Gβ
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState777

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Protein/1340 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase subunit beta
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Stomach
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001307

Gβ
type: Protein
cellular location: Basolateral cell membrane
entity reference: Gβ

ChemicalStructure/PW C000693
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC=N1

direct_interaction
type: InteractionVocabulary

Reference/HMDB HMDB0000895
type: UnificationXref
id: HMDB0000895
db: HMDB

Reference/UniProt P00915
type: UnificationXref
id: P00915
db: UniProt

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/UniProt P20648
type: UnificationXref
id: P20648
db: UniProt

Apical cell membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016324

BoundComplex/527 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: BoundComplex/527 Basolateral cell membrane
stoichiometric coefficient: 1.0

Acetylcholine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15355
xref: Reference/CAS 51-84-3
xref: Reference/HMDB HMDB0000895
xref: Reference/ChemSpider 182
xref: Reference/KEGG Compound C01996
xref: Reference/BioCyc ACETYLCHOLINE
xref: Reference/PubChem-compound 187
chemical formula: C7H16NO2
molecular weight: 146.1181
structure: ChemicalStructure/PW C000714

Histamine H2 receptor
type: Protein
entity reference: Histamine H2 receptor

Compound/PW C000693 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histamine
stoichiometric coefficient: 1.0

Transport10957
type: Transport
participant stoichiometry: Compound/PW C000693 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000693/Stoichiometry/1.0
right: Histamine
spontaneous: false
left: Histamine
name: Histamine (→) Transport: Homo sapiens, Stomach, Enterochromaffin-like cell to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: Reference/UniProt Q9UBI6
organism: BiologicalState777

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Guanosine triphosphate_Guanine nucleotide-binding protein alpha (Homo sapiens)_Adenylate cyclase type 2 (Homo sapiens)
type: Complex
component stoichiometry: Protein/1601 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Protein/864 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Compound/PW C000986 Basolateral cell membrane/Stoichiometry/1.0
cellular location: Basolateral cell membrane
component: Adenylate cyclase type 2
component: Guanosine triphosphate
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reaction213234
type: BiochemicalReaction
participant stoichiometry: BoundComplex/527 Basolateral cell membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Basolateral cell membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Basolateral cell membrane/Stoichiometry/1.0
participant stoichiometry: BoundComplex/529 Basolateral cell membrane/Stoichiometry/1.0
right: Guanosine diphosphate
right: BoundComplex/529 Basolateral cell membrane
spontaneous: false
left: Guanosine triphosphate
left: BoundComplex/527 Basolateral cell membrane
name: Guanosine triphosphate + Histamine H2 receptor (Homo sapiens) + Guanine nucleotide-binding protein alpha (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens) + Guanosine diphosphate → Guanosine diphosphate + Histamine + Histamine H2 receptor (Homo sapiens) + Guanine nucleotide-binding protein alpha (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens) + Guanosine triphosphate
conversion direction: LEFT_TO_RIGHT

Reaction213235
type: BiochemicalReaction
participant stoichiometry: BoundComplex/529/Stoichiometry/1.0
participant stoichiometry: BoundComplex/20/Stoichiometry/1.0
participant stoichiometry: BoundComplex/532/Stoichiometry/1.0
participant stoichiometry: BoundComplex/531/Stoichiometry/1.0
right: Guanine nucleotide-binding protein alpha (Homo sapiens)_Guanosine triphosphate
right: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)
right: Histamine_Histamine H2 receptor (Homo sapiens)
spontaneous: false
left: BoundComplex/529
name: Histamine + Histamine H2 receptor (Homo sapiens) + Guanine nucleotide-binding protein alpha (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens) + Guanosine triphosphate → Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens) + Guanine nucleotide-binding protein alpha (Homo sapiens) + Guanosine triphosphate + Histamine + Histamine H2 receptor (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Protein/3625/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Guanosine triphosphate
type: SmallMolecule
cellular location: Basolateral cell membrane
entity reference: Guanosine triphosphate

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Protein/1601/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
stoichiometric coefficient: 1.0

