Reaction213228
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040526 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C109120 Cytosol/Stoichiometry/1.0
right: Thiodeoxyguanosine-5'-triphosphate
spontaneous: false
left: Thiodeoxyguanosine 5'-diphosphate
name: Thiodeoxyguanosine 5'-diphosphate → Thiodeoxyguanosine-5'-triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/HMDB HMDB0014496
type: UnificationXref
id: HMDB0014496
db: HMDB

Reference/UniProt P63000
type: UnificationXref
id: P63000
db: UniProt

Reference/UniProt O15440
type: UnificationXref
id: O15440
db: UniProt

Compound/PW C008876 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thioguanine
stoichiometric coefficient: 1.0

Compound/PW C000749 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

1-phosphatidyl-1D-myo-inositol 4-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 1-phosphatidyl-1D-myo-inositol 4-phosphate

DNA Synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112931
pathway component: SubPathwayInteraction112931
name: SubPathway

Regulation of Apoptosis of Activated T Cells
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112933
pathway component: SubPathwayInteraction112933
name: SubPathway

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

RNA Synthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway112932
pathway component: SubPathwayInteraction112932
name: SubPathway

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Reference/SMPDB SMP0122727
type: UnificationXref
id: SMP0122727
db: SMPDB

Transport10956
type: Transport
participant stoichiometry: Compound/PW C008876 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008876 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: Thioguanine
spontaneous: false
left: Sodium
left: Thioguanine
name: Thioguanine (→), Sodium (←) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Transport10954
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008876 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008876/Stoichiometry/1.0
right: Thioguanine
right: Sodium
spontaneous: false
left: Sodium
left: Thioguanine
name: Thioguanine (→), Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell
conversion direction: LEFT_TO_RIGHT

Transport10955
type: Transport
participant stoichiometry: Compound/PW C008876 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008876 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: Thioguanine
spontaneous: false
left: Sodium
left: Thioguanine
name: Thioguanine (→), Sodium (←) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/UniProt O15439
type: UnificationXref
id: O15439
db: UniProt

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/HMDB HMDB0061341
type: UnificationXref
id: HMDB0061341
db: HMDB

Reference/UniProt P00492
type: UnificationXref
id: P00492
db: UniProt

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C07648
type: UnificationXref
id: C07648
db: KEGG Compound

6-Thioguanosine monophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 3034646
xref: Reference/ChEBI CHEBI 1267082
xref: Reference/KEGG Compound C16619
xref: Reference/HMDB HMDB0060415
xref: Reference/CAS 15867-02-4
xref: Reference/ChemSpider 2299082
chemical formula: C10H14N5O7PS
molecular weight: 379.03516
structure: ChemicalStructure/PW C040506

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

Compound/PW C008876 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thioguanine
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

ReactionCoupledTransportCatalysis524
type: Catalysis
controller: Multidrug resistance-associated protein 4
controlled: ReactionCoupledTransport481
control type: ACTIVATION

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Sodium/nucleoside cotransporter 2
type: Protein
entity reference: Sodium/nucleoside cotransporter 2

Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Thiodeoxyguanosine-5'-triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thiodeoxyguanosine-5'-triphosphate
name: SubPathwayInput

Compound/PW C040547 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thioguanosine 5'-triphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/CAS 154-42-7
type: UnificationXref
id: 154-42-7
db: CAS

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

Reference/UniProt P51580
type: UnificationXref
id: P51580
db: UniProt

ChemicalStructure/PW C040547
type: ChemicalStructure
structure format: SMILES

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: Reference/UniProt P63000
organism: Homo sapiens

Thioguanine
type: SmallMolecule
cellular location: Cytosol
entity reference: Thioguanine

ChemicalStructure/PW C040546
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Reference/ChemSpider 8319071
type: UnificationXref
id: 8319071
db: ChemSpider

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 2723601
type: UnificationXref
id: 2723601
db: PubChem-compound

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Solute carrier family 28 member 3
type: Protein
entity reference: Solute carrier family 28 member 3

Hypoxanthine-guanine phosphoribosyltransferase
type: Complex
component stoichiometry: Protein/458 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Hypoxanthine-guanine phosphoribosyltransferase

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Methyl-thioguanosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Methyl-thioguanosine monophosphate

