Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

ChemicalStructure/PW C040467
type: ChemicalStructure
structure format: SMILES

Aldosterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000037
xref: Reference/PubChem-compound 24758425
xref: Reference/ChemSpider 24774738
xref: Reference/KEGG Compound C01780
xref: Reference/BioCyc ALDOSTERONE
xref: Reference/ChEBI CHEBI 27584
xref: Reference/CAS 52-39-1
chemical formula: C21H28O5
molecular weight: 360.19366
structure: ChemicalStructure/PW C000026

Compound/PW C040467/Stoichiometry/1.0
type: Stoichiometry
physical entity: Benazeprilat
stoichiometric coefficient: 1.0

BiologicalState787
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

direct_interaction
type: InteractionVocabulary

Reference/BRENDA TISSUE ONTOLOGY BTO 0001073
type: UnificationXref
id: BTO:0001073
db: BRENDA TISSUE ONTOLOGY

Aldosterone
type: SmallMolecule
cellular location: Cytosol
entity reference: Aldosterone
name: SubPathwayOutput

Unknown
type: ProteinReference

Compound/PW C000095 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

NMDA Receptor
type: Complex
cellular location: Cell Membrane
component: Glutamate [NMDA] receptor subunit 3A
component: Glutamate [NMDA] receptor subunit epsilon-3
component: Glutamate [NMDA] receptor subunit 3B
component: Glutamate [NMDA] receptor subunit zeta-1
component: Glutamate [NMDA] receptor subunit epsilon-1
component: Glutamate [NMDA] receptor subunit epsilon-2
component: Glutamate [NMDA] receptor subunit epsilon-4
name: SubPathwayInput

Reference/PubChem-compound 3081372
type: UnificationXref
id: 3081372
db: PubChem-compound

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001980
type: UnificationXref
id: HMDB0001980
db: HMDB

ChemicalStructure/PW C040470
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P30556
type: UnificationXref
id: P30556
db: UniProt

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Reference/CAS 86541-75-5
type: UnificationXref
id: 86541-75-5
db: CAS

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Glutamate [NMDA] receptor subunit 3A
type: ProteinReference
xref: Reference/UniProt Q8TCU5
organism: BiologicalState787

Transport11005
type: Transport
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000095 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458/Stoichiometry/3.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: L-Glutamic acid
right: Hydrogen Ion
right: Sodium
spontaneous: false
left: L-Glutamic acid
left: Sodium
left: Hydrogen Ion
name: L-Glutamic acid (→), Sodium (→), Hydrogen Ion (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Astrocyte
conversion direction: LEFT_TO_RIGHT

Angiotensin-converting enzyme
type: ProteinReference
xref: Reference/UniProt P12821
organism: Homo sapiens

Transport11006
type: Transport
participant stoichiometry: Compound/PW C040467 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040467/Stoichiometry/1.0
right: Benazeprilat
spontaneous: false
left: Benazeprilat
name: Benazeprilat (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Type-1 angiotensin II receptor
type: Protein
cellular location: Basal Cell Membrane
entity reference: Type-1 angiotensin II receptor
name: SubPathwayInput

Angiotensin I
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Angiotensin I

Vasocontriction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113591
pathway component: SubPathwayInteraction113591
name: SubPathway

ChemicalStructure/PW C009037
type: ChemicalStructure
structure format: SMILES

Thirst Sensation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113592
pathway component: SubPathwayInteraction113592
name: SubPathway

Reference/UniProt Q12879
type: UnificationXref
id: Q12879
db: UniProt

Reference/UniProt Q8TCU5
type: UnificationXref
id: Q8TCU5
db: UniProt

Vasopressin Release
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113590
pathway component: SubPathwayInteraction113590
name: SubPathway

Aldosterone Production
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113593
pathway component: SubPathwayInteraction113593
name: SubPathway

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C01780
type: UnificationXref
id: C01780
db: KEGG Compound

Type-1 angiotensin II receptor
type: Protein
entity reference: Type-1 angiotensin II receptor
name: SubPathwayInput