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

BoundComplex/527 Extracellular Space
type: Complex
display name: Histamine H2 receptor (Homo sapiens)_Guanine nucleotide-binding protein alpha (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)_Guanosine diphosphate
component stoichiometry: Protein/1816 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/1601 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/3618 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Protein/3625 Extracellular Space/Stoichiometry/1.0
component stoichiometry: Compound/PW C000936 Extracellular Space/Stoichiometry/1.0
cellular location: Extracellular Space
component: Gβ
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
component: Guanosine diphosphate
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
component: Histamine H2 receptor

Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Reference/UniProt Q08462
type: UnificationXref
id: Q08462
db: UniProt

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Protein/1354 Apical cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase alpha chain 1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/ChEBI CHEBI 16595
type: UnificationXref
id: CHEBI:16595
db: ChEBI

Compound/PW C000457 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbon dioxide

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/UniProt P20309
type: UnificationXref
id: P20309
db: UniProt

Reference/PubChem-compound 3033637
type: UnificationXref
id: 3033637
db: PubChem-compound

BoundComplex/529 Basolateral cell membrane
type: Complex
display name: Histamine_Histamine H2 receptor (Homo sapiens)_Guanine nucleotide-binding protein alpha (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)_Guanosine triphosphate
component stoichiometry: Protein/3618 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Protein/1601 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Compound/PW C000693 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Compound/PW C000986 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Protein/3625 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Protein/1816 Basolateral cell membrane/Stoichiometry/1.0
cellular location: Basolateral cell membrane
component: Guanosine triphosphate
component: Histamine H2 receptor
component: Histamine
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
component: Gβ

Reference/CAS 85166-31-0
type: UnificationXref
id: 85166-31-0
db: CAS

H(+)/K(+) ATPase subunit
type: Complex
component stoichiometry: Protein/1354 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/1340 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Potassium-transporting ATPase alpha chain 1
component: Potassium-transporting ATPase subunit beta

Reference/BioCyc ACETYLCHOLINE
type: UnificationXref
id: ACETYLCHOLINE
db: BioCyc

Reference/CAS 76963-41-2
type: UnificationXref
id: 76963-41-2
db: CAS

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

Reference/UniProt P01350
type: UnificationXref
id: P01350
db: UniProt

Compound/PW C000463 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Reference/HMDB HMDB0014723
type: UnificationXref
id: HMDB0014723
db: HMDB

BoundComplex/529
type: Complex
display name: Histamine_Histamine H2 receptor (Homo sapiens)_Guanine nucleotide-binding protein alpha (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)_Guanosine triphosphate
component stoichiometry: Protein/3625/Stoichiometry/1.0
component stoichiometry: Compound/PW C000986/Stoichiometry/1.0
component stoichiometry: Compound/PW C000693/Stoichiometry/1.0
component stoichiometry: Protein/1816/Stoichiometry/1.0
component stoichiometry: Protein/3618/Stoichiometry/1.0
component stoichiometry: Protein/1601/Stoichiometry/1.0
component: Gβ
component: Histamine H2 receptor
component: Histamine
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
component: Guanosine triphosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Potassium-transporting ATPase subunit beta
type: ProteinReference
xref: Reference/UniProt P51164
organism: Homo sapiens

Compound/PW C000936 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Protein/1354 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase alpha chain 1
stoichiometric coefficient: 1.0

Nizatidine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 127604
xref: Reference/ChemSpider 2298266
xref: Reference/HMDB HMDB0014723
xref: Reference/KEGG Compound C07270
xref: Reference/PubChem-compound 3033637
xref: Reference/CAS 76963-41-2
chemical formula: C12H21N5O2S2
molecular weight: 331.11368
structure: ChemicalStructure/PW C009074

H(+)/K(+) ATPase subunit
type: Complex
component stoichiometry: Protein/1340 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1354 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Potassium-transporting ATPase subunit beta
component: Potassium-transporting ATPase alpha chain 1

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)
type: Complex
component stoichiometry: Protein/3625/Stoichiometry/1.0
component stoichiometry: Protein/3618/Stoichiometry/1.0
component: Gβ
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Histamine_Histamine H2 receptor (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000693/Stoichiometry/1.0
component stoichiometry: Protein/1816/Stoichiometry/1.0
component: Histamine H2 receptor
component: Histamine

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Potassium-transporting ATPase subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: Potassium-transporting ATPase subunit beta

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: Protein
cellular location: Extracellular Space
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Hydrogen Ion
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Hydrogen Ion

