Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0030139
type: UnificationXref
id: GO:0030139
db: GENE ONTOLOGY

Protein/4299/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel protein type 10 subunit alpha
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

Protein/5735/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pro-opiomelanocortin
stoichiometric coefficient: 1.0

TransportCatalysis2094
type: Catalysis
controller: Sodium channel
controlled: Transport10933
control type: ACTIVATION

Acetylcholine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15355
xref: Reference/CAS 51-84-3
xref: Reference/HMDB HMDB0000895
xref: Reference/ChemSpider 182
xref: Reference/KEGG Compound C01996
xref: Reference/BioCyc ACETYLCHOLINE
xref: Reference/PubChem-compound 187
chemical formula: C7H16NO2
molecular weight: 146.1181
structure: ChemicalStructure/PW C000714

Reference/UniProt Q01959
type: UnificationXref
id: Q01959
db: UniProt

Pro-opiomelanocortin
type: Protein
entity reference: Pro-opiomelanocortin

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: Protein
entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Neuronal acetylcholine receptor subunit beta-2
type: Protein
entity reference: Neuronal acetylcholine receptor subunit beta-2

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Neuronal acetylcholine receptor subunit alpha-4
type: Protein
entity reference: Neuronal acetylcholine receptor subunit alpha-4

Glutamate [NMDA] receptor subunit 3A
type: ProteinReference
xref: Reference/UniProt Q8TCU5

Neuroendocrine convertase 2
type: Protein
entity reference: Neuroendocrine convertase 2

Transport11000
type: Transport
participant stoichiometry: Compound/PW C000071 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Extracellular Space/Stoichiometry/1.0
right: γ-Aminobutyric acid
spontaneous: false
left: γ-Aminobutyric acid
name: γ-Aminobutyric acid (?) Transport: Homo sapiens, Neuron, Cytosol to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P40145
type: UnificationXref
id: P40145
db: UniProt

D(1A) dopamine receptor
type: Protein
entity reference: D(1A) dopamine receptor

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: γ-Aminobutyric acid

Reference/UniProt P21728
type: UnificationXref
id: P21728
db: UniProt

Reference/UniProt Q12879
type: UnificationXref
id: Q12879
db: UniProt

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/UniProt Q08462
type: UnificationXref
id: Q08462
db: UniProt

Voltage Gated Potassium Channel
type: Complex
component stoichiometry: Protein/2972/Stoichiometry/4.0
component stoichiometry: Protein/4920/Stoichiometry/4.0
component: Potassium voltage-gated channel subfamily D member 2
component: Kv channel-interacting protein 2

G protein complex
type: Complex
component: Gγ
component: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
component: Guanine nucleotide-binding protein G(i) subunit alpha-1

Protein/1515/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit zeta-1
stoichiometric coefficient: 1.0

Sodium channel
type: Complex
component stoichiometry: Protein/4299/Stoichiometry/1.0
component stoichiometry: Protein/4288/Stoichiometry/1.0
component: Sodium channel protein type 10 subunit alpha
component: Sodium channel subunit beta-1

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

L type Calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/2.0
component stoichiometry: Protein/2712/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Nicotinic Acetylcholine Receptor
type: Complex
component stoichiometry: Protein/5733/Stoichiometry/2.0
component stoichiometry: Protein/5734/Stoichiometry/2.0
component: Neuronal acetylcholine receptor subunit beta-2
component: Neuronal acetylcholine receptor subunit alpha-4

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Gγ
type: Protein
cellular location: Cell Membrane
entity reference: Gγ

Sodium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q07699

Reference/KEGG Compound C00334
type: UnificationXref
id: C00334
db: KEGG Compound

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Transport13651
type: Transport
participant stoichiometry: Compound/PW C001265 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001265 Extracellular Space/Stoichiometry/1.0
right: Substance P
spontaneous: true
left: Substance P
name: Substance P (→) Transport: Homo sapiens, Neuron, Cytoplasm to Homo sapiens, Neuron, Extracellular Space
conversion direction: REVERSIBLE

