ReactionCatalysis169728
type: Catalysis
controller: Dihydrolipoyl dehydrogenase, mitochondrial
controlled: 1.8.1.4
control type: ACTIVATION

Compound/PW C000936/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis169727
type: Catalysis
controller: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
controlled: 1.3.5.1
control type: ACTIVATION

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Lipoamide-E
type: Protein
cellular location: Mitochondrion
entity reference: Lipoamide-E

ReactionCatalysis169725
type: Catalysis
controller: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
controlled: Reaction179857
control type: ACTIVATION

ReactionCatalysis169724
type: Catalysis
controller: Pyruvate dehydrogenase E1
controlled: Reaction179856
control type: ACTIVATION

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

ReactionCatalysis169722
type: Catalysis
controller: DihydroLipoamide S-SuccinylTransferase
controlled: Reaction179854
control type: ACTIVATION

Reference/PubChem-compound 439161
type: UnificationXref
id: 439161
db: PubChem-compound

ReactionCatalysis169721
type: Catalysis
controller: 2-oxoglutarate dehydrogenase, mitochondrial
controlled: 1.2.4.2
control type: ACTIVATION

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/KEGG Compound C00311
type: UnificationXref
id: C00311
db: KEGG Compound

Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 30797
type: UnificationXref
id: CHEBI:30797
db: ChEBI

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Reference/HMDB HMDB0006878
type: UnificationXref
id: HMDB0006878
db: HMDB

DihydroLipoamide S-SuccinylTransferase
type: ProteinReference
xref: Reference/UniProt O45148
organism: Caenorhabditis elegans

Compound/PW C000125 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitric acid
stoichiometric coefficient: 1.0

Succinic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Succinic acid

Reference/HMDB HMDB0000094
type: UnificationXref
id: HMDB0000094
db: HMDB

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reference/HMDB HMDB0003364
type: UnificationXref
id: HMDB0003364
db: HMDB

ReactionCatalysis169718
type: Catalysis
controller: Succinyl-CoA ligase
controlled: 6.2.1.4
control type: ACTIVATION

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Reference/UniProt O17732
type: UnificationXref
id: O17732
db: UniProt

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/SMPDB SMP0121182
type: UnificationXref
id: SMP0121182
db: SMPDB

Reference/ChEBI CHEBI 17594
type: UnificationXref
id: CHEBI:17594
db: ChEBI

Probable citrate synthase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P34575

Pyruvate dehydrogenase E1
type: Complex
component stoichiometry: Protein/14850 Mitochondrion/Stoichiometry/2.0
component stoichiometry: Protein/14845 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
component: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

ReactionCatalysis169709
type: Catalysis
controller: Pyruvate carboxylase, mitochondrial
controlled: Reaction179841
control type: ACTIVATION

ReactionCatalysis169702
type: Catalysis
controller: Isocitrate dehydrogenase
controlled: Reaction179835
control type: ACTIVATION

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChEBI CHEBI 15380
type: UnificationXref
id: CHEBI:15380
db: ChEBI

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Succinyl-CoA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00091
xref: Reference/CAS 604-98-8
xref: Reference/ChemSpider 388307
xref: Reference/PubChem-compound 439161
xref: Reference/ChEBI CHEBI 15380
xref: Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
xref: Reference/HMDB HMDB0001022
chemical formula: C25H40N7O19P3S
molecular weight: 867.1312
structure: ChemicalStructure/PW C000808

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetyl-CoA
name: SubPathwayOutput
name: SubPathwayInput

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Compound/PW C002022 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalosuccinic acid
stoichiometric coefficient: 1.0

Reference/CAS 1948-82-9
type: UnificationXref
id: 1948-82-9
db: CAS

Reference/CAS 97-67-6
type: UnificationXref
id: 97-67-6
db: CAS

Dihydrolipoamide-E
type: Protein
cellular location: Mitochondrion
entity reference: Dihydrolipoamide-E

Dihydrolipoyl dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Dihydrolipoyl dehydrogenase, mitochondrial

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Reference/ChemSpider 947
type: UnificationXref
id: 947
db: ChemSpider

Reference/UniProt Q23500
type: UnificationXref
id: Q23500
db: UniProt

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 30769
type: UnificationXref
id: CHEBI:30769
db: ChEBI

Reference/ChEBI CHEBI 30887
type: UnificationXref
id: CHEBI:30887
db: ChEBI

Isocitric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Isocitric acid

Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

ChemicalStructure/PW C000808
type: ChemicalStructure
structure format: SMILES

Fumaric acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Fumaric acid
name: SubPathwayOutput

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Protein/14892/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

Reference/ChemSpider 1161
type: UnificationXref
id: 1161
db: ChemSpider

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00472
type: UnificationXref
id: C00472
db: KEGG Compound

Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
type: Protein
entity reference: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Oxalosuccinic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxalosuccinic acid

ReactionCatalysis139153
type: Catalysis
controller: Fumarate hydratase, mitochondrial
controlled: 4.2.1.2
control type: ACTIVATION

Compound/PW C001632 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroquinone
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Citrate Cycle
type: Pathway
pathway order: PathwaySubPathway/110134
pathway order: PathwaySubPathway/110133
pathway order: PathwaySubPathway/110132
pathway order: PathwaySubPathway/110131
pathway order: PathwaySubPathway/110130
pathway order: PathwayEnzymeReaction/2124570
pathway order: PathwayEnzymeReaction/2124571
pathway order: PathwayEnzymeReaction/2124611
pathway order: PathwayEnzymeReaction/2124599
pathway order: PathwayEnzymeReaction/2124610
pathway order: PathwayEnzymeReaction/2124579
pathway order: PathwaySubPathway/110129
pathway order: PathwaySubPathway/110128
pathway order: PathwaySubPathway/110126
pathway order: PathwaySubPathway/110125
pathway order: PathwayEnzymeReaction/2124618
pathway order: PathwayEnzymeReaction/2124581
pathway order: PathwayEnzymeReaction/2124580
pathway order: PathwayEnzymeReaction/2124563
pathway order: PathwayEnzymeReaction/2124562
pathway order: PathwayEnzymeReaction/2124620
pathway order: PathwayEnzymeReaction/2124600
pathway order: PathwayEnzymeReaction/2124588
pathway order: PathwayEnzymeReaction/2124569
pathway order: PathwayEnzymeReaction/2124568
pathway order: PathwayEnzymeReaction/2124604
pathway order: PathwaySubPathway/110139
pathway order: PathwaySubPathway/110138
pathway order: PathwaySubPathway/110137
pathway order: PathwaySubPathway/110136
pathway order: PathwayEnzymeReaction/2124607
pathway order: PathwaySubPathway/110135
pathway component: ReactionCatalysis169728
pathway component: ReactionCatalysis169727
pathway component: 1.8.1.4
pathway component: ReactionCatalysis169725
pathway component: ReactionCatalysis169724
pathway component: Reaction179822
pathway component: ReactionCatalysis169722
pathway component: ReactionCatalysis169721
pathway component: ReactionCatalysis169687
pathway component: ReactionCatalysis139153
pathway component: Reaction179829
pathway component: Reaction179828
pathway component: Reaction179827
pathway component: ReactionCatalysis169718
pathway component: Reaction179854
pathway component: 1.2.4.2
pathway component: Reaction179857
pathway component: Reaction179856
pathway component: Alanine, aspartate and glutamate metabolism
pathway component: 6.2.1.4
pathway component: 4.2.1.2
pathway component: Glycolysis / Gluconeogenesis
pathway component: Arginine Biosynthesis
pathway component: Ascorbate and aldarate metabolism
pathway component: 1.3.5.1
pathway component: ReactionCatalysis169709
pathway component: Reaction179841
pathway component: 4.1.1.32
pathway component: ReactionCatalysis169702
pathway component: Tyrosine metabolism
pathway component: Glyoxylate and dicarboxylate metabolism
pathway component: Fatty acid biosynthesis
pathway component: Fatty acid elongation in mitochondria
pathway component: Val, Leu & Ile degradation
pathway component: Fatty acid metabolism
pathway component: D-Gln & D-Glu metabolism
pathway component: Reaction179832
pathway component: ReactionCatalysis139425
pathway component: Reaction179830
pathway component: Reaction179835
pathway component: ReactionCatalysis169699
pathway component: ReactionCatalysis169697
pathway component: ReactionCatalysis169695
pathway component: ReactionCatalysis169694

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: Protein
entity reference: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Pyruvic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Pyruvic acid
name: SubPathwayOutput

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Reference/BioCyc OXALO-SUCCINATE
type: UnificationXref
id: OXALO-SUCCINATE
db: BioCyc

Phosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Phosphate

Protein/14845 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
stoichiometric coefficient: 2.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/UniProt P52899
type: UnificationXref
id: P52899
db: UniProt

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Compound/PW C000063/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citric acid
stoichiometric coefficient: 1.0

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Succinyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Succinyl-CoA
name: SubPathwayOutput

Pyruvate carboxylase 1
type: ProteinReference
xref: Reference/UniProt O17732
organism: Caenorhabditis elegans

Probable malate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt O02640
organism: Caenorhabditis elegans

Reference/UniProt Q93714
type: UnificationXref
id: Q93714
db: UniProt

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Compound/PW C000463 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00149
type: UnificationXref
id: C00149
db: KEGG Compound

