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Nucleus Malonylated Glyceraldehyde- 3-phosphate dehydrogenase Tumor necrosis factor Solute carrier family 2, facilitated glucose transporter member 2 Voltage- dependent anion-selective channel protein 2 Pyruvate carboxylase, mitochondrial Tricarboxylate transport protein, mitochondrial Voltage- dependent anion-selective channel protein 1 Nuclear pore Solute carrier family 2, facilitated glucose transporter member 2 Voltage- dependent anion-selective channel protein 2 Pyruvate carboxylase, mitochondrial Tricarboxylate transport protein, mitochondrial Voltage- dependent anion-selective channel protein 1 Nuclear pore Aconitate hydratase, mitochondrial Malate dehydrogenase, mitochondrial Fumarate hydratase, mitochondrial Succinyl-CoA ligase [ADP/GDP- forming] subunit alpha, mitochondrial Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial Dihydrolipoyllysine- residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial Dihydrolipoyl dehydrogenase, mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial citrate synthase Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Dihydrolipoyllysine- residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Dihydrolipoyl dehydrogenase, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Aconitate hydratase, mitochondrial Cis-aconitate decarboxylase ATP-citrate synthase Acetyl-CoA carboxylase 1 Fatty acid synthase Malate dehydrogenase, cytoplasmic NADP-dependent malic enzyme Nitric oxide synthase, inducible NADPH oxidase 4 ATP-citrate synthase Acetyl-CoA carboxylase 1 Interleukin-6 Interleukin-10 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Dihydrolipoyllysine- residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Dihydrolipoyl dehydrogenase, mitochondrial ATP-citrate synthase Acetyl-CoA carboxylase 1 Fatty acid synthase Glyceraldehyde- 3-phosphate dehydrogenase D-Glucose pyruvate Prostaglandin E2 NO Malonyl-CoA Acetyl-CoA D-Glucose pyruvate Acetyl-CoA Citrate Acetyl-CoA D-Glucose pyruvate pyruvate Citrate Citrate Citrate Acetyl-CoA D-Glucose pyruvate pyruvate Citrate Citrate Acetyl-CoA cis-Aconitic acid H2O Malate NAD Oxaloacetate NADH H+ Fumaric acid H2O Succinic acid ATP CoA Succinyl-CoA ADP Pi Oxoglutaric acid NAD CoA NADH H+ CO2 Isocitric acid NAD CO2 NADH H+ Acetyl-CoA H2O CoA CoA NADP CO2 NADPH Hydroquinone Quinone H2O Itaconic acid CO2 ATP CoA Acetyl-CoA ADP Oxaloacetate Pi ATP HCO3- Malonyl-CoA ADP Pi NADPH Acetyl-CoA CoA H2O NADP CO2 Malate NAD NADH H+ NADP CO2 NADPH pyruvate H+ O2 L-Arginine Citrulline NADP H2O ATP CoA ADP Oxaloacetate Pi ATP HCO3- ADP Pi CoA NADP CO2 NADPH ATP CoA ADP Oxaloacetate Pi ATP HCO3- Malonyl-CoA ADP Pi NADPH Acetyl-CoA CoA H2O NADP CO2 Biotin Manganese Biotin Manganese Magnesium FAD 2Fe-2S 4Fe-4S Biotin Manganese Manganese Heme FAD Flavin Mononucleotide Tetrahydrobiopterin Biotin Manganese Biotin Manganese Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Long chain fatty acid Reactive oxygen species Long chain fatty acid Lipoamide FAD TNFα IL-6 IL-10 TNFα Glycolysis Prostaglandin Synthesis Inflammation Inflammation Malonylation Protein translation Acetylation of histone and non-histone proteins Glycolysis Citric Acid Cycle Membrane expansion Acetylation of histone and non-histone proteins Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 4Fe-4S Thiamine pyrophosphate Lipoamide FAD Thiamine pyrophosphate Lipoamide FAD Thiamine pyrophosphate Intermembrane space Outer membrane Inner membrane Mitochondria Macrophage Cytosol TCA Cycle Dissociation Proinflammatory cytokine mRNA Expression of pro-inflammatory genes Nucleus Pro-inflammatory cytokines Histone acetylation contributes to macrophage activation Membrane expansion is necessary for dendritic cell activation Histone acetylation is important for dendritic cell differentiation Mitochondria Dendritic cell Cytosol Nucleus Expression of pro-inflammatory genes Outer membrane Inner membrane Intermembrane space
