L-Tryptophan + Oxygen → N'-Formylkynurenine
L-Tryptophan (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + L-Tryptophyl-tRNA(Trp) + Pyrophosphate
L-3-Hydroxykynurenine + Oxoglutaric acid → 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
4-(2-Aminophenyl)-2,4-dioxobutanoic acid → Kynurenic acid
L-Kynurenine + NADPH + Oxygen → L-3-Hydroxykynurenine + NADP + Water
L-Kynurenine + Water → 2-Aminobenzoic acid + L-Alanine
L-Kynurenine + Oxoglutaric acid → 4-(2-Aminophenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
Formylanthranilic acid + Water → 2-Aminobenzoic acid + Formic acid
N'-Formylkynurenine + Water → Formylanthranilic acid + L-Alanine
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
5-Hydroxy-L-tryptophan + Oxygen → 5-Hydroxy-N-formylkynurenine
L-Tryptophan + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + 5-Hydroxy-L-tryptophan
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid → Xanthurenic acid
NADPH + Oxygen + Tryptamine → Indoleacetaldehyde + NADP + Water
Indoleacetaldehyde + NAD + Water → Indoleacetic acid + NADH
L-Tryptophan → Carbon dioxide + Tryptamine