ProteinComplex/6637 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gβγ
stoichiometric coefficient: 1.0

Reference/UniProt P20309
type: UnificationXref
id: P20309
db: UniProt

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Sodium channel protein type 10 subunit alpha
type: ProteinReference
xref: Reference/UniProt Q9Y5Y9

Glutamate receptor ionotropic
type: Complex
component stoichiometry: Protein/1515/Stoichiometry/1.0
component stoichiometry: Protein/3065/Stoichiometry/1.0
component stoichiometry: Protein/1520/Stoichiometry/1.0
component: Glutamate [NMDA] receptor subunit 3A
component: Glutamate [NMDA] receptor subunit epsilon-1
component: Glutamate [NMDA] receptor subunit zeta-1

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Protein/5734/Stoichiometry/2.0
type: Stoichiometry
physical entity: Neuronal acetylcholine receptor subunit alpha-4
stoichiometric coefficient: 2.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/UniProt O60266
type: UnificationXref
id: O60266
db: UniProt

Transport154
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytoplasm/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Neuron, Cytoplasm to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport153
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytoplasm/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 18357
type: UnificationXref
id: CHEBI:18357
db: ChEBI

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Transport155
type: Transport
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Protein/5733/Stoichiometry/2.0
type: Stoichiometry
physical entity: Neuronal acetylcholine receptor subunit beta-2
stoichiometric coefficient: 2.0

Protein/5703/Stoichiometry/1.0
type: Stoichiometry
physical entity: Beta-endorphin
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/UniProt P17787
type: UnificationXref
id: P17787
db: UniProt

BiologicalState74
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Neuron

GABAA receptor
type: Complex
component stoichiometry: Protein/3425 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1864 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/3418 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Gamma-aminobutyric acid receptor subunit beta-2
component: Gamma-aminobutyric acid receptor subunit alpha-1
component: Gamma-aminobutyric acid receptor subunit gamma-2

Transport158
type: Transport
participant stoichiometry: Compound/PW C000142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
right: Norepinephrine
spontaneous: false
left: Norepinephrine
name: Norepinephrine (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport157
type: Transport
participant stoichiometry: Protein/5703 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/5703/Stoichiometry/1.0
right: Beta-endorphin
spontaneous: false
left: Beta-endorphin
name: Beta-endorphin (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Compound/PW C000714 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylcholine
stoichiometric coefficient: 1.0

Compound/PW C000071 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

Transport161
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
right: Norepinephrine
right: Sodium
spontaneous: false
left: Sodium
left: Norepinephrine
name: Norepinephrine (→), Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C03758
type: UnificationXref
id: C03758
db: KEGG Compound

Transport163
type: Transport
participant stoichiometry: Compound/PW C000458/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052/Stoichiometry/1.0
right: Dopamine
right: Sodium
spontaneous: false
left: Sodium
left: Dopamine
name: Dopamine (→), Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron
conversion direction: LEFT_TO_RIGHT

Transport162
type: Transport
participant stoichiometry: Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000052/Stoichiometry/1.0
right: Dopamine
spontaneous: false
left: Dopamine
name: Dopamine (→) Transport: Homo sapiens, Neuron to Homo sapiens, Neuron, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18243
type: UnificationXref
id: CHEBI:18243
db: ChEBI

Gamma-aminobutyric acid receptor subunit gamma-2
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid receptor subunit gamma-2

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/UniProt P50148
type: UnificationXref
id: P50148
db: UniProt

Gαq (Homo sapiens)_Guanosine diphosphate_Gβγ (Homo sapiens)_Muscarinic acetylcholine receptor M3 (Homo sapiens)
type: Complex
component stoichiometry: Protein/4884 Cell Membrane/Stoichiometry/1.0
component stoichiometry: ProteinComplex/6637 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1740 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Guanosine diphosphate
component: Muscarinic acetylcholine receptor M3
component: Guanine nucleotide-binding protein G(q) subunit alpha
component: Gβγ

