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DNA topoisomerase 1 Multidrug resistance protein 1 Solute carrier organic anion transporter family member 1B1 Multidrug resistance- associated protein 1 Multidrug resistance protein 1 Canalicular multispecific organic anion transporter 1 Canalicular multispecific organic anion transporter 1 ATP-binding cassette sub-family G member 2 Multidrug resistance protein 1 Canalicular multispecific organic anion transporter 1 Cytochrome P450 3A4 Cytochrome P450 3A5 Cytochrome P450 3A4 Liver carboxylesterase 1 Cocaine esterase UDP- glucuronosyltransferase 1-10 UDP- glucuronosyltransferase 1-1 UDP- glucuronosyltransferase 1-9 UDP- glucuronosyltransferase 1-1 Liver carboxylesterase 1 Cocaine esterase Liver carboxylesterase 1 Cocaine esterase Cholinesterase Liver carboxylesterase 1 Cocaine esterase Irinotecan SN-38 Irinotecan SN-38 SN-38 Glucuronide SN-38 Glucuronide NPC APC H2O Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H2O H2O Irinotecan H2O SN-38 H2O ATP Pi ADP H2O ATP Pi ADP H2O ATP Pi ADP H2O ATP Pi ADP H2O ATP Pi ADP H2O ATP Pi ADP H2O ATP Pi ADP H2O ATP Pi ADP Heme Heme Heme Carboxylate Carboxylate Carboxylate Carboxylate Nucleus Bacterial Glucuronidation
Endoplasmic Reticulum Endoplasmic Reticulum Unknown ABCB1 SLCO1B1 ABCC1 ABCB1 ABCC2 ABCC2 ABCG2 ABCB1 ABCC2 CYP3A4 CYP3A5 CYP3A4 CES1 CES2 UGT1A10 UGT1A1 UGT1A9 UGT1A1 CES1 CES2 CES1 CES2 BCHE CES1 CES2 Irinotecan SN-38 Irinotecan SN-38 SN-38 Glucuronide SN-38 Glucuronide NPC APC Water Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Water Water Irinotecan Water SN-38 Water Adenosine triphosphate Phosphate Adenosine diphosphate Water Adenosine triphosphate Phosphate Adenosine diphosphate Water Adenosine triphosphate Phosphate Adenosine diphosphate Water Adenosine triphosphate Phosphate Adenosine diphosphate Water Adenosine triphosphate Phosphate Adenosine diphosphate Water Adenosine triphosphate Phosphate Adenosine diphosphate Water Adenosine triphosphate Phosphate Adenosine diphosphate Water Adenosine triphosphate Phosphate Adenosine diphosphate Carboxylate Carboxylate Carboxylate Carboxylate