N-Acetylmuramate 6-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25202911
xref: Reference/BioCyc CPD0-881
xref: Reference/ChEBI CHEBI 47968
chemical formula: C11H19NO11P
molecular weight: 372.06958
structure: ChemicalStructure/PW C044522

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reaction180335
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044574/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044575/Stoichiometry/1.0
right: Water
right: 4β-methyl-4α-carboxy-cholesta-8,24-dien-3β-ol
right: NADP
spontaneous: false
left: Oxygen
left: 4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol
left: NADPH
name: 4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol + NADPH + Oxygen → 4β-methyl-4α-carboxy-cholesta-8,24-dien-3β-ol + NADP + Water
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C001065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol
type: SmallMolecule
entity reference: 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol

Reference/HMDB HMDB0001062
type: UnificationXref
id: HMDB0001062
db: HMDB

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Compound/PW C044575/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4β-methyl-4α-carboxy-cholesta-8,24-dien-3β-ol
stoichiometric coefficient: 1.0

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0123000
type: UnificationXref
id: SMP0123000
db: SMPDB

Reference/PubChem-compound 6133
type: UnificationXref
id: 6133
db: PubChem-compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/ChEBI CHEBI 16264
type: UnificationXref
id: CHEBI:16264
db: ChEBI

Bifunctional protein glmU
type: ProteinReference
xref: Reference/UniProt P0ACC7

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15784
xref: Reference/ChemSpider 389821
xref: Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-6-P
xref: Reference/HMDB HMDB0001062
xref: Reference/KEGG Compound C00357
xref: Reference/CAS 102029-88-9
xref: Reference/PubChem-compound 440996
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C000837

ReactionCatalysis177008
type: Catalysis
controller: N-acetylmuramic acid 6-phosphate etherase
controlled: Reaction187283
control type: ACTIVATION

ReactionCatalysis177009
type: Catalysis
controller: N-acetylglucosamine-6-phosphate deacetylase
controlled: Reaction187284
control type: ACTIVATION

ReactionCatalysis177004
type: Catalysis
controller: Beta-hexosaminidase
controlled: 3.2.1.52
control type: ACTIVATION

Compound/PW C044574/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol
stoichiometric coefficient: 1.0

ReactionCatalysis177005
type: Catalysis
controller: N-acetylmuramoyl-L-alanine amidase AmiD
controlled: 3.5.1.28
control type: ACTIVATION

ReactionCatalysis177006
type: Catalysis
controller: 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
controlled: 3.5.1.28
control type: ACTIVATION

ReactionCatalysis177007
type: Catalysis
controller: Anhydro-N-acetylmuramic acid kinase
controlled: Reaction187282
control type: ACTIVATION

5α-cholesta-8,24-dien-3-one
type: SmallMolecule
entity reference: 5α-cholesta-8,24-dien-3-one

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMolecule
entity reference: N-Acetyl-D-Glucosamine 6-Phosphate

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

4β-methyl-4α-carboxy-cholesta-8,24-dien-3β-ol
type: SmallMolecule
entity reference: 4β-methyl-4α-carboxy-cholesta-8,24-dien-3β-ol

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc D-LACTATE
type: UnificationXref
id: D-LACTATE
db: BioCyc

4α-carboxy-5α-cholesta-8,24-dien-3β-ol
type: SmallMolecule
entity reference: 4α-carboxy-5α-cholesta-8,24-dien-3β-ol

Reference/PubChem-compound 90657655
type: UnificationXref
id: 90657655
db: PubChem-compound

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C044579/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5α-cholesta-8,24-dien-3-one
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

ReactionCatalysis177011
type: Catalysis
controller: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
controlled: 2.7.7.23
control type: ACTIVATION

ReactionCatalysis177012
type: Catalysis
controller: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
controlled: Reaction187287
control type: ACTIVATION

4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol
type: SmallMolecule
entity reference: 4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol

Lipopolysaccharide Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113562
pathway component: SubPathwayInteraction113562
xref: Reference/PathWhiz PW000831
xref: Reference/SMPDB SMP0000851
name: SubPathway

