI CHEBI 48861
type: UnificationXref
id: CHEBI:48861
db: ChEBI

Reference/ChemSpider 393471
type: UnificationXref
id: 393471
db: ChemSpider

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/KEGG Compound C01107
type: UnificationXref
id: C01107
db: KEGG Compound

Reference/ChemSpider 394418
type: UnificationXref
id: 394418
db: ChemSpider

Reference/BioCyc ALL-TRANS-HEXAPRENYL-DIPHOSPHATE
type: UnificationXref
id: ALL-TRANS-HEXAPRENYL-DIPHOSPHATE
db: BioCyc

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C001063 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 763-10-0
type: UnificationXref
id: 763-10-0
db: CAS

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Isopentenyl-diphosphate Delta-isomerase
type: ProteinReference
xref: Reference/UniProt P15496
organism: Saccharomyces cerevisiae

Diphosphomevalonate decarboxylase
type: ProteinReference
xref: Reference/UniProt P32377
organism: Saccharomyces cerevisiae

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Farnesyl pyrophosphate synthase
type: ProteinReference
xref: Reference/UniProt P08524
organism: Saccharomyces cerevisiae

Reference/ChemSpider 388531
type: UnificationXref
id: 388531
db: ChemSpider

Phosphomevalonate kinase
type: ProteinReference
xref: Reference/UniProt P24521
organism: Saccharomyces cerevisiae

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

2.7.1.36
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001036 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000152 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Mevalonic acid-5P
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.36
left: Adenosine triphosphate
left: Mevalonic acid
name: Adenosine triphosphate + Mevalonic acid → Adenosine diphosphate + Mevalonic acid-5P
conversion direction: LEFT_TO_RIGHT

2.7.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001036 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000857 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Peroxisome/Stoichiometry/1.0
right: (R)-5-Diphosphomevalonic acid
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.4.2
left: Adenosine triphosphate
left: Mevalonic acid-5P
name: Adenosine triphosphate + Mevalonic acid-5P → (R)-5-Diphosphomevalonic acid + Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Acetoacetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETOACETYL-COA
xref: Reference/PubChem-compound 439214
xref: Reference/ChEBI CHEBI 15345
xref: Reference/CAS 1420-36-6
xref: Reference/HMDB HMDB0001484
xref: Reference/KEGG Compound C00332
xref: Reference/ChemSpider 388353
chemical formula: C25H40N7O18P3S
molecular weight: 851.13635
structure: ChemicalStructure/PW C001142

Compound/PW C001063 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxy-3-methylglutaryl-CoA
stoichiometric coefficient: 1.0

4.1.1.33
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001039 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000857 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Carbon dioxide
right: Isopentenyl pyrophosphate
right: Adenosine diphosphate
right: Phosphate
spontaneous: false
EC number: 4.1.1.33
left: Adenosine triphosphate
left: (R)-5-Diphosphomevalonic acid
name: (R)-5-Diphosphomevalonic acid + Adenosine triphosphate → Adenosine diphosphate + Carbon dioxide + Isopentenyl pyrophosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Acetoacetyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetoacetyl-CoA

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
type: UnificationXref
id: 3-HYDROXY-3-METHYL-GLUTARYL-COA
db: BioCyc

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/PubChem-compound 439418
type: UnificationXref
id: 439418
db: PubChem-compound

Reaction6886
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001142 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
right: 3-Hydroxy-3-methylglutaryl-CoA
right: Coenzyme A
spontaneous: false
left: Water
left: Acetoacetyl-CoA
left: Acetyl-CoA
name: Acetoacetyl-CoA + Acetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

(R)-5-Diphosphomevalonic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001090
xref: Reference/BioCyc CPD-641
xref: Reference/ChEBI CHEBI 15899
xref: Reference/PubChem-compound 439418
xref: Reference/KEGG Compound C01143
xref: Reference/ChemSpider 388531
chemical formula: C6H14O10P2
molecular weight: 308.00623
structure: ChemicalStructure/PW C000857

