Citalopram is a selective serotonin reuptake inhibitor used to manage depression, anxiety. Off-label indications include but are not limited to: treatment of sexual dysfunction, post-stroke behavioral changes, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy. Citalopram binds selectively to the sodium dependent serotonin transporter and blocks the recycling of serotonin from the synapse. As serotonin accumulates it restores the serotonergic function of the 5-hydroxytryptamine 1A receptor leading to decreased anxiety and depressive moods. Citalopram is usually taken orally. The onset of action for depression is about 2 to 4 weeks. However, the full response may take up 8 to 12 weeks.

Citalopram Pathway (New) References