Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Protein/3425 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit beta-2
stoichiometric coefficient: 1.0

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/GENE ONTOLOGY GO 0030139
type: UnificationXref
id: GO:0030139
db: GENE ONTOLOGY

Lorazepam Action Pathway
type: Pathway
pathway order: PathwayTransport/2533396
pathway order: PathwayTransport/2524300
pathway order: PathwayTransport/2524301
pathway order: PathwayTransport/2524299
pathway order: PathwayInteraction/3899
pathway order: PathwayEnzymeReaction/2524296
pathway order: PathwayTransport/2533397
pathway order: PathwaySubPathway/119964
pathway order: PathwayEnzymeReaction/2524297
pathway order: PathwayInteraction/3895
pathway order: PathwaySubPathway/119963
pathway order: PathwayEnzymeReaction/2524298
pathway order: PathwayInteraction/3894
pathway order: PathwayInteraction/3395
pathway order: PathwaySubPathway/119965
pathway component: TransportCatalysis4725
pathway component: 4.6.1.1
pathway component: ReactionCatalysis101095
pathway component: Interaction3894
pathway component: Interaction3895
pathway component: Transport11219
pathway component: Interaction3395
pathway component: Transport15702
pathway component: Transport13624
pathway component: Reaction217622
pathway component: Transport15701
pathway component: Transport11220
pathway component: Interaction3899
pathway component: Glutamate Metabolism
pathway component: ReactionCatalysis207192
pathway component: 4.1.1.15
pathway component: Gi/o signalling
pathway component: TransportCatalysis2352
pathway component: Hyperpolarization
pathway component: ReactionCatalysis2224
xref: Reference/PathWhiz PW126586
xref: Reference/SMPDB SMP0125053
organism: Homo sapiens

BiologicalState787
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

cAMP
type: SmallMolecule
cellular location: Cytosol
entity reference: cAMP

direct_interaction
type: InteractionVocabulary

ChemicalStructure/PW C008733
type: ChemicalStructure
structure format: SMILES

Gamma-aminobutyric acid type B receptor
type: Complex
cellular location: Cell Membrane
component: Gamma-aminobutyric acid type B receptor subunit 1
component: Gamma-aminobutyric acid type B receptor subunit 2
name: SubPathwayInput

Carbon dioxide
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Carbon dioxide

Compound/PW C000041 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

TransportCatalysis4725
type: Catalysis
controller: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
controlled: Transport13624
control type: ACTIVATION

Reference/PubChem-compound 119
type: UnificationXref
id: 119
db: PubChem-compound

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: γ-Aminobutyric acid

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C000095 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Gamma-aminobutyric acid type B receptor subunit 1
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid type B receptor subunit 1

Endocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0030139

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C00698
type: UnificationXref
id: C00698
db: KEGG Compound

Reference/KEGG Compound C00334
type: UnificationXref
id: C00334
db: KEGG Compound

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Chloride ion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17996
xref: Reference/BioCyc CPD-4521
xref: Reference/PubChem-compound 312
xref: Reference/KEGG Compound C00698
xref: Reference/HMDB HMDB0000492
xref: Reference/ChemSpider 306
xref: Reference/CAS 16887-00-6
chemical formula: Cl
molecular weight: 34.968853
structure: ChemicalStructure/PW C000374

Gamma-aminobutyric acid receptor subunit alpha-1
type: Protein
cellular location: Synapse
entity reference: Gamma-aminobutyric acid receptor subunit alpha-1

Protein/667 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutamate decarboxylase 1
stoichiometric coefficient: 2.0

Adenylate cyclase type 1
type: Protein
cellular location: Cytosol
entity reference: Adenylate cyclase type 1
name: SubPathwayOutput

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Transport15702
type: Transport
participant stoichiometry: Compound/PW C008733/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008733 Extracellular Space/Stoichiometry/1.0
right: Lorazepam
spontaneous: false
left: Lorazepam
name: Lorazepam (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reference/CAS 846-49-1
type: UnificationXref
id: 846-49-1
db: CAS

Transport15701
type: Transport
participant stoichiometry: Compound/PW C008733/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008733 Synapse/Stoichiometry/1.0
right: Lorazepam
spontaneous: false
left: Lorazepam
name: Lorazepam (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Vesicular inhibitory amino acid transporter
type: Protein
entity reference: Vesicular inhibitory amino acid transporter

Transport11220
type: Transport
participant stoichiometry: Compound/PW C000071 Endocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Extracellular Space/Stoichiometry/1.0
right: γ-Aminobutyric acid
spontaneous: true
left: γ-Aminobutyric acid
name: γ-Aminobutyric acid (→) Transport: Homo sapiens, Neuron, Endocytic Vesicle to Homo sapiens, Cell, Extracellular Space
conversion direction: REVERSIBLE

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

ReactionCatalysis207192
type: Catalysis
controller: GABAA receptor
controlled: Reaction217622
control type: ACTIVATION

Gamma-aminobutyric acid receptor subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P14867
organism: BiologicalState787

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Protein/3418 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit alpha-1
stoichiometric coefficient: 1.0

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: γ-Aminobutyric acid

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Transport11219
type: Transport
participant stoichiometry: Compound/PW C000071 Endocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Cytosol/Stoichiometry/1.0
right: γ-Aminobutyric acid
spontaneous: true
left: γ-Aminobutyric acid
name: γ-Aminobutyric acid (→) Transport: Homo sapiens, Neuron, Cytosol to Homo sapiens, Neuron, Endocytic Vesicle
conversion direction: REVERSIBLE

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000374
type: ChemicalStructure
structure format: SMILES
structure data: [Cl-]