ReactionCatalysis177010
type: Catalysis
controller: Phosphoglucosamine mutase
controlled: Reaction187285
control type: ACTIVATION

Reference/ChemSpider 8140645
type: UnificationXref
id: 8140645
db: ChemSpider

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Reference/PubChem-compound 439174
type: UnificationXref
id: 439174
db: PubChem-compound

N-acetylmuramoyl-L-alanine amidase AmiD
type: Protein
entity reference: N-acetylmuramoyl-L-alanine amidase AmiD

Beta-hexosaminidase
type: Protein
entity reference: Beta-hexosaminidase

Reference/KEGG Compound C00103
type: UnificationXref
id: C00103
db: KEGG Compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 10326-41-7
type: UnificationXref
id: 10326-41-7
db: CAS

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Putative N-acetylglucosamine-6-phosphate deacetylase
type: Protein
entity reference: Putative N-acetylglucosamine-6-phosphate deacetylase

Reference/PubChem-compound 439165
type: UnificationXref
id: 439165
db: PubChem-compound

Reference/BioCyc GLUCOSAMINE-1P
type: UnificationXref
id: GLUCOSAMINE-1P
db: BioCyc

Reference/PubChem-compound 440272
type: UnificationXref
id: 440272
db: PubChem-compound

Reaction180341
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044578/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044579/Stoichiometry/1.0
right: 5α-cholesta-8,24-dien-3-one
right: Carbon dioxide
right: NADPH
spontaneous: false
left: 4α-carboxy-5α-cholesta-8,24-dien-3β-ol
left: NADP
name: 4α-carboxy-5α-cholesta-8,24-dien-3β-ol + NADP → 5α-cholesta-8,24-dien-3-one + Carbon dioxide + NADPH
conversion direction: LEFT_TO_RIGHT

Glucosamine-1P
type: SmallMoleculeReference
xref: Reference/PubChem-compound 9965052
xref: Reference/BioCyc GLUCOSAMINE-1P
xref: Reference/HMDB HMDB0001109
xref: Reference/ChemSpider 8140645
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C000868

Compound/PW C000146/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Compound/PW C000868/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine-1P
stoichiometric coefficient: 1.0

Reference/ChemSpider 388319
type: UnificationXref
id: 388319
db: ChemSpider

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/CAS 59-56-3
type: UnificationXref
id: 59-56-3
db: CAS

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00357
type: UnificationXref
id: C00357
db: KEGG Compound

Reference/ChemSpider 388311
type: UnificationXref
id: 388311
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Reference/PubChem-compound 25202911
type: UnificationXref
id: 25202911
db: PubChem-compound

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
type: SmallMolecule
entity reference: N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/PathWhiz PW002030
type: UnificationXref
id: PW002030
db: PathWhiz

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

biosynthesis novo 1605518331
type: Pathway
pathway order: PathwayEnzymeReaction/2465744
pathway order: PathwayEnzymeReaction/2465745
pathway order: PathwayEnzymeReaction/2465746
pathway order: PathwayEnzymeReaction/2465747
pathway order: PathwayEnzymeReaction/2465748
pathway order: PathwayEnzymeReaction/2465749
pathway order: PathwayTransport/2465754
pathway order: PathwayEnzymeReaction/2465750
pathway order: PathwayEnzymeReaction/2465751
pathway order: PathwayEnzymeReaction/2465741
pathway order: PathwayEnzymeReaction/2465752
pathway order: PathwayEnzymeReaction/2465742
pathway order: PathwayEnzymeReaction/2465753
pathway order: PathwayEnzymeReaction/2465743
pathway order: PathwaySubPathway/113561
pathway order: PathwaySubPathway/113562
pathway component: Reaction180335
pathway component: TransportCatalysis1607
pathway component: Reaction187287
pathway component: ReactionCatalysis177011
pathway component: 3.2.1.52
pathway component: ReactionCatalysis177012
pathway component: 3.5.1.28
pathway component: Reaction187282
pathway component: Reaction187283
pathway component: Reaction187284
pathway component: Lipopolysaccharide Biosynthesis
pathway component: Reaction187285
pathway component: ReactionCatalysis177010
pathway component: 2.7.7.23
pathway component: Reaction927
pathway component: Reaction213759
pathway component: Transport10434
pathway component: ReactionCatalysis177008
pathway component: ReactionCatalysis177009
pathway component: ReactionCatalysis177004
pathway component: ReactionCatalysis177005
pathway component: ReactionCatalysis177006
pathway component: ReactionCatalysis177007
pathway component: Reaction180341
pathway component: N-Acetylneuraminate, N-Acetylmannosamine, and N-Acetylglucosamine Degradation
xref: Reference/SMPDB SMP0123000
xref: Reference/PathWhiz PW124344
organism: Homo sapiens

