Reference/ChemSpider 141130
type: UnificationXref
id: 141130
db: ChemSpider

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Hepatotoxins
type: SmallMoleculeReference
xref: Reference/KEGG Compound C21758

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Unknown
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Unknown

Reference/PubChem-compound 9650
type: UnificationXref
id: 9650
db: PubChem-compound

Compound/PW C104678 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isonicotinoyl radical
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Compound/PW C104684/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isoniazid α-ketoglutaric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

ChemicalStructure/PW C009392
type: ChemicalStructure
structure format: SMILES
structure data: NNC(=O)C1=CC=NC=C1

Hydrazine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrazine

Acetylisoniazid
type: SmallMoleculeReference
xref: Reference/CAS 1078-38-2
xref: Reference/HMDB HMDB0041821
xref: Reference/KEGG Compound C07585
xref: Reference/ChemSpider 64672
xref: Reference/PubChem-compound 71602
xref: Reference/ChEBI CHEBI 7207
chemical formula: C8H9N3O2
molecular weight: 179.06947
structure: ChemicalStructure/PW C022604

Reference/PubChem-compound 9649
type: UnificationXref
id: 9649
db: PubChem-compound

NAD
type: SmallMolecule
entity reference: NAD

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Hydrogen peroxide
type: SmallMolecule
cellular location: Lysosome
entity reference: Hydrogen peroxide

Pyruvic acid
type: SmallMolecule
entity reference: Pyruvic acid

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

ChemicalStructure/PW C104678
type: ChemicalStructure
structure format: SMILES
structure data: O=[C]C1=CC=NC=C1

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

ChemicalStructure/PW C104679
type: ChemicalStructure
structure format: SMILES

R-S-Glutathione
type: SmallMolecule
entity reference: R-S-Glutathione
name: SubPathwayInput

Glycine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glycine

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Lysosome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005764

Compound/PW C022604 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylisoniazid
stoichiometric coefficient: 1.0

Compound/PW C104686 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacetylhydrazine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Protein/10225 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Isonicotinylglycine
type: SmallMolecule
entity reference: Isonicotinylglycine
name: SubPathwayInput

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

ChemicalStructure/PW C104681
type: ChemicalStructure
structure format: SMILES
structure data: N=N

ChemicalStructure/PW C104680
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C104683
type: ChemicalStructure
structure format: SMILES
structure data: C\C(=N/NC(=O)C1=CC=NC=C1)C(O)=O

ChemicalStructure/PW C104682
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC=NC=C1

Isoniazid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Isoniazid

ChemicalStructure/PW C104685
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)NN

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

ChemicalStructure/PW C104684
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC\C(=N/NC(=O)C1=CC=NC=C1)C(O)=O

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen Ion

ChemicalStructure/PW C104686
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)NNC(C)=O

Unknown
type: ProteinReference
organism: Xenopus laevis

Unknown
type: Protein
cellular location: Cytosol
entity reference: Unknown

Acetylhydrazine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 2422
xref: Reference/PubChem-compound 9650
xref: Reference/KEGG Compound C07447
chemical formula: C2H6N2O
molecular weight: 74.04801
structure: ChemicalStructure/PW C104685

Diacetylhydrazine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 80616
xref: Reference/KEGG Compound C16622
xref: Reference/PubChem-compound 51090948
chemical formula: C4H8N2O2
molecular weight: 116.05858
structure: ChemicalStructure/PW C104686

Isoniazid pyruvate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 51090950
xref: Reference/ChEBI CHEBI 80618
xref: Reference/KEGG Compound C16624
chemical formula: C9H9N3O3
molecular weight: 207.06439
structure: ChemicalStructure/PW C104683

Isoniazid α-ketoglutaric acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 51090951
xref: Reference/ChEBI CHEBI 80619
xref: Reference/KEGG Compound C16625
chemical formula: C11H11N3O5
molecular weight: 265.0699
structure: ChemicalStructure/PW C104684

Diimine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05360
xref: Reference/PubChem-compound 7737
xref: Reference/ChEBI CHEBI 30096
chemical formula: H2N2
molecular weight: 30.021797
structure: ChemicalStructure/PW C104681

Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30096
type: UnificationXref
id: CHEBI:30096
db: ChEBI

Isonicotinic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 9649
xref: Reference/ChEBI CHEBI 6032
xref: Reference/KEGG Compound C07446
chemical formula: C6H5NO2
molecular weight: 123.03203
structure: ChemicalStructure/PW C104682

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Compound/PW C008140 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrazine
stoichiometric coefficient: 1.0

Isonicotinoyl-NADP adduct
type: SmallMoleculeReference
xref: Reference/PubChem-compound 354264354
xref: Reference/KEGG Compound C21760
chemical formula: C27H33N8O18P3
molecular weight: 850.11255
structure: ChemicalStructure/PW C104680

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/PathWhiz PW122377
type: UnificationXref
id: PW122377
db: PathWhiz

NADP
type: SmallMolecule
entity reference: NADP

Reference/KEGG Compound C05361
type: UnificationXref
id: C05361
db: KEGG Compound

Reference/KEGG Compound C05360
type: UnificationXref
id: C05360
db: KEGG Compound

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Acetyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetyl-CoA

Compound/PW C104679/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isonicotinoyl-NAD adduct
stoichiometric coefficient: 1.0

R-S-Glutathione
type: SmallMolecule
cellular location: Cytosol
entity reference: R-S-Glutathione

Isonicotinoyl radical
type: SmallMoleculeReference
xref: Reference/KEGG Compound C21754
xref: Reference/PubChem-compound 354264348
chemical formula: C6H4NO
molecular weight: 106.02929
structure: ChemicalStructure/PW C104678

Isonicotinoyl-NAD adduct
type: SmallMoleculeReference
xref: Reference/KEGG Compound C21759
xref: Reference/PubChem-compound 354264353
chemical formula: C27H32N8O15P2
molecular weight: 770.14624
structure: ChemicalStructure/PW C104679

Acetylisoniazid
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Acetylisoniazid

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

Reference/ChEBI CHEBI 16856
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/TAXONOMY 8355
type: UnificationXref
id: 8355
db: TAXONOMY

Reference/PubChem-compound 124886
type: UnificationXref
id: 124886
db: PubChem-compound

Reference/ChEBI CHEBI 17021
type: UnificationXref
id: CHEBI:17021
db: ChEBI

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Compound/PW C104685 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylhydrazine
stoichiometric coefficient: 1.0

Isonicotinic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Isonicotinic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

R-S-Glutathione
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17021

Compound/PW C104685 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylhydrazine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

Reference/GENE ONTOLOGY GO 0005764
type: UnificationXref
id: GO:0005764
db: GENE ONTOLOGY

SubPathwayInteraction109930
type: Interaction
name: SubPathway109930Reaction
name: SubPathwayReaction
participant: R-S-Glutathione
participant: Isonicotinylglycine
participant: Diacetylhydrazine

Glutathione
type: SmallMolecule
cellular location: Cytosol
entity reference: Glutathione

Reference/PubChem-compound 160607
type: UnificationXref
id: 160607
db: PubChem-compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Compound/PW C009392 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isoniazid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reaction179498
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104678/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104680/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
right: Isonicotinoyl-NADP adduct
spontaneous: true
left: NADP
left: Isonicotinoyl radical
name: Isonicotinoyl radical + NADP → Isonicotinoyl-NADP adduct
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reaction179497
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104678/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104679/Stoichiometry/1.0
right: Isonicotinoyl-NAD adduct
spontaneous: true
left: NAD
left: Isonicotinoyl radical
name: Isonicotinoyl radical + NAD → Isonicotinoyl-NAD adduct
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Glutathione
type: SmallMoleculeReference
xref: Reference/CAS 70-18-8
xref: Reference/HMDB HMDB0000125
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/KEGG Compound C00051
xref: Reference/ChEBI CHEBI 16856
xref: Reference/PubChem-compound 124886
xref: Reference/ChemSpider 111188
chemical formula: C10H17N3O6S
molecular weight: 307.0838
structure: ChemicalStructure/PW C000080

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Unknown
type: Protein
cellular location: Cytoplasm
entity reference: Unknown