Terpenoid Backbone Biosynthesis 1540198538
type: Pathway
pathway order: PathwayEnzymeReaction/2121349
pathway order: PathwayEnzymeReaction/2121348
pathway order: PathwayEnzymeReaction/2121347
pathway order: PathwayEnzymeReaction/2121346
pathway order: PathwayEnzymeReaction/2121345
pathway order: PathwayEnzymeReaction/2121344
pathway order: PathwayEnzymeReaction/2121343
pathway order: PathwayEnzymeReaction/2121342
pathway order: PathwayEnzymeReaction/2121353
pathway order: PathwayEnzymeReaction/2121341
pathway order: PathwayEnzymeReaction/2121352
pathway order: PathwayEnzymeReaction/2121340
pathway order: PathwayEnzymeReaction/2121351
pathway order: PathwayEnzymeReaction/2121350
pathway component: 2.7.1.36
pathway component: ReactionCatalysis6859
pathway component: 2.7.4.2
pathway component: ReactionCatalysis6858
pathway component: 2.5.1.-,2.5.1.1, 2.5.1.29, 2.5.1.10
pathway component: ReactionCatalysis6857
pathway component: 4.1.1.33
pathway component: 2.5.1.-
pathway component: ReactionCatalysis6856
pathway component: 2.5.1.87
pathway component: 2.3.1.9
pathway component: Reaction6886
pathway component: ReactionCatalysis6580
pathway component: 1.1.1.34
pathway component: ReactionCatalysis6922
pathway component: 5.3.3.2
pathway component: ReactionCatalysis6862
pathway component: Reaction6891
pathway component: ReactionCatalysis6861
pathway component: ReactionCatalysis6860
pathway component: Reaction6892
pathway component: ReactionCatalysis6882
pathway component: ReactionCatalysis6921
pathway component: ReactionCatalysis6920
pathway component: ReactionCatalysis6863
xref: Reference/SMPDB SMP0120994
xref: Reference/PathWhiz PW122261
organism: Saccharomyces cerevisiae

Reference/PubChem-compound 445995
type: UnificationXref
id: 445995
db: PubChem-compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C01230
type: UnificationXref
id: C01230
db: KEGG Compound

Isopentenyl pyrophosphate
type: SmallMolecule
entity reference: Isopentenyl pyrophosphate

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

Reference/PubChem-compound 439400
type: UnificationXref
id: 439400
db: PubChem-compound

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Mevalonic acid-5P
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439400
xref: Reference/HMDB HMDB0001343
xref: Reference/ChEBI CHEBI 17436
xref: Reference/KEGG Compound C01107
xref: Reference/BioCyc CPD-499
xref: Reference/ChemSpider 388517
xref: Reference/CAS 73566-35-5
chemical formula: C6H13O7P
molecular weight: 228.03989
structure: ChemicalStructure/PW C001036

Reference/UniProt P12684
type: UnificationXref
id: P12684
db: UniProt

Coenzyme A
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Coenzyme A

Reference/UniProt P12683
type: UnificationXref
id: P12683
db: UniProt

Compound/PW C000940 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 2.0

Reference/BioCyc CPD-499
type: UnificationXref
id: CPD-499
db: BioCyc

Reference/PubChem-compound 647
type: UnificationXref
id: 647
db: PubChem-compound

Reference/UniProt P27796
type: UnificationXref
id: P27796
db: UniProt

Reference/ChemSpider 388517
type: UnificationXref
id: 388517
db: ChemSpider

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Reference/CAS 372-97-4
type: UnificationXref
id: 372-97-4
db: CAS

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ReactionCatalysis6859
type: Catalysis
controller: Isopentenyl-diphosphate Delta-isomerase
controlled: 5.3.3.2
control type: ACTIVATION

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/HMDB HMDB0001343
type: UnificationXref
id: HMDB0001343
db: HMDB

ReactionCatalysis6858
type: Catalysis
controller: Diphosphomevalonate decarboxylase
controlled: 4.1.1.33
control type: ACTIVATION

ChemicalStructure/PW C001142
type: ChemicalStructure
structure format: SMILES

Peroxisome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005777

ReactionCatalysis6857
type: Catalysis
controller: Phosphomevalonate kinase
controlled: 2.7.4.2
control type: ACTIVATION

All-trans-hexaprenyl diphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5280413
xref: Reference/ChemSpider 4444089
xref: Reference/BioCyc ALL-TRANS-HEXAPRENYL-DIPHOSPHATE
xref: Reference/ChEBI CHEBI 17528
xref: Reference/KEGG Compound C01230
xref: Reference/HMDB HMDB0012188
chemical formula: C30H52O7P2
molecular weight: 586.31885
structure: ChemicalStructure/PW C007741

ReactionCatalysis6856
type: Catalysis
controller: mevalonate kinase
controlled: 2.7.1.36
control type: ACTIVATION

