Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Compound/PW C000146 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 3.0

Compound/PW C002165 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Arachidonylglycerol
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChemSpider 127983
type: UnificationXref
id: 127983
db: ChemSpider

Reference/UniProt P28482
type: UnificationXref
id: P28482
db: UniProt

direct_interaction
type: InteractionVocabulary

Compound/PW C000723 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Citrulline
stoichiometric coefficient: 2.0

Nitric oxide synthase, inducible
type: Protein
cellular location: Cytosol
entity reference: Nitric oxide synthase, inducible

Octadecanoate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Octadecanoate

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Reference/KEGG Compound C00327
type: UnificationXref
id: C00327
db: KEGG Compound

ReactionCatalysis202883
type: Catalysis
controller: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
controlled: 3.1.4.11
control type: ACTIVATION

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Adenylyl cyclase complex
type: Complex
cellular location: Cytosol
component: Adenylate cyclase type 8
component: Adenylate cyclase type 2
component: Adenylate cyclase type 9
component: Adenylate cyclase type 4
component: Adenylate cyclase type 1
component: Adenylate cyclase type 6
component: Adenylate cyclase type 5
component: Adenylate cyclase type 3
component: Adenylate cyclase type 7

Interaction3297
type: MolecularInteraction
interaction type: direct_interaction
name: Adenylyl cyclase complex inhibits PKA complex
participant: PKA complex
participant: Adenylyl cyclase complex

Interaction3298
type: MolecularInteraction
interaction type: direct_interaction
name: PKA complex activates Voltage Gated Potassium Channel
participant: Voltage Gated Potassium Channel
participant: PKA complex

ReactionCatalysis202882
type: Catalysis
controller: Sn1-specific diacylglycerol lipase alpha
controlled: 3.1.1.-
control type: ACTIVATION

Interaction3299
type: MolecularInteraction
interaction type: direct_interaction
name: PKA complex activates Focal adhesion kinase 1
participant: PKA complex
participant: Focal adhesion kinase 1

ReactionCatalysis202881
type: Catalysis
controller: Nitric oxide synthase, inducible
controlled: Reaction213297
control type: ACTIVATION

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003378
type: UnificationXref
id: HMDB0003378
db: HMDB

Reference/UniProt P40145
type: UnificationXref
id: P40145
db: UniProt

Potassium voltage-gated channel subfamily D member 2
type: Protein
cellular location: Cell Membrane
entity reference: Potassium voltage-gated channel subfamily D member 2

Octadecanoate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25629
xref: Reference/PubChem-compound 21513394
chemical formula: C18H35O2
molecular weight: 283.2637
structure: ChemicalStructure/PW C109148

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/UniProt Q08462
type: UnificationXref
id: Q08462
db: UniProt

Voltage Gated Potassium Channel
type: Complex
component stoichiometry: Protein/2972/Stoichiometry/4.0
component stoichiometry: Protein/4920/Stoichiometry/4.0
component: Potassium voltage-gated channel subfamily D member 2
component: Kv channel-interacting protein 2

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C000139 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Myo-inositol 1-phosphate
stoichiometric coefficient: 1.0

Protein/2720 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
type: UnificationXref
id: ALPHA-GLUCOSE-16-BISPHOSPHATE
db: BioCyc

Reference/BioCyc ARG
type: UnificationXref
id: ARG
db: BioCyc

ReactionCatalysis202869
type: Catalysis
controller: Focal adhesion kinase 1
controlled: Reaction213279
control type: ACTIVATION

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Reference/BioCyc L-CITRULLINE
type: UnificationXref
id: L-CITRULLINE
db: BioCyc

(S)-3-Butyl-1(3H)-isobenzofuranone
type: SmallMolecule
cellular location: Cytosol
entity reference: (S)-3-Butyl-1(3H)-isobenzofuranone

Reference/ChEBI CHEBI 16480
type: UnificationXref
id: CHEBI:16480
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Protein/2712 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reference/UniProt O60266
type: UnificationXref
id: O60266
db: UniProt

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/BioCyc 1-L-MYO-INOSITOL-1-P
type: UnificationXref
id: 1-L-MYO-INOSITOL-1-P
db: BioCyc

