Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

D-Fructose 2,6-bisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001047
xref: Reference/CAS 79082-92-1
xref: Reference/BioCyc CPD-535
xref: Reference/ChEBI CHEBI 28602
xref: Reference/ChemSpider 94762
xref: Reference/KEGG Compound C00665
xref: Reference/PubChem-compound 105021
chemical formula: C6H14O12P2
molecular weight: 339.99606
structure: ChemicalStructure/PW C000825

7.1.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001006 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000846 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: NAD
right: Hydrogen Ion
right: QH2
spontaneous: false
EC number: 7.1.1.2
left: Coenzyme Q10
left: NADH
name: Coenzyme Q10 + NADH → Hydrogen Ion + NAD + QH2
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O75746
type: UnificationXref
id: O75746
db: UniProt

3.1.3.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Glucose 6-phosphate
right: Water
spontaneous: false
EC number: 3.1.3.9
left: Phosphate
left: D-Glucose
name: D-Glucose + Phosphate ← Glucose 6-phosphate + Water
conversion direction: RIGHT_TO_LEFT

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9NX14
organism: BiologicalState26

Reference/CAS 657-24-9
type: UnificationXref
id: 657-24-9
db: CAS

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
type: ProteinReference
xref: Reference/UniProt O43674
organism: BiologicalState26

2.3.1.85
type: BiochemicalReaction
participant stoichiometry: Compound/Generic626 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
right: Coenzyme A
right: Carbon dioxide
right: NADP
right: Long chain fatty acid
right: Water
spontaneous: false
EC number: 2.3.1.85
left: Malonyl-CoA
left: Acetyl-CoA
left: NADPH
name: Acetyl-CoA + Malonyl-CoA + NADPH → Carbon dioxide + Coenzyme A + Long chain fatty acid + NADP + Water
conversion direction: LEFT_TO_RIGHT

6-phosphofructokinase, liver type
type: Complex
component stoichiometry: Protein/706 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: 6-phosphofructokinase, liver type

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
type: ProteinReference
xref: Reference/UniProt O95139
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
type: ProteinReference
xref: Reference/UniProt P56181
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
type: ProteinReference
xref: Reference/UniProt Q9P0J0
organism: BiologicalState26

Reaction217820
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000940 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000911 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Malonyl-CoA
right: Adenosine diphosphate
spontaneous: false
left: Adenosine triphosphate
left: Acetyl-CoA
left: Hydrogen carbonate
name: Acetyl-CoA + Adenosine triphosphate + Hydrogen carbonate → Adenosine diphosphate + Malonyl-CoA
conversion direction: LEFT_TO_RIGHT

Protein kinase A
type: Complex
component stoichiometry: Protein/1315 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3359 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3358 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1990 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1134 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3357 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1262 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: cAMP-dependent protein kinase catalytic subunit alpha
component: cAMP-dependent protein kinase type I-alpha regulatory subunit
component: cAMP-dependent protein kinase type II-alpha regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit beta
component: cAMP-dependent protein kinase type II-beta regulatory subunit
component: cAMP-dependent protein kinase catalytic subunit gamma
component: cAMP-dependent protein kinase type I-beta regulatory subunit

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
type: ProteinReference
xref: Reference/UniProt O75438
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt O95178
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
type: ProteinReference
xref: Reference/UniProt O43676
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
type: ProteinReference
xref: Reference/UniProt O95168
organism: BiologicalState26

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/ChemSpider 58
type: UnificationXref
id: 58
db: ChemSpider

Reference/UniProt P19404
type: UnificationXref
id: P19404
db: UniProt

Compound/PW C001006 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: QH2
stoichiometric coefficient: 1.0

Acyl carrier protein, mitochondrial
type: ProteinReference
xref: Reference/UniProt O14561
organism: BiologicalState26

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Reaction217836
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000644 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000262 Cytosol/Stoichiometry/1.0
right: 2-Phosphoglyceric acid
spontaneous: false
left: 3-Phosphoglyceric acid
name: 3-Phosphoglyceric acid ↔ 2-Phosphoglyceric acid
conversion direction: REVERSIBLE

Triglyceride
type: SmallMolecule
cellular location: Cytosol
entity reference: Triglyceride
name: SubPathwayOutput
name: SubPathwayInput

Reaction217837
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108866 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000262 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Phosphoenolpyruvate
right: Water
spontaneous: false
left: 2-Phosphoglyceric acid
name: 2-Phosphoglyceric acid ↔ Phosphoenolpyruvate + Water
conversion direction: REVERSIBLE

1.1.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000983 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: NADH
right: Glyceric acid 1,3-biphosphate
spontaneous: false
EC number: 1.1.1.8
left: Phosphate
left: NAD
left: D-Glyceraldehyde 3-phosphate
name: D-Glyceraldehyde 3-phosphate + NAD + Phosphate ↔ Glyceric acid 1,3-biphosphate + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reference/PathWhiz PW126190
type: UnificationXref
id: PW126190
db: PathWhiz

Fructose 1,6-bisphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001058
xref: Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
xref: Reference/CAS 488-69-7
xref: Reference/ChEBI CHEBI 16905
xref: Reference/ChemSpider 393165
xref: Reference/KEGG Compound C00354
xref: Reference/PubChem-compound 445557
chemical formula: C6H14O12P2
molecular weight: 339.99606
structure: ChemicalStructure/PW C000833

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

2.7.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000644 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000983 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Glyceric acid 1,3-biphosphate
spontaneous: false
EC number: 2.7.2.3
left: Adenosine triphosphate
left: 3-Phosphoglyceric acid
name: 3-Phosphoglyceric acid + Adenosine triphosphate ↔ Adenosine diphosphate + Glyceric acid 1,3-biphosphate
conversion direction: REVERSIBLE

1.1.1.37
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108868 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108867 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108867 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: NADH
right: Oxaloacetate
spontaneous: false
EC number: 1.1.1.37
left: NAD
left: Malate
name: Malate + NAD ↔ Hydrogen Ion + NADH + Oxaloacetate
conversion direction: REVERSIBLE

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
type: ProteinReference
xref: Reference/UniProt O43920
organism: BiologicalState26

4.1.2.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
right: Dihydroxyacetone phosphate
right: D-Glyceraldehyde 3-phosphate
spontaneous: false
EC number: 4.1.2.13
left: Fructose 1,6-bisphosphate
name: Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate
conversion direction: REVERSIBLE

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
type: ProteinReference
xref: Reference/UniProt O75380
organism: BiologicalState26

Reaction217830
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001083 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Fructose 6-phosphate
spontaneous: false
left: Glucose 6-phosphate
name: Glucose 6-phosphate ↔ Fructose 6-phosphate
conversion direction: REVERSIBLE

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
type: ProteinReference
xref: Reference/UniProt O00217
organism: BiologicalState26

Transport13788
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Liver, Extracellular Space to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt P19404
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt O75306
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
type: ProteinReference
xref: Reference/UniProt O75489
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt P49821
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
type: ProteinReference
xref: Reference/UniProt O43181
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
type: ProteinReference
xref: Reference/UniProt Q9UI09
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
type: ProteinReference
xref: Reference/UniProt Q9NRX3
organism: BiologicalState26

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/HMDB HMDB0001072
type: UnificationXref
id: HMDB0001072
db: HMDB

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Oxoglutaric acid

Reference/UniProt O43920
type: UnificationXref
id: O43920
db: UniProt

Protein/782 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
stoichiometric coefficient: 2.0

Compound/PW C000414 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

2.7.1.40
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108866 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
right: Pyruvate
spontaneous: false
EC number: 2.7.1.40
left: Phosphoenolpyruvate
left: Adenosine diphosphate
name: Adenosine diphosphate + Phosphoenolpyruvate → Adenosine triphosphate + Pyruvate
conversion direction: LEFT_TO_RIGHT

Reaction217845
type: BiochemicalReaction
participant stoichiometry: Protein/835 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/368 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/356 Cytosol/Stoichiometry/1.0
right: Glucose-6-phosphatase
right: Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
spontaneous: false
left: CREB
name: CREB → Glucose-6-phosphatase + Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
conversion direction: LEFT_TO_RIGHT

Reaction217846
type: BiochemicalReaction
participant stoichiometry: Protein/835 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/368 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/357 Cytosol/Stoichiometry/1.0
right: Glucose-6-phosphatase
right: Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
spontaneous: false
left: CRTC2
name: CRTC2 → Glucose-6-phosphatase + Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
conversion direction: LEFT_TO_RIGHT

5'-AMP-activated protein kinase subunit beta-1
type: Protein
cellular location: Cytosol
entity reference: 5'-AMP-activated protein kinase subunit beta-1