Potassium-transporting ATPase alpha chain 1
type: ProteinReference
xref: Reference/UniProt P20648
organism: Homo sapiens

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Apical cell membrane
entity reference: Inositol 1,4,5-trisphosphate

Protein/1816 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histamine H2 receptor
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Guanine nucleotide-binding protein alpha (Homo sapiens)_Guanosine triphosphate
type: Complex
component stoichiometry: Protein/1601 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Compound/PW C000986 Basolateral cell membrane/Stoichiometry/1.0
cellular location: Basolateral cell membrane
component: Guanosine triphosphate
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Protein/1601 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Inositol 1,4,5-trisphosphate
name: SubPathwayOutput

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/BioCyc inositol 1,4,5-trisphosphate
type: UnificationXref
id: inositol_1,4,5-trisphosphate
db: BioCyc

Parietal Cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000162

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Potassium-transporting ATPase alpha chain 1
type: Protein
cellular location: Cytoplasm
entity reference: Potassium-transporting ATPase alpha chain 1

ChemicalStructure/PW C009074
type: ChemicalStructure
structure format: SMILES
structure data: CN\C(NCCSCC1=CSC(CN(C)C)=N1)=C/[N+]([O-])=O

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/SMPDB SMP0123166
type: UnificationXref
id: SMP0123166
db: SMPDB

BoundComplex/532/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)
stoichiometric coefficient: 1.0

ReactionCatalysis1409
type: Catalysis
controller: Carbonic anhydrase 1
controlled: 4.2.1.1
control type: ACTIVATION

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 388562
type: UnificationXref
id: 388562
db: ChemSpider

Protein/1601 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Protein/1340 Apical cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase subunit beta
stoichiometric coefficient: 1.0

Protein/3625 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
stoichiometric coefficient: 1.0

Histamine H2 receptor
type: Protein
cellular location: Extracellular Space
entity reference: Histamine H2 receptor

Potassium
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Potassium

BoundComplex/529/Stoichiometry/1.0
type: Stoichiometry
physical entity: BoundComplex/529
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: Protein
cellular location: Basolateral cell membrane
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Muscarinic acetylcholine receptor M3
type: ProteinReference
xref: Reference/UniProt P20309
organism: BiologicalState777

Gastrin
type: ProteinReference
xref: Reference/UniProt P01350
organism: BiologicalState777

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Histamine H2 receptor
type: ProteinReference
xref: Reference/UniProt P25021
organism: BiologicalState777

Compound/PW C000936 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Gastrin
type: Protein
cellular location: Basolateral cell membrane
entity reference: Gastrin

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00388
type: UnificationXref
id: C00388
db: KEGG Compound

Guanosine triphosphate
type: SmallMolecule
entity reference: Guanosine triphosphate

Nizatidine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Nizatidine

Reference/ChemSpider 2298266
type: UnificationXref
id: 2298266
db: ChemSpider

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Inositol 1,4,5-trisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001498
xref: Reference/PubChem-compound 439456
xref: Reference/CAS 85166-31-0
xref: Reference/BioCyc inositol 1,4,5-trisphosphate
xref: Reference/KEGG Compound C01245
xref: Reference/ChEBI CHEBI 16595
xref: Reference/ChemSpider 388562
chemical formula: C6H15O15P3
molecular weight: 419.96237
structure: ChemicalStructure/PW C001155

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

SubPathwayInteraction113755
type: Interaction
name: SubPathwayReaction
name: SubPathway113755Reaction
participant: Muscarinic acetylcholine receptor M3
participant: Inositol 1,4,5-trisphosphate
participant: Gastrin/cholecystokinin type B receptor

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

cAMP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cAMP

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Protein/1816/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histamine H2 receptor
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/CAS 51-45-6
type: UnificationXref
id: 51-45-6
db: CAS

Gastrin/cholecystokinin type B receptor
type: Protein
cellular location: Basolateral cell membrane
entity reference: Gastrin/cholecystokinin type B receptor
name: SubPathwayInput

Interaction3462
type: MolecularInteraction
interaction type: direct_interaction
name: Nizatidine inhibits Histamine H2 receptor (Homo sapiens) + Guanine nucleotide-binding protein alpha (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens) + Guanosine diphosphate
participant: Nizatidine
participant: BoundComplex/527 Extracellular Space