L-Arginine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Arginine

Compound/PW C000396 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: L-Arginine
stoichiometric coefficient: 2.0

Adenylate cyclase type 3
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 3

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/BioCyc Phosphatidylinositols
type: UnificationXref
id: Phosphatidylinositols
db: BioCyc

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Cannabinoid receptor 1
type: Protein
cellular location: Extracellular Space
entity reference: Cannabinoid receptor 1

BiologicalState48
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Neuron

Citrulline
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00327
xref: Reference/CAS 372-75-8
xref: Reference/ChEBI CHEBI 16349
xref: Reference/PubChem-compound 6992098
xref: Reference/BioCyc L-CITRULLINE
xref: Reference/HMDB HMDB0000904
xref: Reference/ChemSpider 9367
chemical formula: C6H13N3O3
molecular weight: 175.09569
structure: ChemicalStructure/PW C000723

Reference/CAS 372-75-8
type: UnificationXref
id: 372-75-8
db: CAS

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 55293
type: UnificationXref
id: 55293
db: ChemSpider

Cannabinoid receptor 1
type: Protein
cellular location: Cell Membrane
entity reference: Cannabinoid receptor 1

Reference/HMDB HMDB0000904
type: UnificationXref
id: HMDB0000904
db: HMDB

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/CAS 10102-43-9
type: UnificationXref
id: 10102-43-9
db: CAS

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

Reference/UniProt Q9NS61
type: UnificationXref
id: Q9NS61
db: UniProt

PIP2(18:3(9Z,12Z,15Z)/18:1(9Z))
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53480304
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/HMDB HMDB0010113
xref: Reference/ChemSpider 24767990
chemical formula: C45H81O19P3
molecular weight: 1018.4585
structure: ChemicalStructure/PW C006154

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Reference/PubChem-compound 61361
type: UnificationXref
id: 61361
db: PubChem-compound

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/UniProt P27361
type: UnificationXref
id: P27361
db: UniProt

ChemicalStructure/PW C109148
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCCCC([O-])=O

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Kv channel-interacting protein 2
type: Protein
cellular location: Cell Membrane
entity reference: Kv channel-interacting protein 2

Reference/BioCyc DIACYLGLYCEROL
type: UnificationXref
id: DIACYLGLYCEROL
db: BioCyc

TransportCatalysis2134
type: Catalysis
controller: L type Calcium channel
controlled: Transport10978
control type: ACTIVATION

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: Cytosol
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Adenylate cyclase type 4
type: ProteinReference
xref: Reference/UniProt Q8NFM4
organism: BiologicalState48

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 1

Reference/ChEBI CHEBI 77129
type: UnificationXref
id: CHEBI:77129
db: ChEBI

Reference/ChemSpider 9367
type: UnificationXref
id: 9367
db: ChemSpider

Adenylate cyclase type 7
type: ProteinReference
xref: Reference/UniProt P51828
organism: BiologicalState48

Reference/ChEBI CHEBI 18276
type: UnificationXref
id: CHEBI:18276
db: ChEBI

Sn1-specific diacylglycerol lipase alpha
type: Protein
cellular location: Cell Membrane
entity reference: Sn1-specific diacylglycerol lipase alpha

Reference/KEGG Compound C00282
type: UnificationXref
id: C00282
db: KEGG Compound

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Protein/2706 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Nitric oxide synthase, inducible
type: Complex
component stoichiometry: Protein/869 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Nitric oxide synthase, inducible

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: ProteinReference
xref: Reference/UniProt P63092
organism: BiologicalState48

Reference/KEGG Compound C00165
type: UnificationXref
id: C00165
db: KEGG Compound

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Reference/ChEBI CHEBI 18169
type: UnificationXref
id: CHEBI:18169
db: ChEBI

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Adenylate cyclase type 9
type: ProteinReference
xref: Reference/UniProt O60503
organism: BiologicalState48

Adenylate cyclase type 8
type: ProteinReference
xref: Reference/UniProt P40145
organism: BiologicalState48

Adenylate cyclase type 1
type: ProteinReference
xref: Reference/UniProt Q08828
organism: BiologicalState48

Adenylate cyclase type 3
type: ProteinReference
xref: Reference/UniProt O60266
organism: BiologicalState48

