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SIRT1 NAD-dependent protein deacetylase sirtuin-1 Cellular tumor antigen p53 Forkhead box protein O3 NAD-dependent protein deacetylase sirtuin-1 Retinoic acid receptor RXR-alpha Retinoic acid receptor RXR-beta Retinoic acid receptor RXR-gamma Peroxisome proliferator- activated receptor gamma coactivator 1-alpha Nuclear receptor ROR-alpha Nuclear Factor Kappa B