Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Xanthurenic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000881
xref: Reference/KEGG Compound C02470
xref: Reference/ChEBI CHEBI 217069
xref: Reference/CAS 59-00-7
xref: Reference/BioCyc XANTHURENATE
xref: Reference/ChemSpider 5497
xref: Reference/PubChem-compound 5699
chemical formula: C10H7NO4
molecular weight: 205.0375
structure: ChemicalStructure/PW C000703

Reference/CAS 61-54-1
type: UnificationXref
id: 61-54-1
db: CAS

Reference/PubChem-compound 802
type: UnificationXref
id: 802
db: PubChem-compound

Reference/PubChem-compound 800
type: UnificationXref
id: 800
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C000935 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N'-Formylkynurenine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439280
type: UnificationXref
id: 439280
db: PubChem-compound

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/CAS 492-27-3
type: UnificationXref
id: 492-27-3
db: CAS

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Compound/PW C000019 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00328
type: UnificationXref
id: C00328
db: KEGG Compound

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/ChemSpider 1118
type: UnificationXref
id: 1118
db: ChemSpider

Reference/PubChem-compound 910
type: UnificationXref
id: 910
db: PubChem-compound

Reference/HMDB HMDB0001190
type: UnificationXref
id: HMDB0001190
db: HMDB

RNA/25 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophyl-tRNA(Trp)
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

1.13.11.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: N'-Formylkynurenine
spontaneous: false
EC number: 1.13.11.52
left: Oxygen
left: L-Tryptophan
name: L-Tryptophan + Oxygen → N'-Formylkynurenine
conversion direction: LEFT_TO_RIGHT

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: Reference/UniProt P20711
organism: Homo sapiens

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/HMDB HMDB0002281
type: UnificationXref
id: HMDB0002281
db: HMDB

Protein/289 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Aldehyde dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChEBI CHEBI 17442
type: UnificationXref
id: CHEBI:17442
db: ChEBI

Indoleacetaldehyde
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001190
xref: Reference/KEGG Compound C00637
xref: Reference/PubChem-compound 800
xref: Reference/CAS 2591-98-2
xref: Reference/ChEBI CHEBI 18086
xref: Reference/ChemSpider 778
xref: Reference/BioCyc INDOLE ACETALDEHYDE
chemical formula: C10H9NO
molecular weight: 159.06842
structure: ChemicalStructure/PW C000926

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Compound/PW C000092 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Aldehyde dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P05091
organism: Homo sapiens

ChemicalStructure/PW C002055
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)C1=C(NC=O)C=CC(O)=C1)C(O)=O

ChemicalStructure/PW C002057
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC=CC=C1NC=O

ChemicalStructure/PW C002053
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C(C=CC=C1O)C(=O)CC(=O)C(O)=O

Transport138
type: Transport
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000741 Extracellular Space/Stoichiometry/1.0
right: L-Tryptophan
spontaneous: false
left: L-Tryptophan
name: L-Tryptophan (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

N'-Formylkynurenine
type: SmallMoleculeReference
xref: Reference/ChemSpider 886
xref: Reference/HMDB HMDB0001200
xref: Reference/KEGG Compound C02406
xref: Reference/PubChem-compound 910
xref: Reference/ChEBI CHEBI 18377
xref: Reference/BioCyc N-FORMYLKYNURENINE
xref: Reference/CAS 1022-31-7
chemical formula: C11H12N2O4
molecular weight: 236.07971
structure: ChemicalStructure/PW C000935

Reference/KEGG Compound C00108
type: UnificationXref
id: C00108
db: KEGG Compound

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Reference/KEGG Compound C02406
type: UnificationXref
id: C02406
db: KEGG Compound

Reference/ChemSpider 5735
type: UnificationXref
id: 5735
db: ChemSpider

L-Kynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Kynurenine

Reference/CAS 73-22-3
type: UnificationXref
id: 73-22-3
db: CAS

L-3-Hydroxykynurenine
type: SmallMoleculeReference
xref: Reference/BioCyc 3-HYDROXY-L-KYNURENINE
xref: Reference/ChemSpider 11318
xref: Reference/ChEBI CHEBI 17380
xref: Reference/KEGG Compound C03227
xref: Reference/PubChem-compound 11811
xref: Reference/HMDB HMDB0011631
xref: Reference/CAS 606-14-4
chemical formula: C10H12N2O4
molecular weight: 224.07971
structure: ChemicalStructure/PW C007219

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Compound/PW C000358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxy-L-tryptophan
stoichiometric coefficient: 1.0

Tryptophan--tRNA ligase, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Tryptophan--tRNA ligase, mitochondrial

ChemicalStructure/PW C000926
type: ChemicalStructure
structure format: SMILES
structure data: O=CCC1=CNC2=C1C=CC=C2

