115456Pathway biosynthesis novo 1617096865MetabolicPW124614CenterPathwayVisualizationContext12489024502950#000099PathwayVisualization115319115456 biosynthesis novo 1617096865Metabolic11CellCL:00000003NeuronCL:00005404Cardiomyocyte CL:00007461Homo sapiens9606EukaryoteHuman4Arabidopsis thaliana3702EukaryoteThale cress12Mus musculus10090EukaryoteMouse5Bos taurus9913EukaryoteCattle17Rattus norvegicus10116EukaryoteRat127kjhkjh0989088Eukaryote157Acinetobacter baumannii 107673Prokaryote138human0046323Eukaryote2Bacteria2ProkaryoteBacteria18Saccharomyces cerevisiae4932EukaryoteYeast62Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)62977Prokaryote25Escherichia coli (strain K12)83333Prokaryote1CytosolGO:000582936MembraneGO:00160205CytoplasmGO:000573710Cell MembraneGO:000588611Extracellular SpaceGO:000561514Mitochondrial Outer MembraneGO:00057418Blood VesselBTO:0001102741124BrainBTO:000014289166KidneyBTO:000067171811PW_BS00000141811PW_BS00004115284PW_BS0001525181PW_BS0000512111PW_BS0000021321121PW_BS000132124151PW_BS0001241181171PW_BS0001188792411273PW_BS000552228361PW_BS0000248511PW_BS00000814101PW_BS00001486961111PW_BS0005528976111571PW_BS0005529786111381PW_BS000569151141PW_BS0001512881441PW_BS000024372102PW_BS0000282111018PW_BS0000246531624PW_BS0005087711PW_BS00051881124111573PW_BS0005482371025PW_BS0000242402-HydroxyestradiolHMDB00003382-Hydroxyestradiol is generated from estradiol by a Cytochrome P450. 2-Hydroxyestradiol binds, with a low affinity, to estrogen receptors. It inhbits catechol-O-methyltransferase (COMT) activity. Inactivity of COMT blocks inactivation of catechol hormones and catecholamine neutransmitters. 2-Hydroxyestradiol is also reported to inhibit angiongensis and tumor cell growth (PMID: 9472688).362-05-0C05301247304287442-HYDROXY-ESTRADIOL216475DB07706[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C(O)=C3C18H24O3InChI=1S/C18H24O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,17,19-21H,2-7H2,1H3/t11-,12+,14-,17-,18-/m0/s1DILDHNKDVHLEQB-XSSYPUMDSA-N(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-4,5,14-triol288.3814288.172544634-3.753(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-4,5,14-triol00FDB021962(17b)-estra-1,3, 5(10)-triene-2,3,17-triol;(17beta)- estra-1,3, 5 (10)-triene-2,3,17-triol;(17beta)-estra-1,3,5(10)-triene-2,3,17-triol;1,3,5(10)-estratriene-2,3,17beta-triol;17beta-2-hydroxyestradiol;2,3,17b-trihydroxyestra-1,3,5(10)-triene;2-hydroxy-17beta-estradiol;2-hydroxy-estradiol;2-hydroxyestradiol;2-oh-estradiol;Ecs;Estra-1,3,5 (10)-triene-2,3,17.beta.-triol;Estra-1,3,5(10)-triene-2,3,17-beta-triol;Estra-1,3,5(10)-triene-2,3,17-triol (acd/name 4.0);Estra-1,3,5(10)-triene-2,3,17b-triol;Estra-1,3,5(10)-triene-2,3,17beta-triol;2-hydroxyestradiol-17beta;2-oh-e2;(17b)-estra-1,3,5(10)-triene-2,3,17-triol;(17β)-estra-1,3,5(10)-triene-2,3,17-triol;2-hydroxy-17b-estradiol;2-hydroxy-17β-estradiol;2-hydroxyestradiol-17b;2-hydroxyestradiol-17βPW_C000240Ecs11-MethylhistidineHMDB0000001One-methylhistidine (1-MHis) is derived mainly from the anserine of dietary flesh sources, especially poultry. The enzyme, carnosinase, splits anserine into b-alanine and 1-MHis. High levels of 1-MHis tend to inhibit the enzyme carnosinase and increase anserine levels. Conversely, genetic variants with deficient carnosinase activity in plasma show increased 1-MHis excretions when they consume a high meat diet. Reduced serum carnosinase activity is also found in patients with Parkinson's disease and multiple sclerosis and patients following a cerebrovascular accident. Vitamin E deficiency can lead to 1-methylhistidinuria from increased oxidative effects in skeletal muscle.332-80-9C01152702039750599CPD-182383153DB04151CN1C=NC(C[C@H](N)C(O)=O)=C1C7H11N3O2InChI=1S/C7H11N3O2/c1-10-3-5(9-4-10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)/t6-/m0/s1BRMWTNUJHUMWMS-LURJTMIESA-N(2S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid169.1811169.085126611-1.3921 methylhistidine00FDB0121191 methylhistidine;1-mhis;1-methyl histidine;1-methyl-histidine;1-methyl-l-histidine;1-n-methyl-l-histidine;L-1-methylhistidine;N1-methyl-l-histidine;Pi-methylhistidine;(2s)-2-amino-3-(1-methyl-1h-imidazol-4-yl)propanoic acid;1-methylhistidine;(2s)-2-amino-3-(1-methyl-1h-imidazol-4-yl)propanoatePW_C0000011-Mhis666016661417367152743751422632781581321210551241236191181406888791766Tumor necrosis factorP01375Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiationHMDBP02070TNF6p21.3X01394142442803432288048881344061414057586914088789714201597815'-nucleotidaseP21589Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
HMDBP00001NT5E6q14-q21AF06906713.1.3.5600015166624187541480043288135604372136165211138718653139122771140386811141419237237699-cis-epoxycarotenoid dioxygenase NCED3, chloroplasticQ9LRR7
Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity. Catalyzes the first step of abscisic-acid biosynthesis from carotenoids, in response to water stress.
NCED341.13.11.51172871,4-Alpha-Glucan branching enzymeA1Z992AGBE102.4.1.18; 3.2.1.-309877724081false18543010large20019030987781156false0010regular10011011964571766869212false11501758proteinlarge8030119645812false8253658subunitregular150701196459237692false3502708subunitregular150701196460172872false008subunitregular15070121042212false008subunitregular150703940309877739413098778499811964574999119645850001196459500111964605174121042247148984000.20.20112779811864714906505901.01.00273382584714914005101.01.0021490240471492001.01.0021490240467569M47 295 C79 270 1848 225 1900 295 1false61853.00.08724531500201.01.0160152796394546780113602244142802132796405000751751254417550