Acetylhydrazine
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Acetylhydrazine

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 64672
type: UnificationXref
id: 64672
db: ChemSpider

Compound/PW C104680/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isonicotinoyl-NADP adduct
stoichiometric coefficient: 1.0

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/KEGG Compound C21754
type: UnificationXref
id: C21754
db: KEGG Compound

Reference/CAS 54-85-3
type: UnificationXref
id: 54-85-3
db: CAS

Compound/Generic535 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hepatotoxins
stoichiometric coefficient: 1.0

Isoniazid
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Isoniazid

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C21758
type: UnificationXref
id: C21758
db: KEGG Compound

Reference/KEGG Compound C21759
type: UnificationXref
id: C21759
db: KEGG Compound

Reference/PubChem-compound 354264353
type: UnificationXref
id: 354264353
db: PubChem-compound

Reference/PubChem-compound 354264354
type: UnificationXref
id: 354264354
db: PubChem-compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/ChEBI CHEBI 6032
type: UnificationXref
id: CHEBI:6032
db: ChEBI

Reference/KEGG Compound C07447
type: UnificationXref
id: C07447
db: KEGG Compound

Unknown
type: Protein
cellular location: Lysosome
entity reference: Unknown

Unknown
type: Protein
cellular location: Mitochondrion
entity reference: Unknown

Reference/ChEBI CHEBI 6030
type: UnificationXref
id: CHEBI:6030
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxygen

Reference/KEGG Compound C07446
type: UnificationXref
id: C07446
db: KEGG Compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Compound/PW C000080 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

Reference/PubChem-compound 71602
type: UnificationXref
id: 71602
db: PubChem-compound

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Diimine
type: SmallMolecule
cellular location: Lysosome
entity reference: Diimine

Compound/PW C104681 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diimine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/PubChem-compound 354264348
type: UnificationXref
id: 354264348
db: PubChem-compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Compound/PW C008140 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrazine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000125
type: UnificationXref
id: HMDB0000125
db: HMDB

Reference/KEGG Compound C07585
type: UnificationXref
id: C07585
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Acetylisoniazid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetylisoniazid

Reference/CAS 2015-20-5
type: UnificationXref
id: 2015-20-5
db: CAS

Reference/PubChem-compound 3767
type: UnificationXref
id: 3767
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Glutathione S-transferase omega-2
type: Complex
component stoichiometry: Protein/10225 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Unknown

Coenzyme A
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Coenzyme A

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C104683/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isoniazid pyruvate
stoichiometric coefficient: 1.0

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reaction179502
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009392/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104683/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164/Stoichiometry/1.0
right: Water
right: Isoniazid pyruvate
spontaneous: false
left: Pyruvic acid
left: Isoniazid
name: Isoniazid + Pyruvic acid → Isoniazid pyruvate + Water
conversion direction: LEFT_TO_RIGHT

Reference/CAS 70-18-8
type: UnificationXref
id: 70-18-8
db: CAS

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Diacetylhydrazine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Diacetylhydrazine

Reference/BioCyc OXIDIZED-GLUTATHIONE
type: UnificationXref
id: OXIDIZED-GLUTATHIONE
db: BioCyc

Reference/HMDB HMDB0041912
type: UnificationXref
id: HMDB0041912
db: HMDB

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Reaction179503
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104684/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009392/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134/Stoichiometry/1.0
right: Water
right: Isoniazid α-ketoglutaric acid
spontaneous: false
left: Oxoglutaric acid
left: Isoniazid
name: Isoniazid + Oxoglutaric acid → Isoniazid α-ketoglutaric acid + Water
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

Compound/PW C104682 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isonicotinic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Myeloperoxidase
type: Complex
component stoichiometry: Protein/10225 Lysosome/Stoichiometry/2.0
cellular location: Lysosome
component: Unknown

Water
type: SmallMolecule
entity reference: Water

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/PubChem-compound 51090950
type: UnificationXref
id: 51090950
db: PubChem-compound

Reference/PubChem-compound 51090951
type: UnificationXref
id: 51090951
db: PubChem-compound