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/ChemSpider 5743
type: UnificationXref
id: 5743
db: ChemSpider

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

2.7.4.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.4.3
left: Adenosine monophosphate
left: Adenosine triphosphate
name: Adenosine monophosphate + Adenosine triphosphate ← Adenosine diphosphate
conversion direction: RIGHT_TO_LEFT

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

3.1.4.53
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: Adenosine monophosphate
spontaneous: false
EC number: 3.1.4.53
left: cAMP
left: Water
name: Water + cAMP → Adenosine monophosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

2.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108867 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: L-Glutamic acid
right: Oxaloacetate
spontaneous: false
EC number: 2.6.1.1
left: L-Aspartic acid
left: Oxoglutaric acid
name: L-Aspartic acid + Oxoglutaric acid ↔ L-Glutamic acid + Oxaloacetate
conversion direction: REVERSIBLE

ADP/ATP translocase 4
type: ProteinReference
xref: Reference/UniProt Q9H0C2

Reaction217842
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000825 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: D-Fructose 2,6-bisphosphate
right: Water
spontaneous: false
left: Phosphate
left: Fructose 6-phosphate
name: Fructose 6-phosphate + Phosphate → D-Fructose 2,6-bisphosphate + Water
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
type: ProteinReference
xref: Reference/UniProt O96000
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
type: ProteinReference
xref: Reference/UniProt O43677
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 subunit C2
type: ProteinReference
xref: Reference/UniProt O95298
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
type: ProteinReference
xref: Reference/UniProt P17568
organism: BiologicalState26

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P28331
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
type: ProteinReference
xref: Reference/UniProt P17568
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
type: ProteinReference
xref: Reference/UniProt O95169
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
type: ProteinReference
xref: Reference/UniProt Q9Y6M9
organism: BiologicalState26

DNA/356 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001083
type: ChemicalStructure
structure format: SMILES

Glucagon
type: Protein
cellular location: Extracellular Space
entity reference: Glucagon

Compound/PW C001083 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucose 6-phosphate
stoichiometric coefficient: 1.0

Reference/UniProt O14561
type: UnificationXref
id: O14561
db: UniProt

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

L-Aspartic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Aspartic acid

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GAP
xref: Reference/ChEBI CHEBI 17138
xref: Reference/HMDB HMDB0001112
xref: Reference/ChemSpider 709
xref: Reference/KEGG Compound C00661
xref: Reference/PubChem-compound 729
xref: Reference/CAS 591-59-3
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C000869

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/UniProt O75306
type: UnificationXref
id: O75306
db: UniProt

Protein/3359 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-beta regulatory subunit
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Reference/UniProt O96000
type: UnificationXref
id: O96000
db: UniProt

Reference/KEGG Compound C00236
type: UnificationXref
id: C00236
db: KEGG Compound

Reference/UniProt P54619
type: UnificationXref
id: P54619
db: UniProt

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Phosphoenolpyruvate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoenolpyruvate

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

Compound/PW C000936 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/UniProt O95167
type: UnificationXref
id: O95167
db: UniProt

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit

Reference/UniProt O95169
type: UnificationXref
id: O95169
db: UniProt

Reference/UniProt O95168
type: UnificationXref
id: O95168
db: UniProt

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

5'-AMP-activated protein kinase subunit gamma-1
type: ProteinReference
xref: Reference/UniProt P54619
organism: BiologicalState26

5'-AMP-activated protein kinase subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q9Y478
organism: BiologicalState26

5'-AMP-activated protein kinase catalytic subunit alpha-1
type: ProteinReference
xref: Reference/UniProt Q13131
organism: BiologicalState26

Fructose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructose 6-phosphate

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Compound/PW C000095 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Mitochondrial 2-oxoglutarate/malate carrier protein
type: Protein
entity reference: Mitochondrial 2-oxoglutarate/malate carrier protein

Oxidative Phosphorylation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway116823
pathway component: SubPathwayInteraction116823
name: SubPathway

NADH dehydrogenase
type: Complex
cellular location: Mitochondrial Inner Membrane
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
component: NADH-ubiquinone oxidoreductase chain 4L
component: NADH dehydrogenase [ubiquinone] 1 subunit C2
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
component: NADH-ubiquinone oxidoreductase chain 1
component: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
component: NADH-ubiquinone oxidoreductase chain 5
component: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
component: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
component: NADH-ubiquinone oxidoreductase chain 2
component: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
component: NADH-ubiquinone oxidoreductase chain 6
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
component: NADH-ubiquinone oxidoreductase chain 3
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
component: Acyl carrier protein, mitochondrial
component: Cytochrome c oxidase subunit NDUFA4
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
component: NADH-ubiquinone oxidoreductase chain 4
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
name: SubPathwayInput

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

Insulin resistance
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway116827
pathway component: SubPathwayInteraction116827
name: SubPathway

Triglyceride Synthesis & Storage
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway116826
pathway component: SubPathwayInteraction116826
name: SubPathway

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

Reference/KEGG Compound C11378
type: UnificationXref
id: C11378
db: KEGG Compound

Coenzyme Q10
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001072
xref: Reference/BioCyc UBIQUINONE-10
xref: Reference/PubChem-compound 5281915
xref: Reference/ChemSpider 4445197
xref: Reference/CAS 303-98-0
xref: Reference/KEGG Compound C11378
xref: Reference/ChEBI CHEBI 46245
chemical formula: C59H90O4
molecular weight: 862.6839
structure: ChemicalStructure/PW C000846

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

Reference/UniProt P16118
type: UnificationXref
id: P16118
db: UniProt

NADH-ubiquinone oxidoreductase chain 4L
type: ProteinReference
xref: Reference/UniProt P03901
organism: BiologicalState26

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

NADH-ubiquinone oxidoreductase chain 5
type: ProteinReference
xref: Reference/UniProt P03915
organism: BiologicalState26

DNA/357 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: CRTC2
stoichiometric coefficient: 1.0

NADH-ubiquinone oxidoreductase chain 6
type: ProteinReference
xref: Reference/UniProt P03923
organism: BiologicalState26

Reference/UniProt Q9H0C2
type: UnificationXref
id: Q9H0C2
db: UniProt

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/BioCyc FRUCTOSE-6P
type: UnificationXref
id: FRUCTOSE-6P
db: BioCyc

NADH-ubiquinone oxidoreductase chain 2
type: ProteinReference
xref: Reference/UniProt P03891
organism: BiologicalState26

Glucose-6-phosphatase
type: ProteinReference
xref: Reference/UniProt P35575
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2
type: ProteinReference
xref: Reference/UniProt E9PQ53
organism: BiologicalState26

NADH-ubiquinone oxidoreductase chain 3
type: ProteinReference
xref: Reference/UniProt P03897
organism: BiologicalState26

Reference/PubChem-compound 105021
type: UnificationXref
id: 105021
db: PubChem-compound

NADH-ubiquinone oxidoreductase chain 4
type: ProteinReference
xref: Reference/UniProt P03905
organism: BiologicalState26

Reference/UniProt O95139
type: UnificationXref
id: O95139
db: UniProt

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

NADH-ubiquinone oxidoreductase chain 1
type: ProteinReference
xref: Reference/UniProt P03886
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

NADH-ubiquinone oxidoreductase chain 2
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH-ubiquinone oxidoreductase chain 2

Reference/ChEBI CHEBI 17138
type: UnificationXref
id: CHEBI:17138
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/UniProt P28331
type: UnificationXref
id: P28331
db: UniProt

Pyruvate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyruvate

Reaction217819
type: BiochemicalReaction
participant stoichiometry: Compound/PW C108867 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108866 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytosol/Stoichiometry/1.0
right: Phosphoenolpyruvate
right: Guanosine diphosphate
right: Carbon dioxide
spontaneous: false
left: Guanosine triphosphate
left: Oxaloacetate
name: Guanosine triphosphate + Oxaloacetate → Carbon dioxide + Guanosine diphosphate + Phosphoenolpyruvate
conversion direction: LEFT_TO_RIGHT

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q16795
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
type: ProteinReference
xref: Reference/UniProt O95299
organism: BiologicalState26

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C01352
type: UnificationXref
id: C01352
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
type: ProteinReference
xref: Reference/UniProt Q16718
organism: BiologicalState26

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
type: ProteinReference
xref: Reference/UniProt P56556
organism: BiologicalState26

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
type: ProteinReference
xref: Reference/UniProt O95182
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
type: ProteinReference
xref: Reference/UniProt P51970
organism: BiologicalState26