Glutamate [NMDA] receptor subunit epsilon-3
type: Protein
cellular location: Cell Membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-3

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

ReactionCatalysis1347
type: Catalysis
controller: Renin
controlled: 3.4.23.15
control type: ACTIVATION

Type-1 angiotensin II receptor
type: Protein
cellular location: Cell Membrane
entity reference: Type-1 angiotensin II receptor
name: SubPathwayInput

BiologicalState681
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Kidney
tissue: Kidney

Reference/UniProt O60391
type: UnificationXref
id: O60391
db: UniProt

Reference/ChEBI CHEBI 2719
type: UnificationXref
id: CHEBI:2719
db: ChEBI

Reference/PubChem-compound 24758425
type: UnificationXref
id: 24758425
db: PubChem-compound

Protein/2016 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Angiotensinogen
stoichiometric coefficient: 1.0

Angiotensin II
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001035
xref: Reference/ChEBI CHEBI 2719
xref: Reference/PubChem-compound 172198
xref: Reference/ChemSpider 150504
xref: Reference/CAS 4474-91-3
xref: Reference/KEGG Compound C02135
chemical formula: C50H71N13O12
molecular weight: 1045.5345
structure: ChemicalStructure/PW C000816

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/ChEBI CHEBI 3011
type: UnificationXref
id: CHEBI:3011
db: ChEBI

Excitatory amino acid transporter 3
type: Protein
entity reference: Excitatory amino acid transporter 3

Angiotensin-converting enzyme
type: Protein
cellular location: Extracellular Space
entity reference: Angiotensin-converting enzyme

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
cellular location: Cell Membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Reference/BioCyc ALDOSTERONE
type: UnificationXref
id: ALDOSTERONE
db: BioCyc

Reference/SMPDB SMP0123054
type: UnificationXref
id: SMP0123054
db: SMPDB

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/CAS 4474-91-3
type: UnificationXref
id: 4474-91-3
db: CAS

Reference/ChemSpider 24774738
type: UnificationXref
id: 24774738
db: ChemSpider

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Kidney
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000671

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/UniProt P00797
type: UnificationXref
id: P00797
db: UniProt

Glutamate [NMDA] receptor subunit 3A
type: Protein
cellular location: Cell Membrane
entity reference: Glutamate [NMDA] receptor subunit 3A

ChemicalStructure/PW C000816
type: ChemicalStructure
structure format: SMILES

3.4.23.15
type: BiochemicalReaction
participant stoichiometry: Protein/2016 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040470 Extracellular Space/Stoichiometry/1.0
right: Angiotensin I
spontaneous: false
EC number: 3.4.23.15
left: Angiotensinogen
name: Angiotensinogen → Angiotensin I
conversion direction: LEFT_TO_RIGHT

Benazeprilat
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Benazeprilat

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/UniProt Q05586
type: UnificationXref
id: Q05586
db: UniProt

BiologicalState597
type: BioSource
cell type: Astrocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Astrocyte
tissue: Brain

Glutamate [NMDA] receptor subunit epsilon-2
type: Protein
cellular location: Cell Membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-2

ChemicalStructure/PW C000026
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Compound/PW C000816 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Angiotensin II
stoichiometric coefficient: 1.0

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

BiologicalState85
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain
tissue: Brain

Reaction1600
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040467/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009037/Stoichiometry/1.0
right: Benazeprilat
spontaneous: false
left: Benazepril
name: Benazepril → Benazeprilat
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 53477739
type: UnificationXref
id: 53477739
db: PubChem-compound

Reference/BioCyc D-Heptoses
type: UnificationXref
id: D-Heptoses
db: BioCyc

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reaction212596
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000816 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040470 Extracellular Space/Stoichiometry/1.0
right: Angiotensin II
spontaneous: false
left: Angiotensin I
name: Angiotensin I → Angiotensin II
conversion direction: LEFT_TO_RIGHT

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Renin
type: Protein
cellular location: Extracellular Space
entity reference: Renin

Cathepsin G
type: ProteinReference
xref: Reference/UniProt P08311
organism: Homo sapiens