Reference/HMDB HMDB0015049
type: UnificationXref
id: HMDB0015049
db: HMDB

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: Reference/UniProt P23975

Compound/PW C001265 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Substance P
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Compound/PW C000071 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0124482
type: UnificationXref
id: SMP0124482
db: SMPDB

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/PubChem-compound 44359816
type: UnificationXref
id: 44359816
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

Mu-type opioid receptor
type: Protein
entity reference: Mu-type opioid receptor

Adenylyl cyclase complex
type: Complex
component: Adenylate cyclase type 3
component: Adenylate cyclase type 9
component: Adenylate cyclase type 1
component: Adenylate cyclase type 6
component: Adenylate cyclase type 8
component: Adenylate cyclase type 5
component: Adenylate cyclase type 2
component: Adenylate cyclase type 4
component: Adenylate cyclase type 7

Reference/UniProt Q9NS61
type: UnificationXref
id: Q9NS61
db: UniProt

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

Compound/PW C000714 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetylcholine
stoichiometric coefficient: 1.0

TransportCatalysis2134
type: Catalysis
controller: L type Calcium channel
controlled: Transport10978
control type: ACTIVATION

Adenylate cyclase type 4
type: ProteinReference
xref: Reference/UniProt Q8NFM4

Adenylate cyclase type 7
type: ProteinReference
xref: Reference/UniProt P51828

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Sodium
type: SmallMolecule
entity reference: Sodium

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

ChemicalStructure/PW C001265
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000052
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CC(O)=C(O)C=C1

Acetylcholine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Acetylcholine

Anileridine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0015049
xref: Reference/CAS 144-14-9
xref: Reference/ChEBI CHEBI 61203
xref: Reference/ChemSpider 8600
xref: Reference/PubChem-compound 8944
chemical formula: C22H28N2O2
molecular weight: 352.2151
structure: ChemicalStructure/PW C009361

Adenylate cyclase type 2
type: Protein
entity reference: Adenylate cyclase type 2

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Reference/UniProt Q9Y5Y9
type: UnificationXref
id: Q9Y5Y9
db: UniProt

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Acetylcholine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Acetylcholine

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Acetylcholine
type: SmallMolecule
cellular location: Endocytic Vesicle
entity reference: Acetylcholine

Guanine nucleotide-binding protein G(q) subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Guanine nucleotide-binding protein G(q) subunit alpha

Adenylate cyclase type 9
type: ProteinReference
xref: Reference/UniProt O60503

Adenylate cyclase type 8
type: ProteinReference
xref: Reference/UniProt P40145

Adenylate cyclase type 1
type: ProteinReference
xref: Reference/UniProt Q08828

Adenylate cyclase type 3
type: ProteinReference
xref: Reference/UniProt O60266

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenylate cyclase type 5
type: ProteinReference
xref: Reference/UniProt O95622

Adenylate cyclase type 6
type: ProteinReference
xref: Reference/UniProt O43306

Interaction3219
type: MolecularInteraction
interaction type: direct_interaction
name: Dopamine activates D(1A) dopamine receptor
participant: Dopamine
participant: D(1A) dopamine receptor

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Reference/CAS 51-84-3
type: UnificationXref
id: 51-84-3
db: CAS

Reference/CAS 51-61-6
type: UnificationXref
id: 51-61-6
db: CAS

Reference/UniProt P01189
type: UnificationXref
id: P01189
db: UniProt

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Beta-endorphin
type: Protein
cellular location: Extracellular Space
entity reference: Beta-endorphin

Reference/BioCyc NOREPINEPHRINE
type: UnificationXref
id: NOREPINEPHRINE
db: BioCyc

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Sodium-dependent dopamine transporter
type: ProteinReference
xref: Reference/UniProt Q01959

Reference/BioCyc DOPAMINE
type: UnificationXref
id: DOPAMINE
db: BioCyc

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Gamma-aminobutyric acid receptor subunit gamma-2
type: ProteinReference
xref: Reference/UniProt P18507
organism: BiologicalState74

Reference/UniProt P18507
type: UnificationXref
id: P18507
db: UniProt

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: Reference/UniProt P50148
organism: BiologicalState74