Mevalonic acid-5P
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Mevalonic acid-5P

Reference/HMDB HMDB0001347
type: UnificationXref
id: HMDB0001347
db: HMDB

Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C000857 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-5-Diphosphomevalonic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc GERANYL-PP
type: UnificationXref
id: GERANYL-PP
db: BioCyc

Hexaprenyl pyrophosphate synthase, mitochondrial
type: Protein
entity reference: Hexaprenyl pyrophosphate synthase, mitochondrial

ditrans,polycis-polyprenyl diphosphate synthase RER2
type: Protein
entity reference: ditrans,polycis-polyprenyl diphosphate synthase RER2

dehydrodolichyl diphosphate syntase complex subunit NUS1
type: Protein
entity reference: dehydrodolichyl diphosphate syntase complex subunit NUS1

ditrans,polycis-polyprenyl diphosphate synthase SRT1
type: Protein
entity reference: ditrans,polycis-polyprenyl diphosphate synthase SRT1

Reference/PubChem-compound 46926091
type: UnificationXref
id: 46926091
db: PubChem-compound

Reference/UniProt P07277
type: UnificationXref
id: P07277
db: UniProt

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Adenosine diphosphate
type: SmallMolecule
cellular location: Peroxisome
entity reference: Adenosine diphosphate

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

ChemicalStructure/PW C000857
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@](O)(CCOP(O)(=O)OP(O)(O)=O)CC(O)=O

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Compound/PW C007741/Stoichiometry/1.0
type: Stoichiometry
physical entity: All-trans-hexaprenyl diphosphate
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001036
type: ChemicalStructure
structure format: SMILES
structure data: C[C@@](O)(CCOP(O)(O)=O)CC(O)=O

Reference/UniProt Q03175
type: UnificationXref
id: Q03175
db: UniProt

5.3.3.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001039 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000874 Peroxisome/Stoichiometry/1.0
right: Dimethylallylpyrophosphate
spontaneous: false
EC number: 5.3.3.2
left: Isopentenyl pyrophosphate
name: Isopentenyl pyrophosphate ↔ Dimethylallylpyrophosphate
conversion direction: REVERSIBLE

ReactionCatalysis6862
type: Catalysis
controller: Farnesyl pyrophosphate synthase
controlled: Reaction6892
control type: ACTIVATION

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reaction6891
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001039 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000874 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000993 Cytoplasm/Stoichiometry/1.0
right: Geranyl-PP
right: Pyrophosphate
spontaneous: false
left: Dimethylallylpyrophosphate
left: Isopentenyl pyrophosphate
name: Dimethylallylpyrophosphate + Isopentenyl pyrophosphate → Geranyl-PP + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis6861
type: Catalysis
controller: Geranylgeranyl pyrophosphate synthase
controlled: Reaction6891
control type: ACTIVATION

Mevalonic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Mevalonic acid

ReactionCatalysis6860
type: Catalysis
controller: Farnesyl pyrophosphate synthase
controlled: Reaction6891
control type: ACTIVATION

Reaction6892
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001039 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000768 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000993 Cytoplasm/Stoichiometry/1.0
right: Farnesyl pyrophosphate
right: Pyrophosphate
spontaneous: false
left: Isopentenyl pyrophosphate
left: Geranyl-PP
name: Geranyl-PP + Isopentenyl pyrophosphate → Farnesyl pyrophosphate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

ReactionCatalysis6863
type: Catalysis
controller: Geranylgeranyl pyrophosphate synthase
controlled: Reaction6892
control type: ACTIVATION

Reference/BioCyc ACETOACETYL-COA
type: UnificationXref
id: ACETOACETYL-COA
db: BioCyc

Farnesyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00448
xref: Reference/HMDB HMDB0000961
xref: Reference/ChemSpider 393270
xref: Reference/ChEBI CHEBI 17407
xref: Reference/CAS 372-97-4
xref: Reference/BioCyc FARNESYL-PP
xref: Reference/PubChem-compound 445713
chemical formula: C15H28O7P2
molecular weight: 382.13104
structure: ChemicalStructure/PW C000768

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Farnesyl pyrophosphate synthase
type: Protein
cellular location: Cytoplasm
entity reference: Farnesyl pyrophosphate synthase

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/KEGG Compound C01143
type: UnificationXref
id: C01143
db: KEGG Compound

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 436
type: UnificationXref
id: 436
db: ChemSpider