Reference/ChemSpider 762
type: UnificationXref
id: 762
db: ChemSpider

Adenylate cyclase type 5
type: ProteinReference
xref: Reference/UniProt O95622
organism: BiologicalState48

Adenylate cyclase type 6
type: ProteinReference
xref: Reference/UniProt O43306
organism: BiologicalState48

TransportCatalysis2142
type: Catalysis
controller: Voltage Gated Potassium Channel
controlled: Transport10988
control type: ACTIVATION

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Compound/PW C003230 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)
stoichiometric coefficient: 1.0

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/PubChem-compound 5282280
type: UnificationXref
id: 5282280
db: PubChem-compound

ChemicalStructure/PW C000396
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=N)C(O)=O

Compound/PW C001065 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 4.0

Reference/KEGG Compound C00062
type: UnificationXref
id: C00062
db: KEGG Compound

Compound/PW C109148 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Octadecanoate
stoichiometric coefficient: 1.0

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Reference/HMDB HMDB0001362
type: UnificationXref
id: HMDB0001362
db: HMDB

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Reference/SMPDB SMP0122771
type: UnificationXref
id: SMP0122771
db: SMPDB

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

ChemicalStructure/PW C013237
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC1OC(=O)C2=C1C=CC=C2

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Hydrogen
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Hydrogen

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: Reference/UniProt Q00722
organism: BiologicalState48

Compound/PW C002165 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Arachidonylglycerol
stoichiometric coefficient: 1.0

Nitric oxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003378
xref: Reference/CAS 10102-43-9
xref: Reference/PubChem-compound 145068
xref: Reference/ChEBI CHEBI 16480
xref: Reference/ChemSpider 127983
xref: Reference/KEGG Compound C00533
xref: Reference/BioCyc NITRIC-OXIDE
chemical formula: NO
molecular weight: 29.997988
structure: ChemicalStructure/PW C001867

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/UniProt O43306
type: UnificationXref
id: O43306
db: UniProt

Reference/KEGG Compound C17854
type: UnificationXref
id: C17854
db: KEGG Compound

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState48

Interaction3268
type: MolecularInteraction
interaction type: direct_interaction
name: (S)-3-Butyl-1(3H)-isobenzofuranone activates Adenylyl cyclase complex
participant: (S)-3-Butyl-1(3H)-isobenzofuranone
participant: Adenylyl cyclase complex

Reference/ChEBI CHEBI 52392
type: UnificationXref
id: CHEBI:52392
db: ChEBI

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Interaction3269
type: MolecularInteraction
interaction type: direct_interaction
name: Cannabinoid receptor 1 CNR1 activates Guanine nucleotide-binding protein alpha
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
participant: Cannabinoid receptor 1

Nitric oxide synthase, inducible
type: ProteinReference
xref: Reference/UniProt P35228
organism: BiologicalState48

Adenylate cyclase type 2
type: ProteinReference
xref: Reference/UniProt Q08462
organism: BiologicalState48

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Mitogen-activated protein kinase
type: Complex
cellular location: Cytosol
component: Mitogen-activated protein kinase 3
component: Mitogen-activated protein kinase 1
name: SubPathwayInput

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Kv channel-interacting protein 2
type: ProteinReference
xref: Reference/UniProt Q9NS61
organism: BiologicalState48

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Reference/HMDB HMDB0004666
type: UnificationXref
id: HMDB0004666
db: HMDB

ChemicalStructure/PW C002165
type: ChemicalStructure
structure format: SMILES
structure data: [H]C(CO)(CO)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Transport10989
type: Transport
participant stoichiometry: Compound/PW C002165 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002165 Extracellular Space/Stoichiometry/1.0
right: 2-Arachidonylglycerol
spontaneous: false
left: 2-Arachidonylglycerol
name: 2-Arachidonylglycerol (→) Transport: Homo sapiens, Neuron, Cell Membrane to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Potassium voltage-gated channel subfamily D member 2
type: ProteinReference
xref: Reference/UniProt Q9NZV8
organism: BiologicalState48

Reference/UniProt Q05397
type: UnificationXref
id: Q05397
db: UniProt

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Transport10988
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Neuron, Cytosol to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Adenylate cyclase type 9
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 9

