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Acetyl-CoA acetyltransferase, mitochondrial Hydroxymethylglutaryl- CoA synthase 3- hydroxymethyl- 3- methylglutaryl- CoA lyase, cytoplasmic Mevalonate kinase Phosphomevalonate kinase Diphosphomevalonate decarboxylase Farnesyl pyrophosphate synthase Farnesyl pyrophosphate synthase Squalene synthase Squalene monooxygenase Lanosterol synthase Acetyl-CoA Acetoacetyl-CoA CoA Acetyl-CoA H2O 3-Hydroxy-3- methylglutaryl- CoA CoA NADPH H+ NADP CoA Mevalonate ATP Mevalonate-5P ADP ATP Mevalonate-5PP ADP ATP Isopentenyl-PP ADP Pi CO2 Dimethylallylpyrophosphate PPi Geranyl-PP Isopentenyl pyrophosphate Farnesyl pyrophosphate PPi H+ NADPH PPi NADP Squalene O2 FMNH2 (S)-2,3- Epoxysqualene H+ H2O Flavin Mononucleotide Lanosterol Cholesterol Magnesium Magnesium Magnesium FAD El proceso se lleva acabo mayormente en la mitocondria hepatica Inhibida por el Mevalonato y Colesterol La insulina y hormona tiroidea AUMENTAN su actividad El glucagon y glucocorticoides DISMINUYEN su actividad