Compound/PW C009037/Stoichiometry/1.0
type: Stoichiometry
physical entity: Benazepril
stoichiometric coefficient: 1.0

Reference/CAS 9041-90-1 484-42-4
type: UnificationXref
id: 9041-90-1 484-42-4
db: CAS

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Type-1 angiotensin II receptor
type: ProteinReference
xref: Reference/UniProt P30556
organism: BiologicalState681

Astrocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000127

ChemicalStructure/PW C001326
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/PW C040467 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Benazeprilat
stoichiometric coefficient: 1.0

Reference/UniProt Q14957
type: UnificationXref
id: Q14957
db: UniProt

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

BiologicalState826
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Pituitary Gland
tissue: Pituitary Gland

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Glutamate [NMDA] receptor subunit epsilon-4
type: Protein
cellular location: Cell Membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-4

Excitatory amino acid transporter 3
type: ProteinReference
xref: Reference/UniProt P43005

Sodium
type: SmallMolecule
entity reference: Sodium

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

Interaction2935
type: MolecularInteraction
interaction type: direct_interaction
name: Benazeprilat inhibits Angiotensin-converting enzyme
participant: Angiotensin-converting enzyme
participant: Benazeprilat

Reference/UniProt P43005
type: UnificationXref
id: P43005
db: UniProt

Benazeprilat
type: SmallMolecule
entity reference: Benazeprilat

Cathepsin G
type: Protein
cellular location: Extracellular Space
entity reference: Cathepsin G

Angiotensinogen
type: ProteinReference
xref: Reference/UniProt P01019
organism: Homo sapiens

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/UniProt O15399
type: UnificationXref
id: O15399
db: UniProt

Compound/PW C040470 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Angiotensin I
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00840
type: UnificationXref
id: C00840
db: KEGG Compound

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/CELL TYPE ONTOLOGY CL 0000127
type: UnificationXref
id: CL:0000127
db: CELL TYPE ONTOLOGY

BiologicalState41
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

Reference/PubChem-compound 5463984
type: UnificationXref
id: 5463984
db: PubChem-compound

Hydrogen Ion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Hydrogen Ion

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Basal Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0009925

Benazeprilat
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0060582
xref: Reference/CAS 86541-78-8
xref: Reference/ChemSpider 4576478
xref: Reference/PubChem-compound 5463984
chemical formula: C22H24N2O5
molecular weight: 396.16852
structure: ChemicalStructure/PW C040467

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Renin
type: ProteinReference
xref: Reference/UniProt P00797
organism: Homo sapiens

Chymase
type: ProteinReference
xref: Reference/UniProt P23946
organism: Homo sapiens

Reference/HMDB HMDB0000037
type: UnificationXref
id: HMDB0000037
db: HMDB

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Angiotensin I
type: SmallMoleculeReference
xref: Reference/CAS 9041-90-1 484-42-4
xref: Reference/ChemSpider 2338989
xref: Reference/HMDB HMDB0061196
xref: Reference/PubChem-compound 3081372
xref: Reference/KEGG Compound C00873
chemical formula: C62H89N17O14
molecular weight: 1295.6775
structure: ChemicalStructure/PW C040470

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/CAS 11000-17-2
type: UnificationXref
id: 11000-17-2
db: CAS

L-Glutamic acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Glutamic acid

Reference/PubChem-compound 172198
type: UnificationXref
id: 172198
db: PubChem-compound

Reference/HMDB HMDB0061196
type: UnificationXref
id: HMDB0061196
db: HMDB

ReactionCatalysis202223
type: Catalysis
controller: Chymase
controlled: Reaction212596
control type: ACTIVATION

ReactionCatalysis202224
type: Catalysis
controller: Cathepsin G
controlled: Reaction212596
control type: ACTIVATION

Interaction3356
type: MolecularInteraction
interaction type: direct_interaction
name: Type-1 angiotensin II receptor inhibits Excitatory amino acid transporter 3
participant: Excitatory amino acid transporter 3
participant: Type-1 angiotensin II receptor

