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Pathway Description
Paromomycin Action Pathway (New)
Homo sapiens
Drug Action Pathway
Paromomycin is an aminoglycoside antibiotic that is commonly used to treat acute or chronic intestinal amebiasis and also used in adjunction for managing hepatic comas. It is produced from Streptomyces rimosus var. paromomycinus and acts to inhibit protein synthesis by binding to 16S ribosomal RNA. This halts protein synthesis as paramomycin binds to the A site which impairs any further addition to the polypeptide chain as the tRNA cannot bind to the A site and take on the growing polypeptide chain whilst also adding the amino acid it carrys to the chain. This leads to early termination of the polypeptide leading to a non functional protein being produced, continously inhibition leads to accumulation of defective proteins and bacterial death.
References
Paromomycin Pathway (New) References
Moradzadeh R, Golmohammadi P, Ashraf H, Nadrian H, Fakoorziba MR: Effectiveness of Paromomycin on Cutaneous Leishmaniasis in Iran: A Systematic Review and Meta-Analysis. Iran J Med Sci. 2019 May;44(3):185-195.
Pubmed: 31182884
Kim DH, Chung HJ, Bleys J, Ghohestani RF: Is paromomycin an effective and safe treatment against cutaneous leishmaniasis? A meta-analysis of 14 randomized controlled trials. PLoS Negl Trop Dis. 2009;3(2):e381. doi: 10.1371/journal.pntd.0000381. Epub 2009 Feb 17.
Pubmed: 19221595
Hepburn NC, Tidman MJ, Hunter JA: Aminosidine (paromomycin) versus sodium stibogluconate for the treatment of American cutaneous leishmaniasis. Trans R Soc Trop Med Hyg. 1994 Nov-Dec;88(6):700-3. doi: 10.1016/0035-9203(94)90237-2.
Pubmed: 7886779
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
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