Mitochondria Nucleus Mitochondria Nucleus GAPDH TNF SLC2A2 VDAC2 PC SLC25A1 VDAC1 Unknown SLC2A2 VDAC2 PC SLC25A1 VDAC1 Unknown ACO2 MDH2 FH SUCLG1 SUCLG2 DHTKD1 DLST DLD IDH3A IDH3B IDH3G CIT2 PDHA1 DLAT DLD SDHA SDHB SDHC SDHD ACO2 ACOD1 ACLY ACACA FASN MDH1 ME1 NOS2 NOX4 ACLY ACACA IL6 IL10 PDHA1 DLAT DLD ACLY ACACA FASN GAPDH D-Glucose pyruvate Prostaglandin E2 Nitric oxide Malonyl-CoA Acetyl-CoA D-Glucose pyruvate Acetyl-CoA Citrate Acetyl-CoA D-Glucose pyruvate pyruvate Citrate Citrate Citrate Acetyl-CoA D-Glucose pyruvate pyruvate Citrate Citrate Acetyl-CoA cis-Aconitic acid Water Malate NAD Oxaloacetate NADH Hydrogen Ion Fumaric acid Water Succinic acid Adenosine triphosphate Coenzyme A Succinyl-CoA Adenosine diphosphate Phosphate Oxoglutaric acid NAD Coenzyme A NADH Hydrogen Ion Carbon dioxide Isocitric acid NAD Carbon dioxide NADH Hydrogen Ion Acetyl-CoA Water Coenzyme A Coenzyme A NADP Carbon dioxide NADPH Hydroquinone Quinone Water Itaconic acid Carbon dioxide Adenosine triphosphate Coenzyme A Acetyl-CoA Adenosine diphosphate Oxaloacetate Phosphate Adenosine triphosphate Hydrogen carbonate Malonyl-CoA Adenosine diphosphate Phosphate NADPH Acetyl-CoA Coenzyme A Water NADP Carbon dioxide Malate NAD NADH Hydrogen Ion NADP Carbon dioxide NADPH pyruvate Hydrogen Ion Oxygen L-Arginine Citrulline NADP Water Adenosine triphosphate Coenzyme A Adenosine diphosphate Oxaloacetate Phosphate Adenosine triphosphate Hydrogen carbonate Adenosine diphosphate Phosphate Coenzyme A NADP Carbon dioxide NADPH Adenosine triphosphate Coenzyme A Adenosine diphosphate Oxaloacetate Phosphate Adenosine triphosphate Hydrogen carbonate Malonyl-CoA Adenosine diphosphate Phosphate NADPH Acetyl-CoA Coenzyme A Water NADP Carbon dioxide PDHB Long chain fatty acid Reactive oxygen species Long chain fatty acid TNFα IL-6 IL-10 TNFα Glycolysis Prostaglandin Synthesis Inflammation Inflammation Malonylation Protein translation Acetylation of histone and non-histone proteins Glycolysis Citric Acid Cycle Membrane expansion Acetylation of histone and non-histone proteins PDHB
Mitochondria Nucleus Mitochondria Nucleus GAPDH TNF SLC2A2 VDAC2 PC SLC25A1 VDAC1 SLC2A2 VDAC2 PC SLC25A1 VDAC1 ACO2 MDH2 FH SUCLG1 SUCLG2 DHTKD1 DLST DLD IDH3A IDH3B IDH3G CIT2 PDHA1 DLAT DLD SDHA SDHB SDHC SDHD ACO2 ACOD1 ACLY ACACA FASN MDH1 ME1 NOS2 NOX4 ACLY ACACA IL6 IL10 PDHA1 DLAT DLD ACLY ACACA FASN GAPDH D-Glc pyruv PGE2 NO MalyCoA Ac-CoA D-Glc pyruv Ac-CoA Citrate Ac-CoA D-Glc pyruv pyruv Citrate Citrate Citrate Ac-CoA D-Glc pyruv pyruv Citrate Citrate Ac-CoA Aconiti H2O Malate NAD Oxalo NADH H+ Fumarat H2O Succini ATP CoA Suc-CoA ADP Pi AKG NAD CoA NADH H+ CO2 I-cita NAD CO2 NADH H+ Ac-CoA H2O CoA CoA NADP CO2 NADPH Quinol Quinone H2O ItacnAc CO2 ATP CoA Ac-CoA ADP Oxalo Pi ATP HCO3 MalyCoA ADP Pi NADPH Ac-CoA CoA H2O NADP CO2 Malate NAD NADH H+ NADP CO2 NADPH pyruv H+ O2 Arg Citruln NADP H2O ATP CoA ADP Oxalo Pi ATP HCO3 ADP Pi CoA NADP CO2 NADPH ATP CoA ADP Oxalo Pi ATP HCO3 MalyCoA ADP Pi NADPH Ac-CoA CoA H2O NADP CO2 PDHB L c f a Re ox s L c f a TNFα IL-6 IL-10 TNFα PW000146 Pro Syn PW123878 PW123878 Malon Pro tra A o h a PW000146 PW000005 Mem exp A o h a PDHB