ReactionCatalysis202225
type: Catalysis
controller: Angiotensin-converting enzyme
controlled: Reaction212596
control type: ACTIVATION

Interaction3357
type: MolecularInteraction
interaction type: direct_interaction
name: L-Glutamic acid activates NMDA Receptor
participant: NMDA Receptor
participant: L-Glutamic acid

Reference/HMDB HMDB0014682
type: UnificationXref
id: HMDB0014682
db: HMDB

Reference/KEGG Compound C06843
type: UnificationXref
id: C06843
db: KEGG Compound

Reference/CAS 86541-78-8
type: UnificationXref
id: 86541-78-8
db: CAS

Reference/ChemSpider 2338989
type: UnificationXref
id: 2338989
db: ChemSpider

Interaction2822
type: MolecularInteraction
interaction type: direct_interaction
name: Angiotensin II activates Type-1 angiotensin II receptor
participant: Angiotensin II
participant: Type-1 angiotensin II receptor

Reference/PathWhiz PW124399
type: UnificationXref
id: PW124399
db: PathWhiz

TransportCatalysis2163
type: Catalysis
controller: Excitatory amino acid transporter 3
controlled: Transport11005
control type: ACTIVATION

Chymase
type: Protein
cellular location: Extracellular Space
entity reference: Chymase

TransportCatalysis2164
type: Catalysis
controller: Unknown
controlled: Transport11006
control type: ACTIVATION

Reference/CAS 52-39-1
type: UnificationXref
id: 52-39-1
db: CAS

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Angiotensin II
type: SmallMolecule
entity reference: Angiotensin II

Glutamate [NMDA] receptor subunit zeta-1
type: ProteinReference
xref: Reference/UniProt Q05586
organism: BiologicalState787

Reference/ChemSpider 4576478
type: UnificationXref
id: 4576478
db: ChemSpider

Reference/UniProt P08311
type: UnificationXref
id: P08311
db: UniProt

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
cellular location: Cell Membrane
entity reference: Glutamate [NMDA] receptor subunit zeta-1

Angiotensin II
type: SmallMolecule
cellular location: Basal Cell Membrane
entity reference: Angiotensin II

SubPathwayInteraction113590
type: Interaction
name: SubPathway113590Reaction
name: SubPathwayReaction
participant: Type-1 angiotensin II receptor
participant: Vasopressin

SubPathwayInteraction113591
type: Interaction
name: SubPathwayReaction
name: SubPathway113591Reaction
participant: Type-1 angiotensin II receptor

Reference/KEGG Compound C00873
type: UnificationXref
id: C00873
db: KEGG Compound

SubPathwayInteraction113592
type: Interaction
name: SubPathwayReaction
name: SubPathway113592Reaction
participant: NMDA Receptor

SubPathwayInteraction113593
type: Interaction
name: SubPathway113593Reaction
name: SubPathwayReaction
participant: Type-1 angiotensin II receptor
participant: Aldosterone

Reference/KEGG Compound C02135
type: UnificationXref
id: C02135
db: KEGG Compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Glutamate [NMDA] receptor subunit 3B
type: ProteinReference
xref: Reference/UniProt O60391
organism: BiologicalState787

Unknown
type: Protein
entity reference: Unknown

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt P12821
type: UnificationXref
id: P12821
db: UniProt

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Glutamate [NMDA] receptor subunit epsilon-3
type: ProteinReference
xref: Reference/UniProt Q14957
organism: BiologicalState787

Glutamate [NMDA] receptor subunit epsilon-2
type: ProteinReference
xref: Reference/UniProt Q13224
organism: BiologicalState787

Reference/ChemSpider 4514935
type: UnificationXref
id: 4514935
db: ChemSpider

Glutamate [NMDA] receptor subunit epsilon-4
type: ProteinReference
xref: Reference/UniProt O15399
organism: BiologicalState787