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Phosphoglucosamine mutase
type: Protein
entity reference: Phosphoglucosamine mutase

Reference/BioCyc GLC-1-P
type: UnificationXref
id: GLC-1-P
db: BioCyc

Protein/2363/Stoichiometry/4.0
type: Stoichiometry
physical entity: Putative N-acetylglucosamine-6-phosphate deacetylase
stoichiometric coefficient: 4.0

Reference/SMPDB SMP0000851
type: UnificationXref
id: SMP0000851
db: SMPDB

N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 45479497
chemical formula: C19H29N2O12
molecular weight: 477.1726
structure: ChemicalStructure/PW C041112

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/KEGG Compound C00256
type: UnificationXref
id: C00256
db: KEGG Compound

1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
type: ProteinReference
xref: Reference/UniProt P13016

Reference/ChEBI CHEBI 7125
type: UnificationXref
id: CHEBI:7125
db: ChEBI

Reference/KEGG Compound C00140
type: UnificationXref
id: C00140
db: KEGG Compound

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Compound/PW C044578/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4α-carboxy-5α-cholesta-8,24-dien-3β-ol
stoichiometric coefficient: 1.0

Compound/PW C007243/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol
stoichiometric coefficient: 1.0

2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53481017
xref: Reference/BioCyc CPD-9871
xref: Reference/HMDB HMDB0011661
chemical formula: C38H60O3
molecular weight: 564.4542
structure: ChemicalStructure/PW C007243

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

S-Adenosylhomocysteine
type: SmallMolecule
entity reference: S-Adenosylhomocysteine

ChemicalStructure/PW C041303
type: ChemicalStructure
structure format: SMILES

N-Acetylmuramate 6-phosphate
type: SmallMolecule
entity reference: N-Acetylmuramate 6-phosphate

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Glucosamine-1P
type: SmallMolecule
entity reference: Glucosamine-1P

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

Compound/PW C000921/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

D-glucosamine 6-phosphate
type: SmallMolecule
entity reference: D-glucosamine 6-phosphate
name: SubPathwayInput

D-glucosamine 6-phosphate
type: SmallMoleculeReference
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C042580

Compound/PW C000143/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Compound/PW C040768 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
type: UnificationXref
id: N-ACETYL-D-GLUCOSAMINE-1-P
db: BioCyc

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Reference/HMDB HMDB0001586
type: UnificationXref
id: HMDB0001586
db: HMDB

Water
type: SmallMolecule
entity reference: Water

Unknown
type: Protein
entity reference: Unknown

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reaction927
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001207/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: D-Glucose
right: Phosphate
spontaneous: false
left: Water
left: Glucose 1-phosphate
name: Glucose 1-phosphate + Water → D-Glucose + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 22298942
type: UnificationXref
id: 22298942
db: PubChem-compound

Reference/ChEBI CHEBI 47968
type: UnificationXref
id: CHEBI:47968
db: ChEBI

Reaction213759
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042943/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007243/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Hydrogen Ion
right: 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol
spontaneous: false
left: 2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol
left: S-Adenosylmethionine
name: 2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol + S-Adenosylmethionine → 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + Hydrogen Ion + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001109
type: UnificationXref
id: HMDB0001109
db: HMDB

