Reference/KEGG Compound C03824
type: UnificationXref
id: C03824
db: KEGG Compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

2-Amino-3-carboxymuconic acid semialdehyde
type: SmallMolecule
entity reference: 2-Amino-3-carboxymuconic acid semialdehyde
name: SubPathwayOutput

2-Amino-3-Carboxymuconate Semialdehyde Degradation
type: Pathway
pathway order: PathwaySubPathway/110143
pathway order: PathwaySubPathway/110142
pathway order: PathwayEnzymeReaction/2123911
pathway order: PathwayEnzymeReaction/2123912
pathway order: PathwayEnzymeReaction/2123913
pathway order: PathwayEnzymeReaction/2123914
pathway order: PathwayEnzymeReaction/2123915
pathway component: Glutaryl-CoA degradation
pathway component: ReactionCatalysis169519
pathway component: 1.2.1.32
pathway component: Reaction179637
pathway component: ReactionCatalysis169523
pathway component: ReactionCatalysis169522
pathway component: ReactionCatalysis169521
pathway component: ReactionCatalysis169520
pathway component: 3.5.99.5
pathway component: 1.2.4.2
pathway component: 1.1.1.-
pathway component: L-tryptophan degradation
xref: Reference/PathWhiz PW122411
xref: Reference/SMPDB SMP0121131
organism: Homo sapiens

Reference/BioCyc 2K-ADIPATE
type: UnificationXref
id: 2K-ADIPATE
db: BioCyc

Reference/PubChem-compound 25245156
type: UnificationXref
id: 25245156
db: PubChem-compound

NADH
type: SmallMolecule
entity reference: NADH

Protein/882 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/CAS 16597-58-3
type: UnificationXref
id: 16597-58-3
db: CAS

Unknown
type: ProteinReference
organism: Homo sapiens

Reference/UniProt Q8TDX5
type: UnificationXref
id: Q8TDX5
db: UniProt

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Oxoadipic acid
type: SmallMoleculeReference
xref: Reference/CAS 3184-35-8
xref: Reference/ChEBI CHEBI 15753
xref: Reference/HMDB HMDB0000225
xref: Reference/PubChem-compound 71
xref: Reference/KEGG Compound C00322
xref: Reference/BioCyc 2K-ADIPATE
xref: Reference/ChemSpider 70
chemical formula: C6H8O5
molecular weight: 160.03717
structure: ChemicalStructure/PW C000150

Reference/ChemSpider 4444266
type: UnificationXref
id: 4444266
db: ChemSpider

Protein/4308 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
entity reference: NAD

SubPathwayInteraction110143
type: Interaction
name: SubPathway110143Reaction
name: SubPathwayReaction
participant: Glutaryl-CoA

Reference/KEGG Compound C00322
type: UnificationXref
id: C00322
db: KEGG Compound

SubPathwayInteraction110142
type: Interaction
name: SubPathway110142Reaction
name: SubPathwayReaction
participant: 2-Amino-3-carboxymuconic acid semialdehyde

2-Aminomuconic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5280499
xref: Reference/ChEBI CHEBI 15745
xref: Reference/CAS 4548-99-6
xref: Reference/ChemSpider 4444139
xref: Reference/HMDB HMDB0001241
xref: Reference/KEGG Compound C02220
xref: Reference/BioCyc 2-AMINO-MUCONATE
chemical formula: C6H7NO4
molecular weight: 157.0375
structure: ChemicalStructure/PW C000958

Reference/BioCyc 2-AMINO-MUCONATE
type: UnificationXref
id: 2-AMINO-MUCONATE
db: BioCyc

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Protein/52 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dihydrolipoyl dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

2-Aminomuconic acid
type: SmallMolecule
entity reference: 2-Aminomuconic acid

(3E)-2-oxohex-3-enedioate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25245156
xref: Reference/ChEBI CHEBI 64908
chemical formula: C6H4O5
molecular weight: 156.00697
structure: ChemicalStructure/PW C104699

Reference/UniProt P09622
type: UnificationXref
id: P09622
db: UniProt

2-Amino-3-carboxymuconic acid semialdehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Amino-3-carboxymuconic acid semialdehyde

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 64908
type: UnificationXref
id: CHEBI:64908
db: ChEBI

Oxoadipic acid
type: SmallMolecule
entity reference: Oxoadipic acid

Reference/ChEBI CHEBI 995
type: UnificationXref
id: CHEBI:995
db: ChEBI

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

2-aminomuconic semialdehyde dehydrogenase
type: ProteinReference
xref: Reference/UniProt Q9H2A2
organism: Homo sapiens

Reference/ChemSpider 4444139
type: UnificationXref
id: 4444139
db: ChemSpider

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/ChemSpider 70
type: UnificationXref
id: 70
db: ChemSpider

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5280499
type: UnificationXref
id: 5280499
db: PubChem-compound

Reference/PubChem-compound 71
type: UnificationXref
id: 71
db: PubChem-compound

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Compound/PW C001032 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutaryl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C104699
type: ChemicalStructure
structure format: SMILES
structure data: [H]\C(CC([O-])=O)=C(\[H])C(=O)C([O-])=O