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

L-Tryptophan
type: SmallMoleculeReference
xref: Reference/CAS 73-22-3
xref: Reference/KEGG Compound C00078
xref: Reference/ChEBI CHEBI 16828
xref: Reference/PubChem-compound 6305
xref: Reference/BioCyc TRP
xref: Reference/HMDB HMDB0000929
xref: Reference/ChemSpider 6066
chemical formula: C11H12N2O2
molecular weight: 204.08987
structure: ChemicalStructure/PW C000741

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/PathWhiz PW123953
type: UnificationXref
id: PW123953
db: PathWhiz

Reference/ChEBI CHEBI 17380
type: UnificationXref
id: CHEBI:17380
db: ChEBI

ReactionCatalysis2059
type: Catalysis
controller: Indoleamine 2,3-dioxygenase 1
controlled: 1.13.11.52
control type: ACTIVATION

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

2-Aminobenzoic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00108
xref: Reference/ChEBI CHEBI 30754
xref: Reference/HMDB HMDB0001123
xref: Reference/ChemSpider 222
xref: Reference/CAS 118-92-3
xref: Reference/PubChem-compound 227
xref: Reference/BioCyc ANTHRANILATE
chemical formula: C7H7NO2
molecular weight: 137.04768
structure: ChemicalStructure/PW C000877

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc L-ALPHA-ALANINE
type: UnificationXref
id: L-ALPHA-ALANINE
db: BioCyc

Reference/CAS 56-41-7
type: UnificationXref
id: 56-41-7
db: CAS

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

ChemicalStructure/PW C000935
type: ChemicalStructure
structure format: SMILES
structure data: NC(CC(=O)C1=CC=CC=C1NC=O)C(O)=O

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C007219
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(=O)C1=CC=CC(O)=C1N)C(O)=O

Reference/UniProt P20711
type: UnificationXref
id: P20711
db: UniProt

Kynurenine 3-monooxygenase
type: Protein
cellular location: Cytosol
entity reference: Kynurenine 3-monooxygenase

Compound/PW C002053 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
stoichiometric coefficient: 1.0

Tryptophan--tRNA ligase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9UGM6
organism: Homo sapiens

Reference/UniProt Q9UGM6
type: UnificationXref
id: Q9UGM6
db: UniProt

Tetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrobiopterin

Reference/ChemSpider 388413
type: UnificationXref
id: 388413
db: ChemSpider

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Indoleacetaldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Indoleacetaldehyde

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Tryptophan--tRNA ligase, cytoplasmic
type: Complex
component stoichiometry: Protein/543 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Tryptophan--tRNA ligase, cytoplasmic

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

ReactionCatalysis168807
type: Catalysis
controller: Tryptophan--tRNA ligase, mitochondrial
controlled: Reaction178712
control type: ACTIVATION

ReactionCatalysis168806
type: Catalysis
controller: Tryptophan--tRNA ligase, cytoplasmic
controlled: Reaction178712
control type: ACTIVATION

Reference/CAS 59-00-7
type: UnificationXref
id: 59-00-7
db: CAS

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/ChEBI CHEBI 18344
type: UnificationXref
id: CHEBI:18344
db: ChEBI

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/UniProt Q8N5Z0
type: UnificationXref
id: Q8N5Z0
db: UniProt

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C00272
type: UnificationXref
id: C00272
db: KEGG Compound

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8N5Z0
organism: Homo sapiens

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/CAS 1022-31-7
type: UnificationXref
id: 1022-31-7
db: CAS

4a-Hydroxytetrahydrobiopterin
type: SmallMolecule
cellular location: Cytosol
entity reference: 4a-Hydroxytetrahydrobiopterin

Indoleamine 2,3-dioxygenase 1
type: ProteinReference
xref: Reference/UniProt P14902
organism: Homo sapiens

Reference/ChemSpider 778
type: UnificationXref
id: 778
db: ChemSpider

Compound/PW C000741 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00398
type: UnificationXref
id: C00398
db: KEGG Compound

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Formic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Formic acid

Tryptophan--tRNA ligase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt P23381
organism: Homo sapiens

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/KEGG Compound C00041
type: UnificationXref
id: C00041
db: KEGG Compound

Reference/BioCyc TETRA-H-BIOPTERIN
type: UnificationXref
id: TETRA-H-BIOPTERIN
db: BioCyc

Reference/KEGG Compound C15522
type: UnificationXref
id: C15522
db: KEGG Compound

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/ChemSpider 389612
type: UnificationXref
id: 389612
db: ChemSpider

Reference/ChemSpider 389615
type: UnificationXref
id: 389615
db: ChemSpider

Kynureninase
type: ProteinReference
xref: Reference/UniProt Q16719
organism: Homo sapiens

Reference/KEGG Compound C01252
type: UnificationXref
id: C01252
db: KEGG Compound

Compound/PW C000207 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tryptamine
stoichiometric coefficient: 1.0

