Compound/PW C104589 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Anthranilic Acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Compound/PW C001026 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Amino-3-carboxymuconic acid semialdehyde
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/UniProt P48775
type: UnificationXref
id: P48775
db: UniProt

ChemicalStructure/PW C000566
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC(=O)C2=CC=CC=C2N1

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/CAS 16597-58-3
type: UnificationXref
id: 16597-58-3
db: CAS

Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Quinolinic acid
type: SmallMoleculeReference
xref: Reference/CAS 89-00-9
xref: Reference/ChEBI CHEBI 16675
xref: Reference/HMDB HMDB0000232
xref: Reference/ChemSpider 1037
xref: Reference/BioCyc QUINOLINATE
xref: Reference/KEGG Compound C03722
xref: Reference/PubChem-compound 1066
chemical formula: C7H5NO4
molecular weight: 167.02185
structure: ChemicalStructure/PW C000156

Reference/CAS 492-27-3
type: UnificationXref
id: 492-27-3
db: CAS

Reference/KEGG Compound C00328
type: UnificationXref
id: C00328
db: KEGG Compound

Reference/ChemSpider 4444266
type: UnificationXref
id: 4444266
db: ChemSpider

Trypto
type: Pathway
pathway order: PathwayEnzymeReaction/2121848
pathway order: PathwayEnzymeReaction/2121849
pathway order: PathwayEnzymeReaction/2121851
pathway order: PathwayEnzymeReaction/2121841
pathway order: PathwayEnzymeReaction/2121842
pathway order: PathwayEnzymeReaction/2121843
pathway order: PathwayEnzymeReaction/2121844
pathway order: PathwayEnzymeReaction/2121846
pathway component: 1.13.11.11
pathway component: 1.14.13.9
pathway component: ReactionCatalysis154508
pathway component: ReactionCatalysis1357
pathway component: Reaction164146
pathway component: ReactionCatalysis154613
pathway component: Reaction164147
pathway component: ReactionCatalysis154510
pathway component: ReactionCatalysis1351
pathway component: 3.5.1.9
pathway component: Reaction1622
pathway component: ReactionCatalysis1361
pathway component: ReactionCatalysis1353
pathway component: 1.13.11.6
pathway component: Reaction164272
xref: Reference/SMPDB SMP0121026
xref: Reference/PathWhiz PW122293
organism: Homo sapiens

Anthranilic Acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 227
chemical formula: C7H7NO2
molecular weight: 137.04768
structure: ChemicalStructure/PW C104589

Reference/PubChem-compound 910
type: UnificationXref
id: 910
db: PubChem-compound

ChemicalStructure/PW C000581
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)C1=C(N)C(O)=CC=C1)C(O)=O

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/PubChem-compound 25244175
type: UnificationXref
id: 25244175
db: PubChem-compound

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Kynureninase
type: Protein
cellular location: Cytoplasm
entity reference: Kynureninase

Reference/KEGG Compound C03722
type: UnificationXref
id: C03722
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

L-3-Hydroxykynurenine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-3-Hydroxykynurenine

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/ChEBI CHEBI 995
type: UnificationXref
id: CHEBI:995
db: ChEBI

Reference/PubChem-compound 86
type: UnificationXref
id: 86
db: PubChem-compound

N'-Formylkynurenine
type: SmallMoleculeReference
xref: Reference/ChemSpider 886
xref: Reference/HMDB HMDB0001200
xref: Reference/KEGG Compound C02406
xref: Reference/PubChem-compound 910
xref: Reference/ChEBI CHEBI 18377
xref: Reference/BioCyc N-FORMYLKYNURENINE
xref: Reference/CAS 1022-31-7
chemical formula: C11H12N2O4
molecular weight: 236.07971
structure: ChemicalStructure/PW C000935

Reference/KEGG Compound C02406
type: UnificationXref
id: C02406
db: KEGG Compound

Reference/HMDB HMDB0000684
type: UnificationXref
id: HMDB0000684
db: HMDB

ReactionCatalysis1357
type: Catalysis
controller: Kynurenine 3-monooxygenase
controlled: 1.14.13.9
control type: ACTIVATION

Kynurenic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Kynurenic acid

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

Kynurenine--oxoglutarate transaminase 3
type: ProteinReference
xref: Reference/UniProt Q6YP21
organism: BiologicalState393

L-3-Hydroxykynurenine
type: SmallMoleculeReference
xref: Reference/BioCyc 3-HYDROXY-L-KYNURENINE
xref: Reference/ChemSpider 11318
xref: Reference/ChEBI CHEBI 17380
xref: Reference/KEGG Compound C03227
xref: Reference/PubChem-compound 11811
xref: Reference/HMDB HMDB0011631
xref: Reference/CAS 606-14-4
chemical formula: C10H12N2O4
molecular weight: 224.07971
structure: ChemicalStructure/PW C007219