Interaction3354
type: MolecularInteraction
interaction type: direct_interaction
name: γ-Aminobutyric acid activates GABAA receptor
participant: γ-Aminobutyric acid
participant: GABAA receptor

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/UniProt O43306
type: UnificationXref
id: O43306
db: UniProt

Reference/ChemSpider 661
type: UnificationXref
id: 661
db: ChemSpider

Transport303
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/2.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Glutamate [NMDA] receptor subunit zeta-1
type: ProteinReference
xref: Reference/UniProt Q05586

Interaction3140
type: MolecularInteraction
interaction type: direct_interaction
name: Norepinephrine activates Alpha-1A adrenergic receptor
participant: Norepinephrine
participant: Alpha-1A adrenergic receptor

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/UniProt P62873
type: UnificationXref
id: P62873
db: UniProt

Interaction3389
type: MolecularInteraction
interaction type: direct_interaction
name: Beta-endorphin activates Mu-type opioid receptor
participant: Mu-type opioid receptor
participant: Beta-endorphin

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Adenylate cyclase type 2
type: ProteinReference
xref: Reference/UniProt Q08462

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Glutamate [NMDA] receptor subunit 3A
type: Protein
entity reference: Glutamate [NMDA] receptor subunit 3A

Reference/CAS 144-14-9
type: UnificationXref
id: 144-14-9
db: CAS

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/UniProt P35372
type: UnificationXref
id: P35372
db: UniProt

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

ReactionCatalysis169637
type: Catalysis
controller: Adenylyl cyclase complex
controlled: 4.6.1.1
control type: ACTIVATION

TransportCatalysis2101
type: Catalysis
controller: Voltage Gated Potassium Channel
controlled: Transport10939
control type: ACTIVATION

Kv channel-interacting protein 2
type: ProteinReference
xref: Reference/UniProt Q9NS61

Glutamate [NMDA] receptor subunit epsilon-1
type: ProteinReference
xref: Reference/UniProt Q12879

Compound/PW C001265 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Substance P
stoichiometric coefficient: 1.0

Sodium channel subunit beta-1
type: Protein
entity reference: Sodium channel subunit beta-1

Gamma-aminobutyric acid receptor subunit beta-2
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid receptor subunit beta-2

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Potassium voltage-gated channel subfamily D member 2
type: ProteinReference
xref: Reference/UniProt Q9NZV8

Reference/UniProt Q07699
type: UnificationXref
id: Q07699
db: UniProt

Gβγ
type: Complex
cellular location: Cell Membrane
component: Gβ
component: Gγ

Reference/UniProt P16519
type: UnificationXref
id: P16519
db: UniProt

Sodium channel protein type 10 subunit alpha
type: Protein
entity reference: Sodium channel protein type 10 subunit alpha

Reference/BioCyc 4-AMINO-BUTYRATE
type: UnificationXref
id: 4-AMINO-BUTYRATE
db: BioCyc

Reference/HMDB HMDB0000073
type: UnificationXref
id: HMDB0000073
db: HMDB

Protein/2706/Stoichiometry/2.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000071
type: ChemicalStructure
structure format: SMILES
structure data: NCCCC(O)=O

Protein/2972/Stoichiometry/4.0
type: Stoichiometry
physical entity: Kv channel-interacting protein 2
stoichiometric coefficient: 4.0

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Transport10978
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Compound/PW C000041/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Reference/PathWhiz PW125962
type: UnificationXref
id: PW125962
db: PathWhiz

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000457 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Gβ
type: ProteinReference
xref: Reference/UniProt P62873
organism: BiologicalState74

Protein/3425 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit beta-2
stoichiometric coefficient: 1.0

Reference/CAS 51-41-2
type: UnificationXref
id: 51-41-2
db: CAS

Reference/CAS 33507-63-0
type: UnificationXref
id: 33507-63-0
db: CAS

Dopamine
type: SmallMolecule
entity reference: Dopamine

Reference/HMDB HMDB0000895
type: UnificationXref
id: HMDB0000895
db: HMDB

TransportCatalysis118
type: Catalysis
controller: Nicotinic Acetylcholine Receptor
controlled: Transport155
control type: ACTIVATION