Reference/KEGG Compound C00043
type: UnificationXref
id: C00043
db: KEGG Compound

Transport10434
type: Transport
participant stoichiometry: Compound/PW C040768 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040768 Periplasmic Space/Stoichiometry/1.0
right: Hydrogen Ion
right: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
spontaneous: false
left: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
left: Hydrogen Ion
name: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala (→), Hydrogen Ion (→) Transport: Homo sapiens, Periplasmic Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Protein/7866/Stoichiometry/2.0
type: Stoichiometry
physical entity: Unknown
stoichiometric coefficient: 2.0

Anhydro-N-acetylmuramic acid kinase
type: Protein
entity reference: Anhydro-N-acetylmuramic acid kinase

Reference/BioCyc UTP
type: UnificationXref
id: UTP
db: BioCyc

Reference/ChemSpider 389821
type: UnificationXref
id: 389821
db: ChemSpider

ChemicalStructure/PW C042943
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5903
type: UnificationXref
id: 5903
db: ChemSpider

ChemicalStructure/PW C040765
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

ChemicalStructure/PW C040768
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 16077
type: UnificationXref
id: CHEBI:16077
db: ChEBI

diphosphate
type: SmallMolecule
entity reference: diphosphate

Compound/PW C000837/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-Glucosamine 6-Phosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001367
type: UnificationXref
id: HMDB0001367
db: HMDB

Compound/PW C000192/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000029/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/UniProt P0AE16
type: UnificationXref
id: P0AE16
db: UniProt

Reference/PubChem-compound 445675
type: UnificationXref
id: 445675
db: PubChem-compound

Reference/CAS 6866-69-9
type: UnificationXref
id: 6866-69-9
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

ChemicalStructure/PW C001010
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](O)C(O)=O

N-acetylglucosamine-6-phosphate deacetylase
type: Complex
component stoichiometry: Protein/2363/Stoichiometry/4.0
component: Putative N-acetylglucosamine-6-phosphate deacetylase

Compound/PW C040768/Stoichiometry/1.0
type: Stoichiometry
physical entity: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
stoichiometric coefficient: 1.0

N-acetylmuramic acid 6-phosphate etherase
type: Complex
component stoichiometry: Protein/7866/Stoichiometry/2.0
component: Unknown

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Reference/HMDB HMDB0000285
type: UnificationXref
id: HMDB0000285
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/BioCyc CPD0-881
type: UnificationXref
id: CPD0-881
db: BioCyc

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/KEGG Compound C00075
type: UnificationXref
id: C00075
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Phosphate
type: SmallMolecule
entity reference: Phosphate

Bifunctional protein glmU
type: Protein
entity reference: Bifunctional protein glmU

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Compound/PW C041303/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Ala-γ-D-Glu-DAP-D-Ala
stoichiometric coefficient: 1.0

Periplasmic Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005620

Reference/PubChem-compound 9965052
type: UnificationXref
id: 9965052
db: PubChem-compound

Reference/HMDB HMDB0000290
type: UnificationXref
id: HMDB0000290
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/UniProt Q9Y303
type: UnificationXref
id: Q9Y303
db: UniProt

4α-formyl-4β-methyl-5α-cholesta-8,24-dien-3β-ol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 90658366
chemical formula: C29H46O2
molecular weight: 426.3498
structure: ChemicalStructure/PW C044574

4β-methyl-4α-carboxy-cholesta-8,24-dien-3β-ol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 90657655
chemical formula: C29H45O3
molecular weight: 441.33743
structure: ChemicalStructure/PW C044575

Reference/ChEBI CHEBI 42111
type: UnificationXref
id: CHEBI:42111
db: ChEBI

4α-carboxy-5α-cholesta-8,24-dien-3β-ol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 90659076
chemical formula: C28H43O3
molecular weight: 427.32178
structure: ChemicalStructure/PW C044578

