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Serine hydroxymethyltransferase, cytosolic Methylenetetrahydrofolate reductase Methionine synthase Cystathionine gamma-lyase Cystathionine beta-synthase Cystathionine beta-synthase Betaine-- homocysteine S- methyltransferase 1 DNA (cytosine-5)- methyltransferase 1 S- adenosylmethionine decarboxylase proenzyme Spermidine synthase S-methyl-5'- thioadenosine phosphorylase Adenosylhomocysteinase Betaine-- homocysteine S- methyltransferase 1 L-amino-acid oxidase Methionine--tRNA ligase, cytoplasmic Methionyl-tRNA formyltransferase, mitochondrial S- adenosylmethionine synthase Choline dehydrogenase, mitochondrial Methionine-R- sulfoxide reductase B3 Methionine-R- sulfoxide reductase B2, mitochondrial L-Homoserine L-Cysteine Homocysteine Tetrahydrofolic acid L-Serine 5,10-Methylene- THF Glycine 5- Methyltetrahydrofolic acid L-Methionine L-Cystathionine H2O 2-Ketobutyric acid L-Serine H2O L-Serine H2O S- Adenosylmethionine Glycine S- Adenosylhomocysteine Sarcosine S- Adenosylmethioninamine CO2 Putrescine 5'- Methylthioadenosine Spermidine Pi 5- Methylthioribose 1-phosphate L-Methionine Adenosine βine Dimethylglycine H2O O2 2-Oxo-4- methylthiobutanoic acid NH3 H2O2 ATP AMP PPi 10- Formyltetrahydrofolate Tetrahydrofolic acid ATP Pi PPi Choline Methionine sulfoxide Pyridoxal 5'-phosphate FAD Zinc (II) ion Pyridoxal 5'-phosphate Pyridoxal 5'-phosphate Pyridoxal 5'-phosphate Zinc (II) ion NAD Zinc (II) ion FAD Magnesium Potassium FAD Zinc Zinc Acceptor Reduced acceptor oxidized thioredoxin reduced thioredoxin tRNA(Met) L- Methionyl- tRNA(Met) N- formylmethionyl- tRNA(fMet) Glycine and Serine Metabolism Cysteine Metabolism Sulfate/Sulfite Metabolism Intracellular space Nuclear envelope Mitochondria Mitochondria
Mitochondria SHMT1 MTHFR MTR CTH CBS CBS BHMT DNMT1 AMD1 SRM MTAP AHCY BHMT IL4I1 MARS MTFMT MAT2A MAT2B CHDH MSRB3 MSRB2 L-Homoserine L-Cysteine Homocysteine Tetrahydrofolic acid L-Serine 5,10-Methylene- THF Glycine 5- Methyltetrahydrofolic acid L-Methionine L-Cystathionine Water 2-Ketobutyric acid L-Serine Water L-Serine Water S- Adenosylmethionine Glycine S- Adenosylhomocysteine Sarcosine S- Adenosylmethioninamine Carbon dioxide Putrescine 5'- Methylthioadenosine Spermidine Phosphate 5- Methylthioribose 1-phosphate L-Methionine Adenosine βine Dimethylglycine Water Oxygen 2-Oxo-4- methylthiobutanoic acid Ammonia Hydrogen peroxide Adenosine triphosphate Adenosine monophosphate Pyrophosphate 10- Formyltetrahydrofolate Tetrahydrofolic acid Adenosine triphosphate Phosphate Pyrophosphate Choline Methionine sulfoxide Acceptor Reduced acceptor oxidized thioredoxin reduced thioredoxin tRNA(Met) L-Methionyl- tRNA(Met) N- formylmethionyl- tRNA(fMet) Glycine and Serine Metabolism Cysteine Metabolism Sulfate/Sulfite Metabolism
SHMT1 MTHFR MTR CTH CBS CBS BHMT DNMT1 AMD1 SRM MTAP AHCY BHMT IL4I1 MARS MTFMT MAT2A MAT2B CHDH MSRB3 MSRB2 Homoser Cys Hcys THFA Ser 5XM-THF Gly 5-MTHFa Met L-Cystt H2O 2KBA Ser H2O Ser H2O SAMe Gly SAH Sar Dadomet CO2 Putrsce MTA Spermd Pi 5MTR1P Met Adenosi βine DMglyc H2O O2 KMTB NH3 H2O2 ATP AMP PPi 10-FTHF THFA ATP Pi PPi Choline Met-Sof Pyr-5'P FAD Zinc Pyr-5'P Pyr-5'P Pyr-5'P Zinc NAD Zinc FAD Mg2+ K+ FAD Zinc Zinc Accepto RA OT RT TRNAMET LMTM NFTF PW000157 PW000018 PW000040 Intracellular space Nuclear envelope Mitochondria Mitochondria
Mitochondria SHMT1 MTHFR MTR CTH CBS CBS BHMT DNMT1 AMD1 SRM MTAP AHCY BHMT IL4I1 MARS MTFMT MAT2A MAT2B CHDH MSRB3 MSRB2 Homoser Cys Hcys THFA Ser 5XM-THF Gly 5-MTHFa Met L-Cystt H2O 2KBA Ser H2O Ser H2O SAMe Gly SAH Sar Dadomet CO2 Putrsce MTA Spermd Pi 5MTR1P Met Adenosi βine DMglyc H2O O2 KMTB NH3 H2O2 ATP AMP Ppi 10-FTHF THFA ATP Pi Ppi Choline Met-Sof Accepto RA OT RT TRNAMET LMTM NFTF PW000157 PW000018 PW000040