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reaction1846
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040546 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040526 Cytosol/Stoichiometry/1.0
right: Thiodeoxyguanosine 5'-diphosphate
spontaneous: false
left: Thioguanosine 5'-diphosphate
name: Thioguanosine 5'-diphosphate → Thiodeoxyguanosine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reaction1847
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040526 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040527 Cytosol/Stoichiometry/1.0
right: 1-phosphatidyl-1D-myo-inositol 4-phosphate
spontaneous: false
left: Thiodeoxyguanosine 5'-diphosphate
name: Thiodeoxyguanosine 5'-diphosphate → 1-phosphatidyl-1D-myo-inositol 4-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C109120
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reaction1844
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040546 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040506 Cytosol/Stoichiometry/1.0
right: Thioguanosine 5'-diphosphate
spontaneous: false
left: 6-Thioguanosine monophosphate
name: 6-Thioguanosine monophosphate → Thioguanosine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

2.1.1.67
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040506 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040525 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Methyl-thioguanosine monophosphate
spontaneous: false
EC number: 2.1.1.67
left: 6-Thioguanosine monophosphate
left: S-Adenosylmethionine
name: 6-Thioguanosine monophosphate + S-Adenosylmethionine → Methyl-thioguanosine monophosphate + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Thioguanosine 5'-triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thioguanosine 5'-triphosphate
name: SubPathwayInput

Reference/HMDB HMDB0060875
type: UnificationXref
id: HMDB0060875
db: HMDB

Reference/HMDB HMDB0060874
type: UnificationXref
id: HMDB0060874
db: HMDB

Reference/HMDB HMDB0061266
type: UnificationXref
id: HMDB0061266
db: HMDB

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Reference/PubChem-compound 3034646
type: UnificationXref
id: 3034646
db: PubChem-compound

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Interaction3209
type: MolecularInteraction
interaction type: direct_interaction
name: Thioguanosine 5'-triphosphate inhibits Ras-related C3 botulinum toxin substrate 1
participant: Ras-related C3 botulinum toxin substrate 1
participant: Thioguanosine 5'-triphosphate

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

ChemicalStructure/PW C008876
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=S)C2=C(N1)N=CN2

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Compound/PW C008876/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thioguanine
stoichiometric coefficient: 1.0

Multidrug resistance-associated protein 5
type: Protein
cellular location: Cell Membrane
entity reference: Multidrug resistance-associated protein 5

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Compound/PW C000190 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

Sodium/nucleoside cotransporter 1
type: Protein
entity reference: Sodium/nucleoside cotransporter 1

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Reference/ChemSpider 2005804
type: UnificationXref
id: 2005804
db: ChemSpider

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/PubChem-compound 10143562
type: UnificationXref
id: 10143562
db: PubChem-compound

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/ChEBI CHEBI 9555
type: UnificationXref
id: CHEBI:9555
db: ChEBI

Reference/UniProt O43868
type: UnificationXref
id: O43868
db: UniProt

Multidrug resistance-associated protein 4
type: Protein
cellular location: Cell Membrane
entity reference: Multidrug resistance-associated protein 4

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

ReactionCoupledTransport481
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040506 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: 6-Thioguanosine monophosphate
spontaneous: false
left: Adenosine triphosphate
left: Water
left: 6-Thioguanosine monophosphate
name: 6-Thioguanosine monophosphate + Adenosine triphosphate + Water → 6-Thioguanosine monophosphate + Adenosine diphosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

BiologicalState26
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Thioguanosine 5'-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thioguanosine 5'-diphosphate

Reference/UniProt Q9HAS3
type: UnificationXref
id: Q9HAS3
db: UniProt

ChemicalStructure/PW C040506
type: ChemicalStructure
structure format: SMILES

Sodium/nucleoside cotransporter 2
type: ProteinReference
xref: Reference/UniProt O43868

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Sodium
type: SmallMolecule
entity reference: Sodium

Protein/458 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hypoxanthine-guanine phosphoribosyltransferase
stoichiometric coefficient: 4.0

Compound/PW C040527 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-phosphatidyl-1D-myo-inositol 4-phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C16619
type: UnificationXref
id: C16619
db: KEGG Compound

Hypoxanthine-guanine phosphoribosyltransferase
type: Protein
cellular location: Cytosol
entity reference: Hypoxanthine-guanine phosphoribosyltransferase

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

Reference/PubChem-compound 53936469
type: UnificationXref
id: 53936469
db: PubChem-compound

