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Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Solute carrier family 22 member 7 Multidrug resistance protein 1 Leukotriene- B(4) omega- hydroxylase 1 Leukotriene A-4 hydrolase Leukotriene C4 synthase Gamma- glutamyltranspeptidase 1 Glutathione peroxidase 1 Prostacyclin synthase Prostaglandin- H2 D-isomerase Aldo-keto reductase family 1 member C3 Thromboxane-A synthase Prostaglandin E synthase Prostamide/prostaglandin F synthase Carbonyl reductase [NADPH] 1 Arachidonate 15-lipoxygenase Cytochrome P450 2C8 Cytochrome P450 2C8 Cytochrome P450 2C8 Cytochrome P450 2C8 Cytochrome P450 2C8 Cytochrome P450 2B6 Epoxide hydratase 2 Cytochrome P450 2B6 Epoxide hydratase 2 Arachidonate 5-lipoxygenase Arachidonate 5-lipoxygenase Glutathione peroxidase 1 Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Cytochrome P450 2B6 Epoxide hydratase 2 Cytochrome P450 2B6 Epoxide hydratase 2 Arachidonate 15-lipoxygenase B Cytochrome P450 2E1 Arachidonate 12- lipoxygenase, 12R-type Cytochrome P450 2J2 Cytochrome P450 2U1 Cytochrome P450 4A11 Cytochrome P450 2U1 Arachidonate 12- lipoxygenase, 12S-type Cytosolic phospholipase A2 beta Cytochrome P450 4F8 Leukotriene- B(4) omega- hydroxylase 2 Aspirin Aspirin 20-Hydroxy-leukotriene B4 20-Carboxy-leukotriene B4 Leukotriene B4 NADPH O 2 NADP H 2 O Leukotriene A4 H 2 O 12-Keto-leukotriene B4 Glutathione Leukotriene C4 H 2 O Leukotriene D4 L-Glutamic acid 5,6-Epoxytetraene 15(S)-HPETE Glutathione 15(S)-HETE Oxidized glutathione H 2 O δ-12-Prostaglandin J2 15-Deoxy-d-12,14-PGJ2 6-Keto-prostaglandin F1a 6-Ketoprostaglandin E1 5-HETE 5-KETE Prostaglandin J2 Prostaglandin I2 Prostaglandin D2 Prostaglandin H2 NADPH 11-Epi-PGF2a NADP Thromboxane A2 Prostaglandin E2 Prostaglandin F2a NADPH NADP Prostaglandin A2 Prostaglandin-c2 Thromboxane B2 Prostaglandin B2 11-Dehydro-thromboxane B2 Arachidonic acid O 2 O 2 11H-14,15-EETA H 2 O O 2 11,14,15-THETA H 2 O O 2 15H-11,12-EETA H 2 O O 2 11,12,15-THETA H 2 O O 2 16(R)-HETE H 2 O O 2 14,15-Epoxy-5,8,11- eicosatrienoic acid H 2 O H 2 O 14,15-DiHETrE O 2 11,12-Epoxyeicosatrienoic acid H 2 O H 2 O 11,12-DiHETrE 5-HPETE O 2 H 2 O O 2 H 2 O Glutathione Oxidized glutathione H 2 O Prostaglandin G2 H 2 O O 2 O 2 8,9-Epoxyeicosatrienoic acid H 2 O H 2 O 8,9-DiHETrE O 2 5,6-Epoxy-8,11,14- eicosatrienoic acid H 2 O H 2 O 5,6-DHET O 2 8(S)-HPETE O 2 19(S)-HETE H 2 O O 2 12(R)-HPETE 8-HETE Arachidonic acid 8-Isoprostane O 2 H 2 O O 2 H 2 O