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Nephron Nephron Epithelial Cells Amiloride- sensitive sodium channel subunit alpha Amiloride- sensitive sodium channel subunit beta Amiloride- sensitive sodium channel subunit delta Amiloride- sensitive sodium channel subunit gamma Potassium channel subfamily K member 1 Urea transporter 2 Urea transporter 2 Chloride channel protein ClC-Ka Chloride channel protein ClC-Ka Na+ Na+ K+ K+ Na+ K+ K+ Urea Urea Urea HCO3- HCO3- Cl- Cl- Cl- H2O H2O H2O H2O Cl- Cl- Spironolactone Spironolactone Spironolactone Kidney LATE DISTAL CONVOLUTED TUBULE Nephron Lumen Interstitium/Interstidial Fluid -50mV 0mV Spironolactone enters the nephron in the kidney via the bloodstream Blocks the epithelium sodium channel (ENaC) by directly binding to it Sodium reabsorption is inhibited COLLECTING DUCT Urea is reabsorbed in the collecting duct & K+ potassium is spared as a result of Amiloride ENaC Blood Vessel
Nephron Nephron Epithelial Cells SCNN1A SCNN1B SCNN1D SCNN1G KCNK1 SLC14A2 SLC14A2 CLCNKA CLCNKA Sodium Sodium Potassium Potassium Sodium Potassium Potassium Urea Urea Urea Hydrogen carbonate Hydrogen carbonate Chloride ion Chloride ion Chloride ion Water Water Water Water Chloride ion Chloride ion Spironolactone Spironolactone Spironolactone
Nephron Nephron Epithelial Cells SCNN1A SCNN1B SCNN1D SCNN1G KCNK1 SLC14A2 SLC14A2 CLCNKA CLCNKA Na+ Na+ K+ K+ Na+ K+ K+ Urea Urea Urea HCO3- HCO3- Cl- Cl- Cl- H2O H2O H2O H2O Cl- Cl- Sptone Sptone Sptone Kidney LATE DISTAL CONVOLUTED TUBULE Nephron Lumen Interstitium/Interstidial Fluid -50mV 0mV Spironolactone enters the nephron in the kidney via the bloodstream Blocks the epithelium sodium channel (ENaC) by directly binding to it Sodium reabsorption is inhibited COLLECTING DUCT Urea is reabsorbed in the collecting duct & K+ potassium is spared as a result of Amiloride ENaC Blood Vessel
Nephron Nephron Epithelial Cells SCNN1A SCNN1B SCNN1D SCNN1G KCNK1 SLC14A2 SLC14A2 CLCNKA CLCNKA Na+ Na+ K+ K+ Na+ K+ K+ Urea Urea Urea HCO3 HCO3 Cl Cl Cl H2O H2O H2O H2O Cl Cl Sptone Sptone Sptone