TransportCatalysis117
type: Catalysis
controller: Nicotinic Acetylcholine Receptor
controlled: Transport154
control type: ACTIVATION

TransportCatalysis116
type: Catalysis
controller: Nicotinic Acetylcholine Receptor
controlled: Transport153
control type: ACTIVATION

Reference/UniProt P01203
type: UnificationXref
id: P01203
db: UniProt

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

Sodium-dependent noradrenaline transporter
type: Protein
entity reference: Sodium-dependent noradrenaline transporter

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P63096

Reference/PubChem-compound 119
type: UnificationXref
id: 119
db: PubChem-compound

Alpha-1A adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P35348
organism: BiologicalState74

Reference/UniProt Q8NFM4
type: UnificationXref
id: Q8NFM4
db: UniProt

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Reference/UniProt P51828
type: UnificationXref
id: P51828
db: UniProt

cAMP
type: SmallMolecule
entity reference: cAMP

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Substance P
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Substance P

TransportCatalysis127
type: Catalysis
controller: Sodium-dependent dopamine transporter
controlled: Transport163
control type: ACTIVATION

Reference/UniProt Q8TCU5
type: UnificationXref
id: Q8TCU5
db: UniProt

TransportCatalysis125
type: Catalysis
controller: Sodium-dependent noradrenaline transporter
controlled: Transport161
control type: ACTIVATION

Substance P
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Substance P

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

TransportCatalysis123
type: Catalysis
controller: Glutamate receptor ionotropic
controlled: Transport155
control type: ACTIVATION

Reference/UniProt P59768
type: UnificationXref
id: P59768
db: UniProt

Endocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0030139

Interaction3400
type: MolecularInteraction
interaction type: direct_interaction
name: G protein complex inhibits Adenylyl cyclase complex
participant: G protein complex
participant: Adenylyl cyclase complex

Compound/PW C000457 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Dopamine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Dopamine

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Protein/4920/Stoichiometry/4.0
type: Stoichiometry
physical entity: Potassium voltage-gated channel subfamily D member 2
stoichiometric coefficient: 4.0

Muscarinic acetylcholine receptor M3
type: Protein
cellular location: Cell Membrane
entity reference: Muscarinic acetylcholine receptor M3

Reference/BioCyc ACETYLCHOLINE
type: UnificationXref
id: ACETYLCHOLINE
db: BioCyc

ChemicalStructure/PW C009361
type: ChemicalStructure
structure format: SMILES

Transport10939
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: true
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: REVERSIBLE

Beta-endorphin
type: ProteinReference
xref: Reference/UniProt P01203
organism: BiologicalState74

Reference/UniProt P35348
type: UnificationXref
id: P35348
db: UniProt

Transport10933
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: true
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Neuron, Extracellular Space to Homo sapiens, Neuron, Cytosol
conversion direction: REVERSIBLE

Protein/2712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
stoichiometric coefficient: 1.0

Anileridine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Anileridine

Reference/ChemSpider 23215821
type: UnificationXref
id: 23215821
db: ChemSpider

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/HMDB HMDB0001897
type: UnificationXref
id: HMDB0001897
db: HMDB

Norepinephrine
type: SmallMolecule
entity reference: Norepinephrine

Norepinephrine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00547
xref: Reference/ChEBI CHEBI 18357
xref: Reference/CAS 51-41-2
xref: Reference/HMDB HMDB0000216
xref: Reference/PubChem-compound 439260
xref: Reference/ChemSpider 388394
xref: Reference/BioCyc NOREPINEPHRINE
chemical formula: C8H11NO3
molecular weight: 169.0739
structure: ChemicalStructure/PW C000142

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: Reference/UniProt P62873

Gamma-aminobutyric acid receptor subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P14867
organism: BiologicalState74

Protein/3418 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit alpha-1
stoichiometric coefficient: 1.0