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
type: ProteinReference
xref: Reference/UniProt O15239
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
type: ProteinReference
xref: Reference/UniProt O43678
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
type: ProteinReference
xref: Reference/UniProt O95167
organism: BiologicalState26

Cytochrome c oxidase subunit NDUFA4
type: ProteinReference
xref: Reference/UniProt O00483
organism: BiologicalState26

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Compound/PW C001280 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,1-Dimethylbiguanide
stoichiometric coefficient: 1.0

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Glutamic acid

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

Reaction110775
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: Pyrophosphate
right: cAMP
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

BiologicalState26
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Protein/706 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: 6-phosphofructokinase, liver type
stoichiometric coefficient: 4.0

Reference/UniProt P06733
type: UnificationXref
id: P06733
db: UniProt

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

Oxaloacetate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxaloacetate
name: SubPathwayInput

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: ProteinReference
xref: Reference/UniProt P21695
organism: BiologicalState26

NADH-ubiquinone oxidoreductase chain 5
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH-ubiquinone oxidoreductase chain 5

Reference/ChemSpider 3949
type: UnificationXref
id: 3949
db: ChemSpider

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

2.7.1.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Fructose 1,6-bisphosphate
spontaneous: false
EC number: 2.7.1.11
left: Adenosine triphosphate
left: Fructose 6-phosphate
name: Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate
conversion direction: LEFT_TO_RIGHT

3.1.3.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000833 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Fructose 6-phosphate
spontaneous: false
EC number: 3.1.3.11
left: Fructose 1,6-bisphosphate
left: Water
name: Fructose 1,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P06744
type: UnificationXref
id: P06744
db: UniProt

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

DNA/357 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: CRTC2
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C040034 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

NADH dehydrogenase
type: Complex
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
component: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
component: Cytochrome c oxidase subunit NDUFA4
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
component: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
component: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
component: NADH-ubiquinone oxidoreductase chain 4L
component: NADH-ubiquinone oxidoreductase chain 4
component: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
component: NADH-ubiquinone oxidoreductase chain 3
component: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
component: NADH-ubiquinone oxidoreductase chain 6
component: NADH-ubiquinone oxidoreductase chain 5
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
component: Acyl carrier protein, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
component: NADH-ubiquinone oxidoreductase chain 2
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
component: NADH-ubiquinone oxidoreductase chain 1
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
component: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
component: NADH dehydrogenase [ubiquinone] 1 subunit C2
component: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
component: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Reference/UniProt Q9Y478
type: UnificationXref
id: Q9Y478
db: UniProt

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

Reference/UniProt O95178
type: UnificationXref
id: O95178
db: UniProt

3-Phosphoglyceric acid
type: SmallMoleculeReference
xref: Reference/BioCyc G3P
xref: Reference/PubChem-compound 724
xref: Reference/ChEBI CHEBI 17050
xref: Reference/ChemSpider 704
xref: Reference/CAS 820-11-1
xref: Reference/KEGG Compound C00597
xref: Reference/HMDB HMDB0000807
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C000644

5.3.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
right: D-Glyceraldehyde 3-phosphate
spontaneous: false
EC number: 5.3.1.1
left: Dihydroxyacetone phosphate
name: Dihydroxyacetone phosphate ↔ D-Glyceraldehyde 3-phosphate
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 4170
type: UnificationXref
id: CHEBI:4170
db: ChEBI

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/BioCyc DPG
type: UnificationXref
id: DPG
db: BioCyc

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

6-phosphofructokinase, liver type
type: Protein
cellular location: Cytosol
entity reference: 6-phosphofructokinase, liver type

Reference/UniProt P30613
type: UnificationXref
id: P30613
db: UniProt

Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001006
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

Reference/ChemSpider 663
type: UnificationXref
id: 663
db: ChemSpider

Reference/UniProt O95182
type: UnificationXref
id: O95182
db: UniProt

3-Phosphoglyceric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Phosphoglyceric acid

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Solute carrier family 22 member 1
type: ProteinReference
xref: Reference/UniProt O15245

Reference/PubChem-compound 724
type: UnificationXref
id: 724
db: PubChem-compound

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Fructose-1,6-bisphosphatase 1
type: ProteinReference
xref: Reference/UniProt P09467
organism: BiologicalState26

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
type: ProteinReference
xref: Reference/UniProt P16118
organism: BiologicalState26

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/KEGG Compound C00085
type: UnificationXref
id: C00085
db: KEGG Compound

Reference/UniProt O75380
type: UnificationXref
id: O75380
db: UniProt

Reference/KEGG Compound C00083
type: UnificationXref
id: C00083
db: KEGG Compound

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Hydrogen Ion

Reference/PubChem-compound 729
type: UnificationXref
id: 729
db: PubChem-compound

Phosphoglycerate mutase 1
type: Protein
cellular location: Cytosol
entity reference: Phosphoglycerate mutase 1

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Glucose-6-phosphate isomerase
type: Complex
component stoichiometry: Protein/751 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Glucose-6-phosphate isomerase

Reference/BioCyc QH2
type: UnificationXref
id: QH2
db: BioCyc

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit gamma
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit gamma

Reference/KEGG Compound C00092
type: UnificationXref
id: C00092
db: KEGG Compound

Reference/BioCyc G3P
type: UnificationXref
id: G3P
db: BioCyc

Glucose-6-phosphate isomerase
type: ProteinReference
xref: Reference/UniProt P06744
organism: BiologicalState26

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Reference/HMDB HMDB0001270
type: UnificationXref
id: HMDB0001270
db: HMDB

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Compound/PW C000869 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

Compound/PW C000986 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 10663
type: UnificationXref
id: 10663
db: PubChem-compound

Reference/HMDB HMDB0001047
type: UnificationXref
id: HMDB0001047
db: HMDB

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Reference/BioCyc FADH2
type: UnificationXref
id: FADH2
db: BioCyc

Reference/ChemSpider 393165
type: UnificationXref
id: 393165
db: ChemSpider

Triosephosphate isomerase
type: Complex
component stoichiometry: Protein/1472 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Triosephosphate isomerase

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

ChemicalStructure/PW C001280
type: ChemicalStructure
structure format: SMILES
structure data: CN(C)C(=N)NC(N)=N

Reference/UniProt P01275
type: UnificationXref
id: P01275
db: UniProt

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

Reference/UniProt P17858
type: UnificationXref
id: P17858
db: UniProt

Protein/1262 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit alpha
stoichiometric coefficient: 1.0

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Adenylate kinase isoenzyme 1
type: ProteinReference
xref: Reference/UniProt P00568
organism: BiologicalState26

Reference/HMDB HMDB0001058
type: UnificationXref
id: HMDB0001058
db: HMDB

Compound/PW C108866 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvate
stoichiometric coefficient: 1.0

Adenylate cyclase type 10
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 10

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Adenosine triphosphate
name: SubPathwayOutput

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Reference/UniProt P56181
type: UnificationXref
id: P56181
db: UniProt

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Reference/UniProt P51970
type: UnificationXref
id: P51970
db: UniProt

NADH-ubiquinone oxidoreductase chain 4
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH-ubiquinone oxidoreductase chain 4

Reference/CAS 820-11-1
type: UnificationXref
id: 820-11-1
db: CAS

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

TransportCatalysis4833
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 2
controlled: Transport13788
control type: ACTIVATION

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/PubChem-compound 446013
type: UnificationXref
id: 446013
db: PubChem-compound

1,1-Dimethylbiguanide
type: SmallMolecule
cellular location: Cytosol
entity reference: 1,1-Dimethylbiguanide

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

Protein/1134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit gamma
stoichiometric coefficient: 1.0

Reference/UniProt P35575
type: UnificationXref
id: P35575
db: UniProt

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

NADH-ubiquinone oxidoreductase chain 6
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH-ubiquinone oxidoreductase chain 6

TransportCatalysis4845
type: Catalysis
controller: Solute carrier family 22 member 1
controlled: Transport13807
control type: ACTIVATION

Triosephosphate isomerase
type: Protein
cellular location: Cytosol
entity reference: Triosephosphate isomerase

TransportCatalysis4843
type: Catalysis
controller: ADP/ATP translocase 4
controlled: Transport13805
control type: ACTIVATION

TransportCatalysis4841
type: Catalysis
controller: Mitochondrial 2-oxoglutarate/malate carrier protein
controlled: Transport13801
control type: ACTIVATION

Reference/UniProt Q16795
type: UnificationXref
id: Q16795
db: UniProt

TransportCatalysis4842
type: Catalysis
controller: NADH dehydrogenase
controlled: Transport13804
control type: ACTIVATION

TransportCatalysis4840
type: Catalysis
controller: Calcium-binding mitochondrial carrier protein Aralar1
controlled: Transport13800
control type: ACTIVATION