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

ReactionCatalysis1351
type: Catalysis
controller: Tryptophan 2,3-dioxygenase
controlled: 1.13.11.11
control type: ACTIVATION

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H29N7O17P3
molecular weight: 744.08325
structure: ChemicalStructure/PW C000143

ReactionCatalysis1353
type: Catalysis
controller: Kynurenine formamidase
controlled: 3.5.1.9
control type: ACTIVATION

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C000156 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinolinic acid
stoichiometric coefficient: 1.0

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

1.14.13.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007219 Cytoplasm/Stoichiometry/1.0
right: L-3-Hydroxykynurenine
right: Water
right: NADP
spontaneous: false
EC number: 1.14.13.9
left: Oxygen
left: L-Kynurenine
left: NADPH
name: L-Kynurenine + NADPH + Oxygen → L-3-Hydroxykynurenine + NADP + Water
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc 3-HYDROXY-ANTHRANILATE
type: UnificationXref
id: 3-HYDROXY-ANTHRANILATE
db: BioCyc

Reference/PubChem-compound 11811
type: UnificationXref
id: 11811
db: PubChem-compound

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Protein/1061 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: 3-hydroxyanthranilate 3,4-dioxygenase
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 17380
type: UnificationXref
id: CHEBI:17380
db: ChEBI

Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Anthranilic Acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Anthranilic Acid

3.5.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000092 Cytoplasm/Stoichiometry/1.0
right: L-Kynurenine
right: Formic acid
spontaneous: false
EC number: 3.5.1.9
left: N'-Formylkynurenine
left: Water
name: N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C104589
type: ChemicalStructure
structure format: SMILES
structure data: NC1=CC=CC=C1C(O)=O

Reference/ChemSpider 1037
type: UnificationXref
id: 1037
db: ChemSpider

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

1.13.11.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000741 Cytoplasm/Stoichiometry/1.0
right: N'-Formylkynurenine
spontaneous: false
EC number: 1.13.11.11
left: Oxygen
left: L-Tryptophan
name: L-Tryptophan + Oxygen → N'-Formylkynurenine
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Tryptophan 2,3-dioxygenase
type: ProteinReference
xref: Reference/UniProt P48775
organism: BiologicalState393

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Quinolinic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Quinolinic acid

ChemicalStructure/PW C000935
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O

Reference/CAS 548-93-6
type: UnificationXref
id: 548-93-6
db: CAS

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

ChemicalStructure/PW C007219
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(=O)C1=CC=CC(O)=C1N)C(O)=O

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/PubChem-compound 5280673
type: UnificationXref
id: 5280673
db: PubChem-compound

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 87
type: UnificationXref
id: 87
db: ChemSpider

Reference/ChemSpider 84
type: UnificationXref
id: 84
db: ChemSpider

Compound/PW C000741 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Oxygen
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxygen

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/PubChem-compound 227
type: UnificationXref
id: 227
db: PubChem-compound

3-Hydroxyanthranilic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001476
xref: Reference/BioCyc 3-HYDROXY-ANTHRANILATE
xref: Reference/PubChem-compound 86
xref: Reference/KEGG Compound C00632
xref: Reference/ChemSpider 84
xref: Reference/CAS 548-93-6
xref: Reference/ChEBI CHEBI 15793
chemical formula: C7H7NO3
molecular weight: 153.04259
structure: ChemicalStructure/PW C001137

Reference/PubChem-compound 161166
type: UnificationXref
id: 161166
db: PubChem-compound

Reference/KEGG Compound C02794
type: UnificationXref
id: C02794
db: KEGG Compound

Reference/HMDB HMDB0001200
type: UnificationXref
id: HMDB0001200
db: HMDB

Reference/HMDB HMDB0000232
type: UnificationXref
id: HMDB0000232
db: HMDB

Reference/BioCyc QUINOLINATE
type: UnificationXref
id: QUINOLINATE
db: BioCyc

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

2-Amino-3-carboxymuconic acid semialdehyde
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444266
xref: Reference/PubChem-compound 5280673
xref: Reference/ChEBI CHEBI 995
xref: Reference/KEGG Compound C04409
xref: Reference/CAS 16597-58-3
xref: Reference/BioCyc 2-AMINO-3-CARBOXYMUCONATE SEMIAL
xref: Reference/HMDB HMDB0001330
chemical formula: C7H7NO5
molecular weight: 185.03242
structure: ChemicalStructure/PW C001026

Reference/ChEBI CHEBI 16946
type: UnificationXref
id: CHEBI:16946
db: ChEBI

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

Kynurenine formamidase
type: Protein
cellular location: Cytoplasm
entity reference: Kynurenine formamidase

