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Neutral and basic amino acid transport protein rBAT B(0,+)-type amino acid transporter 1 Unknown Unknown Tryptophan 2,3-dioxygenase Kynurenine/alpha- aminoadipate aminotransferase, mitochondrial Kynurenic acid L-Tryptophan L-Tryptophan L-Tryptophan L-Tryptophan Kynurenic acid L-Kynurenine Heme Pyridoxal 5'-phosphate Disrupts electron transport chain and oxidative phosphorylation causing muscle atrophy AhR activation leading to renal impairment Hepatic Liver Cell Intestinal Lumen Intestinal epithelial cells Intestinal epithelial cells Intestinal microbe Tryptophan obtained from high protein foods