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
type: ProteinReference
xref: Reference/UniProt P35558
organism: BiologicalState26

cAMP
type: SmallMolecule
entity reference: cAMP

Reference/CAS 643-13-0
type: UnificationXref
id: 643-13-0
db: CAS

Reference/CAS 1981-49-3
type: UnificationXref
id: 1981-49-3
db: CAS

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

FADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: FADH
name: SubPathwayOutput
name: SubPathwayInput

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Reference/PubChem-compound 59
type: UnificationXref
id: 59
db: PubChem-compound

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
type: Complex
component stoichiometry: Protein/744 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

NADH
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: NADH

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/ChEBI CHEBI 46245
type: UnificationXref
id: CHEBI:46245
db: ChEBI

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Malonyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Malonyl-CoA

Reference/HMDB HMDB0001401
type: UnificationXref
id: HMDB0001401
db: HMDB

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Fructose-1,6-bisphosphatase 1
type: Protein
cellular location: Cytosol
entity reference: Fructose-1,6-bisphosphatase 1

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Triglyceride
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00422

SubPathwayInteraction116821
type: Interaction
name: SubPathway116821Reaction
name: SubPathwayReaction
participant: FADH
participant: Oxaloacetate
participant: NADH

NAD
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: NAD

SubPathwayInteraction116823
type: Interaction
name: SubPathwayReaction
name: SubPathway116823Reaction
participant: NADH dehydrogenase
participant: Adenosine triphosphate
participant: FADH
participant: NADH

Reference/ChEBI CHEBI 15946
type: UnificationXref
id: CHEBI:15946
db: ChEBI

SubPathwayInteraction116826
type: Interaction
name: SubPathway116826Reaction
name: SubPathwayReaction
participant: Triglyceride
participant: Long chain fatty acid

SubPathwayInteraction116827
type: Interaction
name: SubPathway116827Reaction
name: SubPathwayReaction
participant: Triglyceride

2-Phosphoglyceric acid
type: SmallMoleculeReference
xref: Reference/CAS 2553-59-5
xref: Reference/ChemSpider 58
xref: Reference/BioCyc 2-PG
xref: Reference/ChEBI CHEBI 24344
xref: Reference/PubChem-compound 59
xref: Reference/HMDB HMDB0000362
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C000262

Reference/UniProt P40925
type: UnificationXref
id: P40925
db: UniProt

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Reference/UniProt Q9NX14
type: UnificationXref
id: Q9NX14
db: UniProt

Triosephosphate isomerase
type: ProteinReference
xref: Reference/UniProt P60174
organism: BiologicalState26

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/ChEBI CHEBI 28602
type: UnificationXref
id: CHEBI:28602
db: ChEBI

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Fructose 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 643-13-0
xref: Reference/HMDB HMDB0000124
xref: Reference/KEGG Compound C00085
xref: Reference/ChEBI CHEBI 15946
xref: Reference/BioCyc FRUCTOSE-6P
xref: Reference/PubChem-compound 69507
xref: Reference/ChemSpider 62713
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000079

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

Reference/ChEBI CHEBI 15531
type: UnificationXref
id: CHEBI:15531
db: ChEBI

Reference/UniProt Q13085
type: UnificationXref
id: Q13085
db: UniProt

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/UniProt P22694
type: UnificationXref
id: P22694
db: UniProt

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

ChemicalStructure/PW C000262
type: ChemicalStructure
structure format: SMILES
structure data: OCC(OP(O)(O)=O)C(O)=O

Reference/GENE ONTOLOGY GO 0005758
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

DNA/356 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000057
type: UnificationXref
id: SMP0000057
db: SMPDB

Reference/UniProt P35558
type: UnificationXref
id: P35558
db: UniProt

Malate dehydrogenase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt P40925
organism: BiologicalState26

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Compound/PW C000825 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Fructose 2,6-bisphosphate
stoichiometric coefficient: 1.0

NADH-ubiquinone oxidoreductase chain 1
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH-ubiquinone oxidoreductase chain 1

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

cAMP-specific 3',5'-cyclic phosphodiesterase 4B
type: Protein
entity reference: cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Compound/Generic626 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Long chain fatty acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5958
type: UnificationXref
id: 5958
db: PubChem-compound

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: L-Glutamic acid

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Reference/UniProt O43181
type: UnificationXref
id: O43181
db: UniProt

Oxaloacetate
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Oxaloacetate

Solute carrier family 22 member 1
type: Protein
entity reference: Solute carrier family 22 member 1

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: BiologicalState26

Alpha-enolase
type: ProteinReference
xref: Reference/UniProt P06733
organism: BiologicalState26

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Reference/HMDB HMDB0000124
type: UnificationXref
id: HMDB0000124
db: HMDB

Reference/HMDB HMDB0000362
type: UnificationXref
id: HMDB0000362
db: HMDB

Acetyl-CoA carboxylase 1
type: Protein
cellular location: Cytosol
entity reference: Acetyl-CoA carboxylase 1

Malate
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Malate

Protein/1990 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-alpha regulatory subunit
stoichiometric coefficient: 1.0

Compound/PW C000262 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Phosphoglyceric acid
stoichiometric coefficient: 1.0

ReactionCatalysis207368
type: Catalysis
controller: Malate dehydrogenase, cytoplasmic
controlled: 1.1.1.37
control type: ACTIVATION

ChemicalStructure/PW C000846
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ReactionCatalysis207366
type: Catalysis
controller: Alpha-enolase
controlled: Reaction217837
control type: ACTIVATION

ReactionCatalysis207365
type: Catalysis
controller: Phosphoglycerate mutase 1
controlled: Reaction217836
control type: ACTIVATION

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Hydrogen Ion

ReactionCatalysis207364
type: Catalysis
controller: Phosphoglycerate kinase 1
controlled: 2.7.2.3
control type: ACTIVATION

ReactionCatalysis207363
type: Catalysis
controller: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
controlled: 1.1.1.8
control type: ACTIVATION

Reference/UniProt P03905
type: UnificationXref
id: P03905
db: UniProt

ReactionCatalysis207362
type: Catalysis
controller: Fructose-bisphosphate aldolase B
controlled: 4.1.2.13
control type: ACTIVATION

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

D-Glucose
type: SmallMolecule
cellular location: Extracellular Space
entity reference: D-Glucose

Reference/UniProt P03901
type: UnificationXref
id: P03901
db: UniProt

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9NX14
organism: BiologicalState26

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Fructose-bisphosphate aldolase B
type: Protein
cellular location: Cytosol
entity reference: Fructose-bisphosphate aldolase B

Reference/UniProt P03915
type: UnificationXref
id: P03915
db: UniProt

Mitochondrial 2-oxoglutarate/malate carrier protein
type: ProteinReference
xref: Reference/UniProt Q02978

ReactionCatalysis207374
type: Catalysis
controller: Pyruvate kinase PKLR
controlled: 2.7.1.40
control type: ACTIVATION

ReactionCatalysis207373
type: Catalysis
controller: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
controlled: 3.1.4.53
control type: ACTIVATION

ReactionCatalysis207372
type: Catalysis
controller: Adenylate kinase isoenzyme 1
controlled: 2.7.4.3
control type: ACTIVATION

ReactionCatalysis207371
type: Catalysis
controller: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
controlled: Reaction217842
control type: ACTIVATION

Protein/368 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucose-6-phosphatase
stoichiometric coefficient: 1.0

ReactionCatalysis207370
type: Catalysis
controller: Aspartate aminotransferase, mitochondrial
controlled: 2.6.1.1
control type: ACTIVATION

ReactionCatalysis101096
type: Catalysis
controller: Adenylate cyclase type 10
controlled: Reaction110775
control type: ACTIVATION

Reference/UniProt Q16718
type: UnificationXref
id: Q16718
db: UniProt

Acetyl-CoA carboxylase 1
type: ProteinReference
xref: Reference/UniProt Q13085
organism: BiologicalState26

Reference/UniProt P09467
type: UnificationXref
id: P09467
db: UniProt

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

ReactionCatalysis207349
type: Catalysis
controller: Acetyl-CoA carboxylase 1
controlled: Reaction217820
control type: ACTIVATION

Reference/CAS 524-14-1
type: UnificationXref
id: 524-14-1
db: CAS

ReactionCatalysis207348
type: Catalysis
controller: Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
controlled: Reaction217819
control type: ACTIVATION

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

ChemicalStructure/PW C000825
type: ChemicalStructure
structure format: SMILES

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

Coenzyme Q10
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Coenzyme Q10

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/UniProt P03923
type: UnificationXref
id: P03923
db: UniProt

