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Tryptophan--tRNA ligase, cytoplasmic Tryptophan 2,3-dioxygenase Kynureninase Kynurenine formamidase Kynurenine formamidase Kynureninase Kynurenine/alpha- aminoadipate aminotransferase, mitochondrial Kynurenine 3-monooxygenase Kynureninase Catalase Kynurenine/alpha- aminoadipate aminotransferase, mitochondrial 3- hydroxyanthranilate 3,4-dioxygenase 2-amino-3- carboxymuconate- 6-semialdehyde decarboxylase Tryptophan 5-hydroxylase 1 Aromatic-L- amino-acid decarboxylase Kynurenine 3-monooxygenase Aldehyde dehydrogenase, mitochondrial Acetylserotonin O- methyltransferase Kynurenine formamidase Indoleamine 2,3-dioxygenase 1 Aromatic-L- amino-acid decarboxylase Kynurenine 3-monooxygenase Serotonin N- acetyltransferase Acetylserotonin O- methyltransferase Cytochrome P450 1A1 Indoleamine 2,3-dioxygenase 1 Indolethylamine N- methyltransferase Indoleamine 2,3-dioxygenase 1 Aromatic-L- amino-acid decarboxylase Kynurenine 3-monooxygenase Aldehyde dehydrogenase, mitochondrial Indolethylamine N- methyltransferase Aldehyde oxidase Indoleamine 2,3-dioxygenase 1 Tryptophan--tRNA ligase, mitochondrial Quinolinic acid L-Tryptophan L-Tryptophan O2 N'- Formylkynurenine H2O Formylanthranilic acid L-Alanine H2O L-Kynurenine Formic acid H2O 2-Aminobenzoic acid Formic acid H2O L-Alanine 4-(2- Aminophenyl)- 2,4- dioxobutanoic acid Kynurenic acid Oxoglutaric acid L-Glutamic acid NADPH O2 L-3- Hydroxykynurenine NADP H2O H2O 3- Hydroxyanthranilic acid L-Alanine O2 Cinnavalininate H2O Oxoglutaric acid 4-(2-Amino-3- hydroxyphenyl)- 2,4- dioxobutanoic acid L-Glutamic acid Xanthurenic acid O2 2-Amino-3- carboxymuconic acid semialdehyde 2-Aminomuconic acid semialdehyde CO2 Tetrahydrobiopterin O2 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Serotonin CO2 NADPH O2 5- Hydroxyindoleacetaldehyde NADP H2O NAD H2O 5- Hydroxyindoleacetic acid NADH S- Adenosylmethionine 5- Methoxyindoleacetate S- Adenosylhomocysteine 5-Hydroxy-N- formylkynurenine H2O 5- Hydroxykynurenine Formic acid O2 5- Hydroxykynurenamine CO2 NADPH O2 4,6- Dihydroxyquinoline NADP H2O Acetyl-CoA N-Acetylserotonin CoA S- Adenosylmethionine Melatonin S- Adenosylhomocysteine O2 6- Hydroxymelatonin H2O O2 Acetyl-N- formyl-5- methoxykynurenamine S- Adenosylmethionine N-Methylserotonin S- Adenosylhomocysteine O2 Formyl-5- hydroxykynurenamine Tryptamine CO2 NADPH O2 Indoleacetaldehyde NADP H2O NAD H2O Indoleacetic acid NADH S- Adenosylmethionine N- Methyltryptamine S- Adenosylhomocysteine H2O O2 H2O2 O2 ATP AMP PPi ATP AMP PPi Heme Pyrophosphate Pyrophosphate Pyridoxal 5'-phosphate FAD Pyrophosphate Heme NADP Pyridoxal 5'-phosphate Fe2+ Fe2+ Pyridoxal 5'-phosphate FAD Heme Pyridoxal 5'-phosphate FAD Heme Heme Heme Pyridoxal 5'-phosphate FAD FAD Molybdopterin 2Fe-2S Heme Reduced flavoprotein Oxidized flavoprotein tRNA(Trp) L- Tryptophyl- tRNA(Trp) tRNA(Trp) L- Tryptophyl- tRNA(Trp) Nicotinate and Nicotinamide Metabolism Extracellular space Intracellular space Mitochondria Endoplasmic Reticulum Peroxisome