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15467
xref: Reference/ChemSpider 388357
xref: Reference/CAS 1553-55-5
xref: Reference/BioCyc 3-HYDROXY-3-METHYL-GLUTARYL-COA
xref: Reference/KEGG Compound C00356
xref: Reference/HMDB HMDB0001375
xref: Reference/PubChem-compound 439218
chemical formula: C27H44N7O20P3S
molecular weight: 911.1575
structure: ChemicalStructure/PW C001063

Reference/ChEBI CHEBI 25351
type: UnificationXref
id: CHEBI:25351
db: ChEBI

Compound/PW C000170/Stoichiometry/13.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 13.0

ChemicalStructure/PW C000152
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)(CCO)CC(O)=O

Reference/PubChem-compound 439214
type: UnificationXref
id: 439214
db: PubChem-compound

3-ketoacyl-CoA thiolase, peroxisomal
type: Protein
cellular location: Cytoplasm
entity reference: 3-ketoacyl-CoA thiolase, peroxisomal

All-trans-hexaprenyl diphosphate
type: SmallMolecule
entity reference: All-trans-hexaprenyl diphosphate

Compound/PW C000152 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mevalonic acid
stoichiometric coefficient: 1.0

Isopentenyl pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Isopentenyl pyrophosphate

Compound/PW C001039/Stoichiometry/13.0
type: Stoichiometry
physical entity: Isopentenyl pyrophosphate
stoichiometric coefficient: 13.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0001120
type: UnificationXref
id: HMDB0001120
db: HMDB

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Reference/HMDB HMDB0001484
type: UnificationXref
id: HMDB0001484
db: HMDB

Reference/PubChem-compound 439218
type: UnificationXref
id: 439218
db: PubChem-compound

Reference/UniProt P35196
type: UnificationXref
id: P35196
db: UniProt

Reference/ChemSpider 4444089
type: UnificationXref
id: 4444089
db: ChemSpider

Reference/BioCyc CPD-4211
type: UnificationXref
id: CPD-4211
db: BioCyc

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/BioCyc FARNESYL-PP
type: UnificationXref
id: FARNESYL-PP
db: BioCyc

Reference/CAS 73566-35-5
type: UnificationXref
id: 73566-35-5
db: CAS

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/PubChem-compound 5280413
type: UnificationXref
id: 5280413
db: PubChem-compound

Compound/PW C001036 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mevalonic acid-5P
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000961
type: UnificationXref
id: HMDB0000961
db: HMDB

Reference/GENE ONTOLOGY GO 0005777
type: UnificationXref
id: GO:0005777
db: GENE ONTOLOGY

ChemicalStructure/PW C044584
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis6882
type: Catalysis
controller: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
controlled: 1.1.1.34
control type: ACTIVATION

Dimethylallylpyrophosphate
type: SmallMolecule
cellular location: Peroxisome
entity reference: Dimethylallylpyrophosphate

Reference/HMDB HMDB0001375
type: UnificationXref
id: HMDB0001375
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Farnesyl pyrophosphate synthase
type: Complex
component stoichiometry: Protein/11193 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Farnesyl pyrophosphate synthase

Reference/CAS 358-71-4
type: UnificationXref
id: 358-71-4
db: CAS

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

(R)-5-Diphosphomevalonic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: (R)-5-Diphosphomevalonic acid

Unknown
type: Protein
entity reference: Unknown

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Diphosphomevalonate decarboxylase
type: Protein
cellular location: Cytoplasm
entity reference: Diphosphomevalonate decarboxylase

Compound/PW C000993 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Geranyl-PP
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000768
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Coenzyme A

Compound/PW C000857 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: (R)-5-Diphosphomevalonic acid
stoichiometric coefficient: 1.0

ditrans,polycis-polyprenyl diphosphate synthase SRT1
type: ProteinReference
xref: Reference/UniProt Q03175
organism: Saccharomyces cerevisiae

Hexaprenyl pyrophosphate synthase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P18900
organism: Saccharomyces cerevisiae

3-Hydroxy-3-methylglutaryl-CoA
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 3-Hydroxy-3-methylglutaryl-CoA

dehydrodolichyl diphosphate syntase complex subunit NUS1
type: ProteinReference
xref: Reference/UniProt Q12063
organism: Saccharomyces cerevisiae

Compound/PW C001142 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetoacetyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C002145/Stoichiometry/1.0
type: Stoichiometry
physical entity: Geranylgeranyl-PP
stoichiometric coefficient: 1.0

ditrans,polycis-polyprenyl diphosphate synthase RER2
type: ProteinReference
xref: Reference/UniProt P35196
organism: Saccharomyces cerevisiae