Reference/ChemSpider 388307
type: UnificationXref
id: 388307
db: ChemSpider

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Guanosine triphosphate
type: SmallMolecule
entity reference: Guanosine triphosphate

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Quinone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Quinone

Hydroquinone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002434
xref: Reference/ChemSpider 764
xref: Reference/PubChem-compound 785
xref: Reference/CAS 123-31-9
xref: Reference/BioCyc 236-TRICHLOROHYDROQUINONE
xref: Reference/ChEBI CHEBI 17594
xref: Reference/KEGG Compound C00530
chemical formula: C6H6O2
molecular weight: 110.03678
structure: ChemicalStructure/PW C001632

ReactionCatalysis169687
type: Catalysis
controller: Malate dehydrogenase, mitochondrial
controlled: Reaction179822
control type: ACTIVATION

Reference/KEGG Compound C00158
type: UnificationXref
id: C00158
db: KEGG Compound

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/HMDB HMDB0002434
type: UnificationXref
id: HMDB0002434
db: HMDB

Protein/Generic267 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrolipoamide-E
stoichiometric coefficient: 1.0

Probable ATP-citrate synthase
type: Protein
entity reference: Probable ATP-citrate synthase

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

Water
type: SmallMolecule
entity reference: Water

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Protein/17332/Stoichiometry/4.0
type: Stoichiometry
physical entity: Probable ATP-citrate synthase
stoichiometric coefficient: 4.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine diphosphate

Reference/UniProt O02640
type: UnificationXref
id: O02640
db: UniProt

ChemicalStructure/PW C000051
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C\C(=C\C(O)=O)C(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Alanine, aspartate and glutamate metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110129
pathway component: SubPathwayInteraction110129
name: SubPathway

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Compound/PW C000808/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

Reference/UniProt Q09508
type: UnificationXref
id: Q09508
db: UniProt

Reference/ChemSpider 764
type: UnificationXref
id: 764
db: ChemSpider

ChemicalStructure/PW C000063
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(O)(CC(O)=O)C(O)=O

Reference/CAS 604-98-8
type: UnificationXref
id: 604-98-8
db: CAS

Glycolysis / Gluconeogenesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110125
pathway component: SubPathwayInteraction110125
name: SubPathway

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

Arginine Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110126
pathway component: SubPathwayInteraction110126
name: SubPathway

Ascorbate and aldarate metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110128
pathway component: SubPathwayInteraction110128
name: SubPathway

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxoglutaric acid
name: SubPathwayInput

Reference/PubChem-compound 785
type: UnificationXref
id: 785
db: PubChem-compound

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

Citric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Citric acid

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/HMDB HMDB0000156
type: UnificationXref
id: HMDB0000156
db: HMDB

Protein/14903 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Probable malate dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

NAD
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NAD

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Tyrosine metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110132
pathway component: SubPathwayInteraction110132
name: SubPathway

Arginine Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110133
pathway component: SubPathwayInteraction110133
name: SubPathway

Alanine, aspartate and glutamate metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110134
pathway component: SubPathwayInteraction110134
name: SubPathway

Glyoxylate and dicarboxylate metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110135
pathway component: SubPathwayInteraction110135
name: SubPathway

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Fatty acid biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110136
pathway component: SubPathwayInteraction110136
name: SubPathway

Quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4489
xref: Reference/CAS 106-51-4
xref: Reference/KEGG Compound C00472
xref: Reference/ChEBI CHEBI 16509
xref: Reference/BioCyc CPD-8130
xref: Reference/PubChem-compound 4650
xref: Reference/HMDB HMDB0003364
chemical formula: C6H4O2
molecular weight: 108.021126
structure: ChemicalStructure/PW C001860

Fatty acid elongation in mitochondria
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110137
pathway component: SubPathwayInteraction110137
name: SubPathway

Phosphoenolypyruvate CarboxyKinase
type: ProteinReference
xref: Reference/UniProt Q7JKI2

Val, Leu & Ile degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110138
pathway component: SubPathwayInteraction110138
name: SubPathway

Fatty acid metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110139
pathway component: SubPathwayInteraction110139
name: SubPathway

D-Gln & D-Glu metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110130
pathway component: SubPathwayInteraction110130
name: SubPathway

Val, Leu & Ile degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway110131
pathway component: SubPathwayInteraction110131
name: SubPathway

Fumarate hydratase, mitochondrial
type: Complex
component stoichiometry: Protein/14897 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Probable fumarate hydratase, mitochondrial

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

2-oxoglutarate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: 2-oxoglutarate dehydrogenase, mitochondrial

