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Pathway Description
Dicomarol
Homo sapiens
Drug Action Pathway
Dicomarol is an anticoagulant agent that antagonizes the metabolism of vitamin K, by doing so inhibits the function of clotting factors within the body. It appears to target prothrombin, and coagulation factors VII, IX and X. Mainly inhibiting vitamin K reductase, which reduces vitamin K so that it can be used as the cofactor for future reactions. This is commonly used to decrease blood clotting in patients who suffer from deep vein thrombosis which is local cogulation within the circulatory system that can lead to infarction and or a stroke. Dicomarol originates from sweet clover and is often administered through oral ingestion. Try avoiding herbs and supplements that could interfere with anticoagulant activity such as ginseng, ginkgo, ginger and garlic.
References
Dicomarol References
National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 54676038, Dicumarol. Retrieved July 22, 2021 from https://pubchem.ncbi.nlm.nih.gov/compound/Dicumarol.
Timson DJ: Dicoumarol: A Drug which Hits at Least Two Very Different Targets in Vitamin K Metabolism. Curr Drug Targets. 2017;18(5):500-510. doi: 10.2174/1389450116666150722141906.
Pubmed: 26201483
Tie JK, Stafford DW: Structural and functional insights into enzymes of the vitamin K cycle. J Thromb Haemost. 2016 Feb;14(2):236-47. doi: 10.1111/jth.13217. Epub 2016 Jan 29.
Pubmed: 26663892
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