PathWhiz

Pathway Description

Metoprolol Metabolic pathway

Homo sapiens

Metabolic Pathway

Metoprolol goes through significant first-pass hepatic metabolism which covers around 50% of the administered dose. The metabolism of metoprolol is mainly driven by the activity of CYP2D63 and to a lesser extent due to the activity of CYP3A4. The metabolism of metoprolol is mainly represented by reactions of hydroxylation and O-demethylation.

References

Metoprolol Metabolic pathway References

Law V, Knox C, Djoumbou Y, Jewison T, Guo AC, Liu Y, Maciejewski A, Arndt D, Wilson M, Neveu V, Tang A, Gabriel G, Ly C, Adamjee S, Dame ZT, Han B, Zhou Y, Wishart DS: DrugBank 4.0: shedding new light on drug metabolism. Nucleic Acids Res. 2014 Jan;42(Database issue):D1091-7. doi: 10.1093/nar/gkt1068. Epub 2013 Nov 6.

Pubmed: 24203711

Highlighted elements will appear in red.

Highlight Compounds

	alpha-Hydroxymetoprolol
	Deisopropylmetoprolol
	Heme
	Metoprolol
	O-Demethylmetoprolol

Highlight Proteins

	Cytochrome P450 2C19
	Cytochrome P450 2D6
	Cytochrome P450 3A4

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