Reference/ChemSpider 305
type: UnificationXref
id: 305
db: ChemSpider

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/UniProt Q7JKI2
type: UnificationXref
id: Q7JKI2
db: UniProt

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

Reference/UniProt O61199
type: UnificationXref
id: O61199
db: UniProt

S-Acetyldihydrolipoamide-E
type: SmallMolecule
cellular location: Mitochondrion
entity reference: S-Acetyldihydrolipoamide-E

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Protein/14897 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Probable fumarate hydratase, mitochondrial
stoichiometric coefficient: 4.0

Protein/14907 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate carboxylase 1
stoichiometric coefficient: 4.0

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Compound/PW C000125 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitric acid
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Isocitrate dehydrogenase [NADP]
type: ProteinReference
xref: Reference/UniProt H9G2T4
organism: Caenorhabditis elegans

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001022
type: UnificationXref
id: HMDB0001022
db: HMDB

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Compound/Generic542 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Succinyldihydrolipoamide-E
stoichiometric coefficient: 1.0

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Reference/CAS 585-84-2
type: UnificationXref
id: 585-84-2
db: CAS

Reference/KEGG Compound C00091
type: UnificationXref
id: C00091
db: KEGG Compound

Reference/PathWhiz PW122475
type: UnificationXref
id: PW122475
db: PathWhiz

Oxalacetic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxalacetic acid
name: SubPathwayInput

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

S-Acetyldihydrolipoamide-E
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24906332
xref: Reference/KEGG Compound C16255
xref: Reference/HMDB HMDB0006878
xref: Reference/ChEBI CHEBI 50623
xref: Reference/ChemSpider 21865772
chemical formula: C10H19NO2S2
molecular weight: 249.08572
structure: ChemicalStructure/PW C002986

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q09508
organism: Caenorhabditis elegans

Hydroquinone
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydroquinone

Compound/PW C000088 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 21865772
type: UnificationXref
id: 21865772
db: ChemSpider

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Compound/PW C000940 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Compound/PW C000986/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Probable ATP-citrate synthase
type: ProteinReference
xref: Reference/UniProt P53585

Reference/HMDB HMDB0000193
type: UnificationXref
id: HMDB0000193
db: HMDB

Reference/HMDB HMDB0000072
type: UnificationXref
id: HMDB0000072
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

cis-Aconitic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cis-Aconitic acid

Reference/PubChem-compound 972
type: UnificationXref
id: 972
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Compound/PW C000101 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Malic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Reference/BioCyc CIS-ACONITATE
type: UnificationXref
id: CIS-ACONITATE
db: BioCyc

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

ChemicalStructure/PW C002022
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(C(O)=O)C(=O)C(O)=O

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

Compound/PW C000134 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 2.0

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

L-Malic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000156
xref: Reference/ChEBI CHEBI 30797
xref: Reference/KEGG Compound C00149
xref: Reference/ChemSpider 193317
xref: Reference/PubChem-compound 222656
xref: Reference/CAS 97-67-6
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C000101

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

Probable cytoplasmic aconitate hydratase
type: Protein
cellular location: Cytoplasm
entity reference: Probable cytoplasmic aconitate hydratase

ChemicalStructure/PW C002986
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)SCCC(S)CCCCC(N)=O

Succinic acid
type: SmallMolecule
entity reference: Succinic acid

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/BioCyc CIT
type: UnificationXref
id: CIT
db: BioCyc

Probable malate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Probable malate dehydrogenase, mitochondrial

Compound/PW C001860 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinone
stoichiometric coefficient: 1.0

Reference/UniProt O44451
type: UnificationXref
id: O44451
db: UniProt

Compound/PW C002986 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Acetyldihydrolipoamide-E
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Pyruvate carboxylase, mitochondrial
type: Complex
component stoichiometry: Protein/14907 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Pyruvate carboxylase 1

Compound/PW C000180/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

ChemicalStructure/PW C000101
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

4.1.1.32
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148/Stoichiometry/1.0
right: Guanosine diphosphate
right: Carbon dioxide
right: Phosphoenolpyruvic acid
spontaneous: false
EC number: 4.1.1.32
left: Oxalacetic acid
left: Guanosine triphosphate
name: Guanosine triphosphate + Oxalacetic acid ↔ Carbon dioxide + Guanosine diphosphate + Phosphoenolpyruvic acid
conversion direction: REVERSIBLE

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Isocitric acid
type: SmallMoleculeReference
xref: Reference/CAS 320-77-4
xref: Reference/BioCyc threo-d(s)-iso-citrate
xref: Reference/ChEBI CHEBI 30887
xref: Reference/ChemSpider 1161
xref: Reference/HMDB HMDB0000193
xref: Reference/KEGG Compound C00311
xref: Reference/PubChem-compound 1198
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C000125

