Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState73

L type Calcium channel
type: Complex
component stoichiometry: Protein/2712 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/2720 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/2706 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/UniProt P28482
type: UnificationXref
id: P28482
db: UniProt

Adenylate cyclase type 8
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 8

direct_interaction
type: InteractionVocabulary

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Reference/UniProt Q8NFM4
type: UnificationXref
id: Q8NFM4
db: UniProt

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Focal adhesion kinase 1
type: ProteinReference
xref: Reference/UniProt Q05397
organism: BiologicalState73

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Adenylyl cyclase complex
type: Complex
cellular location: Cytosol
component: Adenylate cyclase type 8
component: Adenylate cyclase type 2
component: Adenylate cyclase type 9
component: Adenylate cyclase type 4
component: Adenylate cyclase type 1
component: Adenylate cyclase type 6
component: Adenylate cyclase type 5
component: Adenylate cyclase type 3
component: Adenylate cyclase type 7

Interaction3297
type: MolecularInteraction
interaction type: direct_interaction
name: Adenylyl cyclase complex inhibits PKA complex
participant: PKA complex
participant: Adenylyl cyclase complex

Interaction3298
type: MolecularInteraction
interaction type: direct_interaction
name: PKA complex activates Voltage Gated Potassium Channel
participant: Voltage Gated Potassium Channel
participant: PKA complex

Reference/UniProt P51828
type: UnificationXref
id: P51828
db: UniProt

Interaction3299
type: MolecularInteraction
interaction type: direct_interaction
name: PKA complex activates Focal adhesion kinase 1
participant: PKA complex
participant: Focal adhesion kinase 1

Reference/UniProt P40145
type: UnificationXref
id: P40145
db: UniProt

Potassium voltage-gated channel subfamily D member 2
type: Protein
cellular location: Cell Membrane
entity reference: Potassium voltage-gated channel subfamily D member 2

Protein/2972 Cell Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Kv channel-interacting protein 2
stoichiometric coefficient: 4.0

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/UniProt Q08462
type: UnificationXref
id: Q08462
db: UniProt

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Voltage Gated Potassium Channel
type: Complex
component stoichiometry: Protein/2972/Stoichiometry/4.0
component stoichiometry: Protein/4920/Stoichiometry/4.0
component: Potassium voltage-gated channel subfamily D member 2
component: Kv channel-interacting protein 2

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Protein/2720 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Protein/4920/Stoichiometry/4.0
type: Stoichiometry
physical entity: Potassium voltage-gated channel subfamily D member 2
stoichiometric coefficient: 4.0

ReactionCatalysis202869
type: Catalysis
controller: Focal adhesion kinase 1
controlled: Reaction213279
control type: ACTIVATION

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Adenylate cyclase type 1
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 1

(S)-3-Butyl-1(3H)-isobenzofuranone
type: SmallMolecule
cellular location: Cytosol
entity reference: (S)-3-Butyl-1(3H)-isobenzofuranone

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Protein/2712 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reference/UniProt O60266
type: UnificationXref
id: O60266
db: UniProt

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt P28482
organism: BiologicalState73

Interaction3300
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha inhibits L type Calcium channel
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
participant: L type Calcium channel

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Adenylate cyclase type 7
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 7

Reference/UniProt Q9NZV8
type: UnificationXref
id: Q9NZV8
db: UniProt

Reference/UniProt P13861
type: UnificationXref
id: P13861
db: UniProt

Interaction3307
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha activates Mitogen-activated protein kinase
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
participant: Mitogen-activated protein kinase

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

BiologicalState73
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Neuron

Adenylate cyclase type 3
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 3

PKA complex
type: Complex
cellular location: Cytosol
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-beta regulatory subunit

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Mitogen-activated protein kinase 3
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 3

Reference/HMDB HMDB0032064
type: UnificationXref
id: HMDB0032064
db: HMDB

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/ChemSpider 55293
type: UnificationXref
id: 55293
db: ChemSpider

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612
organism: BiologicalState73

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Cannabinoid receptor 1
type: Protein
cellular location: Cell Membrane
entity reference: Cannabinoid receptor 1