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/KEGG Compound C01245
type: UnificationXref
id: C01245
db: KEGG Compound

Basolateral cell membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016323

Reference/ChEBI CHEBI 127604
type: UnificationXref
id: CHEBI:127604
db: ChEBI

Histamine
type: SmallMolecule
entity reference: Histamine

Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Gβ
type: Protein
cellular location: Extracellular Space
entity reference: Gβ

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: ProteinReference
xref: Reference/UniProt P63092
organism: BiologicalState777

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Nizatidine Mechanism of Action
type: Pathway
pathway order: PathwayEnzymeReaction/2466977
pathway order: PathwayEnzymeReaction/2466976
pathway order: PathwaySubPathway/113755
pathway order: PathwayEnzymeReaction/2466979
pathway order: PathwayEnzymeReaction/2466978
pathway order: PathwayEnzymeReaction/2466975
pathway order: PathwayTransport/2466980
pathway order: PathwayInteraction/2828
pathway order: PathwayInteraction/3239
pathway order: PathwayInteraction/3238
pathway order: PathwayInteraction/3237
pathway order: PathwayInteraction/3236
pathway order: PathwayInteraction/3235
pathway order: PathwayInteraction/3234
pathway order: PathwayInteraction/3462
pathway component: Reaction179759
pathway component: Transport10957
pathway component: ReactionCatalysis1409
pathway component: Interaction3234
pathway component: Interaction3235
pathway component: Interaction3236
pathway component: Interaction3237
pathway component: Interaction3462
pathway component: Reaction213234
pathway component: Reaction213235
pathway component: 4.2.1.1
pathway component: Interaction3238
pathway component: Interaction3239
pathway component: Gq Signalling Pathway
pathway component: 3.6.3.10
pathway component: ReactionCoupledTransportCatalysis13
pathway component: Interaction2828
xref: Reference/PathWhiz PW124514
xref: Reference/SMPDB SMP0123166
organism: Homo sapiens

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001155
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P63092
type: UnificationXref
id: P63092
db: UniProt

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: Extracellular Space
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Gq Signalling Pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway113755
pathway component: SubPathwayInteraction113755
name: SubPathway

BoundComplex/20/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein alpha (Homo sapiens)_Guanosine triphosphate
stoichiometric coefficient: 1.0

Guanosine diphosphate
type: SmallMolecule
cellular location: Basolateral cell membrane
entity reference: Guanosine diphosphate

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/CAS 51-84-3
type: UnificationXref
id: 51-84-3
db: CAS

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen carbonate

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Guanosine diphosphate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Guanosine diphosphate

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

4.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: Hydrogen carbonate
spontaneous: false
EC number: 4.2.1.1
left: Carbon dioxide
left: Water
name: Carbon dioxide + Water → Hydrogen Ion + Hydrogen carbonate
conversion direction: LEFT_TO_RIGHT

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Reference/PubChem-compound 439456
type: UnificationXref
id: 439456
db: PubChem-compound

Carbonic anhydrase 1
type: Protein
cellular location: Cytoplasm
entity reference: Carbonic anhydrase 1

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Protein/3618 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβ
stoichiometric coefficient: 1.0

Gβ
type: Protein
entity reference: Gβ

Gastrin/cholecystokinin type B receptor
type: ProteinReference
xref: Reference/UniProt P32239
organism: BiologicalState777

Reference/PubChem-compound 774
type: UnificationXref
id: 774
db: PubChem-compound

Reference/UniProt P32239
type: UnificationXref
id: P32239
db: UniProt

Reaction179759
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: cAMP
right: Pyrophosphate
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C000693 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Interaction3234
type: MolecularInteraction
interaction type: direct_interaction
name: Histamine activates Histamine H2 receptor (Homo sapiens) + Guanine nucleotide-binding protein alpha (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens) + Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens) + Guanosine diphosphate
participant: Histamine
participant: BoundComplex/527 Basolateral cell membrane

Interaction3235
type: MolecularInteraction
interaction type: direct_interaction
name: Guanine nucleotide-binding protein alpha (Homo sapiens) + Guanosine triphosphate activates Guanosine triphosphate + Guanine nucleotide-binding protein alpha (Homo sapiens) + Adenylate cyclase type 2 (Homo sapiens)
participant: Guanosine triphosphate_Guanine nucleotide-binding protein alpha (Homo sapiens)_Adenylate cyclase type 2 (Homo sapiens)
participant: Guanine nucleotide-binding protein alpha (Homo sapiens)_Guanosine triphosphate