Reference/ChEBI CHEBI 18344
type: UnificationXref
id: CHEBI:18344
db: ChEBI

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

Kynurenine 3-monooxygenase
type: Protein
cellular location: Cytoplasm
entity reference: Kynurenine 3-monooxygenase

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/PathWhiz PW122293
type: UnificationXref
id: PW122293
db: PathWhiz

Compound/PW C007219 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-3-Hydroxykynurenine
stoichiometric coefficient: 1.0

Reaction1622
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000156 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001026 Cytoplasm/Stoichiometry/1.0
right: Quinolinic acid
spontaneous: false
left: 2-Amino-3-carboxymuconic acid semialdehyde
name: 2-Amino-3-carboxymuconic acid semialdehyde → Quinolinic acid
conversion direction: LEFT_TO_RIGHT

1.13.11.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001026 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001137 Cytoplasm/Stoichiometry/1.0
right: 2-Amino-3-carboxymuconic acid semialdehyde
spontaneous: false
EC number: 1.13.11.6
left: Oxygen
left: 3-Hydroxyanthranilic acid
name: 3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde
conversion direction: LEFT_TO_RIGHT

Reference/CAS 1022-31-7
type: UnificationXref
id: 1022-31-7
db: CAS

Reference/HMDB HMDB0001330
type: UnificationXref
id: HMDB0001330
db: HMDB

L-Kynurenine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Kynurenine

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

ReactionCatalysis154508
type: Catalysis
controller: Kynurenine--oxoglutarate transaminase 3
controlled: Reaction164146
control type: ACTIVATION

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

3-Hydroxyanthranilic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3-Hydroxyanthranilic acid

Kynurenine--oxoglutarate transaminase 3
type: Protein
cellular location: Cytoplasm
entity reference: Kynurenine--oxoglutarate transaminase 3

ChemicalStructure/PW C001026
type: ChemicalStructure
structure format: SMILES
structure data: N\C(C(O)=O)=C(\C=C/C=O)/C(O)=O

ReactionCatalysis154510
type: Catalysis
controller: Kynureninase
controlled: Reaction164147
control type: ACTIVATION

Reference/KEGG Compound C04409
type: UnificationXref
id: C04409
db: KEGG Compound

Kynureninase
type: ProteinReference
xref: Reference/UniProt Q16719
organism: BiologicalState393

Kynurenine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt O15229
organism: BiologicalState393

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/ChemSpider 886
type: UnificationXref
id: 886
db: ChemSpider

Reference/HMDB HMDB0001476
type: UnificationXref
id: HMDB0001476
db: HMDB

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

BiologicalState393
type: BioSource
name: Liver
tissue: Liver

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/UniProt Q16719
type: UnificationXref
id: Q16719
db: UniProt

Reference/BioCyc 2-AMINO-3-CARBOXYMUCONATE SEMIAL
type: UnificationXref
id: 2-AMINO-3-CARBOXYMUCONATE_SEMIAL
db: BioCyc

Reference/CAS 484-78-6
type: UnificationXref
id: 484-78-6
db: CAS

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

3,4-Dihydroxyphenylacetaldehyde
type: Complex
component stoichiometry: Protein/1061 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: 3-hydroxyanthranilate 3,4-dioxygenase

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Compound/PW C000581 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroxykynurenine
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/ChEBI CHEBI 18377
type: UnificationXref
id: CHEBI:18377
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/UniProt Q6YP21
type: UnificationXref
id: Q6YP21
db: UniProt

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Reference/CAS 89-00-9
type: UnificationXref
id: 89-00-9
db: CAS

Reaction164146
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000566 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
right: Kynurenic acid
spontaneous: false
left: L-Kynurenine
name: L-Kynurenine → Kynurenic acid
conversion direction: LEFT_TO_RIGHT

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

ReactionCatalysis154613
type: Catalysis
controller: Kynureninase
controlled: Reaction164272
control type: ACTIVATION

3-hydroxyanthranilate 3,4-dioxygenase
type: ProteinReference
xref: Reference/UniProt P46952
organism: BiologicalState393

Reaction164147
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104589 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000538 Cytoplasm/Stoichiometry/1.0
right: Anthranilic Acid
spontaneous: false
left: L-Kynurenine
name: L-Kynurenine → Anthranilic Acid
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000156
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC=CN=C1C(O)=O

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Reference/ChemSpider 3712
type: UnificationXref
id: 3712
db: ChemSpider

L-Kynurenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000684
xref: Reference/KEGG Compound C00328
xref: Reference/ChemSpider 141580
xref: Reference/ChEBI CHEBI 16946
xref: Reference/PubChem-compound 161166
xref: Reference/CAS 2922-83-0
xref: Reference/BioCyc L-KYNURENINE
chemical formula: C10H12N2O3
molecular weight: 208.0848
structure: ChemicalStructure/PW C000538