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

ChemicalStructure/PW C000833
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis207359
type: Catalysis
controller: Glucose-6-phosphate isomerase
controlled: Reaction217830
control type: ACTIVATION

ReactionCatalysis207358
type: Catalysis
controller: Glucose-6-phosphatase
controlled: 3.1.3.9
control type: ACTIVATION

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

Reference/BioCyc GLC-6-P
type: UnificationXref
id: GLC-6-P
db: BioCyc

ReactionCatalysis207355
type: Catalysis
controller: NADH dehydrogenase
controlled: 7.1.1.2
control type: ACTIVATION

ReactionCatalysis207350
type: Catalysis
controller: Fatty acid synthase
controlled: 2.3.1.85
control type: ACTIVATION

Reference/ChEBI CHEBI 6801
type: UnificationXref
id: CHEBI:6801
db: ChEBI

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

ChemicalStructure/PW C000644
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C(O)=O

Reference/KEGG Compound C07151
type: UnificationXref
id: C07151
db: KEGG Compound

Compound/PW C001280 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,1-Dimethylbiguanide
stoichiometric coefficient: 1.0

Phosphoglycerate kinase 1
type: Protein
cellular location: Cytosol
entity reference: Phosphoglycerate kinase 1

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt P31321
type: UnificationXref
id: P31321
db: UniProt

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Malonyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15531
xref: Reference/KEGG Compound C00083
xref: Reference/BioCyc MALONYL-COA
xref: Reference/CAS 524-14-1
xref: Reference/HMDB HMDB0001175
xref: Reference/PubChem-compound 10663
xref: Reference/ChemSpider 10213
chemical formula: C24H38N7O19P3S
molecular weight: 853.1156
structure: ChemicalStructure/PW C000911

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Glucose-6-phosphate isomerase
type: Protein
cellular location: Cytosol
entity reference: Glucose-6-phosphate isomerase

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/UniProt P31323
type: UnificationXref
id: P31323
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Reference/UniProt P22612
type: UnificationXref
id: P22612
db: UniProt

5'-AMP-activated protein kinase
type: Complex
cellular location: Cytosol
component: 5'-AMP-activated protein kinase catalytic subunit alpha-1
component: 5'-AMP-activated protein kinase subunit beta-1
component: 5'-AMP-activated protein kinase subunit gamma-1

cAMP-dependent protein kinase type I-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Reference/PathWhiz PW000005
type: UnificationXref
id: PW000005
db: PathWhiz

Compound/PW C000846 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme Q10
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000869
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C=O

Reference/UniProt P05062
type: UnificationXref
id: P05062
db: UniProt

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Compound/PW C108867 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Solute carrier family 2, facilitated glucose transporter member 2
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 2

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: Complex
component stoichiometry: Protein/782 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

CREB
type: Dna
cellular location: Cytosol
entity reference: CREB

Compound/PW C040034 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

NADH-ubiquinone oxidoreductase chain 4L
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH-ubiquinone oxidoreductase chain 4L

Aspartate aminotransferase, mitochondrial
type: Protein
cellular location: Mitochondrial Intermembrane Space
entity reference: Aspartate aminotransferase, mitochondrial

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/CAS 2553-59-5
type: UnificationXref
id: 2553-59-5
db: CAS

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Malate dehydrogenase, cytoplasmic
type: Protein
cellular location: Cytosol
entity reference: Malate dehydrogenase, cytoplasmic

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP

Glucose-6-phosphatase
type: Protein
cellular location: Cytosol
entity reference: Glucose-6-phosphatase

direct_interaction
type: InteractionVocabulary

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

Phosphoglycerate mutase 1
type: ProteinReference
xref: Reference/UniProt P18669
organism: BiologicalState26

Reference/PubChem-compound 4091
type: UnificationXref
id: 4091
db: PubChem-compound

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Compound/PW C000041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Pyruvate kinase PKLR
type: Complex
component stoichiometry: Protein/712 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Pyruvate kinase isozymes R/L

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

2-Phosphoglyceric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Phosphoglyceric acid

D-Fructose 2,6-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Fructose 2,6-bisphosphate

Aspartate aminotransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P00505
organism: BiologicalState26

Reference/HMDB HMDB0001197
type: UnificationXref
id: HMDB0001197
db: HMDB

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Reference/PubChem-compound 5281915
type: UnificationXref
id: 5281915
db: PubChem-compound

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

FADH
type: SmallMoleculeReference
xref: Reference/PubChem-compound 446013
xref: Reference/ChEBI CHEBI 17877
xref: Reference/BioCyc FADH2
xref: Reference/KEGG Compound C01352
xref: Reference/ChemSpider 393487
xref: Reference/HMDB HMDB0001197
xref: Reference/CAS 1910-41-4
chemical formula: C27H35N9O15P2
molecular weight: 787.1728
structure: ChemicalStructure/PW C000932

Reference/ChemSpider 709
type: UnificationXref
id: 709
db: ChemSpider

Compound/PW C000123 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/ChemSpider 704
type: UnificationXref
id: 704
db: ChemSpider

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/CAS 488-69-7
type: UnificationXref
id: 488-69-7
db: CAS

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Glyceric acid 1,3-biphosphate
type: SmallMoleculeReference
xref: Reference/CAS 1981-49-3
xref: Reference/ChemSpider 663
xref: Reference/BioCyc DPG
xref: Reference/HMDB HMDB0001270
xref: Reference/KEGG Compound C00236
xref: Reference/PubChem-compound 683
chemical formula: C3H8O10P2
molecular weight: 265.95926
structure: ChemicalStructure/PW C000983

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Adenylate kinase isoenzyme 1
type: Protein
cellular location: Cytosol
entity reference: Adenylate kinase isoenzyme 1

Alpha-enolase
type: Protein
cellular location: Cytosol
entity reference: Alpha-enolase

Reference/UniProt Q02978
type: UnificationXref
id: Q02978
db: UniProt

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00597
type: UnificationXref
id: C00597
db: KEGG Compound

Reference/KEGG Compound C00354
type: UnificationXref
id: C00354
db: KEGG Compound

Reference/UniProt P60174
type: UnificationXref
id: P60174
db: UniProt

Reference/ChemSpider 94762
type: UnificationXref
id: 94762
db: ChemSpider

Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Fructose 1,6-bisphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fructose 1,6-bisphosphate

Fatty acid synthase
type: ProteinReference
xref: Reference/UniProt P49327
organism: BiologicalState26

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000932
type: ChemicalStructure
structure format: SMILES

CRTC2
type: Dna
cellular location: Cytosol
entity reference: CRTC2

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH
name: SubPathwayOutput
name: SubPathwayInput

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/CAS 1910-41-4
type: UnificationXref
id: 1910-41-4
db: CAS

Reference/UniProt Q9UI09
type: UnificationXref
id: Q9UI09
db: UniProt

Reference/UniProt Q9NRX3
type: UnificationXref
id: Q9NRX3
db: UniProt

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Protein/278 Mitochondrial Intermembrane Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Aspartate aminotransferase, mitochondrial
stoichiometric coefficient: 2.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Compound/PW C000123 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/UniProt P17568
type: UnificationXref
id: P17568
db: UniProt

Reference/UniProt O00483
type: UnificationXref
id: O00483
db: UniProt

Adenosine monophosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine monophosphate

Calcium-binding mitochondrial carrier protein Aralar1
type: Protein
entity reference: Calcium-binding mitochondrial carrier protein Aralar1

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

CREB
type: Dna
cellular location: Nucleus
entity reference: CREB

Reference/UniProt O75438
type: UnificationXref
id: O75438
db: UniProt

Reference/UniProt P18669
type: UnificationXref
id: P18669
db: UniProt

Reference/ChemSpider 62713
type: UnificationXref
id: 62713
db: ChemSpider

ChemicalStructure/PW C000911
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00390
type: UnificationXref
id: C00390
db: KEGG Compound

Reference/CAS 56275-39-9
type: UnificationXref
id: 56275-39-9
db: CAS

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Water
type: SmallMolecule
entity reference: Water

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose

Reference/UniProt Q9P0J0
type: UnificationXref
id: Q9P0J0
db: UniProt

ChemicalStructure/PW C108867
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

ChemicalStructure/PW C108866
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Long chain fatty acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Long chain fatty acid
name: SubPathwayInput

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

ChemicalStructure/PW C108868
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CC(O)=O)C(O)=O

Compound/PW C000463 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Malate
type: SmallMolecule
cellular location: Cytosol
entity reference: Malate

cAMP-dependent protein kinase type II-beta regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit