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 50623
type: UnificationXref
id: CHEBI:50623
db: ChEBI

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Protein/14888/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Malate dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/14903 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Probable malate dehydrogenase, mitochondrial

Isocitrate dehydrogenase [NADP]
type: Protein
cellular location: Cytosol
entity reference: Isocitrate dehydrogenase [NADP]

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen Ion

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/KEGG Compound C16254
type: UnificationXref
id: C16254
db: KEGG Compound

Reference/KEGG Compound C16255
type: UnificationXref
id: C16255
db: KEGG Compound

Isocitrate dehydrogenase [NADP] cytoplasmic
type: Complex
component stoichiometry: Protein/17674 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Isocitrate dehydrogenase [NADP]

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

S-Succinyldihydrolipoamide-E
type: SmallMolecule
cellular location: Mitochondrion
entity reference: S-Succinyldihydrolipoamide-E

Oxalacetic acid
type: SmallMolecule
entity reference: Oxalacetic acid

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Reference/PubChem-compound 4650
type: UnificationXref
id: 4650
db: PubChem-compound

Reference/ChemSpider 558863
type: UnificationXref
id: 558863
db: ChemSpider

Reference/CAS 77-92-9
type: UnificationXref
id: 77-92-9
db: CAS

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine triphosphate

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

S-Succinyldihydrolipoamide-E
type: SmallMoleculeReference
xref: Reference/KEGG Compound C16254

Probable cytoplasmic aconitate hydratase
type: ProteinReference
xref: Reference/UniProt Q23500
organism: Caenorhabditis elegans

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C000063 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Citric acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 643757
type: UnificationXref
id: 643757
db: PubChem-compound

Reaction179822
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000101 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrion/Stoichiometry/1.0
right: Oxalacetic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
left: NAD
left: L-Malic acid
name: L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid
conversion direction: REVERSIBLE

DihydroLipoamide S-SuccinylTransferase
type: Protein
cellular location: Mitochondrion
entity reference: DihydroLipoamide S-SuccinylTransferase

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/PubChem-compound C15972
type: UnificationXref
id: C15972
db: PubChem-compound

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/BioCyc 236-TRICHLOROHYDROQUINONE
type: UnificationXref
id: 236-TRICHLOROHYDROQUINONE
db: BioCyc

Reference/PubChem-compound C15973
type: UnificationXref
id: C15973
db: PubChem-compound

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Phosphoenolypyruvate CarboxyKinase
type: Protein
entity reference: Phosphoenolypyruvate CarboxyKinase

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reaction179829
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000051 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Cytoplasm/Stoichiometry/1.0
right: cis-Aconitic acid
right: Water
spontaneous: false
left: Isocitric acid
name: Isocitric acid ↔ Water + cis-Aconitic acid
conversion direction: REVERSIBLE

Reaction179828
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002022 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
right: Oxoglutaric acid
right: Carbon dioxide
spontaneous: false
left: Oxalosuccinic acid
name: Oxalosuccinic acid ↔ Carbon dioxide + 2 Oxoglutaric acid
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reaction179827
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002022 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: Oxalosuccinic acid
right: Hydrogen Ion
right: NADPH
spontaneous: false
left: Isocitric acid
left: NADP
name: Isocitric acid + NADP ↔ Hydrogen Ion + NADPH + Oxalosuccinic acid
conversion direction: REVERSIBLE

Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C05379
type: UnificationXref
id: C05379
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0003974
type: UnificationXref
id: HMDB0003974
db: HMDB

Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Oxalosuccinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003974
xref: Reference/PubChem-compound 972
xref: Reference/CAS 1948-82-9
xref: Reference/ChEBI CHEBI 7815
xref: Reference/BioCyc OXALO-SUCCINATE
xref: Reference/ChemSpider 947
xref: Reference/KEGG Compound C05379
chemical formula: C6H6O7
molecular weight: 190.01135
structure: ChemicalStructure/PW C002022

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Isocitrate dehydrogenase
type: Complex
component stoichiometry: Protein/14873 Mitochondrion/Stoichiometry/1.0
component stoichiometry: Protein/14870 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
component: Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Reference/UniProt Q19749
type: UnificationXref
id: Q19749
db: UniProt

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/UniProt H9G2T4
type: UnificationXref
id: H9G2T4
db: UniProt

Reaction179841
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Oxalacetic acid
spontaneous: false
left: Adenosine triphosphate
left: Hydrogen carbonate
left: Pyruvic acid
name: Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid ↔ Adenosine diphosphate + Oxalacetic acid + Phosphate
conversion direction: REVERSIBLE