Interaction3236
type: MolecularInteraction
interaction type: direct_interaction
name: Adenylate cyclase type 2 activates Guanosine triphosphate + Guanine nucleotide-binding protein alpha (Homo sapiens) + Adenylate cyclase type 2 (Homo sapiens)
participant: Adenylate cyclase type 2
participant: Guanosine triphosphate_Guanine nucleotide-binding protein alpha (Homo sapiens)_Adenylate cyclase type 2 (Homo sapiens)

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Interaction3237
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates H(+)/K(+) ATPase subunit
participant: H(+)/K(+) ATPase subunit
participant: cAMP

Reference/UniProt P25021
type: UnificationXref
id: P25021
db: UniProt

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ChemicalStructure/PW C000714
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OCC[N+](C)(C)C

Protein/3625 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
stoichiometric coefficient: 1.0

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Compound/PW C040034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001498
type: UnificationXref
id: HMDB0001498
db: HMDB

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Interaction3238
type: MolecularInteraction
interaction type: direct_interaction
name: Gastrin activates Gastrin/cholecystokinin type B receptor
participant: Gastrin
participant: Gastrin/cholecystokinin type B receptor

Compound/PW C000693/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histamine
stoichiometric coefficient: 1.0

Interaction3239
type: MolecularInteraction
interaction type: direct_interaction
name: Inositol 1,4,5-trisphosphate activates H(+)/K(+) ATPase subunit
participant: H(+)/K(+) ATPase subunit
participant: Inositol 1,4,5-trisphosphate

Interaction2828
type: MolecularInteraction
interaction type: direct_interaction
name: Acetylcholine activates Muscarinic acetylcholine receptor M3
participant: Muscarinic acetylcholine receptor M3
participant: Acetylcholine

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Potassium-transporting ATPase subunit beta
type: Protein
cellular location: Apical cell membrane
entity reference: Potassium-transporting ATPase subunit beta

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
type: Protein
cellular location: Basolateral cell membrane
entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Guanine nucleotide-binding protein alpha (Homo sapiens)_Guanosine triphosphate
type: Complex
component stoichiometry: Compound/PW C000986/Stoichiometry/1.0
component stoichiometry: Protein/1601/Stoichiometry/1.0
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
component: Guanosine triphosphate

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/CELL TYPE ONTOLOGY CL 0000162
type: UnificationXref
id: CL:0000162
db: CELL TYPE ONTOLOGY

Adenylate cyclase type 2
type: ProteinReference
xref: Reference/UniProt Q08462
organism: BiologicalState777

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: Protein
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Protein/864 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenylate cyclase type 2
stoichiometric coefficient: 1.0

Reference/KEGG Compound C07270
type: UnificationXref
id: C07270
db: KEGG Compound

ReactionCoupledTransportCatalysis13
type: Catalysis
controller: H(+)/K(+) ATPase subunit
controlled: 3.6.3.10
control type: ACTIVATION

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Histamine H2 receptor
type: Protein
cellular location: Basolateral cell membrane
entity reference: Histamine H2 receptor

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Protein/3618 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβ
stoichiometric coefficient: 1.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Carbonic anhydrase 1
type: ProteinReference
xref: Reference/UniProt P00915
organism: BiologicalState777

Reference/BioCyc HISTAMINE
type: UnificationXref
id: HISTAMINE
db: BioCyc

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Protein/1354 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase alpha chain 1
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Muscarinic acetylcholine receptor M3
type: Protein
cellular location: Basolateral cell membrane
entity reference: Muscarinic acetylcholine receptor M3
name: SubPathwayInput

Histamine
type: SmallMolecule
cellular location: Basolateral cell membrane
entity reference: Histamine

Reference/BRENDA TISSUE ONTOLOGY BTO 0001307
type: UnificationXref
id: BTO:0001307
db: BRENDA TISSUE ONTOLOGY

