PathWhiz

Pathway Description

Nebivolol Metabolic Pathway

Homo sapiens

Metabolic Pathway

Nebivolol is metabolized mainly by glucuronidation and CYP2D6 mediated hydroxylation. Metabolism involves n-dealkylation, hydroxylation, oxidation, and glucuronidation. Aromatic hydroxyl and acyclic oxide metabolites are active, while n-dealkylated and glucuronides are inactive. (DrugBank)

References

Nebivolol Metabolic Pathway References

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.

Pubmed: 29126136

Highlighted elements will appear in red.

Highlight Compounds

	4-hydroxy Nebivolol
	Heme
	Nebivolol

Highlight Proteins

	Cytochrome P450 2C19
	Cytochrome P450 2D6
	Cytochrome P450 3A4
	Solute carrier organic anion transporter family member 1A2

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