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxoglutaric acid

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

SubPathwayInteraction110139
type: Interaction
name: SubPathwayReaction
name: SubPathway110139Reaction
participant: Acetyl-CoA

SubPathwayInteraction110138
type: Interaction
name: SubPathway110138Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

SubPathwayInteraction110137
type: Interaction
name: SubPathway110137Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

SubPathwayInteraction110136
type: Interaction
name: SubPathwayReaction
name: SubPathway110136Reaction
participant: Acetyl-CoA

Compound/PW C001034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

SubPathwayInteraction110135
type: Interaction
name: SubPathway110135Reaction
name: SubPathwayReaction
participant: Oxalacetic acid

SubPathwayInteraction110134
type: Interaction
name: SubPathwayReaction
name: SubPathway110134Reaction
participant: Oxalacetic acid

SubPathwayInteraction110133
type: Interaction
name: SubPathwayReaction
name: SubPathway110133Reaction
participant: Fumaric acid

SubPathwayInteraction110132
type: Interaction
name: SubPathway110132Reaction
name: SubPathwayReaction
participant: Fumaric acid

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

SubPathwayInteraction110131
type: Interaction
name: SubPathway110131Reaction
name: SubPathwayReaction
participant: Succinyl-CoA

SubPathwayInteraction110130
type: Interaction
name: SubPathwayReaction
name: SubPathway110130Reaction
participant: Oxoglutaric acid

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Compound/PW C000051 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cis-Aconitic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Phosphoenolpyruvic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Phosphoenolpyruvic acid
name: SubPathwayInput

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

cis-Aconitic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 643757
xref: Reference/KEGG Compound C00417
xref: Reference/HMDB HMDB0000072
xref: Reference/ChEBI CHEBI 32805
xref: Reference/BioCyc CIS-ACONITATE
xref: Reference/ChemSpider 558863
xref: Reference/CAS 585-84-2
chemical formula: C6H6O6
molecular weight: 174.01643
structure: ChemicalStructure/PW C000051

Reference/CAS 320-77-4
type: UnificationXref
id: 320-77-4
db: CAS

Reaction179832
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000063/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000148/Stoichiometry/1.0
right: Water
right: Acetyl-CoA
right: Oxalacetic acid
spontaneous: false
left: Coenzyme A
left: Citric acid
name: Citric acid + Coenzyme A ↔ Acetyl-CoA + Oxalacetic acid + Water
conversion direction: REVERSIBLE

Protein/14873 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
stoichiometric coefficient: 1.0

Reference/BioCyc threo-d(s)-iso-citrate
type: UnificationXref
id: threo-d(s)-iso-citrate
db: BioCyc

Reaction179830
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000051 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000063 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
right: cis-Aconitic acid
right: Water
spontaneous: false
left: Citric acid
name: Citric acid ↔ Water + cis-Aconitic acid
conversion direction: REVERSIBLE

Isocitric acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Isocitric acid

Reference/UniProt P34575
type: UnificationXref
id: P34575
db: UniProt

Reaction179835
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000125 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrion/Stoichiometry/2.0
right: Carbon dioxide
right: Oxoglutaric acid
right: Hydrogen Ion
right: NADH
spontaneous: false
left: NAD
left: Isocitric acid
name: Isocitric acid + NAD ↔ Carbon dioxide + Hydrogen Ion + NADH + 2 Oxoglutaric acid
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

SubPathwayInteraction110129
type: Interaction
name: SubPathway110129Reaction
name: SubPathwayReaction
participant: Oxoglutaric acid

SubPathwayInteraction110128
type: Interaction
name: SubPathway110128Reaction
name: SubPathwayReaction
participant: Oxoglutaric acid

ReactionCatalysis169699
type: Catalysis
controller: ATP-citrate synthase
controlled: Reaction179832
control type: ACTIVATION

SubPathwayInteraction110126
type: Interaction
name: SubPathway110126Reaction
name: SubPathwayReaction
participant: Oxoglutaric acid

SubPathwayInteraction110125
type: Interaction
name: SubPathwayReaction
name: SubPathway110125Reaction
participant: Phosphoenolpyruvic acid
participant: Pyruvic acid

ReactionCatalysis169697
type: Catalysis
controller: Probable citrate synthase, mitochondrial
controlled: Reaction179832
control type: ACTIVATION

ReactionCatalysis169695
type: Catalysis
controller: Probable cytoplasmic aconitate hydratase
controlled: Reaction179830
control type: ACTIVATION

ReactionCatalysis169694
type: Catalysis
controller: Probable cytoplasmic aconitate hydratase
controlled: Reaction179829
control type: ACTIVATION