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

BoundComplex/527 Basolateral cell membrane
type: Complex
display name: Histamine H2 receptor (Homo sapiens)_Guanine nucleotide-binding protein alpha (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Homo sapiens)_Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (Homo sapiens)_Guanosine diphosphate
component stoichiometry: Protein/3618 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Protein/1601 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Compound/PW C000936 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Protein/3625 Basolateral cell membrane/Stoichiometry/1.0
component stoichiometry: Protein/1816 Basolateral cell membrane/Stoichiometry/1.0
cellular location: Basolateral cell membrane
component: Histamine H2 receptor
component: Guanosine diphosphate
component: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
component: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
component: Gβ

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0016323
type: UnificationXref
id: GO:0016323
db: GENE ONTOLOGY

BoundComplex/531/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histamine_Histamine H2 receptor (Homo sapiens)
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0016324
type: UnificationXref
id: GO:0016324
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 18295
type: UnificationXref
id: CHEBI:18295
db: ChEBI

Reference/PubChem-compound 187
type: UnificationXref
id: 187
db: PubChem-compound

Reference/HMDB HMDB0000870
type: UnificationXref
id: HMDB0000870
db: HMDB

Reference/ChemSpider 753
type: UnificationXref
id: 753
db: ChemSpider

Protein/1816 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histamine H2 receptor
stoichiometric coefficient: 1.0

H(+)/K(+) ATPase subunit
type: Complex
component stoichiometry: Protein/1340 Apical cell membrane/Stoichiometry/1.0
component stoichiometry: Protein/1354 Apical cell membrane/Stoichiometry/1.0
cellular location: Apical cell membrane
component: Potassium-transporting ATPase subunit beta
component: Potassium-transporting ATPase alpha chain 1

Compound/PW C000986/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Protein/1340 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium-transporting ATPase subunit beta
stoichiometric coefficient: 1.0

Histamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000870
xref: Reference/ChemSpider 753
xref: Reference/PubChem-compound 774
xref: Reference/BioCyc HISTAMINE
xref: Reference/CAS 51-45-6
xref: Reference/ChEBI CHEBI 18295
xref: Reference/KEGG Compound C00388
chemical formula: C5H9N3
molecular weight: 111.07965
structure: ChemicalStructure/PW C000693

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

BoundComplex/529 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: BoundComplex/529 Basolateral cell membrane
stoichiometric coefficient: 1.0

Reference/UniProt P51164
type: UnificationXref
id: P51164
db: UniProt

Acetylcholine
type: SmallMolecule
cellular location: Basolateral cell membrane
entity reference: Acetylcholine

Reference/ChEBI CHEBI 15355
type: UnificationXref
id: CHEBI:15355
db: ChEBI

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Potassium-transporting ATPase alpha chain 1
type: Protein
cellular location: Cell Membrane
entity reference: Potassium-transporting ATPase alpha chain 1

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Reference/KEGG Compound C01996
type: UnificationXref
id: C01996
db: KEGG Compound

Histamine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Histamine

BiologicalState777
type: BioSource
cell type: Parietal Cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Stomach, Parietal Cell
tissue: Stomach

Reference/PathWhiz PW124514
type: UnificationXref
id: PW124514
db: PathWhiz

Adenosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine diphosphate

Potassium-transporting ATPase subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: Potassium-transporting ATPase subunit beta

Adenylate cyclase type 2
type: Protein
cellular location: Basolateral cell membrane
entity reference: Adenylate cyclase type 2

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Compound/PW C000986 Basolateral cell membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

3.6.3.10
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000457 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cell Membrane/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Hydrogen Ion
right: Potassium
spontaneous: false
EC number: 3.6.3.10
left: Hydrogen Ion
left: Adenosine triphosphate
left: Water
left: Potassium
name: Adenosine triphosphate + Hydrogen Ion + Potassium + Water → Adenosine diphosphate + Hydrogen Ion + Phosphate + Potassium
conversion direction: LEFT_TO_RIGHT

Potassium-transporting ATPase alpha chain 1
type: Protein
cellular location: Apical cell membrane
entity reference: Potassium-transporting ATPase alpha chain 1

Protein/3618/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβ
stoichiometric coefficient: 1.0

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Reference/ChemSpider 182
type: UnificationXref
id: 182
db: ChemSpider

Reference/UniProt Q9UBI6
type: UnificationXref
id: Q9UBI6
db: UniProt