Reference/BioCyc 3-HYDROXY-L-KYNURENINE
type: UnificationXref
id: 3-HYDROXY-L-KYNURENINE
db: BioCyc

Reference/KEGG Compound C01717
type: UnificationXref
id: C01717
db: KEGG Compound

2-Amino-3-carboxymuconic acid semialdehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 2-Amino-3-carboxymuconic acid semialdehyde

Reference/HMDB HMDB0000715
type: UnificationXref
id: HMDB0000715
db: HMDB

Reference/ChEBI CHEBI 15793
type: UnificationXref
id: CHEBI:15793
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/CAS 606-14-4
type: UnificationXref
id: 606-14-4
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PubChem-compound 3845
type: UnificationXref
id: 3845
db: PubChem-compound

ChemicalStructure/PW C001137
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C(O)C=CC=C1C(O)=O

Reaction164272
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000581 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001137 Cytoplasm/Stoichiometry/1.0
right: 3-Hydroxyanthranilic acid
spontaneous: false
left: Hydroxykynurenine
name: Hydroxykynurenine → 3-Hydroxyanthranilic acid
conversion direction: LEFT_TO_RIGHT

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

Compound/PW C001137 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxyanthranilic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03227
type: UnificationXref
id: C03227
db: KEGG Compound

Reference/KEGG Compound C00632
type: UnificationXref
id: C00632
db: KEGG Compound

Reference/BioCyc L-KYNURENINE
type: UnificationXref
id: L-KYNURENINE
db: BioCyc

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Reference/HMDB HMDB0000732
type: UnificationXref
id: HMDB0000732
db: HMDB

Reference/UniProt P46952
type: UnificationXref
id: P46952
db: UniProt

ReactionCatalysis1361
type: Catalysis
controller: 3,4-Dihydroxyphenylacetaldehyde
controlled: 1.13.11.6
control type: ACTIVATION

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/CAS 2922-83-0
type: UnificationXref
id: 2922-83-0
db: CAS

Reference/UniProt Q63HM1
type: UnificationXref
id: Q63HM1
db: UniProt

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

N'-Formylkynurenine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N'-Formylkynurenine

Hydroxykynurenine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydroxykynurenine

Reference/SMPDB SMP0121026
type: UnificationXref
id: SMP0121026
db: SMPDB

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/HMDB HMDB0011631
type: UnificationXref
id: HMDB0011631
db: HMDB

ChemicalStructure/PW C000538
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O

Reference/ChEBI CHEBI 16675
type: UnificationXref
id: CHEBI:16675
db: ChEBI

Reference/ChemSpider 11318
type: UnificationXref
id: 11318
db: ChemSpider

Kynurenine formamidase
type: ProteinReference
xref: Reference/UniProt Q63HM1
organism: BiologicalState393

Kynurenic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 3712
xref: Reference/PubChem-compound 3845
xref: Reference/KEGG Compound C01717
xref: Reference/HMDB HMDB0000715
xref: Reference/CAS 492-27-3
xref: Reference/ChEBI CHEBI 18344
chemical formula: C10H7NO3
molecular weight: 189.04259
structure: ChemicalStructure/PW C000566

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/BioCyc N-FORMYLKYNURENINE
type: UnificationXref
id: N-FORMYLKYNURENINE
db: BioCyc

3-hydroxyanthranilate 3,4-dioxygenase
type: Protein
cellular location: Cytoplasm
entity reference: 3-hydroxyanthranilate 3,4-dioxygenase

Compound/PW C000566 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Kynurenic acid
stoichiometric coefficient: 1.0

Reference/UniProt O15229
type: UnificationXref
id: O15229
db: UniProt

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C000092 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

L-Tryptophan
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Tryptophan

Reference/ChEBI CHEBI 1547
type: UnificationXref
id: CHEBI:1547
db: ChEBI

Reference/ChemSpider 141580
type: UnificationXref
id: 141580
db: ChemSpider

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Tryptophan 2,3-dioxygenase
type: Protein
cellular location: Cytoplasm
entity reference: Tryptophan 2,3-dioxygenase

Compound/PW C000935 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: N'-Formylkynurenine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1066
type: UnificationXref
id: 1066
db: PubChem-compound

Formic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Formic acid

Hydroxykynurenine
type: SmallMoleculeReference
xref: Reference/BioCyc 3-HYDROXY-L-KYNURENINE
xref: Reference/HMDB HMDB0000732
xref: Reference/PubChem-compound 25244175
xref: Reference/ChemSpider 87
xref: Reference/CAS 484-78-6
xref: Reference/ChEBI CHEBI 1547
xref: Reference/KEGG Compound C02794
chemical formula: C10H12N2O4
molecular weight: 224.07971
structure: ChemicalStructure/PW C000581