WARS TDO2 KYNU AFMID AFMID KYNU AADAT KMO KYNU CAT AADAT HAAO ACMSD TPH1 DDC KMO ALDH2 ASMT AFMID IDO1 DDC KMO AANAT ASMT CYP1A1 IDO1 INMT IDO1 DDC KMO ALDH2 INMT AOX1 IDO1 WARS2 Quinolinic acid L-Tryptophan L-Tryptophan Oxygen N'- Formylkynurenine Water Formylanthranilic acid L-Alanine Water L-Kynurenine Formic acid Water 2-Aminobenzoic acid Formic acid Water L-Alanine 4-(2- Aminophenyl)- 2,4- dioxobutanoic acid Kynurenic acid Oxoglutaric acid L-Glutamic acid NADPH Oxygen L-3- Hydroxykynurenine NADP Water Water 3- Hydroxyanthranilic acid L-Alanine Oxygen Cinnavalininate Water Oxoglutaric acid 4-(2-Amino-3- hydroxyphenyl)- 2,4- dioxobutanoic acid L-Glutamic acid Xanthurenic acid Oxygen 2-Amino-3- carboxymuconic acid semialdehyde 2-Aminomuconic acid semialdehyde Carbon dioxide Tetrahydrobiopterin Oxygen 5-Hydroxy-L- tryptophan 4a- Hydroxytetrahydrobiopterin Serotonin Carbon dioxide NADPH Oxygen 5- Hydroxyindoleacetaldehyde NADP Water NAD Water 5- Hydroxyindoleacetic acid NADH S- Adenosylmethionine 5- Methoxyindoleacetate S- Adenosylhomocysteine 5-Hydroxy-N- formylkynurenine Water 5- Hydroxykynurenine Formic acid Oxygen 5- Hydroxykynurenamine Carbon dioxide NADPH Oxygen 4,6- Dihydroxyquinoline NADP Water Acetyl-CoA N-Acetylserotonin Coenzyme A S- Adenosylmethionine Melatonin S- Adenosylhomocysteine Oxygen 6- Hydroxymelatonin Water Oxygen Acetyl-N- formyl-5- methoxykynurenamine S- Adenosylmethionine N-Methylserotonin S- Adenosylhomocysteine Oxygen Formyl-5- hydroxykynurenamine Tryptamine Carbon dioxide NADPH Oxygen Indoleacetaldehyde NADP Water NAD Water Indoleacetic acid NADH S- Adenosylmethionine N- Methyltryptamine S- Adenosylhomocysteine Water Oxygen Hydrogen peroxide Oxygen Adenosine triphosphate Adenosine monophosphate Pyrophosphate Adenosine triphosphate Adenosine monophosphate Pyrophosphate Reduced flavoprotein Oxidized flavoprotein tRNA(Trp) L- Tryptophyl- tRNA(Trp) tRNA(Trp) L- Tryptophyl- tRNA(Trp) Nicotinate and Nicotinamide Metabolism
WARS TDO2 KYNU AFMID AFMID KYNU AADAT KMO KYNU CAT AADAT HAAO ACMSD TPH1 DDC KMO ALDH2 ASMT AFMID IDO1 DDC KMO AANAT ASMT CYP1A1 IDO1 INMT IDO1 DDC KMO ALDH2 INMT AOX1 IDO1 WARS2 Quinoli Trp Trp O2 Formylk H2O Formyla Ala H2O L-Kynr Formate H2O 2AA Formate H2O Ala 42A24D Kynuren AKG Glu NADPH O2 L-3-HK NADP H2O H2O 3-OHAa Ala O2 CinVal H2O AKG 42A3H24 Glu Xanthur O2 2Am3CSa 2-AaSa CO2 BH4 O2 5-HTP 4aHtHbp 5-HT CO2 NADPH O2 5-Hial NADP H2O NAD H2O 5HIDA NADH SAMe Methoxy SAH 5HNFKN H2O 5HKnn Formate O2 5-Hkynm CO2 NADPH O2 46Q NADP H2O Ac-CoA NAsertn CoA SAMe Meltn SAH O2 6HMeltn H2O O2 AceNf5m SAMe NMetser SAH O2 F5H Tryptam CO2 NADPH O2 Tryptal NADP H2O NAD H2O Indolaa NADH SAMe N-Metrp SAH H2O O2 H2O2 O2 ATP AMP PPi ATP AMP PPi Heme Ppi Ppi Pyr-5'P FAD Ppi Heme NADP Pyr-5'P Fe2+ Fe2+ Pyr-5'P FAD Heme Pyr-5'P FAD Heme Heme Heme Pyr-5'P FAD FAD mlyBdpn 2Fe2S Heme RF OF TRNATRP LTTT TRNATRP LTTT PW000151 Extracellular space Intracellular space Mitochondria Endoplasmic Reticulum Peroxisome
WARS TDO2 KYNU AFMID AFMID KYNU AADAT KMO KYNU CAT AADAT HAAO ACMSD TPH1 DDC KMO ALDH2 ASMT AFMID IDO1 DDC KMO AANAT ASMT CYP1A1 IDO1 INMT IDO1 DDC KMO ALDH2 INMT AOX1 IDO1 WARS2 Quinoli Trp Trp O2 Formylk H2O Formyla Ala H2O L-Kynr Formate H2O 2AA Formate H2O Ala 42A24D Kynuren AKG Glu NADPH O2 L-3-HK NADP H2O H2O 3-OHAa Ala O2 CinVal H2O AKG 42A3H24 Glu Xanthur O2 2Am3CSa 2-AaSa CO2 BH4 O2 5-HTP 4aHtHbp 5-HT CO2 NADPH O2 5-Hial NADP H2O NAD H2O 5HIDA NADH SAMe Methoxy SAH 5HNFKN H2O 5HKnn Formate O2 5-Hkynm CO2 NADPH O2 46Q NADP H2O Ac-CoA NAsertn CoA SAMe Meltn SAH O2 6HMeltn H2O O2 AceNf5m SAMe NMetser SAH O2 F5H Tryptam CO2 NADPH O2 Tryptal NADP H2O NAD H2O Indolaa NADH SAMe N-Metrp SAH H2O O2 H2O2 O2 ATP AMP Ppi ATP AMP Ppi RF OF TRNATRP LTTT TRNATRP LTTT PW000151