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Unknown 3-oxoacyl- [acyl- carrier- protein] reductase (3R)- hydroxymyristoyl- [acyl- carrier- protein] dehydratase Enoyl-[acyl- carrier- protein] reductase [NADH] 3-oxoacyl- [acyl- carrier- protein] synthase 1 3-oxoacyl- [acyl- carrier- protein] reductase ATP-citrate synthase Acetyl-CoA carboxylase 1 H+ Acetyl-CoA CO2 CoA H+ NADPH NADP H2O H+ NADH NAD H+ CO2 H+ NADPH NADP Citrate Acetyl-CoA Malonyl-CoA Palmityl-CoA Biotin Manganese a malonyl-[acp] acetoacetyl- [acp] (R)-3- hydroxybutanoyl- [acp] crotonyl-[acp] butyryl-[acp] a malonyl-[acp] a holo-[acyl- carrier protein] 3-oxo- hexanoyl- [acp] (R)-3- hydroxyhexanoyl- [acp] B-cetoacil-ACP sintasa Transportador de grupos acilo: Proteína transportadora de acilo (ACP) Agente reductor Agente oxidante REGULACION Agente reductor Agente oxidante El glucagón y la adrenalina, desencadenan su inactivación El CITRATO es un activador alostérico que aumenta la Vmax Paso limitante de la velocidad de la biosintesis El proceso se lleva a cabo en el citosol y sucede en el higado