Reference/ChemSpider 886
type: UnificationXref
id: 886
db: ChemSpider

Reference/KEGG Compound C02470
type: UnificationXref
id: C02470
db: KEGG Compound

Compound/PW C000134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/HMDB HMDB0000027
type: UnificationXref
id: HMDB0000027
db: HMDB

Reference/UniProt P17752
type: UnificationXref
id: P17752
db: UniProt

L-Tryptophyl-tRNA(Trp)
type: RnaReference
xref: Reference/ChEBI CHEBI 29159
organism: Homo sapiens

Reference/BioCyc TRP
type: UnificationXref
id: TRP
db: BioCyc

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

Xanthurenic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Xanthurenic acid

Reference/ChEBI CHEBI 217069
type: UnificationXref
id: CHEBI:217069
db: ChEBI

Reference/BioCyc CPD-476
type: UnificationXref
id: CPD-476
db: BioCyc

Reference/ChEBI CHEBI 18377
type: UnificationXref
id: CHEBI:18377
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reference/HMDB HMDB0001123
type: UnificationXref
id: HMDB0001123
db: HMDB

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 29159
type: UnificationXref
id: CHEBI:29159
db: ChEBI

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Reference/ChemSpider 3712
type: UnificationXref
id: 3712
db: ChemSpider

Indoleacetic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Indoleacetic acid

L-Kynurenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000684
xref: Reference/KEGG Compound C00328
xref: Reference/ChemSpider 141580
xref: Reference/ChEBI CHEBI 16946
xref: Reference/PubChem-compound 161166
xref: Reference/CAS 2922-83-0
xref: Reference/BioCyc L-KYNURENINE
chemical formula: C10H12N2O3
molecular weight: 208.0848
structure: ChemicalStructure/PW C000538

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

4-(2-Aminophenyl)-2,4-dioxobutanoic acid
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-476
xref: Reference/HMDB HMDB0000978
xref: Reference/KEGG Compound C01252
xref: Reference/ChEBI CHEBI 17442
xref: Reference/PubChem-compound 472
xref: Reference/ChemSpider 459
chemical formula: C10H9NO4
molecular weight: 207.05316
structure: ChemicalStructure/PW C000778

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C000703 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xanthurenic acid
stoichiometric coefficient: 1.0

Kynurenine formamidase
type: Protein
cellular location: Cytosol
entity reference: Kynurenine formamidase

Reference/CAS 606-14-4
type: UnificationXref
id: 606-14-4
db: CAS

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Tryptophan 5-hydroxylase 1
type: ProteinReference
xref: Reference/UniProt P17752
organism: Homo sapiens

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/PubChem-compound 3845
type: UnificationXref
id: 3845
db: PubChem-compound

Reference/ChemSpider 780
type: UnificationXref
id: 780
db: ChemSpider

Reference/HMDB HMDB0000161
type: UnificationXref
id: HMDB0000161
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

L-Alanine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00041
xref: Reference/ChemSpider 5735
xref: Reference/ChEBI CHEBI 16977
xref: Reference/BioCyc L-ALPHA-ALANINE
xref: Reference/HMDB HMDB0000161
xref: Reference/CAS 56-41-7
xref: Reference/PubChem-compound 5950
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000105

Kynureninase
type: Protein
cellular location: Cytosol
entity reference: Kynureninase

Reference/CAS 17528-72-2
type: UnificationXref
id: 17528-72-2
db: CAS

L-Alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Alanine

Reference/KEGG Compound C00078
type: UnificationXref
id: C00078
db: KEGG Compound

Reference/ChemSpider 114908
type: UnificationXref
id: 114908
db: ChemSpider

Reference/KEGG Compound C05645
type: UnificationXref
id: C05645
db: KEGG Compound

Reference/KEGG Compound C03227
type: UnificationXref
id: C03227
db: KEGG Compound

Reference/KEGG Compound C05648
type: UnificationXref
id: C05648
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/CAS 2922-83-0
type: UnificationXref
id: 2922-83-0
db: CAS

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

5-Hydroxy-L-tryptophan
type: SmallMoleculeReference
xref: Reference/ChemSpider 388413
xref: Reference/CAS 4350-09-8
xref: Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
xref: Reference/ChEBI CHEBI 17780
xref: Reference/KEGG Compound C00643
xref: Reference/PubChem-compound 439280
xref: Reference/HMDB HMDB0000472
chemical formula: C11H12N2O3
molecular weight: 220.0848
structure: ChemicalStructure/PW C000358

Aldehyde dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/289 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Aldehyde dehydrogenase, mitochondrial

Reference/ChEBI CHEBI 18086
type: UnificationXref
id: CHEBI:18086
db: ChEBI

Reference/KEGG Compound C05653
type: UnificationXref
id: C05653
db: KEGG Compound

Compound/PW C000566 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Kynurenic acid
stoichiometric coefficient: 1.0