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: γ-Aminobutyric acid

Gγ
type: ProteinReference
xref: Reference/UniProt P59768

Reference/PubChem-compound 681
type: UnificationXref
id: 681
db: PubChem-compound

Reference/UniProt Q9NZV8
type: UnificationXref
id: Q9NZV8
db: UniProt

Protein/4884 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Muscarinic acetylcholine receptor M3
stoichiometric coefficient: 1.0

γ-Aminobutyric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000112
xref: Reference/ChemSpider 116
xref: Reference/PubChem-compound 119
xref: Reference/CAS 56-12-2
xref: Reference/BioCyc 4-AMINO-BUTYRATE
xref: Reference/ChEBI CHEBI 16865
xref: Reference/KEGG Compound C00334
chemical formula: C4H9NO2
molecular weight: 103.06333
structure: ChemicalStructure/PW C000071

Reference/HMDB HMDB0000216
type: UnificationXref
id: HMDB0000216
db: HMDB

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Protein/3065/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit 3A
stoichiometric coefficient: 1.0

Gamma-aminobutyric acid receptor subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid receptor subunit alpha-1

Adenylate cyclase type 4
type: Protein
entity reference: Adenylate cyclase type 4

Adenylate cyclase type 7
type: Protein
entity reference: Adenylate cyclase type 7

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Gamma-aminobutyric acid receptor subunit beta-2
type: ProteinReference
xref: Reference/UniProt P47870
organism: BiologicalState74

Reference/ChEBI CHEBI 16865
type: UnificationXref
id: CHEBI:16865
db: ChEBI

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/UniProt Q05586
type: UnificationXref
id: Q05586
db: UniProt

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Adenylate cyclase type 3
type: Protein
entity reference: Adenylate cyclase type 3

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Adenylate cyclase type 9
type: Protein
entity reference: Adenylate cyclase type 9

ChemicalStructure/PW C000142
type: ChemicalStructure
structure format: SMILES
structure data: NC[C@H](O)C1=CC(O)=C(O)C=C1

Adenylate cyclase type 1
type: Protein
entity reference: Adenylate cyclase type 1

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: γ-Aminobutyric acid

Adenylate cyclase type 6
type: Protein
entity reference: Adenylate cyclase type 6

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Adenylate cyclase type 8
type: Protein
entity reference: Adenylate cyclase type 8

Interaction3537
type: MolecularInteraction
interaction type: direct_interaction
name: Anileridine activates Mu-type opioid receptor
participant: Anileridine
participant: Mu-type opioid receptor

Adenylate cyclase type 5
type: Protein
entity reference: Adenylate cyclase type 5

ReactionCatalysis1410
type: Catalysis
controller: Neuroendocrine convertase 2
controlled: 3.4.21.94
control type: ACTIVATION

Neuroendocrine convertase 2
type: ProteinReference
xref: Reference/UniProt P16519
organism: BiologicalState74

Neuronal acetylcholine receptor subunit alpha-4
type: ProteinReference
xref: Reference/UniProt P43681

Pro-opiomelanocortin
type: ProteinReference
xref: Reference/UniProt P01189
organism: BiologicalState74

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

D(1A) dopamine receptor
type: ProteinReference
xref: Reference/UniProt P21728
organism: BiologicalState74

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Sodium-dependent dopamine transporter
type: Protein
entity reference: Sodium-dependent dopamine transporter

Neuronal acetylcholine receptor subunit beta-2
type: ProteinReference
xref: Reference/UniProt P17787

Interaction3324
type: MolecularInteraction
interaction type: direct_interaction
name: Mu-type opioid receptor activates G protein complex
participant: G protein complex
participant: Mu-type opioid receptor

Muscarinic acetylcholine receptor M3
type: ProteinReference
xref: Reference/UniProt P20309
organism: BiologicalState74

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Reference/HMDB HMDB0000112
type: UnificationXref
id: HMDB0000112
db: HMDB

Reference/ChemSpider 116
type: UnificationXref
id: 116
db: ChemSpider

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/UniProt Q08828
type: UnificationXref
id: Q08828
db: UniProt