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/CAS 53847-30-6
type: UnificationXref
id: 53847-30-6
db: CAS

Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3)
type: Complex
component stoichiometry: Protein/1001 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1007 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Guanylate cyclase soluble subunit beta-1
component: Guanylate cyclase soluble subunit alpha-2

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

Interaction3270
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha inhibits Adenylyl cyclase complex
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
participant: Adenylyl cyclase complex

Protein/2972/Stoichiometry/4.0
type: Stoichiometry
physical entity: Kv channel-interacting protein 2
stoichiometric coefficient: 4.0

Transport10978
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Reference/UniProt Q00722
type: UnificationXref
id: Q00722
db: UniProt

2-AG on CB1
type: Pathway
pathway order: PathwayEnzymeReaction/2463255
pathway order: PathwayInteraction/3270
pathway order: PathwayInteraction/469
pathway order: PathwayEnzymeReaction/2463383
pathway order: PathwayTransport/2463376
pathway order: PathwayTransport/2463257
pathway order: PathwayTransport/2463378
pathway order: PathwayEnzymeReaction/2463357
pathway order: PathwayInteraction/3307
pathway order: PathwayInteraction/3314
pathway order: PathwaySubPathway/113030
pathway order: PathwayInteraction/3269
pathway order: PathwayInteraction/3268
pathway order: PathwayEnzymeReaction/2463380
pathway order: PathwayInteraction/3300
pathway order: PathwayInteraction/3299
pathway order: PathwayInteraction/3321
pathway order: PathwayInteraction/3298
pathway order: PathwayInteraction/3297
pathway component: TransportCatalysis2134
pathway component: Transport10989
pathway component: Interaction3300
pathway component: Interaction3268
pathway component: Interaction3269
pathway component: Transport10988
pathway component: Interaction3321
pathway component: Interaction3307
pathway component: Interaction3270
pathway component: ReactionCatalysis202869
pathway component: Transport10978
pathway component: ReactionCatalysis202883
pathway component: Interaction469
pathway component: Interaction3314
pathway component: Reaction213297
pathway component: 3.1.1.-
pathway component: Interaction3297
pathway component: 3.1.4.11
pathway component: Interaction3298
pathway component: ReactionCatalysis202882
pathway component: Reaction213279
pathway component: Interaction3299
pathway component: ReactionCatalysis202881
pathway component: TransportCatalysis2142
pathway component: MAPK/ERK Signaling Pathway
xref: Reference/SMPDB SMP0122771
xref: Reference/PathWhiz PW124102
organism: Homo sapiens

ChemicalStructure/PW C003230
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001051
type: ChemicalStructure
structure format: SMILES
structure data: [H][H]

Reference/ChemSpider 17215924
type: UnificationXref
id: 17215924
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState48

Sn1-specific diacylglycerol lipase alpha
type: ProteinReference
xref: Reference/UniProt Q9Y4D2
organism: BiologicalState48

L type Calcium channel
type: Complex
component stoichiometry: Protein/2712 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/2720 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/2706 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent calcium channel subunit alpha-2/delta-2

Adenylate cyclase type 8
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 8

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

L-Arginine
type: SmallMoleculeReference
xref: Reference/BioCyc ARG
xref: Reference/ChEBI CHEBI 16467
xref: Reference/CAS 74-79-3
xref: Reference/KEGG Compound C00062
xref: Reference/ChemSpider 6082
xref: Reference/PubChem-compound 28782
xref: Reference/HMDB HMDB0000517
chemical formula: C6H14N4O2
molecular weight: 174.11168
structure: ChemicalStructure/PW C000396

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

2-Arachidonylglycerol
type: SmallMolecule
cellular location: Extracellular Space
entity reference: 2-Arachidonylglycerol

Reference/PubChem-compound 58838673
type: UnificationXref
id: 58838673
db: PubChem-compound

Reference/PubChem-compound 6992098
type: UnificationXref
id: 6992098
db: PubChem-compound

2-Arachidonylglycerol
type: SmallMolecule
cellular location: Cell Membrane
entity reference: 2-Arachidonylglycerol