Reference/UniProt P23381
type: UnificationXref
id: P23381
db: UniProt

Compound/PW C000538 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Kynurenine
stoichiometric coefficient: 1.0

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
type: Complex
component stoichiometry: Protein/370 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

Tryptamine
type: SmallMoleculeReference
xref: Reference/CAS 61-54-1
xref: Reference/PubChem-compound 1150
xref: Reference/ChEBI CHEBI 16765
xref: Reference/HMDB HMDB0000303
xref: Reference/ChemSpider 1118
xref: Reference/BioCyc TRYPTAMINE
xref: Reference/KEGG Compound C00398
chemical formula: C10H12N2
molecular weight: 160.10005
structure: ChemicalStructure/PW C000207

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Kynurenine formamidase
type: ProteinReference
xref: Reference/UniProt Q63HM1
organism: Homo sapiens

Kynurenic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 3712
xref: Reference/PubChem-compound 3845
xref: Reference/KEGG Compound C01717
xref: Reference/HMDB HMDB0000715
xref: Reference/CAS 492-27-3
xref: Reference/ChEBI CHEBI 18344
chemical formula: C10H7NO3
molecular weight: 189.04259
structure: ChemicalStructure/PW C000566

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

4a-Hydroxytetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/CAS 70110-58-6
xref: Reference/PubChem-compound 129803
xref: Reference/KEGG Compound C15522
xref: Reference/ChemSpider 114908
xref: Reference/HMDB HMDB0002281
xref: Reference/ChEBI CHEBI 15374
chemical formula: C9H15N5O4
molecular weight: 257.1124
structure: ChemicalStructure/PW C001541

Tryptophan-Kynurenine Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2461078
pathway order: PathwayEnzymeReaction/2461079
pathway order: PathwayEnzymeReaction/2461112
pathway order: PathwayEnzymeReaction/2461087
pathway order: PathwayEnzymeReaction/2461098
pathway order: PathwayEnzymeReaction/2461077
pathway order: PathwayEnzymeReaction/2461088
pathway order: PathwayEnzymeReaction/2461083
pathway order: PathwayTransport/2461115
pathway order: PathwayEnzymeReaction/2461084
pathway order: PathwayEnzymeReaction/2461108
pathway order: PathwayEnzymeReaction/2461109
pathway order: PathwayEnzymeReaction/2461107
pathway order: PathwayEnzymeReaction/2461113
pathway order: PathwayEnzymeReaction/2461114
pathway order: PathwayEnzymeReaction/2461081
pathway order: PathwayEnzymeReaction/2461092
pathway order: PathwayEnzymeReaction/2461082
pathway order: PathwayEnzymeReaction/2461080
pathway component: Reaction1619
pathway component: Reaction1615
pathway component: 1.14.13.9
pathway component: Reaction178712
pathway component: 3.7.1.3
pathway component: ReactionCatalysis1360
pathway component: Reaction1614
pathway component: 3.5.1.9
pathway component: ReactionCatalysis1384
pathway component: ReactionCatalysis1383
pathway component: ReactionCatalysis1363
pathway component: 1.13.11.52
pathway component: ReactionCatalysis1385
pathway component: ReactionCatalysis2059
pathway component: ReactionCatalysis168807
pathway component: Transport138
pathway component: ReactionCatalysis168806
pathway component: 1.13.11.11
pathway component: ReactionCatalysis1357
pathway component: ReactionCatalysis1356
pathway component: 1.14.16.4
pathway component: ReactionCatalysis1351
pathway component: ReactionCatalysis1373
pathway component: 1.2.1.3
pathway component: ReactionCatalysis1353
pathway component: Reaction1620
pathway component: 4.1.1.28
pathway component: ReactionCatalysis1352
pathway component: ReactionCatalysis1355
pathway component: ReactionCatalysis1354
xref: Reference/PathWhiz PW123953
xref: Reference/SMPDB SMP0122638
organism: Homo sapiens

Compound/PW C000778 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-(2-Aminophenyl)-2,4-dioxobutanoic acid
stoichiometric coefficient: 1.0

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/HMDB HMDB0000197
type: UnificationXref
id: HMDB0000197
db: HMDB

Reference/ChemSpider 141580
type: UnificationXref
id: 141580
db: ChemSpider

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Formylanthranilic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Formylanthranilic acid

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

5-Hydroxy-L-tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxy-L-tryptophan

Tryptophan--tRNA ligase, cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Tryptophan--tRNA ligase, cytoplasmic

Reference/CAS 118-92-3
type: UnificationXref
id: 118-92-3
db: CAS

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Protein/370 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
stoichiometric coefficient: 2.0

Reference/INSDC 948275
type: UnificationXref
id: 948275
db: INSDC

Reference/UniProt P48775
type: UnificationXref
id: P48775
db: UniProt

ChemicalStructure/PW C000566
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC(=O)C2=CC=CC=C2N1

