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NADPH-dependent methylglyoxal reductase lactoylglutathione lyase hydroxyacylglutathione hydrolase hydroxyacylglutathione hydrolase D-lactate dehydrogenase 1 D-lactate dehydrogenase 2 D-lactate dehydrogenase 3 pyruvate kinase I pyruvate kinase II L-lactate dehydrogenase pyruvate carboxylase 2 pyruvate carboxylase 1 phosphoenolpyruvate carboxykinase malate dehydrogenase malate dehydrogenase Pyruvate decarboxylase isozyme 1 pyruvate decarboxylase 2 Pyruvate decarboxylase isozyme 3 alcohol dehydrogenase subunit I alcohol dehydrogenase subunit 2 Unknown Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase complex protein X component, mitochondrial Glutathione reductase Unknown Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase complex protein X component, mitochondrial Glutathione reductase Unknown Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase complex protein X component, mitochondrial Glutathione reductase acetyl-CoA hydrolase acetate--CoA ligase 1 acetate--CoA ligase ACS2 acetate--CoA ligase 1 acetate--CoA ligase ACS2 2-isopropylmalate synthase 2-isopropylmalate synthase LEU9 acetyl-CoA C- acetyltransferase Homocitrate synthase, mitochondrial Acetyl-CoA carboxylase Lactaldehyde NADP Pyruvaldehyde NADP H+ Glutathione S- Lactoylglutathione H2O Glutathione D-Lactic acid ferricytochrome c Pyruvic acid ferrocytochrome c H+ ATP ADP Phosphoenolpyruvic acid L-Lactic acid ferricytochrome c Ferrocytochrome H+ ATP HCO3- ADP Pi Oxalacetic acid ATP Oxalacetic acid ADP CO2 NADH H+ L-Malic acid NAD NADH H+ L-Malic acid NAD H+ CO2 Acetaldehyde H+ NADH Ethanol NAD Thiamine pyrophosphate CO2 2-(a- Hydroxyethyl)thiamine diphosphate Thiamine pyrophosphate CoA Acetyl-CoA H2O CoA Acetic acid AMP CoA Acetyl adenylate PPi Acetic acid ATP 2-Isopropylmalic acid CoA Acetyl-CoA H2O α-Ketoisovaleric acid CoA Acetoacetyl-CoA H2O Homocitric acid CoA ATP HCO3- ADP PPi Malonyl-CoA Lipoamide-E S- Acetyldihydrolipoamide- E Dihydrolipoamide- E
Mitochondria GRE2 GLO1 GLO2 GLO4 DLD1 DLD2 DLD3 PYK1 PYK2 Unknown PYC2 PYC1 PCK1 MAE1 MAE1 PDC1 PDC5 PDC6 ADH7 ADH6 Unknown PDB1 PDX1 GLR1 Unknown PDB1 PDX1 GLR1 Unknown PDB1 PDX1 GLR1 ACH1 ACS1 ACS2 ACS1 ACS2 LEU4 LEU9 ERG10 LYS21 ACC1 Lactaldehyde NADP Pyruvaldehyde NADP Hydrogen Ion Glutathione S- Lactoylglutathione Water Glutathione D-Lactic acid ferricytochrome c Pyruvic acid ferrocytochrome c Hydrogen Ion Adenosine triphosphate Adenosine diphosphate Phosphoenolpyruvic acid L-Lactic acid ferricytochrome c Ferrocytochrome Hydrogen Ion Adenosine triphosphate Hydrogen carbonate Adenosine diphosphate Phosphate Oxalacetic acid Adenosine triphosphate Oxalacetic acid Adenosine diphosphate Carbon dioxide NADH Hydrogen Ion L-Malic acid NAD NADH Hydrogen Ion L-Malic acid NAD Hydrogen Ion Carbon dioxide Acetaldehyde Hydrogen Ion NADH Ethanol NAD Thiamine pyrophosphate Carbon dioxide 2-(a- Hydroxyethyl)thiamine diphosphate Thiamine pyrophosphate Coenzyme A Acetyl-CoA Water Coenzyme A Acetic acid Adenosine monophosphate Coenzyme A Acetyl adenylate Pyrophosphate Acetic acid Adenosine triphosphate 2-Isopropylmalic acid Coenzyme A Acetyl-CoA Water α-Ketoisovaleric acid Coenzyme A Acetoacetyl-CoA Water Homocitric acid Coenzyme A Adenosine triphosphate Hydrogen carbonate Adenosine diphosphate Pyrophosphate Malonyl-CoA Lipoamide-E S- Acetyldihydrolipoamide- E Dihydrolipoamide- E