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/UniProt Q8NFM4
type: UnificationXref
id: Q8NFM4
db: UniProt

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: Protein
cellular location: Cytosol
entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Reference/KEGG Compound C04006
type: UnificationXref
id: C04006
db: KEGG Compound

Interaction469
type: MolecularInteraction
interaction type: direct_interaction
name: Nitric oxide activates Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3)
participant: Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3)
participant: Nitric oxide

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Focal adhesion kinase 1
type: ProteinReference
xref: Reference/UniProt Q05397
organism: BiologicalState48

DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)

Reference/UniProt P51828
type: UnificationXref
id: P51828
db: UniProt

Protein/2972 Cell Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Kv channel-interacting protein 2
stoichiometric coefficient: 4.0

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C001867 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0007179
type: UnificationXref
id: HMDB0007179
db: HMDB

Reference/ChEBI CHEBI 25629
type: UnificationXref
id: CHEBI:25629
db: ChEBI

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Cytosol
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/HMDB HMDB0010113
type: UnificationXref
id: HMDB0010113
db: HMDB

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/UniProt Q02153
type: UnificationXref
id: Q02153
db: UniProt

Protein/4920/Stoichiometry/4.0
type: Stoichiometry
physical entity: Potassium voltage-gated channel subfamily D member 2
stoichiometric coefficient: 4.0

Reference/PubChem-compound 21513394
type: UnificationXref
id: 21513394
db: PubChem-compound

Compound/PW C006154 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(18:3(9Z,12Z,15Z)/18:1(9Z))
stoichiometric coefficient: 1.0

Reference/UniProt P35228
type: UnificationXref
id: P35228
db: UniProt

Reference/ChemSpider 4445451
type: UnificationXref
id: 4445451
db: ChemSpider

Myo-inositol 1-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000213
xref: Reference/ChemSpider 17215924
xref: Reference/CAS 2831-74-5
xref: Reference/KEGG Compound C04006
xref: Reference/BioCyc 1-L-MYO-INOSITOL-1-P
xref: Reference/ChEBI CHEBI 18169
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000139

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Adenylate cyclase type 1
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 1

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Guanylate cyclase soluble subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: Guanylate cyclase soluble subunit beta-1

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt P28482
organism: BiologicalState48

Interaction3300
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha inhibits L type Calcium channel
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
participant: L type Calcium channel

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/PubChem-compound 9543881
type: UnificationXref
id: 9543881
db: PubChem-compound

Adenylate cyclase type 7
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 7

Reference/UniProt Q9NZV8
type: UnificationXref
id: Q9NZV8
db: UniProt

Reference/HMDB HMDB0000213
type: UnificationXref
id: HMDB0000213
db: HMDB

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/UniProt P13861
type: UnificationXref
id: P13861
db: UniProt

Interaction3307
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha activates Mitogen-activated protein kinase
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
participant: Mitogen-activated protein kinase

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

PKA complex
type: Complex
cellular location: Cytosol
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-beta regulatory subunit

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/CAS 2831-74-5
type: UnificationXref
id: 2831-74-5
db: CAS

Guanylate cyclase soluble subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P33402
organism: BiologicalState48

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Guanylate cyclase soluble subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02153
organism: BiologicalState48

ChemicalStructure/PW C000139
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Protein/869 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Nitric oxide synthase, inducible
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)
type: SmallMoleculeReference
xref: Reference/BioCyc DIACYLGLYCEROL
xref: Reference/KEGG Compound C00165
xref: Reference/ChemSpider 7822831
xref: Reference/PubChem-compound 9543881
xref: Reference/ChEBI CHEBI 77129
xref: Reference/HMDB HMDB0007179
chemical formula: C43H72O5
molecular weight: 668.53796
structure: ChemicalStructure/PW C003230

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Mitogen-activated protein kinase 3
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 3

Compound/PW C001420 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 4.0

Hydrogen
type: SmallMoleculeReference
xref: Reference/PubChem-compound 58838673
xref: Reference/CAS 1333-74-0
xref: Reference/ChemSpider 762
xref: Reference/BioCyc ALPHA-GLUCOSE-16-BISPHOSPHATE
xref: Reference/KEGG Compound C00282
xref: Reference/HMDB HMDB0001362
xref: Reference/ChEBI CHEBI 18276
chemical formula: H2
molecular weight: 2.01565
structure: ChemicalStructure/PW C001051