Ammonium
type: SmallMolecule
entity reference: Ammonium

Reference/ChEBI CHEBI 15524
type: UnificationXref
id: CHEBI:15524
db: ChEBI

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Compound/PW C000958 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Aminomuconic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/UniProt Q96HY7
type: UnificationXref
id: Q96HY7
db: UniProt

2-Aminomuconic acid semialdehyde
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444230
xref: Reference/KEGG Compound C03824
xref: Reference/BioCyc 2-AMINOMUCONATE SEMIALDEHYDE
xref: Reference/ChEBI CHEBI 15745
xref: Reference/CAS 245128-91-0
xref: Reference/HMDB HMDB0001280
xref: Reference/PubChem-compound 5280625
chemical formula: C6H7NO3
molecular weight: 141.04259
structure: ChemicalStructure/PW C000991

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/CAS 103192-48-9
type: UnificationXref
id: 103192-48-9
db: CAS

Reference/PubChem-compound 5280673
type: UnificationXref
id: 5280673
db: PubChem-compound

Reference/HMDB HMDB0000225
type: UnificationXref
id: HMDB0000225
db: HMDB

Compound/PW C000150/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoadipic acid
stoichiometric coefficient: 1.0

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/ChEBI CHEBI 15745
type: UnificationXref
id: CHEBI:15745
db: ChEBI

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Oxoadipic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxoadipic acid

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

2-Amino-3-carboxymuconic acid semialdehyde
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444266
xref: Reference/PubChem-compound 5280673
xref: Reference/ChEBI CHEBI 995
xref: Reference/KEGG Compound C04409
xref: Reference/CAS 16597-58-3
xref: Reference/BioCyc 2-AMINO-3-CARBOXYMUCONATE SEMIAL
xref: Reference/HMDB HMDB0001330
chemical formula: C7H7NO5
molecular weight: 185.03242
structure: ChemicalStructure/PW C001026

Reference/CAS 4548-99-6
type: UnificationXref
id: 4548-99-6
db: CAS

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChEBI CHEBI 15753
type: UnificationXref
id: CHEBI:15753
db: ChEBI

Compound/PW C000958/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Aminomuconic acid
stoichiometric coefficient: 1.0

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
type: ProteinReference
xref: Reference/UniProt Q8TDX5
organism: Homo sapiens

Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Glutaryl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc GLUTARYL-COA
xref: Reference/CAS 103192-48-9
xref: Reference/ChEBI CHEBI 15524
xref: Reference/PubChem-compound 439252
xref: Reference/HMDB HMDB0001339
xref: Reference/KEGG Compound C00527
xref: Reference/ChemSpider 388388
chemical formula: C26H42N7O19P3S
molecular weight: 881.1469
structure: ChemicalStructure/PW C001032

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/HMDB HMDB0001339
type: UnificationXref
id: HMDB0001339
db: HMDB

Glutaryl-CoA
type: SmallMolecule
entity reference: Glutaryl-CoA
name: SubPathwayInput

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
type: Protein
cellular location: Cytosol
entity reference: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Reference/HMDB HMDB0001330
type: UnificationXref
id: HMDB0001330
db: HMDB

Reference/CAS 3184-35-8
type: UnificationXref
id: 3184-35-8
db: CAS

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q96HY7
organism: Homo sapiens

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Water
type: SmallMolecule
entity reference: Water

2-Aminomuconic acid semialdehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Aminomuconic acid semialdehyde

Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001026
type: ChemicalStructure
structure format: SMILES
structure data: N\C(C(O)=O)=C(\C=C/C=O)/C(O)=O

Compound/PW C001026 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Amino-3-carboxymuconic acid semialdehyde
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04409
type: UnificationXref
id: C04409
db: KEGG Compound

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/KEGG Compound C02220
type: UnificationXref
id: C02220
db: KEGG Compound

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Carbon dioxide

ChemicalStructure/PW C001032
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

Reference/BioCyc 2-AMINO-3-CARBOXYMUCONATE SEMIAL
type: UnificationXref
id: 2-AMINO-3-CARBOXYMUCONATE_SEMIAL
db: BioCyc

Oxoglutarate dehydrogenase complex
type: Complex
component stoichiometry: Protein/52 Mitochondrion/Stoichiometry/2.0
component stoichiometry: Protein/882 Mitochondrion/Stoichiometry/1.0
component stoichiometry: Protein/4308 Mitochondrion/Stoichiometry/1.0
cellular location: Mitochondrion
component: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
component: Dihydrolipoyl dehydrogenase, mitochondrial
component: Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Compound/PW C104699/Stoichiometry/1.0
type: Stoichiometry
physical entity: (3E)-2-oxohex-3-enedioate
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Coenzyme A

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

1.2.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000150 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001032 Mitochondrion/Stoichiometry/1.0
right: Carbon dioxide
right: Glutaryl-CoA
right: NADH
spontaneous: false
EC number: 1.2.4.2
left: NAD
left: Coenzyme A
left: Oxoadipic acid
name: Coenzyme A + NAD + Oxoadipic acid → Carbon dioxide + Glutaryl-CoA + NADH
conversion direction: LEFT_TO_RIGHT