Vasopressin
type: SmallMoleculeReference
xref: Reference/CAS 11000-17-2
xref: Reference/PubChem-compound 53477739
xref: Reference/KEGG Compound C00840
xref: Reference/BioCyc D-Heptoses
xref: Reference/HMDB HMDB0001980
chemical formula: C46H65N13O12S2
molecular weight: 1055.4318
structure: ChemicalStructure/PW C001326

Glutamate [NMDA] receptor subunit epsilon-1
type: ProteinReference
xref: Reference/UniProt Q12879
organism: BiologicalState787

Reference/HMDB HMDB0001035
type: UnificationXref
id: HMDB0001035
db: HMDB

Compound/PW C040034 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/UniProt P01019
type: UnificationXref
id: P01019
db: UniProt

Reference/UniProt P23946
type: UnificationXref
id: P23946
db: UniProt

Reference/ChEBI CHEBI 27584
type: UnificationXref
id: CHEBI:27584
db: ChEBI

Reference/ChemSpider 150504
type: UnificationXref
id: 150504
db: ChemSpider

Moexipril Mechanism of Action (New)
type: Pathway
pathway order: PathwayEnzymeReaction/2466099
pathway order: PathwayTransport/2466101
pathway order: PathwayTransport/2466100
pathway order: PathwayInteraction/2935
pathway order: PathwayEnzymeReaction/2466096
pathway order: PathwayEnzymeReaction/2466095
pathway order: PathwayInteraction/2822
pathway order: PathwayEnzymeReaction/2466098
pathway order: PathwaySubPathway/113590
pathway order: PathwayEnzymeReaction/2466097
pathway order: PathwaySubPathway/113591
pathway order: PathwayInteraction/3357
pathway order: PathwaySubPathway/113592
pathway order: PathwayInteraction/3356
pathway order: PathwaySubPathway/113593
pathway component: 3.4.23.15
pathway component: ReactionCatalysis202223
pathway component: ReactionCatalysis202224
pathway component: Interaction3356
pathway component: ReactionCatalysis202225
pathway component: Interaction3357
pathway component: Reaction212596
pathway component: Transport11005
pathway component: Transport11006
pathway component: Interaction2935
pathway component: ReactionCatalysis1347
pathway component: Interaction2822
pathway component: TransportCatalysis2163
pathway component: Vasocontriction
pathway component: Thirst Sensation
pathway component: Reaction1600
pathway component: TransportCatalysis2164
pathway component: Vasopressin Release
pathway component: Aldosterone Production
xref: Reference/SMPDB SMP0123054
xref: Reference/PathWhiz PW124399
organism: Homo sapiens

Pituitary Gland
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001073

Vasopressin
type: SmallMolecule
entity reference: Vasopressin
name: SubPathwayOutput

L-Glutamic acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: L-Glutamic acid

Reference/HMDB HMDB0060582
type: UnificationXref
id: HMDB0060582
db: HMDB

Reference/UniProt Q13224
type: UnificationXref
id: Q13224
db: UniProt

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Angiotensinogen
type: Protein
cellular location: Extracellular Space
entity reference: Angiotensinogen

Reference/GENE ONTOLOGY GO 0009925
type: UnificationXref
id: GO:0009925
db: GENE ONTOLOGY

Reference/PubChem-compound 40466887
type: UnificationXref
id: 40466887
db: PubChem-compound

Compound/PW C000458/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000671
type: UnificationXref
id: BTO:0000671
db: BRENDA TISSUE ONTOLOGY

Benazepril
type: SmallMolecule
entity reference: Benazepril

Angiotensin II
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Angiotensin II

Glutamate [NMDA] receptor subunit 3B
type: Protein
cellular location: Cell Membrane
entity reference: Glutamate [NMDA] receptor subunit 3B

Benazepril
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 3011
xref: Reference/ChemSpider 4514935
xref: Reference/CAS 86541-75-5
xref: Reference/PubChem-compound 40466887
xref: Reference/HMDB HMDB0014682
xref: Reference/KEGG Compound C06843
chemical formula: C24H28N2O5
molecular weight: 424.19983
structure: ChemicalStructure/PW C009037

Angiotensin II
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Angiotensin II