Reaction179509
type: BiochemicalReaction
participant stoichiometry: Compound/PW C022667 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104682 Cytoplasm/Stoichiometry/1.0
right: Isonicotinylglycine
spontaneous: false
left: Glycine
left: Isonicotinic acid
name: Glycine + Isonicotinic acid → Isonicotinylglycine
conversion direction: LEFT_TO_RIGHT

Compound/PW C022667 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isonicotinylglycine
stoichiometric coefficient: 1.0

Acetylhydrazine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetylhydrazine

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

ReactionCatalysis169437
type: Catalysis
controller: Glutathione S-transferase omega-2
controlled: Reaction179549
control type: ACTIVATION

ReactionCatalysis169436
type: Catalysis
controller: Unknown
controlled: Reaction179548
control type: ACTIVATION

Compound/Generic2 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: R-S-Glutathione
stoichiometric coefficient: 1.0

ReactionCatalysis169435
type: Catalysis
controller: Unknown
controlled: Reaction179547
control type: ACTIVATION

ReactionCatalysis169434
type: Catalysis
controller: Unknown
controlled: Reaction179546
control type: ACTIVATION

ReactionCatalysis169433
type: Catalysis
controller: Unknown
controlled: Reaction179545
control type: ACTIVATION

Excretion
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109930
pathway component: SubPathwayInteraction109930
name: SubPathway

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

ReactionCatalysis169432
type: Catalysis
controller: Unknown
controlled: Reaction179544
control type: ACTIVATION

Reference/KEGG Compound C21760
type: UnificationXref
id: C21760
db: KEGG Compound

ReactionCatalysis169431
type: Catalysis
controller: Unknown
controlled: Reaction179543
control type: ACTIVATION

Reference/ChEBI CHEBI 15571
type: UnificationXref
id: CHEBI:15571
db: ChEBI

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

ReactionCatalysis169430
type: Catalysis
controller: Myeloperoxidase
controlled: Reaction179542
control type: ACTIVATION

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Water

Reference/KEGG Compound C00051
type: UnificationXref
id: C00051
db: KEGG Compound

Reference/KEGG Compound C16623
type: UnificationXref
id: C16623
db: KEGG Compound

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/KEGG Compound C16624
type: UnificationXref
id: C16624
db: KEGG Compound

Reference/KEGG Compound C16625
type: UnificationXref
id: C16625
db: KEGG Compound

Reference/SMPDB SMP0121107
type: UnificationXref
id: SMP0121107
db: SMPDB

Isonicotinoyl radical
type: SmallMolecule
cellular location: Lysosome
entity reference: Isonicotinoyl radical

Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/KEGG Compound C16622
type: UnificationXref
id: C16622
db: KEGG Compound

Reference/PubChem-compound 51090948
type: UnificationXref
id: 51090948
db: PubChem-compound

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Compound/PW C001783 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/HMDB HMDB0015086
type: UnificationXref
id: HMDB0015086
db: HMDB

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C000164/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Isonicotinoyl-NADP adduct
type: SmallMolecule
entity reference: Isonicotinoyl-NADP adduct

Isoniazid α-ketoglutaric acid
type: SmallMolecule
entity reference: Isoniazid α-ketoglutaric acid

Hepatotoxins
type: SmallMolecule
cellular location: Cytosol
entity reference: Hepatotoxins

Reference/ChEBI CHEBI 7207
type: UnificationXref
id: CHEBI:7207
db: ChEBI

Isoniazid pyruvate
type: SmallMolecule
entity reference: Isoniazid pyruvate

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Diacetylhydrazine
type: SmallMolecule
entity reference: Diacetylhydrazine
name: SubPathwayInput

Isonicotinoyl-NAD adduct
type: SmallMolecule
entity reference: Isonicotinoyl-NAD adduct

Water
type: SmallMolecule
cellular location: Lysosome
entity reference: Water

Isonicotinylglycine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 160607
xref: Reference/ChemSpider 141130
xref: Reference/CAS 2015-20-5
xref: Reference/HMDB HMDB0041912
xref: Reference/KEGG Compound C16623
chemical formula: C8H8N2O3
molecular weight: 180.0535
structure: ChemicalStructure/PW C022667

