Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Reference/ChEBI CHEBI 200929
type: UnificationXref
id: CHEBI:200929
db: ChEBI

ReactionCoupledTransportCatalysis4
type: Catalysis
controller: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
controlled: 3.6.3.8
control type: ACTIVATION

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Bupranolol Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2499440
pathway order: PathwayTransport/2499442
pathway order: PathwayInteraction/3555
pathway order: PathwayTransport/2499443
pathway order: PathwayInteraction/2851
pathway order: PathwaySubPathway/116554
pathway order: PathwayTransport/2499441
pathway order: PathwaySubPathway/116557
pathway order: PathwaySubPathway/116558
pathway order: PathwayEnzymeReaction/2499439
pathway order: PathwayTransport/2499444
pathway order: PathwaySubPathway/116555
pathway order: PathwaySubPathway/116556
pathway component: Reaction179579
pathway component: TransportCatalysis9
pathway component: ReactionCoupledTransportCatalysis4
pathway component: Transport35
pathway component: Interaction2851
pathway component: Interaction3555
pathway component: Transport36
pathway component: TransportCatalysis10
pathway component: SubPathwayControl116554
pathway component: SubPathwayControl116555
pathway component: SubPathwayControl116556
pathway component: SubPathwayControl116558
pathway component: TransportCatalysis93
pathway component: 3.6.3.8
pathway component: Muscle Contraction
pathway component: TransportCatalysis90
pathway component: Transport119
xref: Reference/SMPDB SMP0124520
xref: Reference/PathWhiz PW126001
organism: Homo sapiens

TransportCatalysis93
type: Catalysis
controller: Voltage-gated T-type calcium channel (ICaT)
controlled: Transport35
control type: ACTIVATION

direct_interaction
type: InteractionVocabulary

TransportCatalysis90
type: Catalysis
controller: Sodium/calcium exchanger 1
controlled: Transport119
control type: ACTIVATION

ChemicalStructure/PW C009944
type: ChemicalStructure
structure format: SMILES
structure data: CC1=CC(OCC(O)CNC(C)(C)C)=C(Cl)C=C1

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Sodium/calcium exchanger 1
type: Protein
entity reference: Sodium/calcium exchanger 1

Transport119
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
right: Sodium
spontaneous: false
left: Sodium
left: Calcium
name: Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reaction179579
type: BiochemicalReaction
participant stoichiometry: Protein/Generic536 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/507 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium_Troponin
spontaneous: false
left: Troponin
left: Calcium
name: Calcium + Troponin → Calcium + Troponin
conversion direction: LEFT_TO_RIGHT

TransportCatalysis9
type: Catalysis
controller: Voltage-depenent L-type calcium channel
controlled: Transport35
control type: ACTIVATION

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Voltage-gated T-type calcium channel (ICaT)
type: Complex
component: Voltage-dependent T-type calcium channel subunit alpha-1G
component: Voltage-dependent T-type calcium channel subunit alpha-1H

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium
name: SubPathwayActivator

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/1845/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent L-type calcium channel subunit alpha-1C

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/1845 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2706 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2720 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit beta-1
name: SubPathwayActivation

Ryanodine receptor 2
type: ProteinReference
xref: Reference/UniProt Q92736

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Ryanodine receptor 2
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Ryanodine receptor 2

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/PathWhiz PW000728
type: UnificationXref
id: PW000728
db: PathWhiz

Compound/PW C001420 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Calcium_Troponin
type: Complex
component stoichiometry: Protein/Generic536 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Troponin
component: Calcium

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Protein/2720 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Protein/3291 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin beta chain
stoichiometric coefficient: 1.0

Reference/UniProt Q13936
type: UnificationXref
id: Q13936
db: UniProt

Adenosine diphosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Adenosine diphosphate

Reference/UniProt O43497
type: UnificationXref
id: O43497
db: UniProt

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/PubChem-compound 2475
type: UnificationXref
id: 2475
db: PubChem-compound

Reference/CELL TYPE ONTOLOGY CL 0000746
type: UnificationXref
id: CL:0000746
db: CELL TYPE ONTOLOGY

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Protein/3195/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Phosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Phosphate

Reference/UniProt Q92736
type: UnificationXref
id: Q92736
db: UniProt

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Protein/3290 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin alpha-1 chain
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Water

Troponin
type: ProteinReference
organism: BiologicalState50

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
name: SubPathwayActivation

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: ProteinReference
xref: Reference/UniProt P16615
organism: BiologicalState47

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Sodium/calcium exchanger 1
type: ProteinReference
xref: Reference/UniProt P32418

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/UniProt P09493
type: UnificationXref
id: P09493
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Cardiomyocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000746

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Voltage-dependent T-type calcium channel subunit alpha-1G
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1G

Voltage-dependent T-type calcium channel subunit alpha-1H
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1H

BiologicalState47
type: BioSource
cell type: Cardiomyocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Cardiomyocyte

Protein/2706 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 1.0

SubPathwayControl116554
type: Interaction
name: SubPathway116554Control
name: ActivatingSubPathwayControl
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
participant: Voltage-depenent L-type calcium channel

SubPathwayControl116555
type: Interaction
name: SubPathway116555Control
name: ActivatingSubPathwayControl
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: Ryanodine receptor 2
participant: cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2

SubPathwayControl116556
type: Interaction
name: SubPathway116556Control
name: ActivatingSubPathwayControl
participant: Calcium activates Ryanodine receptor 2
participant: Ryanodine receptor 2
participant: Calcium

