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Adenylate cyclase type 10 Protein kinase A Protein kinase A Protein kinase A Protein kinase A Protein kinase A Chloride anion exchanger ATPase Na+/K+ transporting family member beta 4 Solute carrier family 12 member 6 Carbonic anhydrase 1 Histamine H2 receptor Guanine nucleotide- binding protein alpha Gβ Protein kinase A Protein kinase A Histamine cAMP Roxatidine Acetate H+ H+ K+ K+ HCO3- HCO3- Cl- Cl- K+ K+ Na+ Na+ Cl- Cl- K+ K+ Roxatidine Acetate ATP H2O CO2 Hydrochloric acid Magnesium Zinc (II) ion GDP Potassium- transporting ATPase subunit beta Potassium- transporting ATPase alpha chain 1 Histamine is released by nearby enterochromaffin-like cells in the gastric glands of the stomach Roxatidine acetate acts as a competitive inhibitor on the H2 receptor and blocks out the action of histamine on the receptor which causes decreased gastric acid secretion from parietal cells into the stomach lumen Parietal Cell Stomach Lumen Blood Vessel The inhibition of the H2 Histamine receptor decreases the gastric acid response to food, caffeine, insulin, betazole, or pentagastrin Inhibition of H2 histamine receptors prevents the activation of adenylate cyclase, leading to low concentrations of cAMP which prevents hydrogen from being pumped into the lumen
ADCY10 PRKACA PRKACB PRKAR1A PRKAR1B PRKAR2B SLC26A3 ATP1B4 SLC12A6 CA1 HRH2 GNAS GNB1 PRKACG PRKAR2A Histamine cAMP Roxatidine Acetate Hydrogen Ion Hydrogen Ion Potassium Potassium Hydrogen carbonate Hydrogen carbonate Chloride ion Chloride ion Potassium Potassium Sodium Sodium Chloride ion Chloride ion Potassium Potassium Roxatidine Acetate Adenosine triphosphate Water Carbon dioxide Hydrochloric acid Guanosine diphosphate ATP4B ATP4A
ADCY10 PRKACA PRKACB PRKAR1A PRKAR1B PRKAR2B SLC26A3 ATP1B4 SLC12A6 CA1 HRH2 GNAS GNB1 PRKACG PRKAR2A Hsm cAMP Roxit H+ H+ K+ K+ HCO3- HCO3- Cl- Cl- K+ K+ Na+ Na+ Cl- Cl- K+ K+ Roxit ATP H2O CO2 HCl Mg2+ Zinc GDP ATP4B ATP4A Histamine is released by nearby enterochromaffin-like cells in the gastric glands of the stomach Roxatidine acetate acts as a competitive inhibitor on the H2 receptor and blocks out the action of histamine on the receptor which causes decreased gastric acid secretion from parietal cells into the stomach lumen Parietal Cell Stomach Lumen Blood Vessel The inhibition of the H2 Histamine receptor decreases the gastric acid response to food, caffeine, insulin, betazole, or pentagastrin Inhibition of H2 histamine receptors prevents the activation of adenylate cyclase, leading to low concentrations of cAMP which prevents hydrogen from being pumped into the lumen
ADCY10 PRKACA PRKACB PRKAR1A PRKAR1B PRKAR2B SLC26A3 ATP1B4 SLC12A6 CA1 HRH2 GNAS GNB1 PRKACG PRKAR2A Hsm cAMP Roxit H+ H+ K+ K+ HCO3 HCO3 Cl Cl K+ K+ Na+ Na+ Cl Cl K+ K+ Roxit ATP H2O CO2 HCl GDP ATP4B ATP4A