ChemicalStructure/PW C000207
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC2=C1C=CC=C2

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001541
type: ChemicalStructure
structure format: SMILES

Compound/PW C000877 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Aminobenzoic acid
stoichiometric coefficient: 1.0

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/PubChem-compound 101399
type: UnificationXref
id: 101399
db: PubChem-compound

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 1125
type: UnificationXref
id: 1125
db: PubChem-compound

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/PubChem-compound 472
type: UnificationXref
id: 472
db: PubChem-compound

Reference/ChEBI CHEBI 2065
type: UnificationXref
id: CHEBI:2065
db: ChEBI

Reference/HMDB HMDB0000303
type: UnificationXref
id: HMDB0000303
db: HMDB

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/ChemSpider 91624
type: UnificationXref
id: 91624
db: ChemSpider

Compound/PW C000128 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indoleacetic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1150
type: UnificationXref
id: 1150
db: PubChem-compound

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Indoleacetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16411
xref: Reference/CAS 87-51-4
xref: Reference/KEGG Compound C00954
xref: Reference/PubChem-compound 802
xref: Reference/ChemSpider 780
xref: Reference/HMDB HMDB0000197
chemical formula: C10H9NO2
molecular weight: 175.06332
structure: ChemicalStructure/PW C000128

Reaction178712
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/25 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000741 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/43 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: L-Tryptophyl-tRNA(Trp)
right: Pyrophosphate
spontaneous: false
left: tRNA(Trp)
left: Adenosine triphosphate
left: L-Tryptophan
name: Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + L-Tryptophyl-tRNA(Trp) + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C002055 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Hydroxy-N-formylkynurenine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Tryptophan 2,3-dioxygenase
type: Protein
cellular location: Cytosol
entity reference: Tryptophan 2,3-dioxygenase

Tetrahydrobiopterin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00272
xref: Reference/HMDB HMDB0000027
xref: Reference/CAS 17528-72-2
xref: Reference/BioCyc TETRA-H-BIOPTERIN
xref: Reference/PubChem-compound 1125
xref: Reference/ChemSpider 1093
xref: Reference/ChEBI CHEBI 15372
chemical formula: C9H15N5O3
molecular weight: 241.1175
structure: ChemicalStructure/PW C000019

Reference/HMDB HMDB0000684
type: UnificationXref
id: HMDB0000684
db: HMDB

ReactionCatalysis1357
type: Catalysis
controller: Kynurenine 3-monooxygenase
controlled: 1.14.13.9
control type: ACTIVATION

ReactionCatalysis1356
type: Catalysis
controller: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
controlled: Reaction1614
control type: ACTIVATION

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

ReactionCatalysis1351
type: Catalysis
controller: Tryptophan 2,3-dioxygenase
controlled: 1.13.11.11
control type: ACTIVATION

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

ReactionCatalysis1353
type: Catalysis
controller: Kynurenine formamidase
controlled: 3.5.1.9
control type: ACTIVATION

ReactionCatalysis1352
type: Catalysis
controller: Kynureninase
controlled: 3.7.1.3
control type: ACTIVATION

ReactionCatalysis1355
type: Catalysis
controller: Kynureninase
controlled: 3.7.1.3
control type: ACTIVATION

ReactionCatalysis1354
type: Catalysis
controller: Kynurenine formamidase
controlled: 3.5.1.9
control type: ACTIVATION

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reaction1619
type: BiochemicalReaction
participant stoichiometry: Compound/PW C007219 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002053 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
right: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
right: L-Glutamic acid
spontaneous: false
left: L-3-Hydroxykynurenine
left: Oxoglutaric acid
name: L-3-Hydroxykynurenine + Oxoglutaric acid → 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Reaction1615
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000778 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000566 Cytosol/Stoichiometry/1.0
right: Kynurenic acid
spontaneous: false
left: 4-(2-Aminophenyl)-2,4-dioxobutanoic acid
name: 4-(2-Aminophenyl)-2,4-dioxobutanoic acid → Kynurenic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16977
type: UnificationXref
id: CHEBI:16977
db: ChEBI

1.14.13.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007219 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: L-3-Hydroxykynurenine
right: NADP
right: Water
spontaneous: false
EC number: 1.14.13.9
left: Oxygen
left: L-Kynurenine
left: NADPH
name: L-Kynurenine + NADPH + Oxygen → L-3-Hydroxykynurenine + NADP + Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

ChemicalStructure/PW C000128
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CNC2=C1C=CC=C2

Reference/PubChem-compound 11811
type: UnificationXref
id: 11811
db: PubChem-compound

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/PubChem-compound 440744
type: UnificationXref
id: 440744
db: PubChem-compound

Reference/ChemSpider 459
type: UnificationXref
id: 459
db: ChemSpider

Reference/PubChem-compound 440741
type: UnificationXref
id: 440741
db: PubChem-compound

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Compound/PW C000741 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