Compound/PW C000134 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 2.0

ReactionCatalysis169693
type: Catalysis
controller: Isocitrate dehydrogenase [NADP] cytoplasmic
controlled: Reaction179828
control type: ACTIVATION

ReactionCatalysis169692
type: Catalysis
controller: Isocitrate dehydrogenase [NADP] cytoplasmic
controlled: Reaction179827
control type: ACTIVATION

Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Citric acid
type: SmallMolecule
entity reference: Citric acid

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Compound/PW C000808 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinyl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000125
type: ChemicalStructure
structure format: SMILES
structure data: OC(C(CC(O)=O)C(O)=O)C(O)=O

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 7815
type: UnificationXref
id: CHEBI:7815
db: ChEBI

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Phosphoenolpyruvic acid
type: SmallMolecule
entity reference: Phosphoenolpyruvic acid

Citric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30769
xref: Reference/BioCyc CIT
xref: Reference/HMDB HMDB0000094
xref: Reference/PubChem-compound 19782904
xref: Reference/KEGG Compound C00158
xref: Reference/CAS 77-92-9
xref: Reference/ChemSpider 305
chemical formula: C6H8O7
molecular weight: 192.02701
structure: ChemicalStructure/PW C000063

1.8.1.4
type: BiochemicalReaction
participant stoichiometry: Protein/Generic267 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic266 Mitochondrion/Stoichiometry/1.0
right: Lipoamide-E
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.8.1.4
left: NAD
left: Dihydrolipoamide-E
name: Dihydrolipoamide-E + NAD ↔ Hydrogen Ion + Lipoamide-E + NADH
conversion direction: REVERSIBLE

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/PubChem-compound 19782904
type: UnificationXref
id: 19782904
db: PubChem-compound

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Compound/PW C000174 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Succinyl-CoA ligase
type: Complex
component stoichiometry: Protein/14892/Stoichiometry/1.0
component stoichiometry: Protein/14888/Stoichiometry/1.0
component: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
component: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

Probable fumarate hydratase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Probable fumarate hydratase, mitochondrial

Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P53596

Reaction179854
type: BiochemicalReaction
participant stoichiometry: Protein/Generic267 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000808 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic542 Mitochondrion/Stoichiometry/1.0
right: Coenzyme A
right: S-Succinyldihydrolipoamide-E
spontaneous: false
left: Dihydrolipoamide-E
left: Succinyl-CoA
name: Dihydrolipoamide-E + Succinyl-CoA ↔ Coenzyme A + S-Succinyldihydrolipoamide-E
conversion direction: REVERSIBLE

Probable fumarate hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt O17214
organism: Caenorhabditis elegans

1.2.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic542 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Protein/Generic266 Mitochondrion/Stoichiometry/1.0
right: Carbon dioxide
right: S-Succinyldihydrolipoamide-E
spontaneous: false
EC number: 1.2.4.2
left: Oxoglutaric acid
left: Lipoamide-E
name: Lipoamide-E + 2 Oxoglutaric acid ? Carbon dioxide + S-Succinyldihydrolipoamide-E

Reaction179857
type: BiochemicalReaction
participant stoichiometry: Protein/Generic267 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002986 Mitochondrion/Stoichiometry/1.0
right: Coenzyme A
right: S-Acetyldihydrolipoamide-E
spontaneous: false
left: Dihydrolipoamide-E
left: Acetyl-CoA
name: Acetyl-CoA + Dihydrolipoamide-E ↔ Coenzyme A + S-Acetyldihydrolipoamide-E
conversion direction: REVERSIBLE

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt P53589

Reaction179856
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000164 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002986 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Protein/Generic266 Mitochondrion/Stoichiometry/1.0
right: Carbon dioxide
right: S-Acetyldihydrolipoamide-E
spontaneous: false
left: Lipoamide-E
left: Pyruvic acid
name: Lipoamide-E + Pyruvic acid ↔ Carbon dioxide + S-Acetyldihydrolipoamide-E
conversion direction: REVERSIBLE

Reference/PubChem-compound 222656
type: UnificationXref
id: 222656
db: PubChem-compound

Reference/UniProt O17214
type: UnificationXref
id: O17214
db: UniProt

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

6.2.1.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000808/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Guanosine diphosphate
right: Succinyl-CoA
right: Phosphate
spontaneous: false
EC number: 6.2.1.4
left: Succinic acid
left: Coenzyme A
left: Guanosine triphosphate
name: Coenzyme A + Guanosine triphosphate + Succinic acid ↔ Guanosine diphosphate + Phosphate + Succinyl-CoA
conversion direction: REVERSIBLE

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Carbon dioxide

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Caenorhabditis elegans
type: BioSource
xref: Reference/TAXONOMY 6239