O 2 20-Hydroxyeicosatetraenoic acid H 2 O O 2 H 2 O O 2 12(S)-HPETE 12(R)-HETE 12-KETE 12(S)-HETE PC(14:0/20:4(5Z,8Z,11Z,14Z)) H 2 O LysoPC(14:0/0:0) NADPH O 2 NADP H 2 O 2,3-Dinor-8iso prostaglandin F1α 2,3-Dinor-8iso prostaglandin F2α Heme Heme Heme Zinc (II) ion Heme Heme Glutathione Fe3+ Heme Heme Heme Heme Heme Heme Magnesium Heme Magnesium Fe3+ Calcium Fe3+ Calcium Heme Heme Heme Magnesium Heme Magnesium Fe3+ Heme Fe3+ Heme Heme Heme Heme Fe3+ Calcium Heme Heme Cytosol Lumen Lumen Cytosol Lumen Cytosol Lumen Cytosol Lumen Smooth Endoplasmic Reticulum Extracellular Space Intracellular Space
Endoplasmic Reticulum PTGS1 PTGS2 SLC22A7 ABCB1 CYP4F2 LTA4H LTC4S GGT1 GPX1 PTGIS PTGDS AKR1C3 TBXAS1 PTGES Unknown CBR1 ALOX15 CYP2C8 CYP2C8 CYP2C8 CYP2C8 CYP2C8 CYP2B6 EPHX2 CYP2B6 EPHX2 ALOX5 ALOX5 GPX1 PTGS1 PTGS2 CYP2B6 EPHX2 CYP2B6 EPHX2 ALOX15B CYP2E1 ALOX12B CYP2J2 CYP2U1 CYP4A11 CYP2U1 ALOX12 PLA2G4B CYP4F8 CYP4F3 Aspirin Aspirin 20-Hydroxy- leukotriene B4 20-Carboxy- leukotriene B4 Leukotriene B4 NADPH Oxygen NADP Water Leukotriene A4 Water 12-Keto- leukotriene B4 Glutathione Leukotriene C4 Water Leukotriene D4 L-Glutamic acid 5,6- Epoxytetraene 15(S)-HPETE Glutathione 15(S)-HETE Oxidized glutathione Water δ-12- Prostaglandin J2 15-Deoxy-d- 12,14-PGJ2 6-Keto- prostaglandin F1a 6- Ketoprostaglandin E1 5-HETE 5-KETE Prostaglandin J2 Prostaglandin I2 Prostaglandin D2 Prostaglandin H2 NADPH 11-Epi-PGF2a NADP Thromboxane A2 Prostaglandin E2 Prostaglandin F2a NADPH NADP Prostaglandin A2 Prostaglandin- c2 Thromboxane B2 Prostaglandin B2 11-Dehydro- thromboxane B2 Arachidonic acid Oxygen Oxygen 11H-14,15-EETA Water Oxygen 11,14,15-THETA Water Oxygen 15H-11,12-EETA Water Oxygen 11,12,15-THETA Water Oxygen 16(R)-HETE Water Oxygen 14,15-Epoxy- 5,8,11- eicosatrienoic acid Water Water 14,15-DiHETrE Oxygen 11,12- Epoxyeicosatrienoic acid Water Water 11,12-DiHETrE 5-HPETE Oxygen Water Oxygen Water Glutathione Oxidized glutathione Water Prostaglandin G2 Water Oxygen Oxygen 8,9- Epoxyeicosatrienoic acid Water Water 8,9-DiHETrE Oxygen 5,6-Epoxy- 8,11,14- eicosatrienoic acid Water Water 5,6-DHET Oxygen 8(S)-HPETE Oxygen 19(S)-HETE Water Oxygen 12(R)-HPETE 8-HETE Arachidonic acid 8-Isoprostane Oxygen Water Oxygen Water Oxygen 20- Hydroxyeicosatetraenoic acid Water Oxygen Water Oxygen 12(S)-HPETE 12(R)-HETE 12-KETE 12(S)-HETE PC(14:0/20:4(5Z,8Z,11Z,14Z)) Water LysoPC(14:0/0:0) NADPH Oxygen NADP Water 2,3-Dinor-8iso prostaglandin F1α 2,3-Dinor-8iso prostaglandin F2α