Reference/BioCyc 4-HYDROXYMETHYLPHENYLHYDRAZINE
type: UnificationXref
id: 4-HYDROXYMETHYLPHENYLHYDRAZINE
db: BioCyc

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

Compound/PW C000134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 8960
type: UnificationXref
id: 8960
db: ChemSpider

ChemicalStructure/PW C022604
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=NNC(=O)C1=CC=NC=C1

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Hepatotoxins
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hepatotoxins

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Hydrazine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0012973
xref: Reference/CAS 302-01-2
xref: Reference/KEGG Compound C05361
xref: Reference/BioCyc 4-HYDROXYMETHYLPHENYLHYDRAZINE
xref: Reference/PubChem-compound 9321
xref: Reference/ChEBI CHEBI 15571
xref: Reference/ChemSpider 8960
chemical formula: H4N2
molecular weight: 32.03745
structure: ChemicalStructure/PW C008140

Compound/PW C104685 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylhydrazine
stoichiometric coefficient: 1.0

Isonicotinoyl radical
type: SmallMolecule
entity reference: Isonicotinoyl radical

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reaction179546
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104682 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104685 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022604 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
right: Acetylhydrazine
right: Isonicotinic acid
spontaneous: false
left: Acetylisoniazid
left: Water
name: Acetylisoniazid + Water → Acetylhydrazine + Isonicotinic acid
conversion direction: LEFT_TO_RIGHT

Reaction179545
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008140 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104685 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
right: Acetylhydrazine
right: Coenzyme A
spontaneous: false
left: Hydrazine
left: Acetyl-CoA
name: Acetyl-CoA + Hydrazine → Acetylhydrazine + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Reaction179544
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022604 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009392 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
right: Acetylisoniazid
right: Coenzyme A
spontaneous: false
left: Isoniazid
left: Acetyl-CoA
name: Acetyl-CoA + Isoniazid → Acetylisoniazid + Coenzyme A
conversion direction: LEFT_TO_RIGHT

Reaction179543
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104682 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008140 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009392 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
right: Isonicotinic acid
right: Hydrazine
spontaneous: false
left: Isoniazid
left: Water
name: Isoniazid + Water → Hydrazine + Isonicotinic acid
conversion direction: LEFT_TO_RIGHT

Reaction179549
type: BiochemicalReaction
participant stoichiometry: Compound/Generic535 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic2 Cytosol/Stoichiometry/1.0
right: R-S-Glutathione
spontaneous: false
left: Glutathione
left: Hepatotoxins
name: Glutathione + Hepatotoxins → R-S-Glutathione
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reaction179548
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic535 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104685 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
right: Water
right: Hepatotoxins
right: NADP
spontaneous: false
left: Acetylhydrazine
left: NADPH
left: Hydrogen Ion
left: Oxygen
name: Acetylhydrazine + Hydrogen Ion + NADPH + Oxygen → Hepatotoxins + NADP + Water
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reaction179547
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104685 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104686 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
right: Diacetylhydrazine
right: Coenzyme A
spontaneous: false
left: Acetylhydrazine
left: Acetyl-CoA
name: Acetyl-CoA + Acetylhydrazine → Coenzyme A + Diacetylhydrazine
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 80619
type: UnificationXref
id: CHEBI:80619
db: ChEBI

Isonicotinylglycine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Isonicotinylglycine

Reaction179542
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009392 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104681 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C104678 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Lysosome/Stoichiometry/2.0
right: Water
right: Isonicotinoyl radical
right: Diimine
spontaneous: false
left: Hydrogen peroxide
left: Isoniazid
name: Hydrogen peroxide + Isoniazid → Diimine + Isonicotinoyl radical + 2 Water
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

Oxoglutaric acid
type: SmallMolecule
entity reference: Oxoglutaric acid

Reference/ChEBI CHEBI 80616
type: UnificationXref
id: CHEBI:80616
db: ChEBI

Reference/ChEBI CHEBI 80618
type: UnificationXref
id: CHEBI:80618
db: ChEBI

Xenopus laevis
type: BioSource
xref: Reference/TAXONOMY 8355

Compound/PW C009392/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isoniazid
stoichiometric coefficient: 1.0