Isocitric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Isocitric acid

Protein/14850 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
stoichiometric coefficient: 2.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

1.3.5.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000174 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001632 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001860 Mitochondrion/Stoichiometry/1.0
right: Fumaric acid
right: Hydroquinone
spontaneous: false
EC number: 1.3.5.1
left: Quinone
left: Succinic acid
name: Quinone + Succinic acid ↔ Fumaric acid + Hydroquinone
conversion direction: REVERSIBLE

Reference/UniProt O45148
type: UnificationXref
id: O45148
db: UniProt

Protein/14870 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
stoichiometric coefficient: 2.0

Reference/TAXONOMY 6239
type: UnificationXref
id: 6239
db: TAXONOMY

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Coenzyme A

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Hydrogen carbonate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen carbonate

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16509
type: UnificationXref
id: CHEBI:16509
db: ChEBI

Reference/UniProt D3YT81
type: UnificationXref
id: D3YT81
db: UniProt

Reference/ChemSpider 4489
type: UnificationXref
id: 4489
db: ChemSpider

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Lipoamide-E
type: ProteinReference
xref: Reference/PubChem-compound C15972
organism: Caenorhabditis elegans

Reference/UniProt Q93353
type: UnificationXref
id: Q93353
db: UniProt

Dihydrolipoamide-E
type: ProteinReference
xref: Reference/PubChem-compound C15973
organism: Caenorhabditis elegans

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/BioCyc CPD-8130
type: UnificationXref
id: CPD-8130
db: BioCyc

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Protein/Generic266 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lipoamide-E
stoichiometric coefficient: 1.0

Reference/CAS 123-31-9
type: UnificationXref
id: 123-31-9
db: CAS

NADH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADH

Guanosine diphosphate
type: SmallMolecule
entity reference: Guanosine diphosphate

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Protein/17674 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Isocitrate dehydrogenase [NADP]
stoichiometric coefficient: 2.0

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Compound/PW C000174/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

Pyruvate carboxylase 1
type: Protein
cellular location: Mitochondrion
entity reference: Pyruvate carboxylase 1

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

ChemicalStructure/PW C001860
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=CC(=O)C=C1

Probable citrate synthase, mitochondrial
type: Protein
entity reference: Probable citrate synthase, mitochondrial

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P52899
organism: Caenorhabditis elegans

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

ATP-citrate synthase
type: Complex
component stoichiometry: Protein/17332/Stoichiometry/4.0
component: Probable ATP-citrate synthase

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q19749
organism: Caenorhabditis elegans

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt O44451
organism: Caenorhabditis elegans

Succinyl-CoA
type: SmallMolecule
entity reference: Succinyl-CoA

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

L-Malic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Malic acid

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

4.2.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000101 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrion/Stoichiometry/1.0
right: Water
right: Fumaric acid
spontaneous: false
EC number: 4.2.1.2
left: L-Malic acid
name: L-Malic acid ↔ Fumaric acid + Water
conversion direction: REVERSIBLE

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001632
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC=C(O)C=C1

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

Reference/ChEBI CHEBI 32805
type: UnificationXref
id: CHEBI:32805
db: ChEBI

Dihydrolipoyl dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt D3YT81
organism: Caenorhabditis elegans

Reference/UniProt P53585
type: UnificationXref
id: P53585
db: UniProt

Compound/PW C000125 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isocitric acid
stoichiometric coefficient: 1.0

Reference/UniProt P53589
type: UnificationXref
id: P53589
db: UniProt

Reference/KEGG Compound C00417
type: UnificationXref
id: C00417
db: KEGG Compound

Compound/PW C000148 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Compound/PW C001104 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1198
type: UnificationXref
id: 1198
db: PubChem-compound

Reference/KEGG Compound C00530
type: UnificationXref
id: C00530
db: KEGG Compound

Reference/ChemSpider 193317
type: UnificationXref
id: 193317
db: ChemSpider

Compound/PW C000148/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/BioCyc 3-METHYLBENZYLSUCCINYL-COA
type: UnificationXref
id: 3-METHYLBENZYLSUCCINYL-COA
db: BioCyc

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

ReactionCatalysis139425
type: Catalysis
controller: Phosphoenolypyruvate CarboxyKinase
controlled: 4.1.1.32
control type: ACTIVATION

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/UniProt P53596
type: UnificationXref
id: P53596
db: UniProt

Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q93353
organism: Caenorhabditis elegans

Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q93714
organism: Caenorhabditis elegans

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/CAS 106-51-4
type: UnificationXref
id: 106-51-4
db: CAS

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 24906332
type: UnificationXref
id: 24906332
db: PubChem-compound

Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

2-oxoglutarate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt O61199
organism: Caenorhabditis elegans