N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
7a-Hydroxy-O-carbamoyl-deacetylcephalosporin C
Penicillin and Cephalosporin Biosynthesis
3 Adenosine triphosphate + L-2-Aminoadipate + L-Cysteine + L-Valine + Water ↔ 3 Adenosine monophosphate + 3 Pyrophosphate + delta-(L-2-Aminoadipyl)-L-cysteinyl-D-valine
Oxygen + delta-(L-2-Aminoadipyl)-L-cysteinyl-D-valine ↔ Isopenicillin N + 2 Water
Oxoglutaric acid + Oxygen + Penicillin N ↔ Deacetoxycephalosporin C + Carbon dioxide + Succinate + Water
Deacetoxycephalosporin C + Oxoglutaric acid + Oxygen ↔ Carbon dioxide + Deacetylcephalosporin C + Succinate
Carbamoyl phosphate + Deacetylcephalosporin C ↔ O-Carbamoyl-deacetylcephalosporin C + Phosphoric acid
Penicillin + Water ↔ Penicilloic acid
Penicillin + Water ↔ 6-Aminopenicillanic acid + Carboxylate
Acetic acid + Deacetylcephalosporin C ↔ Cephalosporin C + Water
O-Carbamoyl-deacetylcephalosporin C + Oxoglutaric acid + Oxygen ↔ 7a-Hydroxy-O-carbamoyl-deacetylcephalosporin C + Carbon dioxide + Succinate
7a-Hydroxy-O-carbamoyl-deacetylcephalosporin C + S-Adenosylmethionine ↔ Cephamycin C + S-Adenosylhomocysteine