5α-cholesta-8,24-dien-3-one
type: SmallMoleculeReference
xref: Reference/PubChem-compound 22298942
chemical formula: C27H42O
molecular weight: 382.32358
structure: ChemicalStructure/PW C044579

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/PubChem-compound 25202885
type: UnificationXref
id: 25202885
db: PubChem-compound

Glucose 1-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001586
xref: Reference/PubChem-compound 439165
xref: Reference/CAS 59-56-3
xref: Reference/BioCyc GLC-1-P
xref: Reference/ChEBI CHEBI 16077
xref: Reference/KEGG Compound C00103
xref: Reference/ChemSpider 388311
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001207

GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala

Reference/UniProt P75949
type: UnificationXref
id: P75949
db: UniProt

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Protein AmpG
type: ProteinReference
xref: Reference/UniProt P0AE16

Reference/UniProt P75820
type: UnificationXref
id: P75820
db: UniProt

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Glucose 1-phosphate
type: SmallMolecule
entity reference: Glucose 1-phosphate

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

ChemicalStructure/PW C000196
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
type: SmallMolecule
cellular location: Cytosol
entity reference: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala

ChemicalStructure/PW C000192
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/UniProt P13016
type: UnificationXref
id: P13016
db: UniProt

Reference/CAS 102029-88-9
type: UnificationXref
id: 102029-88-9
db: CAS

ChemicalStructure/PW C001055
type: ChemicalStructure
structure format: SMILES

N-Acetylneuraminate, N-Acetylmannosamine, and N-Acetylglucosamine Degradation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113561
pathway component: SubPathwayInteraction113561
xref: Reference/PathWhiz PW002030
xref: Reference/SMPDB SMP0002044
name: SubPathway

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Reference/ChEBI CHEBI 58690
type: UnificationXref
id: CHEBI:58690
db: ChEBI

Reference/PubChem-compound 3315
type: UnificationXref
id: 3315
db: PubChem-compound

Reference/HMDB HMDB0011661
type: UnificationXref
id: HMDB0011661
db: HMDB

Compound/PW C044522/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetylmuramate 6-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C001010/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Lactic acid
stoichiometric coefficient: 1.0

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

D-Lactic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001311
xref: Reference/ChemSpider 55423
xref: Reference/BioCyc D-LACTATE
xref: Reference/CAS 10326-41-7
xref: Reference/KEGG Compound C00256
xref: Reference/PubChem-compound 61503
xref: Reference/ChEBI CHEBI 42111
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C001010

1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
type: Protein
entity reference: 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD

Reference/CAS 528-04-1
type: UnificationXref
id: 528-04-1
db: CAS

Reference/UniProt P0ACC7
type: UnificationXref
id: P0ACC7
db: UniProt

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

D-Lactic acid
type: SmallMolecule
entity reference: D-Lactic acid

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/ChEBI CHEBI 60655
type: UnificationXref
id: CHEBI:60655
db: ChEBI

Compound/PW C042580/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-glucosamine 6-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 90659076
type: UnificationXref
id: 90659076
db: PubChem-compound

Reference/BioCyc ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
type: UnificationXref
id: ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
db: BioCyc

Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-6-P
type: UnificationXref
id: N-ACETYL-D-GLUCOSAMINE-6-P
db: BioCyc

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C04256
type: UnificationXref
id: C04256
db: KEGG Compound

SubPathwayInteraction113562
type: Interaction
name: SubPathwayReaction
name: SubPathway113562Reaction
participant: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/ChemSpider 393240
type: UnificationXref
id: 393240
db: ChemSpider

Reference/SMPDB SMP0002044
type: UnificationXref
id: SMP0002044
db: SMPDB

Reference/ChemSpider 55423
type: UnificationXref
id: 55423
db: ChemSpider

2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol
type: SmallMolecule
entity reference: 2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol

1,6-anhydro-N-acetyl-β-muramate
type: SmallMolecule
entity reference: 1,6-anhydro-N-acetyl-β-muramate