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/HMDB HMDB0032064
type: UnificationXref
id: HMDB0032064
db: HMDB

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612
organism: BiologicalState48

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Cannabinoid receptor 1
type: ProteinReference
xref: Reference/UniProt P21554
organism: BiologicalState48

Interaction3321
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha activates Nitric oxide synthase, inducible
participant: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
participant: Nitric oxide synthase, inducible

Reference/UniProt Q08828
type: UnificationXref
id: Q08828
db: UniProt

Reference/ChemSpider 6082
type: UnificationXref
id: 6082
db: ChemSpider

Reference/PathWhiz PW124102
type: UnificationXref
id: PW124102
db: PathWhiz

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

(S)-3-Butyl-1(3H)-isobenzofuranone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0032064
xref: Reference/PubChem-compound 61361
xref: Reference/ChemSpider 55293
xref: Reference/CAS 6066-49-5
xref: Reference/KEGG Compound C17854
chemical formula: C12H14O2
molecular weight: 190.09938
structure: ChemicalStructure/PW C013237

Voltage Gated Potassium Channel
type: Complex
component stoichiometry: Protein/2972 Cell Membrane/Stoichiometry/4.0
component stoichiometry: Protein/4920 Cell Membrane/Stoichiometry/4.0
cellular location: Cell Membrane
component: Kv channel-interacting protein 2
component: Potassium voltage-gated channel subfamily D member 2

PKA complex
type: Complex
cellular location: Cell Membrane
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase type I-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Interaction3314
type: MolecularInteraction
interaction type: direct_interaction
name: 2-Arachidonylglycerol activates Cannabinoid receptor 1 CNR1
participant: 2-Arachidonylglycerol
participant: Cannabinoid receptor 1

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenylate cyclase type 2
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 2

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/UniProt O60503
type: UnificationXref
id: O60503
db: UniProt

ChemicalStructure/PW C000723
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCCNC(N)=O)C(O)=O

Kv channel-interacting protein 2
type: Protein
entity reference: Kv channel-interacting protein 2

SubPathwayInteraction113030
type: Interaction
name: SubPathway113030Reaction
name: SubPathwayReaction
participant: Mitogen-activated protein kinase

PIP2(18:3(9Z,12Z,15Z)/18:1(9Z))
type: SmallMolecule
cellular location: Cytosol
entity reference: PIP2(18:3(9Z,12Z,15Z)/18:1(9Z))

ChemicalStructure/PW C006154
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 53480304
type: UnificationXref
id: 53480304
db: PubChem-compound

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Potassium voltage-gated channel subfamily D member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily D member 2

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/BioCyc NITRIC-OXIDE
type: UnificationXref
id: NITRIC-OXIDE
db: BioCyc

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/UniProt P63092
type: UnificationXref
id: P63092
db: UniProt

Myo-inositol 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Myo-inositol 1-phosphate

Reference/ChemSpider 7822831
type: UnificationXref
id: 7822831
db: ChemSpider

Protein/1001 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanylate cyclase soluble subunit beta-1
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31323
organism: BiologicalState48

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P13861
organism: BiologicalState48

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31321
organism: BiologicalState48

Adenylate cyclase type 5
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 5

Reference/CAS 6066-49-5
type: UnificationXref
id: 6066-49-5
db: CAS

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/PubChem-compound 28782
type: UnificationXref
id: 28782
db: PubChem-compound

DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)

Compound/PW C003230 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/KEGG Compound C00626
type: UnificationXref
id: C00626
db: KEGG Compound

Reference/UniProt O95622
type: UnificationXref
id: O95622
db: UniProt

Mitogen-activated protein kinase 3
type: ProteinReference
xref: Reference/UniProt P27361
organism: BiologicalState48

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/ChemSpider 24767990
type: UnificationXref
id: 24767990
db: ChemSpider