Cannabinoid receptor 1
type: ProteinReference
xref: Reference/UniProt P21554
organism: BiologicalState73

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/UniProt Q08828
type: UnificationXref
id: Q08828
db: UniProt

(S)-3-Butyl-1(3H)-isobenzofuranone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0032064
xref: Reference/PubChem-compound 61361
xref: Reference/ChemSpider 55293
xref: Reference/CAS 6066-49-5
xref: Reference/KEGG Compound C17854
chemical formula: C12H14O2
molecular weight: 190.09938
structure: ChemicalStructure/PW C013237

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/SMPDB SMP0122745
type: UnificationXref
id: SMP0122745
db: SMPDB

Ligand
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Ligand

Reference/UniProt Q9NS61
type: UnificationXref
id: Q9NS61
db: UniProt

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Voltage Gated Potassium Channel
type: Complex
component stoichiometry: Protein/2972 Cell Membrane/Stoichiometry/4.0
component stoichiometry: Protein/4920 Cell Membrane/Stoichiometry/4.0
cellular location: Cell Membrane
component: Kv channel-interacting protein 2
component: Potassium voltage-gated channel subfamily D member 2

Reference/PubChem-compound 61361
type: UnificationXref
id: 61361
db: PubChem-compound

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

PKA complex
type: Complex
cellular location: Cell Membrane
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/UniProt P27361
type: UnificationXref
id: P27361
db: UniProt

Adenylate cyclase type 2
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 2

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/UniProt O60503
type: UnificationXref
id: O60503
db: UniProt

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Kv channel-interacting protein 2
type: Protein
cellular location: Cell Membrane
entity reference: Kv channel-interacting protein 2

CB1 Receptor
type: Pathway
pathway order: PathwayTransport/2463070
pathway order: PathwayInteraction/3270
pathway order: PathwayEnzymeReaction/2463068
pathway order: PathwayInteraction/3307
pathway order: PathwayTransport/2463090
pathway order: PathwayInteraction/3269
pathway order: PathwayInteraction/3268
pathway order: PathwayInteraction/3300
pathway order: PathwayInteraction/3266
pathway order: PathwayInteraction/3299
pathway order: PathwayInteraction/3298
pathway order: PathwayInteraction/3297
pathway component: Interaction3270
pathway component: ReactionCatalysis202869
pathway component: Transport10978
pathway component: TransportCatalysis2134
pathway component: Interaction3300
pathway component: Interaction3268
pathway component: Interaction3269
pathway component: Transport10976
pathway component: Interaction3297
pathway component: Interaction3298
pathway component: Interaction3266
pathway component: Interaction3299
pathway component: Reaction213279
pathway component: Interaction3307
pathway component: TransportCatalysis2132
xref: Reference/SMPDB SMP0122745
xref: Reference/PathWhiz PW124076
organism: Homo sapiens

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

TransportCatalysis2134
type: Catalysis
controller: L type Calcium channel
controlled: Transport10978
control type: ACTIVATION

Kv channel-interacting protein 2
type: Protein
entity reference: Kv channel-interacting protein 2

Adenylate cyclase type 4
type: ProteinReference
xref: Reference/UniProt Q8NFM4
organism: BiologicalState73

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 1

Adenylate cyclase type 7
type: ProteinReference
xref: Reference/UniProt P51828
organism: BiologicalState73

TransportCatalysis2132
type: Catalysis
controller: Voltage Gated Potassium Channel
controlled: Transport10976
control type: ACTIVATION

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Protein/2706 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: ProteinReference
xref: Reference/UniProt P63092
organism: BiologicalState73

Potassium voltage-gated channel subfamily D member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily D member 2

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Adenylate cyclase type 9
type: ProteinReference
xref: Reference/UniProt O60503
organism: BiologicalState73

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Adenylate cyclase type 8
type: ProteinReference
xref: Reference/UniProt P40145
organism: BiologicalState73

Adenylate cyclase type 1
type: ProteinReference
xref: Reference/UniProt Q08828
organism: BiologicalState73