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Reference/PathWhiz PW000831
type: UnificationXref
id: PW000831
db: PathWhiz

Reference/ChEBI CHEBI 15713
type: UnificationXref
id: CHEBI:15713
db: ChEBI

Reference/PubChem-compound 53481017
type: UnificationXref
id: 53481017
db: PubChem-compound

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

ChemicalStructure/PW C040813
type: ChemicalStructure
structure format: SMILES

NADPH
type: SmallMolecule
entity reference: NADPH

GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
type: SmallMolecule
entity reference: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala

Acetic acid
type: SmallMolecule
entity reference: Acetic acid

SubPathwayInteraction113561
type: Interaction
name: SubPathway113561Reaction
name: SubPathwayReaction
participant: D-glucosamine 6-phosphate

N-Acetyl-D-glucosamine
type: SmallMolecule
entity reference: N-Acetyl-D-glucosamine

NADP
type: SmallMolecule
entity reference: NADP

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Compound/PW C040813/Stoichiometry/1.0
type: Stoichiometry
physical entity: diphosphate
stoichiometric coefficient: 1.0

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

N-Acetyl-D-glucosamine
type: SmallMoleculeReference
xref: Reference/BioCyc ALPHA-D-GALACTOSYL-13-BETA-D-GALACTOS
xref: Reference/ChEBI CHEBI 506227
xref: Reference/HMDB HMDB0000215
xref: Reference/KEGG Compound C00140
xref: Reference/ChemSpider 388319
xref: Reference/PubChem-compound 439174
xref: Reference/CAS 7512-17-6
chemical formula: C8H15NO6
molecular weight: 221.08994
structure: ChemicalStructure/PW C000141

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Uridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6133
xref: Reference/CAS 63-39-8
xref: Reference/ChemSpider 5903
xref: Reference/ChEBI CHEBI 15713
xref: Reference/KEGG Compound C00075
xref: Reference/HMDB HMDB0000285
xref: Reference/BioCyc UTP
chemical formula: C9H15N2O15P3
molecular weight: 483.96854
structure: ChemicalStructure/PW C000192

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/HMDB HMDB0000215
type: UnificationXref
id: HMDB0000215
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Oxygen
type: SmallMolecule
entity reference: Oxygen

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

Uridine diphosphate-N-acetylglucosamine
type: SmallMoleculeReference
xref: Reference/CAS 528-04-1
xref: Reference/PubChem-compound 445675
xref: Reference/HMDB HMDB0000290
xref: Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
xref: Reference/KEGG Compound C00043
xref: Reference/ChEBI CHEBI 16264
xref: Reference/ChemSpider 393240
chemical formula: C17H27N3O17P2
molecular weight: 607.08154
structure: ChemicalStructure/PW C000196

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

diphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 3315
chemical formula: C34H28N6O14S4
molecular weight: 872.0546
structure: ChemicalStructure/PW C040813

Reference/HMDB HMDB0001311
type: UnificationXref
id: HMDB0001311
db: HMDB

N-Acetyl-glucosamine 1-phosphate
type: SmallMolecule
entity reference: N-Acetyl-glucosamine 1-phosphate

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000141
type: ChemicalStructure
structure format: SMILES

N-Acetyl-glucosamine 1-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 7125
xref: Reference/ChemSpider 389248
xref: Reference/HMDB HMDB0001367
xref: Reference/PubChem-compound 440272
xref: Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
xref: Reference/CAS 6866-69-9
xref: Reference/KEGG Compound C04256
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C001055

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Uridine diphosphate-N-acetylglucosamine
type: SmallMolecule
entity reference: Uridine diphosphate-N-acetylglucosamine

D-Glucose
type: SmallMolecule
entity reference: D-Glucose

Reference/PathWhiz PW124344
type: UnificationXref
id: PW124344
db: PathWhiz

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Compound/PW C001055/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-glucosamine 1-phosphate
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005620
type: UnificationXref
id: GO:0005620
db: GENE ONTOLOGY