Reference/CAS 1420-36-6
type: UnificationXref
id: 1420-36-6
db: CAS

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C001063
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 17436
type: UnificationXref
id: CHEBI:17436
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Phosphomevalonate kinase
type: Protein
cellular location: Peroxisome
entity reference: Phosphomevalonate kinase

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

3-hydroxy-3-methylglutaryl-coenzyme A reductase
type: Complex
component stoichiometry: Protein/11187 Endoplasmic Reticulum/Stoichiometry/2.0
cellular location: Endoplasmic Reticulum
component: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
component: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000414 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Reference/ChEBI CHEBI 16584
type: UnificationXref
id: CHEBI:16584
db: ChEBI

3-ketoacyl-CoA thiolase, peroxisomal
type: ProteinReference
xref: Reference/UniProt P27796
organism: Saccharomyces cerevisiae

Compound/PW C000170/Stoichiometry/3.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 3.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Compound/PW C001039 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isopentenyl pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C001034 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C000874 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethylallylpyrophosphate
stoichiometric coefficient: 1.0

di-trans, poly-cis-polyprenyl diphosphate (C80)
type: SmallMolecule
entity reference: di-trans, poly-cis-polyprenyl diphosphate (C80)

di-trans, poly-cis-polyprenyl diphosphate (C80)
type: SmallMoleculeReference
xref: Reference/PubChem-compound 46926091
chemical formula: C80H129O7P2
molecular weight: 1263.923
structure: ChemicalStructure/PW C044584

Reference/ChEBI CHEBI 15467
type: UnificationXref
id: CHEBI:15467
db: ChEBI

Reference/ChEBI CHEBI 15345
type: UnificationXref
id: CHEBI:15345
db: ChEBI

Reference/PubChem-compound 1195
type: UnificationXref
id: 1195
db: PubChem-compound

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/TAXONOMY 4932
type: UnificationXref
id: 4932
db: TAXONOMY

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/ChEBI CHEBI 17407
type: UnificationXref
id: CHEBI:17407
db: ChEBI

Reference/ChEBI CHEBI 17528
type: UnificationXref
id: CHEBI:17528
db: ChEBI

Reference/KEGG Compound C00418
type: UnificationXref
id: C00418
db: KEGG Compound

dehydrodolichyl diphosphate synthase complex
type: Complex
component: ditrans,polycis-polyprenyl diphosphate synthase RER2
component: dehydrodolichyl diphosphate syntase complex subunit NUS1
component: ditrans,polycis-polyprenyl diphosphate synthase SRT1

mevalonate kinase
type: Protein
cellular location: Cytoplasm
entity reference: mevalonate kinase

ChemicalStructure/PW C001039
type: ChemicalStructure
structure format: SMILES
structure data: CC(=C)CCOP(O)(=O)OP(O)(O)=O

Compound/PW C001039/Stoichiometry/3.0
type: Stoichiometry
physical entity: Isopentenyl pyrophosphate
stoichiometric coefficient: 3.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000993
type: ChemicalStructure
structure format: SMILES

Compound/PW C001099 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Compound/PW C000152 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mevalonic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001285
type: UnificationXref
id: HMDB0001285
db: HMDB

Protein/11187 Endoplasmic Reticulum/Stoichiometry/2.0
type: Stoichiometry
physical entity: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Compound/PW C000768 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Farnesyl pyrophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 627
type: UnificationXref
id: 627
db: ChemSpider

ChemicalStructure/PW C000874
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)=CCO[P@](O)(=O)OP(O)(O)=O

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/HMDB HMDB0012188
type: UnificationXref
id: HMDB0012188
db: HMDB

1.1.1.34
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001063 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000152 Endoplasmic Reticulum/Stoichiometry/1.0
right: NADP
right: Mevalonic acid
right: Coenzyme A
spontaneous: false
EC number: 1.1.1.34
left: 3-Hydroxy-3-methylglutaryl-CoA
left: NADPH
name: 3-Hydroxy-3-methylglutaryl-CoA + NADPH → Coenzyme A + Mevalonic acid + NADP
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C002145
type: ChemicalStructure
structure format: SMILES

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Isopentenyl pyrophosphate
type: SmallMolecule
cellular location: Peroxisome
entity reference: Isopentenyl pyrophosphate