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reaction1893
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040546 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040547 Cytosol/Stoichiometry/1.0
right: Thioguanosine 5'-triphosphate
spontaneous: false
left: Thioguanosine 5'-diphosphate
name: Thioguanosine 5'-diphosphate → Thioguanosine 5'-triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Solute carrier family 28 member 3
type: ProteinReference
xref: Reference/UniProt Q9HAS3

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Reference/CAS 15867-02-4
type: UnificationXref
id: 15867-02-4
db: CAS

6-Thioguanosine monophosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: 6-Thioguanosine monophosphate

Reference/PathWhiz PW124051
type: UnificationXref
id: PW124051
db: PathWhiz

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

ChemicalStructure/PW C040525
type: ChemicalStructure
structure format: SMILES

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Multidrug resistance-associated protein 5
type: ProteinReference
xref: Reference/UniProt O15440
organism: Homo sapiens

ChemicalStructure/PW C040527
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040526
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Multidrug resistance-associated protein 4
type: ProteinReference
xref: Reference/UniProt O15439
organism: Homo sapiens

Thiodeoxyguanosine 5'-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Thiodeoxyguanosine 5'-diphosphate

ReactionCatalysis1627
type: Catalysis
controller: Thiopurine S-methyltransferase
controlled: 2.1.1.67
control type: ACTIVATION

Compound/PW C040546 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thioguanosine 5'-diphosphate
stoichiometric coefficient: 1.0

Reference/UniProt O00337
type: UnificationXref
id: O00337
db: UniProt

Compound/PW C000458/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: Reference/UniProt P00492
organism: BiologicalState26

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylhomocysteine

2.4.2.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C008876 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000190 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040506 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: 6-Thioguanosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 2.4.2.8
left: Thioguanine
left: Phosphoribosyl pyrophosphate
name: Phosphoribosyl pyrophosphate + Thioguanine → 6-Thioguanosine monophosphate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Ras-related C3 botulinum toxin substrate 1
type: Protein
cellular location: Cell Membrane
entity reference: Ras-related C3 botulinum toxin substrate 1
name: SubPathwayInput

Compound/PW C109120 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiodeoxyguanosine-5'-triphosphate
stoichiometric coefficient: 1.0

Thioguanine Mechanism of Action
type: Pathway
pathway order: PathwayEnzymeReaction/2462672
pathway order: PathwaySubPathway/112931
pathway order: PathwayEnzymeReaction/2462682
pathway order: PathwaySubPathway/112932
pathway order: PathwayTransport/2462676
pathway order: PathwayEnzymeReaction/2462681
pathway order: PathwaySubPathway/112933
pathway order: PathwayTransport/2462675
pathway order: PathwayEnzymeReaction/2462680
pathway order: PathwayTransport/2462674
pathway order: PathwayEnzymeReaction/2462679
pathway order: PathwayEnzymeReaction/2462678
pathway order: PathwayEnzymeReaction/2462677
pathway order: PathwayEnzymeReaction/2462687
pathway order: PathwayEnzymeReaction/2462686
pathway order: PathwayInteraction/3209
pathway component: TransportCatalysis2116
pathway component: TransportCatalysis2115
pathway component: ReactionCoupledTransportCatalysis524
pathway component: TransportCatalysis2117
pathway component: Reaction213228
pathway component: Transport10956
pathway component: Reaction1846
pathway component: Reaction1847
pathway component: ReactionCoupledTransport37
pathway component: Transport10954
pathway component: Transport10955
pathway component: Interaction3209
pathway component: 2.4.2.8
pathway component: DNA Synthesis
pathway component: ReactionCatalysis1954
pathway component: ReactionCatalysis1627
pathway component: Regulation of Apoptosis of Activated T Cells
pathway component: RNA Synthesis
pathway component: Reaction1844
pathway component: 2.1.1.67
pathway component: ReactionCoupledTransportCatalysis37
pathway component: Reaction1893
pathway component: ReactionCoupledTransport481
xref: Reference/PathWhiz PW124051
xref: Reference/SMPDB SMP0122727
organism: Homo sapiens

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Reference/HMDB HMDB0060415
type: UnificationXref
id: HMDB0060415
db: HMDB

Compound/PW C040506 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Thioguanosine monophosphate
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Compound/PW C040526 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thiodeoxyguanosine 5'-diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Methyl-thioguanosine monophosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061327
chemical formula: C11H18N5O7PS
molecular weight: 395.06647
structure: ChemicalStructure/PW C040525