3.7.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000105 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000877 Cytosol/Stoichiometry/1.0
right: 2-Aminobenzoic acid
right: L-Alanine
spontaneous: false
EC number: 3.7.1.3
left: L-Kynurenine
left: Water
name: L-Kynurenine + Water → 2-Aminobenzoic acid + L-Alanine
conversion direction: LEFT_TO_RIGHT

Reaction1614
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000778 Cytosol/Stoichiometry/1.0
right: 4-(2-Aminophenyl)-2,4-dioxobutanoic acid
right: L-Glutamic acid
spontaneous: false
left: Oxoglutaric acid
left: L-Kynurenine
name: L-Kynurenine + Oxoglutaric acid → 4-(2-Aminophenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

3.5.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000538 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: Formic acid
right: L-Kynurenine
spontaneous: false
EC number: 3.5.1.9
left: N'-Formylkynurenine
left: Water
name: N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
conversion direction: LEFT_TO_RIGHT

3.5.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002057 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000877 Cytosol/Stoichiometry/1.0
right: Formic acid
right: 2-Aminobenzoic acid
spontaneous: false
EC number: 3.5.1.9
left: Formylanthranilic acid
left: Water
name: Formylanthranilic acid + Water → 2-Aminobenzoic acid + Formic acid
conversion direction: LEFT_TO_RIGHT

3.7.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000105 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002057 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: Formylanthranilic acid
right: L-Alanine
spontaneous: false
EC number: 3.7.1.3
left: N'-Formylkynurenine
left: Water
name: N'-Formylkynurenine + Water → Formylanthranilic acid + L-Alanine
conversion direction: LEFT_TO_RIGHT

1.13.11.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000935 Cytosol/Stoichiometry/1.0
right: N'-Formylkynurenine
spontaneous: false
EC number: 1.13.11.11
left: Oxygen
left: L-Tryptophan
name: L-Tryptophan + Oxygen → N'-Formylkynurenine
conversion direction: LEFT_TO_RIGHT

tRNA(Trp)
type: Rna
cellular location: Cytoplasm
entity reference: tRNA(Trp)

ChemicalStructure/PW C000019
type: ChemicalStructure
structure format: SMILES

Tryptophan 2,3-dioxygenase
type: ProteinReference
xref: Reference/UniProt P48775
organism: Homo sapiens

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 36575
type: UnificationXref
id: CHEBI:36575
db: ChEBI

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 2591-98-2
type: UnificationXref
id: 2591-98-2
db: CAS

Reference/SMPDB SMP0122638
type: UnificationXref
id: SMP0122638
db: SMPDB

Compound/PW C000741 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Reference/BioCyc INDOLE ACETALDEHYDE
type: UnificationXref
id: INDOLE_ACETALDEHYDE
db: BioCyc

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxoglutaric acid

Reference/PubChem-compound 227
type: UnificationXref
id: 227
db: PubChem-compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

ChemicalStructure/PW C000105
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](N)C(O)=O

Reference/PubChem-compound 5950
type: UnificationXref
id: 5950
db: PubChem-compound

Reference/PubChem-compound 161166
type: UnificationXref
id: 161166
db: PubChem-compound

4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid

Reference/HMDB HMDB0001200
type: UnificationXref
id: HMDB0001200
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/ChEBI CHEBI 16946
type: UnificationXref
id: CHEBI:16946
db: ChEBI

Reference/BioCyc 5-HYDROXY-TRYPTOPHAN
type: UnificationXref
id: 5-HYDROXY-TRYPTOPHAN
db: BioCyc

Reference/ChEBI CHEBI 16828
type: UnificationXref
id: CHEBI:16828
db: ChEBI

1.13.11.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002055 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: 5-Hydroxy-N-formylkynurenine
spontaneous: false
EC number: 1.13.11.52
left: Oxygen
left: 5-Hydroxy-L-tryptophan
name: 5-Hydroxy-L-tryptophan + Oxygen → 5-Hydroxy-N-formylkynurenine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000472
type: UnificationXref
id: HMDB0000472
db: HMDB

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

ChemicalStructure/PW C000358
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=C(O)C=C2)C(O)=O

Reference/ChemSpider 6066
type: UnificationXref
id: 6066
db: ChemSpider

Reference/ChemSpider 222
type: UnificationXref
id: 222
db: ChemSpider

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

tRNA(Trp)
type: RnaReference
xref: Reference/INSDC 948275
organism: Homo sapiens

1.14.16.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001541 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000019 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000358 Cytosol/Stoichiometry/1.0
right: 4a-Hydroxytetrahydrobiopterin
right: 5-Hydroxy-L-tryptophan
spontaneous: false
EC number: 1.14.16.4
left: Oxygen
left: L-Tryptophan
left: Tetrahydrobiopterin
name: L-Tryptophan + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + 5-Hydroxy-L-tryptophan
conversion direction: LEFT_TO_RIGHT