Reference/ChemSpider 4445197
type: UnificationXref
id: 4445197
db: ChemSpider

Reference/CAS 303-98-0
type: UnificationXref
id: 303-98-0
db: CAS

Reference/HMDB HMDB0001112
type: UnificationXref
id: HMDB0001112
db: HMDB

Malate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Malate

Pyruvate kinase isozymes R/L
type: Protein
cellular location: Cytosol
entity reference: Pyruvate kinase isozymes R/L

Reference/UniProt O95299
type: UnificationXref
id: O95299
db: UniProt

Reference/UniProt O95298
type: UnificationXref
id: O95298
db: UniProt

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/UniProt O75489
type: UnificationXref
id: O75489
db: UniProt

Reference/CAS 591-59-3
type: UnificationXref
id: 591-59-3
db: CAS

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P49327
type: UnificationXref
id: P49327
db: UniProt

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

L-Aspartic acid
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: L-Aspartic acid

Transport13809
type: Transport
participant stoichiometry: DNA/356 Nucleus/Stoichiometry/1.0
participant stoichiometry: DNA/356 Cytosol/Stoichiometry/1.0
right: CREB
spontaneous: false
left: CREB
name: CREB (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Nucleus
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O00217
type: UnificationXref
id: O00217
db: UniProt

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

Transport13805
type: Transport
participant stoichiometry: Compound/PW C000414 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine triphosphate
right: Adenosine diphosphate
spontaneous: false
left: Adenosine triphosphate
left: Adenosine diphosphate
name: Adenosine triphosphate (→), Adenosine diphosphate (←) Transport: Homo sapiens, Liver, Hepatocyte, Mitochondrial Intermembrane Space to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport13808
type: Transport
participant stoichiometry: DNA/357 Nucleus/Stoichiometry/1.0
participant stoichiometry: DNA/357 Cytosol/Stoichiometry/1.0
right: CRTC2
spontaneous: false
left: CRTC2
name: CRTC2 (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Nucleus
conversion direction: LEFT_TO_RIGHT

Transport13807
type: Transport
participant stoichiometry: Compound/PW C001280 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001280 Extracellular Space/Stoichiometry/1.0
right: 1,1-Dimethylbiguanide
spontaneous: false
left: 1,1-Dimethylbiguanide
name: 1,1-Dimethylbiguanide (→) Transport: Homo sapiens, Liver, Extracellular Space to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Transport13802
type: Transport
participant stoichiometry: Compound/PW C108868 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108868 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: Malate
spontaneous: false
left: Malate
name: Malate (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Transport13801
type: Transport
participant stoichiometry: Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108868 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: Malate
right: Oxoglutaric acid
spontaneous: false
left: Malate
left: Oxoglutaric acid
name: Malate (←), Oxoglutaric acid (→) Transport: Homo sapiens, Liver, Hepatocyte, Mitochondrial Matrix to Homo sapiens, Liver, Hepatocyte, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Transport13804
type: Transport
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: Hydrogen Ion
spontaneous: false
left: Hydrogen Ion
name: Hydrogen Ion (→) Transport: Homo sapiens, Liver, Hepatocyte, Mitochondrial Matrix to Homo sapiens, Liver, Hepatocyte, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Transport13803
type: Transport
participant stoichiometry: Compound/PW C108867 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C108867 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: Oxaloacetate
spontaneous: false
left: Oxaloacetate
name: Oxaloacetate (→) Transport: Homo sapiens, Liver, Hepatocyte, Mitochondrial Intermembrane Space to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport13800
type: Transport
participant stoichiometry: Compound/PW C000095 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: L-Aspartic acid
right: L-Glutamic acid
spontaneous: false
left: L-Aspartic acid
left: L-Glutamic acid
name: L-Aspartic acid (→), L-Glutamic acid (←) Transport: Homo sapiens, Liver, Hepatocyte, Mitochondrial Matrix to Homo sapiens, Liver, Hepatocyte, Mitochondrial Intermembrane Space
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 445557
type: UnificationXref
id: 445557
db: PubChem-compound

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17050
type: UnificationXref
id: CHEBI:17050
db: ChEBI

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

5'-AMP-activated protein kinase catalytic subunit alpha-1
type: Protein
cellular location: Cytosol
entity reference: 5'-AMP-activated protein kinase catalytic subunit alpha-1

NADH dehydrogenase [ubiquinone] 1 subunit C2
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 subunit C2

Reference/UniProt P11168
type: UnificationXref
id: P11168
db: UniProt

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
type: Protein
cellular location: Cytosol
entity reference: Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Protein/1472 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Triosephosphate isomerase
stoichiometric coefficient: 2.0

Reference/UniProt O43676
type: UnificationXref
id: O43676
db: UniProt

Reference/UniProt O43678
type: UnificationXref
id: O43678
db: UniProt

Reference/UniProt O43677
type: UnificationXref
id: O43677
db: UniProt

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/UniProt O43674
type: UnificationXref
id: O43674
db: UniProt

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

cAMP-specific 3',5'-cyclic phosphodiesterase 4B
type: Protein
cellular location: Cytosol
entity reference: cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Cytochrome c oxidase subunit NDUFA4
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit NDUFA4

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Phosphoglycerate kinase 1
type: ProteinReference
xref: Reference/UniProt P00558
organism: BiologicalState26

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Metformin Action Pathway (New)
type: Pathway
pathway order: PathwayEnzymeReaction/2501413
pathway order: PathwayEnzymeReaction/2501457
pathway order: PathwayEnzymeReaction/2501379
pathway order: PathwayEnzymeReaction/2501410
pathway order: PathwayEnzymeReaction/2501376
pathway order: PathwayEnzymeReaction/2501453
pathway order: PathwayEnzymeReaction/2501418
pathway order: PathwayEnzymeReaction/2501417
pathway order: PathwayInteraction/3729
pathway order: PathwayInteraction/3728
pathway order: PathwayInteraction/3727
pathway order: PathwayInteraction/3725
pathway order: PathwayInteraction/2835
pathway order: PathwayInteraction/3724
pathway order: PathwayInteraction/3723
pathway order: PathwayInteraction/3722
pathway order: PathwaySubPathway/116821
pathway order: PathwayEnzymeReaction/2501449
pathway order: PathwayEnzymeReaction/2501448
pathway order: PathwaySubPathway/116826
pathway order: PathwaySubPathway/116823
pathway order: PathwayEnzymeReaction/2501401
pathway order: PathwayTransport/2501407
pathway order: PathwayEnzymeReaction/2501400
pathway order: PathwayEnzymeReaction/2501488
pathway order: PathwaySubPathway/116827
pathway order: PathwayTransport/2501403
pathway order: PathwayTransport/2501404
pathway order: PathwayTransport/2501374
pathway order: PathwayTransport/2501451
pathway order: PathwayEnzymeReaction/2501477
pathway order: PathwayEnzymeReaction/2501475
pathway order: PathwayTransport/2501415
pathway order: PathwayInteraction/3743
pathway order: PathwayInteraction/3742
pathway order: PathwayInteraction/3740
pathway order: PathwayEnzymeReaction/2501472
pathway order: PathwayEnzymeReaction/2501471
pathway order: PathwayEnzymeReaction/2501390
pathway order: PathwayEnzymeReaction/2501426
pathway order: PathwayTransport/2501428
pathway order: PathwayEnzymeReaction/2501387
pathway order: PathwayTransport/2501469
pathway order: PathwayTransport/2501468
pathway order: PathwayTransport/2501427
pathway order: PathwayEnzymeReaction/2501429
pathway order: PathwayInteraction/3739
pathway order: PathwayInteraction/3737
pathway order: PathwayInteraction/3735
pathway order: PathwayInteraction/3733
pathway order: PathwayInteraction/3732
pathway order: PathwayInteraction/3731
pathway order: PathwayInteraction/3730
pathway order: PathwayEnzymeReaction/2501383
pathway order: PathwayEnzymeReaction/2501382
pathway order: PathwayEnzymeReaction/2501381
pathway component: 7.1.1.2
pathway component: TransportCatalysis4833
pathway component: 3.1.3.9
pathway component: Interaction3740
pathway component: Interaction3742
pathway component: Interaction3743
pathway component: 2.3.1.85
pathway component: ReactionCatalysis207368
pathway component: Reaction217820
pathway component: ReactionCatalysis207366
pathway component: ReactionCatalysis207365
pathway component: ReactionCatalysis207364
pathway component: ReactionCatalysis207363
pathway component: ReactionCatalysis207362
pathway component: ReactionCatalysis347
pathway component: 2.7.1.11
pathway component: TransportCatalysis4845
pathway component: Reaction217836
pathway component: 3.1.3.11
pathway component: Reaction217837
pathway component: ReactionCatalysis342
pathway component: 1.1.1.8
pathway component: TransportCatalysis4843