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

SubPathwayControl116558
type: Interaction
name: SubPathway116558Control
name: ActivatingSubPathwayControl
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP-dependent protein kinase type I-alpha regulatory subunit
participant: Beta-1 adrenergic receptor
participant: G-Protein Signaling Cascade

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

BiologicalState50
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Muscle, Myocyte
tissue: Muscle

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Interaction3555
type: MolecularInteraction
interaction type: direct_interaction
name: Bupranolol inhibits Beta-1 adrenergic receptor ADRB1
participant: Bupranolol
participant: Beta-1 adrenergic receptor

Reference/ChemSpider 2381
type: UnificationXref
id: 2381
db: ChemSpider

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: BiologicalState47

Adenosine triphosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Adenosine triphosphate

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Troponin
type: Protein
cellular location: Cytoplasm
entity reference: Troponin

Bupranolol
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Bupranolol

Reference/SMPDB SMP0000751
type: UnificationXref
id: SMP0000751
db: SMPDB

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

BiologicalState828
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Heart
tissue: Heart

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

TransportCatalysis10
type: Catalysis
controller: Ryanodine receptor 2
controlled: Transport36
control type: ACTIVATION

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195/Stoichiometry/4.0
component: Ryanodine receptor 2

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/UniProt P07951
type: UnificationXref
id: P07951
db: UniProt

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: Reference/UniProt Q13936

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Heart
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000562

Protein/1845/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit alpha-1C
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Compound/PW C001104 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Protein/Generic536 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

SubPathwayInteraction116557
type: Interaction
name: SubPathway116557Reaction
name: SubPathwayReaction
participant: Tropomyosin

Protein/3195 Sarcoplasmic Reticulum/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Tropomyosin
type: Complex
component stoichiometry: Protein/3291 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/3290 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Tropomyosin alpha-1 chain
component: Tropomyosin beta chain
name: SubPathwayInput

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Beta-1 adrenergic receptor
type: Protein
cellular location: Cell Membrane
entity reference: Beta-1 adrenergic receptor
name: SubPathwayActivator

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: Reference/UniProt O43497

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Transport35
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195 Sarcoplasmic Reticulum/Stoichiometry/4.0
cellular location: Sarcoplasmic Reticulum
component: Ryanodine receptor 2
name: SubPathwayActivation

Transport36
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (?) Transport: Homo sapiens, Cardiomyocyte, Sarcoplasmic Reticulum to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha
name: SubPathwayActivation
name: SubPathwayActivator

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Reference/UniProt O95180
type: UnificationXref
id: O95180
db: UniProt

Tropomyosin alpha-1 chain
type: Protein
cellular location: Cytoplasm
entity reference: Tropomyosin alpha-1 chain

Voltage-dependent T-type calcium channel subunit alpha-1H
type: ProteinReference
xref: Reference/UniProt O95180

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Beta-1 adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P08588
organism: BiologicalState828

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState828

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/UniProt P16615
type: UnificationXref
id: P16615
db: UniProt

Interaction2851
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Troponin activates Tropomyosin
participant: Calcium_Troponin
participant: Tropomyosin

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Protein/2706/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

G-Protein Signaling Cascade
type: Pathway
xref: Reference/SMPDB SMP0000751
xref: Reference/PathWhiz PW000728
name: ActivatingSubPathway

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/UniProt P32418
type: UnificationXref
id: P32418
db: UniProt

Ryanodine receptor 2
type: Protein
entity reference: Ryanodine receptor 2

Reference/CAS 14556-46-8
type: UnificationXref
id: 14556-46-8
db: CAS

Reference/SMPDB SMP0124520
type: UnificationXref
id: SMP0124520
db: SMPDB

Compound/PW C000414 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Bupranolol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 200929
xref: Reference/ChemSpider 2381
xref: Reference/HMDB HMDB0015697
xref: Reference/CAS 14556-46-8
xref: Reference/PubChem-compound 2475
chemical formula: C14H22ClNO2
molecular weight: 271.1339
structure: ChemicalStructure/PW C009944

Muscle Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway116557
pathway component: SubPathwayInteraction116557
name: SubPathway

Reference/BRENDA TISSUE ONTOLOGY BTO 0000562
type: UnificationXref
id: BTO:0000562
db: BRENDA TISSUE ONTOLOGY

Calcium activates Ryanodine receptor 2
type: Pathway
name: ActivatingSubPathway

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C001034 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

BoundComplex/507 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Troponin
stoichiometric coefficient: 1.0

Reference/PathWhiz PW126001
type: UnificationXref
id: PW126001
db: PathWhiz

Tropomyosin beta chain
type: Protein
cellular location: Cytoplasm
entity reference: Tropomyosin beta chain

cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2
type: Pathway
name: ActivatingSubPathway

cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
type: Pathway
name: ActivatingSubPathway

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Protein/1845 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit alpha-1C
stoichiometric coefficient: 1.0

Reference/UniProt P08588
type: UnificationXref
id: P08588
db: UniProt

Reference/HMDB HMDB0015697
type: UnificationXref
id: HMDB0015697
db: HMDB

3.6.3.8
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Phosphate
right: Calcium
right: Adenosine diphosphate
spontaneous: false
EC number: 3.6.3.8
left: Adenosine triphosphate
left: Calcium
left: Water
name: Adenosine triphosphate + Calcium + Water → Adenosine diphosphate + Calcium + Phosphate
conversion direction: LEFT_TO_RIGHT

Tropomyosin beta chain
type: ProteinReference
xref: Reference/UniProt P07951
organism: BiologicalState50

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Tropomyosin alpha-1 chain
type: ProteinReference
xref: Reference/UniProt P09493
organism: BiologicalState50

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0