1.1.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104699/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000150/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Oxoadipic acid
right: NAD
spontaneous: false
EC number: 1.1.1.-
left: NADH
left: Hydrogen Ion
left: (3E)-2-oxohex-3-enedioate
name: (3E)-2-oxohex-3-enedioate + Hydrogen Ion + NADH → NAD + Oxoadipic acid
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

NAD
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NAD

Reference/HMDB HMDB0001241
type: UnificationXref
id: HMDB0001241
db: HMDB

ChemicalStructure/PW C000150
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCCC(=O)C(O)=O

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

Reference/UniProt P36957
type: UnificationXref
id: P36957
db: UniProt

1.2.1.32
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000958 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000991 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: NADH
right: 2-Aminomuconic acid
spontaneous: false
EC number: 1.2.1.32
left: NAD
left: 2-Aminomuconic acid semialdehyde
left: Water
name: 2-Aminomuconic acid semialdehyde + NAD + Water → 2-Aminomuconic acid + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reaction179637
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001026 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000991 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
right: 2-Aminomuconic acid semialdehyde
right: Carbon dioxide
spontaneous: false
left: Hydrogen Ion
left: 2-Amino-3-carboxymuconic acid semialdehyde
name: 2-Amino-3-carboxymuconic acid semialdehyde + Hydrogen Ion → 2-Aminomuconic acid semialdehyde + Carbon dioxide
conversion direction: LEFT_TO_RIGHT

Dihydrolipoyl dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P09622
organism: Homo sapiens

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000958
type: ChemicalStructure
structure format: SMILES
structure data: N\C(=C\C=C/C(O)=O)C(O)=O

Glutaryl-CoA degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110143
pathway component: SubPathwayInteraction110143
name: SubPathway

Reference/PathWhiz PW122411
type: UnificationXref
id: PW122411
db: PathWhiz

Reference/CAS 245128-91-0
type: UnificationXref
id: 245128-91-0
db: CAS

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

3.5.99.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C104699/Stoichiometry/1.0
participant stoichiometry: Compound/PW C022608/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000958/Stoichiometry/1.0
right: Ammonium
right: (3E)-2-oxohex-3-enedioate
spontaneous: false
EC number: 3.5.99.5
left: 2-Aminomuconic acid
left: Water
name: 2-Aminomuconic acid + Water → (3E)-2-oxohex-3-enedioate + Ammonium
conversion direction: LEFT_TO_RIGHT

NADH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADH

L-tryptophan degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110142
pathway component: SubPathwayInteraction110142
name: SubPathway

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/BioCyc GLUTARYL-COA
type: UnificationXref
id: GLUTARYL-COA
db: BioCyc

Reference/ChemSpider 4444230
type: UnificationXref
id: 4444230
db: ChemSpider

ReactionCatalysis169523
type: Catalysis
controller: Oxoglutarate dehydrogenase complex
controlled: 1.2.4.2
control type: ACTIVATION

ReactionCatalysis169522
type: Catalysis
controller: Unknown
controlled: 1.1.1.-
control type: ACTIVATION

ReactionCatalysis169521
type: Catalysis
controller: Unknown
controlled: 3.5.99.5
control type: ACTIVATION

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

ReactionCatalysis169520
type: Catalysis
controller: 2-aminomuconic semialdehyde dehydrogenase
controlled: 1.2.1.32
control type: ACTIVATION

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/UniProt Q9H2A2
type: UnificationXref
id: Q9H2A2
db: UniProt

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

ReactionCatalysis169519
type: Catalysis
controller: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
controlled: Reaction179637
control type: ACTIVATION

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Compound/PW C000991 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Aminomuconic acid semialdehyde
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00527
type: UnificationXref
id: C00527
db: KEGG Compound

Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Compound/PW C022608/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Compound/PW C000150 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoadipic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/BioCyc 2-AMINOMUCONATE SEMIALDEHYDE
type: UnificationXref
id: 2-AMINOMUCONATE_SEMIALDEHYDE
db: BioCyc

(3E)-2-oxohex-3-enedioate
type: SmallMolecule
entity reference: (3E)-2-oxohex-3-enedioate

Reference/SMPDB SMP0121131
type: UnificationXref
id: SMP0121131
db: SMPDB

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

2-Aminomuconic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Aminomuconic acid

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt P36957
organism: Homo sapiens

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/PubChem-compound 439252
type: UnificationXref
id: 439252
db: PubChem-compound

Dihydrolipoyl dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Dihydrolipoyl dehydrogenase, mitochondrial

Glutaryl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Glutaryl-CoA

ChemicalStructure/PW C000991
type: ChemicalStructure
structure format: SMILES
structure data: N\C(=C\C=C/C=O)C(O)=O

Reference/HMDB HMDB0001280
type: UnificationXref
id: HMDB0001280
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/PubChem-compound 5280625
type: UnificationXref
id: 5280625
db: PubChem-compound

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 388388
type: UnificationXref
id: 388388
db: ChemSpider

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

2-aminomuconic semialdehyde dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: 2-aminomuconic semialdehyde dehydrogenase