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Y+L amino acid transporter 1 SLC3A2/4F2hc Y+L amino acid transporter 1 Y+L amino acid transporter 1 4F2 cell-surface antigen heavy chain Low affinity cationic amino acid transporter 2 Protein arginine N- methyltransferase 5 Symmetric dimethylarginine L-Arginine L-Arginine L-Arginine L-Arginine Symmetric dimethylarginine S-Adenosylmethionine S-Adenosylhomocysteine Inflammation contributing to chronic kidney disease Cardiovascular disease Intestinal Lumen Intestinal epithelial cells Intestinal epithelial cells L-arginine obtained from protein-rich foods like meat, fish, poultry, dairy and eggs Cytosol SDMA modifies high-density lipoprotein (HDL), inducing endothelial damage and increases monocytic reactive oxygen species (ROS) production, which also causes vascular damage. SDMA acts as a proinflammatory agent. It produces activation of NFκB with enhanced expression of inflammatory cytokines. Hepatocyte
SLC7A7 SLC3A2 Slc7a7 Slc3a2 SLC7A2 PRMT5 Symmetric dimethylarginine L-Arginine L-Arginine L-Arginine L-Arginine Symmetric dimethylarginine S- Adenosylmethionine S- Adenosylhomocysteine Inflammation contributing to chronic kidney disease Cardiovascular disease
SLC7A7 SLC3A2 Slc7a7 Slc3a2 SLC7A2 PRMT5 Sdma Arg Arg Arg Arg Sdma SAMe SAH I c t c Car dis Intestinal Lumen Intestinal epithelial cells Intestinal epithelial cells L-arginine obtained from protein-rich foods like meat, fish, poultry, dairy and eggs Cytosol SDMA modifies high-density lipoprotein (HDL), inducing endothelial damage and increases monocytic reactive oxygen species (ROS) production, which also causes vascular damage. SDMA acts as a proinflammatory agent. It produces activation of NFκB with enhanced expression of inflammatory cytokines. Hepatocyte
SLC7A7 SLC3A2 Slc7a7 Slc3a2 SLC7A2 PRMT5 Sdma Arg Arg Arg Arg Sdma SAMe SAH I c t c Car dis