Reaction1620
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002053 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000703 Cytosol/Stoichiometry/1.0
right: Xanthurenic acid
spontaneous: false
left: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid → Xanthurenic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16411
type: UnificationXref
id: CHEBI:16411
db: ChEBI

Reference/KEGG Compound C00954
type: UnificationXref
id: C00954
db: KEGG Compound

Reference/PubChem-compound 5699
type: UnificationXref
id: 5699
db: PubChem-compound

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 6305
type: UnificationXref
id: 6305
db: PubChem-compound

Reference/HMDB HMDB0000929
type: UnificationXref
id: HMDB0000929
db: HMDB

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440741
xref: Reference/ChemSpider 389612
xref: Reference/HMDB HMDB0004083
xref: Reference/KEGG Compound C05645
chemical formula: C10H9NO5
molecular weight: 223.04807
structure: ChemicalStructure/PW C002053

Reference/CAS 87-51-4
type: UnificationXref
id: 87-51-4
db: CAS

Compound/PW C007219 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-3-Hydroxykynurenine
stoichiometric coefficient: 1.0

5-Hydroxy-N-formylkynurenine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 2065
xref: Reference/ChemSpider 389615
xref: Reference/HMDB HMDB0004086
xref: Reference/KEGG Compound C05648
xref: Reference/PubChem-compound 440744
chemical formula: C11H12N2O5
molecular weight: 252.07462
structure: ChemicalStructure/PW C002055

L-Tryptophan
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Tryptophan

Formylanthranilic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 101399
xref: Reference/ChemSpider 91624
xref: Reference/CAS 3342-77-6
xref: Reference/KEGG Compound C05653
xref: Reference/ChEBI CHEBI 36575
xref: Reference/HMDB HMDB0004089
chemical formula: C8H7NO3
molecular weight: 165.04259
structure: ChemicalStructure/PW C002057

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/CAS 4350-09-8
type: UnificationXref
id: 4350-09-8
db: CAS

Compound/PW C000926 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Indoleacetaldehyde
stoichiometric coefficient: 1.0

Reference/UniProt P05091
type: UnificationXref
id: P05091
db: UniProt

Kynurenine 3-monooxygenase
type: ProteinReference
xref: Reference/UniProt O15229
organism: Homo sapiens

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

N'-Formylkynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: N'-Formylkynurenine

ChemicalStructure/PW C000741
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

Compound/PW C000105 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Reference/UniProt Q16719
type: UnificationXref
id: Q16719
db: UniProt

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

1.14.13.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000926 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000207 Cytosol/Stoichiometry/1.0
right: Indoleacetaldehyde
right: NADP
right: Water
spontaneous: false
EC number: 1.14.13.9
left: Oxygen
left: Tryptamine
left: NADPH
name: NADPH + Oxygen + Tryptamine → Indoleacetaldehyde + NADP + Water
conversion direction: LEFT_TO_RIGHT

1.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000128 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000926 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Indoleacetic acid
right: NADH
spontaneous: false
EC number: 1.2.1.3
left: NAD
left: Indoleacetaldehyde
left: Water
name: Indoleacetaldehyde + NAD + Water → Indoleacetic acid + NADH
conversion direction: LEFT_TO_RIGHT

4.1.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000741 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000207 Cytosol/Stoichiometry/1.0
right: Tryptamine
right: Carbon dioxide
spontaneous: false
EC number: 4.1.1.28
left: L-Tryptophan
name: L-Tryptophan → Carbon dioxide + Tryptamine
conversion direction: LEFT_TO_RIGHT

Compound/PW C001541 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4a-Hydroxytetrahydrobiopterin
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

ChemicalStructure/PW C000703
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=NC2=C(O)C=CC=C2C(O)=C1

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

L-3-Hydroxykynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-3-Hydroxykynurenine

Reference/BioCyc 3-HYDROXY-L-KYNURENINE
type: UnificationXref
id: 3-HYDROXY-L-KYNURENINE
db: BioCyc

Reference/ChEBI CHEBI 16765
type: UnificationXref
id: CHEBI:16765
db: ChEBI

Reference/KEGG Compound C01717
type: UnificationXref
id: C01717
db: KEGG Compound

Reference/HMDB HMDB0004083
type: UnificationXref
id: HMDB0004083
db: HMDB

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 129803
type: UnificationXref
id: 129803
db: PubChem-compound

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

5-Hydroxy-N-formylkynurenine
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Hydroxy-N-formylkynurenine

Reference/HMDB HMDB0000715
type: UnificationXref
id: HMDB0000715
db: HMDB

Reference/ChemSpider 1093
type: UnificationXref
id: 1093
db: ChemSpider

Compound/PW C002057 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formylanthranilic acid
stoichiometric coefficient: 1.0

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

4-(2-Aminophenyl)-2,4-dioxobutanoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 4-(2-Aminophenyl)-2,4-dioxobutanoic acid