Substance P
type: SmallMoleculeReference
xref: Reference/ChemSpider 23215821
xref: Reference/HMDB HMDB0001897
xref: Reference/ChEBI CHEBI 332416
xref: Reference/CAS 33507-63-0
xref: Reference/PubChem-compound 44359816
chemical formula: C63H98N18O13S
molecular weight: 1346.7281
structure: ChemicalStructure/PW C001265

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Compound/PW C000052 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Norepinephrine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Norepinephrine

Dopamine
type: SmallMoleculeReference
xref: Reference/CAS 51-61-6
xref: Reference/KEGG Compound C03758
xref: Reference/ChemSpider 661
xref: Reference/BioCyc DOPAMINE
xref: Reference/HMDB HMDB0000073
xref: Reference/PubChem-compound 681
xref: Reference/ChEBI CHEBI 18243
chemical formula: C8H11NO2
molecular weight: 153.07898
structure: ChemicalStructure/PW C000052

Reference/UniProt P47870
type: UnificationXref
id: P47870
db: UniProt

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/UniProt P14867
type: UnificationXref
id: P14867
db: UniProt

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit zeta-1

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/UniProt O60503
type: UnificationXref
id: O60503
db: UniProt

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Kv channel-interacting protein 2
type: Protein
entity reference: Kv channel-interacting protein 2

Anileridine
type: Pathway
pathway order: PathwayTransport/2499031
pathway order: PathwayTransport/2499008
pathway order: PathwayInteraction/3324
pathway order: PathwayInteraction/3389
pathway order: PathwayInteraction/3400
pathway order: PathwayTransport/2499006
pathway order: PathwayTransport/2499028
pathway order: PathwayTransport/2499007
pathway order: PathwayTransport/2499029
pathway order: PathwayInteraction/3140
pathway order: PathwayTransport/2499020
pathway order: PathwayEnzymeReaction/2499004
pathway order: PathwayEnzymeReaction/2499005
pathway order: PathwayTransport/2499019
pathway order: PathwayInteraction/2867
pathway order: PathwayInteraction/3219
pathway order: PathwayInteraction/3537
pathway order: PathwayTransport/2499013
pathway order: PathwayTransport/2499014
pathway order: PathwayTransport/2499011
pathway order: PathwayTransport/2499012
pathway order: PathwayInteraction/3354
pathway order: PathwayTransport/2499017
pathway order: PathwayTransport/2499018
pathway order: PathwayTransport/2499015
pathway order: PathwayTransport/2499016
pathway component: Transport154
pathway component: Transport153
pathway component: Interaction3140
pathway component: Transport155
pathway component: TransportCatalysis2134
pathway component: Interaction3389
pathway component: Interaction3400
pathway component: Interaction3324
pathway component: Transport13651
pathway component: TransportCatalysis118
pathway component: TransportCatalysis117
pathway component: TransportCatalysis116
pathway component: Transport11092
pathway component: Transport158
pathway component: Transport157
pathway component: 3.4.21.94
pathway component: TransportCatalysis2094
pathway component: Transport10939
pathway component: 4.6.1.1
pathway component: ReactionCatalysis169637
pathway component: Transport161
pathway component: TransportCatalysis2101
pathway component: Transport10978
pathway component: Transport163
pathway component: Transport162
pathway component: Transport10933
pathway component: Interaction3354
pathway component: Transport11000
pathway component: Interaction3537
pathway component: Interaction3219
pathway component: Interaction2867
pathway component: TransportCatalysis127
pathway component: TransportCatalysis125
pathway component: ReactionCatalysis1410
pathway component: TransportCatalysis123
pathway component: Transport303
xref: Reference/PathWhiz PW125962
xref: Reference/SMPDB SMP0124482
organism: Homo sapiens

Compound/PW C000142 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Transport11092
type: Transport
participant stoichiometry: Compound/PW C000714 Endocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000714 Extracellular Space/Stoichiometry/1.0
right: Acetylcholine
spontaneous: false
left: Acetylcholine
name: Acetylcholine (→) Transport: Homo sapiens, Neuron, Endocytic Vesicle to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 332416
type: UnificationXref
id: CHEBI:332416
db: ChEBI