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Compound/PW C001034 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit beta
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit beta

Reference/CAS 56-73-5
type: UnificationXref
id: 56-73-5
db: CAS

Reference/BioCyc 2-PG
type: UnificationXref
id: 2-PG
db: BioCyc

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Protein/744 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
stoichiometric coefficient: 2.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000079
type: ChemicalStructure
structure format: SMILES

Compound/PW C000911 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malonyl-CoA
stoichiometric coefficient: 1.0

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Protein/835 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
stoichiometric coefficient: 1.0

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/UniProt Q07343
type: UnificationXref
id: Q07343
db: UniProt

Glucagon receptor
type: ProteinReference
xref: Reference/UniProt P47871
organism: BiologicalState26

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

Serine/threonine-protein kinase SIK2
type: ProteinReference
xref: Reference/UniProt Q9H0K1
organism: BiologicalState26

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Compound/PW C000041/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Protein/748 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Fructose-1,6-bisphosphatase 1
stoichiometric coefficient: 4.0

cAMP-specific 3',5'-cyclic phosphodiesterase 4B
type: ProteinReference
xref: Reference/UniProt Q07343

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Reference/HMDB HMDB0001175
type: UnificationXref
id: HMDB0001175
db: HMDB

Compound/PW C001134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-535
type: UnificationXref
id: CPD-535
db: BioCyc

6-phosphofructokinase, liver type
type: ProteinReference
xref: Reference/UniProt P17858
organism: BiologicalState26

Adenylate cyclase type 10
type: ProteinReference
xref: Reference/UniProt Q96PN6
organism: BiologicalState26

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: Reference/UniProt P22694
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Interaction3740
type: MolecularInteraction
interaction type: direct_interaction
name: 5'-AMP-activated protein kinase inhibits CRTC2
participant: 5'-AMP-activated protein kinase
participant: CRTC2

Interaction3742
type: MolecularInteraction
interaction type: direct_interaction
name: 5'-AMP-activated protein kinase activates cAMP-specific 3',5'-cyclic phosphodiesterase 4B
participant: 5'-AMP-activated protein kinase
participant: cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Glucagon receptor
type: Protein
cellular location: Extracellular Space
entity reference: Glucagon receptor

Interaction3743
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase A inhibits Pyruvate kinase PKLR
participant: Protein kinase A
participant: Pyruvate kinase PKLR

Compound/PW C000983 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceric acid 1,3-biphosphate
stoichiometric coefficient: 1.0

Compound/PW C000833 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 1,6-bisphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Acetyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Acetyl-CoA

Serine/threonine-protein kinase SIK2
type: Protein
cellular location: Cytosol
entity reference: Serine/threonine-protein kinase SIK2

QH2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001304
xref: Reference/BioCyc QH2
xref: Reference/PubChem-compound 5280344
xref: Reference/KEGG Compound C00390
xref: Reference/CAS 56275-39-9
xref: Reference/ChemSpider 4444052
chemical formula: (C5H8)nC14H20O4
structure: ChemicalStructure/PW C001006

Interaction3730
type: MolecularInteraction
interaction type: direct_interaction
name: 1,1-Dimethylbiguanide activates 5'-AMP-activated protein kinase
participant: 1,1-Dimethylbiguanide
participant: 5'-AMP-activated protein kinase

NADH-ubiquinone oxidoreductase chain 3
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH-ubiquinone oxidoreductase chain 3

Interaction3731
type: MolecularInteraction
interaction type: direct_interaction
name: Adenosine monophosphate inhibits Adenylate Cyclase
participant: Adenosine monophosphate
participant: Adenylate cyclase type 10

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Interaction3732
type: MolecularInteraction
interaction type: direct_interaction
name: Glucagon receptor activates Adenylate Cyclase
participant: Glucagon receptor
participant: Adenylate cyclase type 10

Pyruvate kinase isozymes R/L
type: ProteinReference
xref: Reference/UniProt P30613
organism: BiologicalState26

Compound/PW C108868 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malate
stoichiometric coefficient: 1.0

Interaction3737
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase A activates CREB
participant: Protein kinase A
participant: CREB

Interaction3739
type: MolecularInteraction
interaction type: direct_interaction
name: Serine/threonine-protein kinase SIK2 inhibits CRTC2
participant: Serine/threonine-protein kinase SIK2
participant: CRTC2

Interaction3733
type: MolecularInteraction
interaction type: direct_interaction
name: Glucagon activates Glucagon receptor
participant: Glucagon
participant: Glucagon receptor

Interaction3735
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase A inhibits Serine/threonine-protein kinase SIK2
participant: Protein kinase A
participant: Serine/threonine-protein kinase SIK2

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

CRTC2
type: Dna
cellular location: Nucleus
entity reference: CRTC2

1,1-Dimethylbiguanide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: 1,1-Dimethylbiguanide

CREB
type: DnaReference
organism: BiologicalState26

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

CRTC2
type: DnaReference
organism: BiologicalState26

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

Reference/UniProt Q13131
type: UnificationXref
id: Q13131
db: UniProt

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChEBI CHEBI 16905
type: UnificationXref
id: CHEBI:16905
db: ChEBI

Phosphoenolpyruvate
type: SmallMoleculeReference
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C108866

Reference/UniProt P03886
type: UnificationXref
id: P03886
db: UniProt

Reference/ChemSpider 393487
type: UnificationXref
id: 393487
db: ChemSpider

Oxaloacetate
type: SmallMoleculeReference
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C108867

Malate
type: SmallMoleculeReference
chemical formula: C4H6O5
molecular weight: 134.02153
structure: ChemicalStructure/PW C108868

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine triphosphate

Pyruvate
type: SmallMoleculeReference

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Citric Acid Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway116821
pathway component: SubPathwayInteraction116821
xref: Reference/PathWhiz PW000005
xref: Reference/SMPDB SMP0000057
name: SubPathway

Compound/PW C001144 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/UniProt P03891
type: UnificationXref
id: P03891
db: UniProt

Guanosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine diphosphate

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit

Reference/UniProt Q96PN6
type: UnificationXref
id: Q96PN6
db: UniProt

Glucagon receptor
type: Protein
cellular location: Cell Membrane
entity reference: Glucagon receptor

Oxaloacetate
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxaloacetate

Compound/PW C000644 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Phosphoglyceric acid
stoichiometric coefficient: 1.0

Acyl carrier protein, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Acyl carrier protein, mitochondrial

Compound/PW C108867 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/UniProt P03897
type: UnificationXref
id: P03897
db: UniProt

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Solute carrier family 2, facilitated glucose transporter member 2
type: ProteinReference
xref: Reference/UniProt P11168

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/PubChem-compound 683
type: UnificationXref
id: 683
db: PubChem-compound

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Reference/HMDB HMDB0001304
type: UnificationXref
id: HMDB0001304
db: HMDB

Reference/UniProt P49821
type: UnificationXref
id: P49821
db: UniProt

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/UniProt P13861
type: UnificationXref
id: P13861
db: UniProt

Aspartate aminotransferase, mitochondrial
type: Complex
component stoichiometry: Protein/278 Mitochondrial Intermembrane Space/Stoichiometry/2.0
cellular location: Mitochondrial Intermembrane Space
component: Aspartate aminotransferase, mitochondrial

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/SMPDB SMP0124705
type: UnificationXref
id: SMP0124705
db: SMPDB

1,1-Dimethylbiguanide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C07151
xref: Reference/HMDB HMDB0001921
xref: Reference/CAS 657-24-9
xref: Reference/PubChem-compound 4091
xref: Reference/ChEBI CHEBI 6801
xref: Reference/ChemSpider 3949
chemical formula: C4H11N5
molecular weight: 129.10144
structure: ChemicalStructure/PW C001280

Compound/PW C000721 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/UniProt P00558
type: UnificationXref
id: P00558
db: UniProt

Compound/PW C108868 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malate
stoichiometric coefficient: 1.0

Reference/CAS 79082-92-1
type: UnificationXref
id: 79082-92-1
db: CAS

BiologicalState911
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Protein/1315 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase catalytic subunit beta
stoichiometric coefficient: 1.0

Compound/PW C000940 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Fructose-bisphosphate aldolase B
type: ProteinReference
xref: Reference/UniProt P05062
organism: BiologicalState26

Protein/3357 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type I-beta regulatory subunit
stoichiometric coefficient: 1.0

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen carbonate

Reference/UniProt P00568
type: UnificationXref
id: P00568
db: UniProt

Reference/PubChem-compound 69507
type: UnificationXref
id: 69507
db: PubChem-compound