Adenylate cyclase type 3
type: ProteinReference
xref: Reference/UniProt O60266
organism: BiologicalState73

Reference/UniProt P63092
type: UnificationXref
id: P63092
db: UniProt

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Adenylate cyclase type 5
type: ProteinReference
xref: Reference/UniProt O95622
organism: BiologicalState73

Adenylate cyclase type 6
type: ProteinReference
xref: Reference/UniProt O43306
organism: BiologicalState73

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31323
organism: BiologicalState73

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P13861
organism: BiologicalState73

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31321
organism: BiologicalState73

Adenylate cyclase type 5
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 5

Reference/CAS 6066-49-5
type: UnificationXref
id: 6066-49-5
db: CAS

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Ligand
type: SmallMoleculeReference

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47
organism: BiologicalState73

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

ChemicalStructure/PW C013237
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC1OC(=O)C2=C1C=CC=C2

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555
organism: BiologicalState73

Reference/UniProt O95622
type: UnificationXref
id: O95622
db: UniProt

Mitogen-activated protein kinase 3
type: ProteinReference
xref: Reference/UniProt P27361
organism: BiologicalState73

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/UniProt O43306
type: UnificationXref
id: O43306
db: UniProt

Reference/KEGG Compound C17854
type: UnificationXref
id: C17854
db: KEGG Compound

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641
organism: BiologicalState73

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState73

Interaction3268
type: MolecularInteraction
interaction type: direct_interaction
name: (S)-3-Butyl-1(3H)-isobenzofuranone activates Adenylyl cyclase complex
participant: (S)-3-Butyl-1(3H)-isobenzofuranone
participant: Adenylyl cyclase complex

Interaction3269
type: MolecularInteraction
interaction type: direct_interaction
name: Cannabinoid receptor 1 CNR1 activates Guanine nucleotide-binding protein alpha
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
participant: Cannabinoid receptor 1

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Adenylate cyclase type 6
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 6

Adenylate cyclase type 2
type: ProteinReference
xref: Reference/UniProt Q08462
organism: BiologicalState73

Interaction3266
type: MolecularInteraction
interaction type: direct_interaction
name: Ligand activates Cannabinoid receptor 1 CNR1
participant: Ligand
participant: Cannabinoid receptor 1

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Mitogen-activated protein kinase
type: Complex
cellular location: Cytosol
component: Mitogen-activated protein kinase 3
component: Mitogen-activated protein kinase 1

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Reference/UniProt P31321
type: UnificationXref
id: P31321
db: UniProt

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/UniProt P31323
type: UnificationXref
id: P31323
db: UniProt

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Kv channel-interacting protein 2
type: ProteinReference
xref: Reference/UniProt Q9NS61
organism: BiologicalState73

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Focal adhesion kinase 1
type: Protein
cellular location: Cytosol
entity reference: Focal adhesion kinase 1

Reaction213279
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
spontaneous: false
left: Adenosine diphosphate
left: Hydrogen Ion
name: Adenosine diphosphate + Hydrogen Ion → Adenosine triphosphate
conversion direction: LEFT_TO_RIGHT

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Adenylate cyclase type 4
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 4

Potassium voltage-gated channel subfamily D member 2
type: ProteinReference
xref: Reference/UniProt Q9NZV8
organism: BiologicalState73

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/UniProt Q05397
type: UnificationXref
id: Q05397
db: UniProt

Adenylate cyclase type 9
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 9

Reference/UniProt P21554
type: UnificationXref
id: P21554
db: UniProt

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Interaction3270
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha inhibits Adenylyl cyclase complex
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
participant: Adenylyl cyclase complex

Protein/2972/Stoichiometry/4.0
type: Stoichiometry
physical entity: Kv channel-interacting protein 2
stoichiometric coefficient: 4.0

Transport10978
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Transport10976
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Protein/4920 Cell Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Potassium voltage-gated channel subfamily D member 2
stoichiometric coefficient: 4.0

Reference/PathWhiz PW124076
type: UnificationXref
id: PW124076
db: PathWhiz