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Potassium voltage-gated channel subfamily D member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily D member 2

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/UniProt P63096
type: UnificationXref
id: P63096
db: UniProt

Protein/1864 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit gamma-2
stoichiometric coefficient: 1.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C000458 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Protein/4288/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Protein/5703 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Beta-endorphin
stoichiometric coefficient: 1.0

3.4.21.94
type: BiochemicalReaction
participant stoichiometry: Protein/5703/Stoichiometry/1.0
participant stoichiometry: Protein/5735/Stoichiometry/1.0
right: Beta-endorphin
spontaneous: false
EC number: 3.4.21.94
left: Pro-opiomelanocortin
name: Pro-opiomelanocortin → Beta-endorphin
conversion direction: LEFT_TO_RIGHT

Compound/PW C000458/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

4.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041/Stoichiometry/1.0
right: cAMP
right: Pyrophosphate
spontaneous: false
EC number: 4.6.1.1
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Compound/PW C000142/Stoichiometry/1.0
type: Stoichiometry
physical entity: Norepinephrine
stoichiometric coefficient: 1.0

Reference/ChemSpider 8600
type: UnificationXref
id: 8600
db: ChemSpider

Mu-type opioid receptor
type: ProteinReference
xref: Reference/UniProt P35372
organism: BiologicalState74

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/UniProt O95622
type: UnificationXref
id: O95622
db: UniProt

ChemicalStructure/PW C000714
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)OCC[N+](C)(C)C

Compound/PW C000052/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Potassium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Potassium

Reference/ChemSpider 388394
type: UnificationXref
id: 388394
db: ChemSpider

Alpha-1A adrenergic receptor
type: Protein
entity reference: Alpha-1A adrenergic receptor

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/UniProt P43681
type: UnificationXref
id: P43681
db: UniProt

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: Protein
entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Sodium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Sodium

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Protein/1520/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate [NMDA] receptor subunit epsilon-1
stoichiometric coefficient: 1.0

Protein/1740 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine nucleotide-binding protein G(q) subunit alpha
stoichiometric coefficient: 1.0

Reference/CAS 56-12-2
type: UnificationXref
id: 56-12-2
db: CAS

Reference/PubChem-compound 439260
type: UnificationXref
id: 439260
db: PubChem-compound

Beta-endorphin
type: Protein
entity reference: Beta-endorphin

Reference/PubChem-compound 8944
type: UnificationXref
id: 8944
db: PubChem-compound

Reference/PubChem-compound 187
type: UnificationXref
id: 187
db: PubChem-compound

Reference/UniProt P23975
type: UnificationXref
id: P23975
db: UniProt

Reference/ChEBI CHEBI 15355
type: UnificationXref
id: CHEBI:15355
db: ChEBI

Reference/KEGG Compound C00547
type: UnificationXref
id: C00547
db: KEGG Compound

Gβ
type: Protein
cellular location: Cell Membrane
entity reference: Gβ

Reference/KEGG Compound C01996
type: UnificationXref
id: C01996
db: KEGG Compound

Mu-type opioid receptor
type: Protein
cellular location: Cell Membrane
entity reference: Mu-type opioid receptor

Gγ
type: Protein
entity reference: Gγ

Interaction2867
type: MolecularInteraction
interaction type: direct_interaction
name: Acetylcholine activates Gαq (Homo sapiens) + Guanosine diphosphate + Gβγ (Homo sapiens) + Muscarinic acetylcholine receptor M3 (Homo sapiens)
participant: Acetylcholine
participant: Gαq (Homo sapiens)_Guanosine diphosphate_Gβγ (Homo sapiens)_Muscarinic acetylcholine receptor M3 (Homo sapiens)

Reference/ChEBI CHEBI 61203
type: UnificationXref
id: CHEBI:61203
db: ChEBI

Reference/ChemSpider 182
type: UnificationXref
id: 182
db: ChemSpider