2-Arachidonylglycerol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004666
xref: Reference/KEGG Compound C13856
xref: Reference/ChemSpider 4445451
xref: Reference/ChEBI CHEBI 52392
xref: Reference/CAS 53847-30-6
xref: Reference/PubChem-compound 5282280
chemical formula: C23H38O4
molecular weight: 378.277
structure: ChemicalStructure/PW C002165

Compound/PW C001051 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen
stoichiometric coefficient: 1.0

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Nitric oxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Nitric oxide

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/CAS 1333-74-0
type: UnificationXref
id: 1333-74-0
db: CAS

Reference/PubChem-compound 145068
type: UnificationXref
id: 145068
db: PubChem-compound

Adenylate cyclase type 6
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 6

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt P31321
type: UnificationXref
id: P31321
db: UniProt

Protein/1007 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanylate cyclase soluble subunit alpha-2
stoichiometric coefficient: 1.0

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/ChEBI CHEBI 16467
type: UnificationXref
id: CHEBI:16467
db: ChEBI

Reference/ChEBI CHEBI 16349
type: UnificationXref
id: CHEBI:16349
db: ChEBI

Reference/UniProt P31323
type: UnificationXref
id: P31323
db: UniProt

ChemicalStructure/PW C001867
type: ChemicalStructure
structure format: SMILES
structure data: [N]=O

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Focal adhesion kinase 1
type: Protein
cellular location: Cytosol
entity reference: Focal adhesion kinase 1

Reaction213279
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
spontaneous: false
left: Adenosine diphosphate
left: Hydrogen Ion
name: Adenosine diphosphate + Hydrogen Ion → Adenosine triphosphate
conversion direction: LEFT_TO_RIGHT

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cell Membrane
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Reference/UniProt Q9Y4D2
type: UnificationXref
id: Q9Y4D2
db: UniProt

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

MAPK/ERK Signaling Pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113030
pathway component: SubPathwayInteraction113030
name: SubPathway

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

Adenylate cyclase type 4
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 4

Reference/KEGG Compound C00533
type: UnificationXref
id: C00533
db: KEGG Compound

Compound/PW C000143 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 3.0

Reference/UniProt P21554
type: UnificationXref
id: P21554
db: UniProt

Guanylate cyclase soluble subunit alpha-2
type: Protein
cellular location: Cytosol
entity reference: Guanylate cyclase soluble subunit alpha-2

Reference/UniProt P33402
type: UnificationXref
id: P33402
db: UniProt

Reference/CAS 74-79-3
type: UnificationXref
id: 74-79-3
db: CAS

Protein/4920 Cell Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Potassium voltage-gated channel subfamily D member 2
stoichiometric coefficient: 4.0

Reaction213297
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/4.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/4.0
participant stoichiometry: Compound/PW C000723 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000396 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001867 Cytosol/Stoichiometry/2.0
right: NADP
right: Nitric oxide
right: Citrulline
right: Water
spontaneous: false
left: Oxygen
left: Hydrogen Ion
left: L-Arginine
left: NADPH
name: Hydrogen Ion + 2 L-Arginine + 3 NADPH + 4 Oxygen → 2 Citrulline + 3 NADP + 2 Nitric oxide + 4 Water
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000517
type: UnificationXref
id: HMDB0000517
db: HMDB

3.1.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C109148 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003230 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002165 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001051 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: 2-Arachidonylglycerol
right: Hydrogen
right: Octadecanoate
spontaneous: false
EC number: 3.1.1.-
left: Water
left: DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)
name: DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0) + Water → 2-Arachidonylglycerol + Hydrogen + Octadecanoate
conversion direction: LEFT_TO_RIGHT

3.1.4.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006154 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000139 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003230 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: Myo-inositol 1-phosphate
right: DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)
spontaneous: false
EC number: 3.1.4.11
left: PIP2(18:3(9Z,12Z,15Z)/18:1(9Z))
left: Water
name: PIP2(18:3(9Z,12Z,15Z)/18:1(9Z)) + Water → DG(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0) + Hydrogen Ion + Myo-inositol 1-phosphate
conversion direction: LEFT_TO_RIGHT

Citrulline
type: SmallMolecule
cellular location: Cytosol
entity reference: Citrulline

Reference/KEGG Compound C13856
type: UnificationXref
id: C13856
db: KEGG Compound