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Hydroxymethylglutaryl- CoA synthase, cytoplasmic 3-Hydroxy-3- methylglutaryl- coenzyme A reductase Acetyl-CoA H2O 3-Hydroxy-3-methylglutaryl-CoA NADPH Mevalonic acid NADP CoA Cholesterol Cholesterol Cholesterol Ester Intracelular LDL (Extracelular) Espacio Intramembranal Espacio Extramembranal