Thiodeoxyguanosine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061266
chemical formula: C10H15N5O10P2S
molecular weight: 459.0015
structure: ChemicalStructure/PW C040526

1-phosphatidyl-1D-myo-inositol 4-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061341
xref: Reference/ChEBI CHEBI 17526
chemical formula: C11H19O13P
molecular weight: 390.05634
structure: ChemicalStructure/PW C040527

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Thioguanine
type: SmallMoleculeReference
xref: Reference/CAS 154-42-7
xref: Reference/ChEBI CHEBI 9555
xref: Reference/ChemSpider 2005804
xref: Reference/KEGG Compound C07648
xref: Reference/HMDB HMDB0014496
xref: Reference/PubChem-compound 2723601
chemical formula: C5H5N5S
molecular weight: 167.02657
structure: ChemicalStructure/PW C008876

SubPathwayInteraction112931
type: Interaction
name: SubPathway112931Reaction
name: SubPathwayReaction
participant: Thiodeoxyguanosine-5'-triphosphate

SubPathwayInteraction112932
type: Interaction
name: SubPathway112932Reaction
name: SubPathwayReaction
participant: Thioguanosine 5'-triphosphate

SubPathwayInteraction112933
type: Interaction
name: SubPathwayReaction
name: SubPathway112933Reaction
participant: Ras-related C3 botulinum toxin substrate 1

Sodium/nucleoside cotransporter 1
type: ProteinReference
xref: Reference/UniProt O00337

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Thioguanine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Thioguanine

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

6-Thioguanosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 6-Thioguanosine monophosphate

Compound/PW C040506 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Thioguanosine monophosphate
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ReactionCoupledTransport37
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040506 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: 6-Thioguanosine monophosphate
spontaneous: false
left: 6-Thioguanosine monophosphate
left: Adenosine triphosphate
left: Water
name: 6-Thioguanosine monophosphate + Adenosine triphosphate + Water → 6-Thioguanosine monophosphate + Adenosine diphosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Phosphoribosyl pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoribosyl pyrophosphate

Reference/HMDB HMDB0061327
type: UnificationXref
id: HMDB0061327
db: HMDB

Thiopurine S-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Thiopurine S-methyltransferase

TransportCatalysis2116
type: Catalysis
controller: Solute carrier family 28 member 3
controlled: Transport10955
control type: ACTIVATION

TransportCatalysis2115
type: Catalysis
controller: Sodium/nucleoside cotransporter 2
controlled: Transport10954
control type: ACTIVATION

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

TransportCatalysis2117
type: Catalysis
controller: Sodium/nucleoside cotransporter 1
controlled: Transport10956
control type: ACTIVATION

Thioguanosine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53936469
xref: Reference/HMDB HMDB0060874
chemical formula: C10H15N5O10P2S
molecular weight: 459.0015
structure: ChemicalStructure/PW C040546

Reference/ChEBI CHEBI 17526
type: UnificationXref
id: CHEBI:17526
db: ChEBI

Thioguanosine 5'-triphosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 8319071
xref: Reference/PubChem-compound 10143562
xref: Reference/HMDB HMDB0060875
chemical formula: C10H16N5O13P3S
molecular weight: 538.96783
structure: ChemicalStructure/PW C040547

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/ChEBI CHEBI 1267082
type: UnificationXref
id: CHEBI:1267082
db: ChEBI

Thioguanine
type: SmallMolecule
entity reference: Thioguanine

Thioguanosine 5'-triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Thioguanosine 5'-triphosphate

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

ReactionCoupledTransportCatalysis37
type: Catalysis
controller: Multidrug resistance-associated protein 5
controlled: ReactionCoupledTransport37
control type: ACTIVATION

Reference/ChemSpider 2299082
type: UnificationXref
id: 2299082
db: ChemSpider

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Thiopurine S-methyltransferase
type: ProteinReference
xref: Reference/UniProt P51580
organism: Homo sapiens

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Thiodeoxyguanosine-5'-triphosphate
type: SmallMoleculeReference
chemical formula: C10H16N5O12P3S
molecular weight: 522.9729
structure: ChemicalStructure/PW C109120

Adenosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine diphosphate

ReactionCatalysis1954
type: Catalysis
controller: Hypoxanthine-guanine phosphoribosyltransferase
controlled: 2.4.2.8
control type: ACTIVATION

Compound/PW C040525 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methyl-thioguanosine monophosphate
stoichiometric coefficient: 1.0