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Esterase P Esterase P UDP- glucuronosyltransferase Beta- glucuronidase Unknown SN-38 Glucuronide Irinotecan H2O SN-38 1,4'- Bipiperidine- 1'-carboxylic acid NPC H2O 4-Amino-1- piperidinecarboxylic acid Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H2O D-Glucuronic acid O2 Glutaral H2O [Reduced NADPH--- hemoprotein reductase] [Oxidized NADPH--- hemoprotein reductase] Excretion Lysosome Cytosol
Lysosome Est-P Est-P Ugt301D1 CG15117 Unknown SN-38 Glucuronide Irinotecan Water SN-38 1,4'- Bipiperidine- 1'-carboxylic acid NPC Water 4-Amino-1- piperidinecarboxylic acid Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Water D-Glucuronic acid Oxygen Glutaral Water [Reduced NADPH--- hemoprotein reductase] [Oxidized NADPH--- hemoprotein reductase] Excretion