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: Reference/UniProt P22612
organism: BiologicalState26

Protein/712 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Pyruvate kinase isozymes R/L
stoichiometric coefficient: 4.0

Reference/ChemSpider 4444052
type: UnificationXref
id: 4444052
db: ChemSpider

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

Reference/UniProt Q9Y6M9
type: UnificationXref
id: Q9Y6M9
db: UniProt

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/PubChem-compound 5280344
type: UnificationXref
id: 5280344
db: PubChem-compound

Reference/ChEBI CHEBI 24344
type: UnificationXref
id: CHEBI:24344
db: ChEBI

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Long chain fatty acid
type: SmallMoleculeReference

Reference/UniProt P47871
type: UnificationXref
id: P47871
db: UniProt

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glyceraldehyde 3-phosphate

Malate dehydrogenase, cytoplasmic
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Malate dehydrogenase, cytoplasmic

Reference/UniProt P56556
type: UnificationXref
id: P56556
db: UniProt

Compound/PW C000134 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

5'-AMP-activated protein kinase subunit gamma-1
type: Protein
cellular location: Cytosol
entity reference: 5'-AMP-activated protein kinase subunit gamma-1

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Adenylate cyclase type 10
type: Protein
cellular location: Cell Membrane
entity reference: Adenylate cyclase type 10

Reference/HMDB HMDB0000807
type: UnificationXref
id: HMDB0000807
db: HMDB

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroxyacetone phosphate

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/UniProt P21695
type: UnificationXref
id: P21695
db: UniProt

Protein/751 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glucose-6-phosphate isomerase
stoichiometric coefficient: 2.0

Glucose 6-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00092
xref: Reference/BioCyc GLC-6-P
xref: Reference/HMDB HMDB0001401
xref: Reference/PubChem-compound 5958
xref: Reference/ChemSpider 5743
xref: Reference/CAS 56-73-5
xref: Reference/ChEBI CHEBI 4170
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001083

Compound/PW C108867 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxaloacetate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17877
type: UnificationXref
id: CHEBI:17877
db: ChEBI

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

ChemicalStructure/PW C000983
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP(O)(O)=O)C(=O)OP(O)(O)=O

Protein/3358 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP-dependent protein kinase type II-alpha regulatory subunit
stoichiometric coefficient: 1.0

1,1-Dimethylbiguanide
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: 1,1-Dimethylbiguanide

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 10213
type: UnificationXref
id: 10213
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31323
organism: BiologicalState26

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P13861
organism: BiologicalState26

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: Reference/UniProt P31321
organism: BiologicalState26

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
type: Protein
cellular location: Cytosol
entity reference: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Interaction2835
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates Protein kinase A
participant: Protein kinase A
participant: cAMP

Calcium-binding mitochondrial carrier protein Aralar1
type: ProteinReference
xref: Reference/UniProt O75746

Fatty acid synthase
type: Protein
cellular location: Cytosol
entity reference: Fatty acid synthase

Fructose-1,6-bisphosphatase 1
type: Complex
component stoichiometry: Protein/748 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Fructose-1,6-bisphosphatase 1

Reference/HMDB HMDB0001921
type: UnificationXref
id: HMDB0001921
db: HMDB

Reference/BioCyc FRUCTOSE-16-DIPHOSPHATE
type: UnificationXref
id: FRUCTOSE-16-DIPHOSPHATE
db: BioCyc

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Adenosine diphosphate

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha

ADP/ATP translocase 4
type: Protein
entity reference: ADP/ATP translocase 4

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
type: Protein
entity reference: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

NADH dehydrogenase [ubiquinone] 1 subunit C2
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 subunit C2

Compound/PW C000079 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Glucose 6-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glucose 6-phosphate

Compound/PW C108869 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvate
stoichiometric coefficient: 1.0

Reference/UniProt O15245
type: UnificationXref
id: O15245
db: UniProt

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxoglutaric acid

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/UniProt E9PQ53
type: UnificationXref
id: E9PQ53
db: UniProt

NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

Mitochondrial Intermembrane Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005758

NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

ReactionCatalysis347
type: Catalysis
controller: Triosephosphate isomerase
controlled: 5.3.1.1
control type: ACTIVATION

QH2
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: QH2

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

ReactionCatalysis342
type: Catalysis
controller: 6-phosphofructokinase, liver type
controlled: 2.7.1.11
control type: ACTIVATION

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: Protein
cellular location: Cytosol
entity reference: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

ReactionCatalysis343
type: Catalysis
controller: Fructose-1,6-bisphosphatase 1
controlled: 3.1.3.11
control type: ACTIVATION

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Glyceric acid 1,3-biphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glyceric acid 1,3-biphosphate

Compound/PW C108868 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Malate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Glucagon
type: ProteinReference
xref: Reference/UniProt P01275
organism: BiologicalState911

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/UniProt O15239
type: UnificationXref
id: O15239
db: UniProt

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

Acyl carrier protein, mitochondrial
type: Protein
entity reference: Acyl carrier protein, mitochondrial

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

Reference/UniProt Q9H0K1
type: UnificationXref
id: Q9H0K1
db: UniProt

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

Interaction3727
type: MolecularInteraction
interaction type: direct_interaction
name: 1,1-Dimethylbiguanide inhibits NADH dehydrogenase
participant: NADH dehydrogenase
participant: 1,1-Dimethylbiguanide

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

Interaction3728
type: MolecularInteraction
interaction type: direct_interaction
name: Adenosine monophosphate activates 5'-AMP-activated protein kinase
participant: Adenosine monophosphate
participant: 5'-AMP-activated protein kinase

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Interaction3729
type: MolecularInteraction
interaction type: direct_interaction
name: 5'-AMP-activated protein kinase inhibits Acetyl-CoA carboxylase 1
participant: Acetyl-CoA carboxylase 1
participant: 5'-AMP-activated protein kinase

Interaction3722
type: MolecularInteraction
interaction type: direct_interaction
name: D-Fructose 2,6-bisphosphate activates 6-phosphofructokinase, liver type
participant: D-Fructose 2,6-bisphosphate
participant: 6-phosphofructokinase, liver type

Interaction3723
type: MolecularInteraction
interaction type: direct_interaction
name: D-Fructose 2,6-bisphosphate inhibits Fructose-1,6-bisphosphatase 1
participant: D-Fructose 2,6-bisphosphate
participant: Fructose-1,6-bisphosphatase 1

Interaction3724
type: MolecularInteraction
interaction type: direct_interaction
name: Protein kinase A inhibits 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
participant: Protein kinase A
participant: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Interaction3725
type: MolecularInteraction
interaction type: direct_interaction
name: Adenosine monophosphate inhibits Fructose-1,6-bisphosphatase 1
participant: Adenosine monophosphate
participant: Fructose-1,6-bisphosphatase 1

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

Cytochrome c oxidase subunit NDUFA4
type: Protein
entity reference: Cytochrome c oxidase subunit NDUFA4

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Reference/BioCyc GAP
type: UnificationXref
id: GAP
db: BioCyc

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/KEGG Compound C00661
type: UnificationXref
id: C00661
db: KEGG Compound

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/KEGG Compound C00665
type: UnificationXref
id: C00665
db: KEGG Compound

Reference/KEGG Compound C00422
type: UnificationXref
id: C00422
db: KEGG Compound

Reference/UniProt P00505
type: UnificationXref
id: P00505
db: UniProt

NADH-ubiquinone oxidoreductase chain 4L
type: Protein
entity reference: NADH-ubiquinone oxidoreductase chain 4L

NADH-ubiquinone oxidoreductase chain 4
type: Protein
entity reference: NADH-ubiquinone oxidoreductase chain 4

NADH-ubiquinone oxidoreductase chain 3
type: Protein
entity reference: NADH-ubiquinone oxidoreductase chain 3

NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2

NADH-ubiquinone oxidoreductase chain 6
type: Protein
entity reference: NADH-ubiquinone oxidoreductase chain 6

NADH-ubiquinone oxidoreductase chain 5
type: Protein
entity reference: NADH-ubiquinone oxidoreductase chain 5

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

Reference/BioCyc MALONYL-COA
type: UnificationXref
id: MALONYL-COA
db: BioCyc

Reference/BioCyc UBIQUINONE-10
type: UnificationXref
id: UBIQUINONE-10
db: BioCyc

NADH-ubiquinone oxidoreductase chain 2
type: Protein
entity reference: NADH-ubiquinone oxidoreductase chain 2

NADH-ubiquinone oxidoreductase chain 1
type: Protein
entity reference: NADH-ubiquinone oxidoreductase chain 1