Isonicotinic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Isonicotinic acid

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/CAS 302-01-2
type: UnificationXref
id: 302-01-2
db: CAS

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Isoniazid Metabolism
type: Pathway
pathway order: PathwaySubPathway/109930
pathway order: PathwayEnzymeReaction/2123270
pathway order: PathwayEnzymeReaction/2123271
pathway order: PathwayEnzymeReaction/2123272
pathway order: PathwayEnzymeReaction/2123273
pathway order: PathwayEnzymeReaction/2123263
pathway order: PathwayEnzymeReaction/2123274
pathway order: PathwayEnzymeReaction/2123264
pathway order: PathwayEnzymeReaction/2123275
pathway order: PathwayEnzymeReaction/2123265
pathway order: PathwayEnzymeReaction/2123266
pathway order: PathwayEnzymeReaction/2123267
pathway order: PathwayEnzymeReaction/2123268
pathway order: PathwayEnzymeReaction/2123269
pathway component: Reaction179502
pathway component: Reaction179546
pathway component: Reaction179545
pathway component: Reaction179544
pathway component: Reaction179543
pathway component: Reaction179549
pathway component: Reaction179548
pathway component: ReactionCatalysis169437
pathway component: Reaction179503
pathway component: Reaction179547
pathway component: ReactionCatalysis169436
pathway component: ReactionCatalysis169435
pathway component: ReactionCatalysis169434
pathway component: ReactionCatalysis169433
pathway component: Excretion
pathway component: ReactionCatalysis169432
pathway component: Reaction179498
pathway component: Reaction179542
pathway component: ReactionCatalysis169431
pathway component: Reaction179497
pathway component: ReactionCatalysis169430
pathway component: Reaction179509
xref: Reference/PathWhiz PW122377
xref: Reference/SMPDB SMP0121107
organism: Xenopus laevis

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

ChemicalStructure/PW C022667
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CNC(=O)C1=CC=NC=C1

Compound/PW C000078 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 9321
type: UnificationXref
id: 9321
db: PubChem-compound

Compound/PW C001420 Lysosome/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

NADP
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADP

Acetylhydrazine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetylhydrazine

Compound/PW C104682 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isonicotinic acid
stoichiometric coefficient: 1.0

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 2422
type: UnificationXref
id: CHEBI:2422
db: ChEBI

Reference/ChemSpider 111188
type: UnificationXref
id: 111188
db: ChemSpider

ChemicalStructure/PW C008140
type: ChemicalStructure
structure format: SMILES
structure data: NN

Hydrazine
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Hydrazine

Reference/HMDB HMDB0012973
type: UnificationXref
id: HMDB0012973
db: HMDB

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/PubChem-compound 7737
type: UnificationXref
id: 7737
db: PubChem-compound

Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Compound/PW C104678/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isonicotinoyl radical
stoichiometric coefficient: 1.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/KEGG Compound C07054
type: UnificationXref
id: C07054
db: KEGG Compound

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/Generic535 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hepatotoxins
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

Isoniazid
type: SmallMolecule
cellular location: Lysosome
entity reference: Isoniazid

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/ChemSpider 3635
type: UnificationXref
id: 3635
db: ChemSpider

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/HMDB HMDB0041821
type: UnificationXref
id: HMDB0041821
db: HMDB

Isoniazid
type: SmallMoleculeReference
xref: Reference/ChemSpider 3635
xref: Reference/CAS 54-85-3
xref: Reference/KEGG Compound C07054
xref: Reference/PubChem-compound 3767
xref: Reference/HMDB HMDB0015086
xref: Reference/ChEBI CHEBI 6030
chemical formula: C6H7N3O
molecular weight: 137.05891
structure: ChemicalStructure/PW C009392

NADPH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADPH

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C009392 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isoniazid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/CAS 1078-38-2
type: UnificationXref
id: 1078-38-2
db: CAS

Protein/10225 Lysosome/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Compound/PW C009392 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isoniazid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000080
type: ChemicalStructure
structure format: SMILES

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Compound/PW C022604 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylisoniazid
stoichiometric coefficient: 1.0

Isoniazid
type: SmallMolecule
entity reference: Isoniazid