Uridine triphosphate
type: SmallMolecule
entity reference: Uridine triphosphate

ChemicalStructure/PW C001207
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 440996
type: UnificationXref
id: 440996
db: PubChem-compound

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Beta-hexosaminidase
type: ProteinReference
xref: Reference/UniProt P75949

Protein AmpG
type: Protein
entity reference: Protein AmpG

N-acetylmuramoyl-L-alanine amidase AmiD
type: ProteinReference
xref: Reference/UniProt P75820

TransportCatalysis1607
type: Catalysis
controller: Protein AmpG
controlled: Transport10434
control type: ACTIVATION

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
type: Complex
component stoichiometry: Protein/6211/Stoichiometry/3.0
component: Bifunctional protein glmU
name: SubPathwayInput

Putative N-acetylglucosamine-6-phosphate deacetylase
type: ProteinReference
xref: Reference/UniProt Q9Y303

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Compound/PW C000141/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-glucosamine
stoichiometric coefficient: 1.0

Compound/PW C042943/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol
stoichiometric coefficient: 1.0

ChemicalStructure/PW C007243
type: ChemicalStructure
structure format: SMILES
structure data: COC1=CC(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C1O

L-Ala-γ-D-Glu-DAP-D-Ala
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25202885
chemical formula: C18H30N5O9
molecular weight: 460.20435
structure: ChemicalStructure/PW C041303

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Compound/PW C000196/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate-N-acetylglucosamine
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/UniProt P31120
type: UnificationXref
id: P31120
db: UniProt

Reference/ChEBI CHEBI 15784
type: UnificationXref
id: CHEBI:15784
db: ChEBI

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Compound/PW C041112/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Phosphoglucosamine mutase
type: ProteinReference
xref: Reference/UniProt P31120

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

ChemicalStructure/PW C044574
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C044575
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C044578
type: ChemicalStructure
structure format: SMILES

Compound/PW C000077/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Protein/6211/Stoichiometry/3.0
type: Stoichiometry
physical entity: Bifunctional protein glmU
stoichiometric coefficient: 3.0

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

ChemicalStructure/PW C044579
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
type: UnificationXref
id: UDP-N-ACETYL-D-GLUCOSAMINE
db: BioCyc

ChemicalStructure/PW C000837
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/ChEBI CHEBI 506227
type: UnificationXref
id: CHEBI:506227
db: ChEBI

Reference/PubChem-compound 90658366
type: UnificationXref
id: 90658366
db: PubChem-compound

Reference/PubChem-compound 45479497
type: UnificationXref
id: 45479497
db: PubChem-compound

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Reference/UniProt P77570
type: UnificationXref
id: P77570
db: UniProt

Reference/ChemSpider 389248
type: UnificationXref
id: 389248
db: ChemSpider

ChemicalStructure/PW C041112
type: ChemicalStructure
structure format: SMILES

1,6-anhydro-N-acetyl-β-muramate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58690
chemical formula: C11H16NO7
molecular weight: 274.09268
structure: ChemicalStructure/PW C040765

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

2-methoxy-6-all trans-octaprenyl-2-methoxy-1,4-benzoquinol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 60655
chemical formula: C47H72O3
molecular weight: 684.54816
structure: ChemicalStructure/PW C042943

GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
type: SmallMoleculeReference
xref: Reference/PubChem-compound 45479219
chemical formula: C37H57N7O20
molecular weight: 919.36694
structure: ChemicalStructure/PW C040768

Compound/PW C040768 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-9871
type: UnificationXref
id: CPD-9871
db: BioCyc

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reaction187287
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000196/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001055/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040813/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000192/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Uridine diphosphate-N-acetylglucosamine
right: diphosphate
spontaneous: false
left: N-Acetyl-glucosamine 1-phosphate
left: Hydrogen Ion
left: Uridine triphosphate
name: Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Uridine diphosphate-N-acetylglucosamine + diphosphate
conversion direction: LEFT_TO_RIGHT