Tryptophan 5-hydroxylase 1
type: Protein
cellular location: Cytosol
entity reference: Tryptophan 5-hydroxylase 1

L-Tryptophan
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Tryptophan

Reference/HMDB HMDB0004086
type: UnificationXref
id: HMDB0004086
db: HMDB

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0004089
type: UnificationXref
id: HMDB0004089
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/CAS 70110-58-6
type: UnificationXref
id: 70110-58-6
db: CAS

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/KEGG Compound C00637
type: UnificationXref
id: C00637
db: KEGG Compound

Reference/ChEBI CHEBI 17780
type: UnificationXref
id: CHEBI:17780
db: ChEBI

Reference/BioCyc ANTHRANILATE
type: UnificationXref
id: ANTHRANILATE
db: BioCyc

Aldehyde dehydrogenase, mitochondrial
type: Protein
cellular location: Cytosol
entity reference: Aldehyde dehydrogenase, mitochondrial

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/BioCyc L-KYNURENINE
type: UnificationXref
id: L-KYNURENINE
db: BioCyc

Reference/ChEBI CHEBI 30754
type: UnificationXref
id: CHEBI:30754
db: ChEBI

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Reference/BioCyc XANTHURENATE
type: UnificationXref
id: XANTHURENATE
db: BioCyc

ReactionCatalysis1360
type: Catalysis
controller: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
controlled: Reaction1619
control type: ACTIVATION

Indoleamine 2,3-dioxygenase 1
type: Protein
cellular location: Cytosol
entity reference: Indoleamine 2,3-dioxygenase 1

ReactionCatalysis1363
type: Catalysis
controller: Tryptophan 5-hydroxylase 1
controlled: 1.14.16.4
control type: ACTIVATION

Reference/UniProt Q63HM1
type: UnificationXref
id: Q63HM1
db: UniProt

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/HMDB HMDB0000978
type: UnificationXref
id: HMDB0000978
db: HMDB

ChemicalStructure/PW C000778
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C(C=CC=C1)C(=O)CC(=O)C(O)=O

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/HMDB HMDB0011631
type: UnificationXref
id: HMDB0011631
db: HMDB

Reference/KEGG Compound C00643
type: UnificationXref
id: C00643
db: KEGG Compound

Reference/ChEBI CHEBI 15372
type: UnificationXref
id: CHEBI:15372
db: ChEBI

ChemicalStructure/PW C000538
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(=O)C1=CC=CC=C1N)C(O)=O

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15374
type: UnificationXref
id: CHEBI:15374
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Kynurenic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Kynurenic acid

ReactionCatalysis1373
type: Catalysis
controller: Indoleamine 2,3-dioxygenase 1
controlled: 1.13.11.52
control type: ACTIVATION

RNA/43 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Trp)
stoichiometric coefficient: 1.0

Reference/ChemSpider 11318
type: UnificationXref
id: 11318
db: ChemSpider

Protein/543 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Tryptophan--tRNA ligase, cytoplasmic
stoichiometric coefficient: 2.0

Reference/BioCyc N-FORMYLKYNURENINE
type: UnificationXref
id: N-FORMYLKYNURENINE
db: BioCyc

Reference/UniProt O15229
type: UnificationXref
id: O15229
db: UniProt

Tryptamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Tryptamine

2-Aminobenzoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Aminobenzoic acid

ReactionCatalysis1384
type: Catalysis
controller: Kynurenine 3-monooxygenase
controlled: 1.14.13.9
control type: ACTIVATION

ReactionCatalysis1383
type: Catalysis
controller: Aromatic-L-amino-acid decarboxylase
controlled: 4.1.1.28
control type: ACTIVATION

Reference/BioCyc TRYPTAMINE
type: UnificationXref
id: TRYPTAMINE
db: BioCyc

L-Tryptophan
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Tryptophan

Reference/CAS 3342-77-6
type: UnificationXref
id: 3342-77-6
db: CAS

ReactionCatalysis1385
type: Catalysis
controller: Aldehyde dehydrogenase, mitochondrial
controlled: 1.2.1.3
control type: ACTIVATION

ChemicalStructure/PW C000877
type: ChemicalStructure
structure format: SMILES
structure data: NC1=CC=CC=C1C(O)=O

Reference/ChemSpider 5497
type: UnificationXref
id: 5497
db: ChemSpider

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/UniProt P14902
type: UnificationXref
id: P14902
db: UniProt

Reference/HMDB HMDB0000881
type: UnificationXref
id: HMDB0000881
db: HMDB

L-Tryptophyl-tRNA(Trp)
type: Rna
cellular location: Cytoplasm
entity reference: L-Tryptophyl-tRNA(Trp)

Aromatic-L-amino-acid decarboxylase
type: Protein
cellular location: Cytosol
entity reference: Aromatic-L-amino-acid decarboxylase