3.2.1.52
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040765/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000141/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041112/Stoichiometry/1.0
right: N-Acetyl-D-glucosamine
right: 1,6-anhydro-N-acetyl-β-muramate
spontaneous: false
EC number: 3.2.1.52
left: Water
left: N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
name: N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate + Water → 1,6-anhydro-N-acetyl-β-muramate + N-Acetyl-D-glucosamine
conversion direction: LEFT_TO_RIGHT

3.5.1.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041303/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040768/Stoichiometry/1.0
participant stoichiometry: Compound/PW C041112/Stoichiometry/1.0
right: L-Ala-γ-D-Glu-DAP-D-Ala
right: N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
spontaneous: false
EC number: 3.5.1.28
left: Water
left: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala
name: GlcNAc-1,6-anhMurNAc-L-Ala-?-D-Glu-DAP-D-Ala + Water → L-Ala-γ-D-Glu-DAP-D-Ala + N-acetyl-β-D-glucosamine(anhydrous)-N-acetylmuramate
conversion direction: LEFT_TO_RIGHT

Reaction187282
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040765/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044522/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: N-Acetylmuramate 6-phosphate
spontaneous: false
left: Water
left: 1,6-anhydro-N-acetyl-β-muramate
left: Adenosine triphosphate
name: 1,6-anhydro-N-acetyl-β-muramate + Adenosine triphosphate + Water → Adenosine diphosphate + Hydrogen Ion + N-Acetylmuramate 6-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Reaction187283
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000837/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001010/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044522/Stoichiometry/1.0
right: N-Acetyl-D-Glucosamine 6-Phosphate
right: D-Lactic acid
spontaneous: false
left: Water
left: N-Acetylmuramate 6-phosphate
name: N-Acetylmuramate 6-phosphate + Water ↔ D-Lactic acid + N-Acetyl-D-Glucosamine 6-Phosphate
conversion direction: REVERSIBLE

Reaction187284
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000837/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042580/Stoichiometry/1.0
right: D-glucosamine 6-phosphate
right: Acetic acid
spontaneous: false
left: N-Acetyl-D-Glucosamine 6-Phosphate
left: Water
name: N-Acetyl-D-Glucosamine 6-Phosphate + Water → Acetic acid + D-glucosamine 6-phosphate
conversion direction: LEFT_TO_RIGHT

Reaction187285
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000868/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042580/Stoichiometry/1.0
right: Glucosamine-1P
spontaneous: false
left: D-glucosamine 6-phosphate
name: D-glucosamine 6-phosphate ↔ Glucosamine-1P
conversion direction: REVERSIBLE

2.7.7.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000868/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001055/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: N-Acetyl-glucosamine 1-phosphate
right: Coenzyme A
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.7.23
left: Acetyl-CoA
left: Glucosamine-1P
name: Acetyl-CoA + Glucosamine-1P → Coenzyme A + Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Unknown
type: ProteinReference

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

S-Adenosylmethionine
type: SmallMolecule
entity reference: S-Adenosylmethionine

Compound/PW C040765/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,6-anhydro-N-acetyl-β-muramate
stoichiometric coefficient: 1.0

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ChemicalStructure/PW C042580
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 61503
type: UnificationXref
id: 61503
db: PubChem-compound

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

L-Ala-γ-D-Glu-DAP-D-Ala
type: SmallMolecule
entity reference: L-Ala-γ-D-Glu-DAP-D-Ala

ChemicalStructure/PW C044522
type: ChemicalStructure
structure format: SMILES

Anhydro-N-acetylmuramic acid kinase
type: ProteinReference
xref: Reference/UniProt P77570

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000868
type: ChemicalStructure
structure format: SMILES

Compound/PW C000749/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Reference/CAS 63-39-8
type: UnificationXref
id: 63-39-8
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Compound/PW C001207/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucose 1-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 45479219
type: UnificationXref
id: 45479219
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Periplasmic Space
entity reference: Hydrogen Ion

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Compound/PW C040034 Periplasmic Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/CAS 7512-17-6
type: UnificationXref
id: 7512-17-6
db: CAS