γ-Aminobutyric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000112
xref: Reference/ChemSpider 116
xref: Reference/PubChem-compound 119
xref: Reference/CAS 56-12-2
xref: Reference/BioCyc 4-AMINO-BUTYRATE
xref: Reference/ChEBI CHEBI 16865
xref: Reference/KEGG Compound C00334
chemical formula: C4H9NO2
molecular weight: 103.06333
structure: ChemicalStructure/PW C000071

SubPathwayInteraction119965
type: Interaction
name: SubPathway119965Reaction
name: SubPathwayReaction
participant: Chloride ion

Reference/UniProt Q99259
type: UnificationXref
id: Q99259
db: UniProt

SubPathwayInteraction119964
type: Interaction
name: SubPathway119964Reaction
name: SubPathwayReaction
participant: L-Glutamic acid

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

GABAA receptor
type: Complex
component stoichiometry: Protein/3425 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1864 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/3418 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Gamma-aminobutyric acid receptor subunit beta-2
component: Gamma-aminobutyric acid receptor subunit alpha-1
component: Gamma-aminobutyric acid receptor subunit gamma-2

Gamma-aminobutyric acid receptor subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid receptor subunit alpha-1

Compound/PW C000071 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

Reference/UniProt O75899
type: UnificationXref
id: O75899
db: UniProt

Reference/PubChem-compound 312
type: UnificationXref
id: 312
db: PubChem-compound

Gamma-aminobutyric acid receptor subunit beta-2
type: ProteinReference
xref: Reference/UniProt P47870
organism: BiologicalState787

Gamma-aminobutyric acid type B receptor subunit 2
type: ProteinReference
xref: Reference/UniProt O75899
organism: BiologicalState787

Reference/ChEBI CHEBI 16865
type: UnificationXref
id: CHEBI:16865
db: ChEBI

Reference/UniProt Q9UBS5
type: UnificationXref
id: Q9UBS5
db: UniProt

Interaction3894
type: MolecularInteraction
interaction type: direct_interaction
name: cAMP activates γ-Aminobutyric acid
participant: γ-Aminobutyric acid
participant: cAMP

Interaction3895
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates γ-Aminobutyric acid
participant: γ-Aminobutyric acid
participant: Calcium

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

SubPathwayInteraction119963
type: Interaction
name: SubPathwayReaction
name: SubPathway119963Reaction
participant: Adenylate cyclase type 1
participant: Gamma-aminobutyric acid type B receptor

Gamma-aminobutyric acid receptor subunit gamma-2
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid receptor subunit gamma-2

Transport13624
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Neuron, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Glutamate decarboxylase 1
type: Complex
component stoichiometry: Protein/667 Cell Membrane/Stoichiometry/2.0
cellular location: Cell Membrane
component: Glutamate decarboxylase 1

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: γ-Aminobutyric acid

Interaction3899
type: MolecularInteraction
interaction type: direct_interaction
name: Lorazepam activates GABAA receptor
participant: GABAA receptor
participant: Lorazepam

Compound/PW C008733/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lorazepam
stoichiometric coefficient: 1.0

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

4.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cytosol/Stoichiometry/1.0
right: Pyrophosphate
right: cAMP
spontaneous: false
EC number: 4.6.1.1
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Compound/PW C000071 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: Protein
entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0000112
type: UnificationXref
id: HMDB0000112
db: HMDB

Reference/ChemSpider 116
type: UnificationXref
id: 116
db: ChemSpider

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/UniProt Q08828
type: UnificationXref
id: Q08828
db: UniProt

Gamma-aminobutyric acid type B receptor subunit 1
type: ProteinReference
xref: Reference/UniProt Q9UBS5
organism: BiologicalState787

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Chloride ion
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Chloride ion

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Reference/UniProt P47870
type: UnificationXref
id: P47870
db: UniProt

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/UniProt P14867
type: UnificationXref
id: P14867
db: UniProt

Lorazepam
type: SmallMolecule
cellular location: Synapse
entity reference: Lorazepam

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid
name: SubPathwayOutput

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/SMPDB SMP0000072
type: UnificationXref
id: SMP0000072
db: SMPDB

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Gamma-aminobutyric acid receptor subunit gamma-2
type: Protein
cellular location: Synapse
entity reference: Gamma-aminobutyric acid receptor subunit gamma-2

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Compound/PW C008733 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lorazepam
stoichiometric coefficient: 1.0

Reference/ChemSpider 3821
type: UnificationXref
id: 3821
db: ChemSpider

Vesicular inhibitory amino acid transporter
type: ProteinReference
xref: Reference/UniProt Q9H598

Glutamate decarboxylase 1
type: ProteinReference
xref: Reference/UniProt Q99259
organism: BiologicalState787

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

Reference/PubChem-compound 3958
type: UnificationXref
id: 3958
db: PubChem-compound

Lorazepam
type: SmallMolecule
entity reference: Lorazepam

Reference/PathWhiz PW126586
type: UnificationXref
id: PW126586
db: PathWhiz

Gi/o signalling
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119963
pathway component: SubPathwayInteraction119963
name: SubPathway

Hyperpolarization
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119965
pathway component: SubPathwayInteraction119965
name: SubPathway

Reference/HMDB HMDB0000492
type: UnificationXref
id: HMDB0000492
db: HMDB

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/ChEBI CHEBI 17996
type: UnificationXref
id: CHEBI:17996
db: ChEBI

Reference/ChEBI CHEBI 116959
type: UnificationXref
id: CHEBI:116959
db: ChEBI

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

ReactionCatalysis101095
type: Catalysis
controller: Adenylate cyclase type 1
controlled: 4.6.1.1
control type: ACTIVATION

Reference/CAS 16887-00-6
type: UnificationXref
id: 16887-00-6
db: CAS

Adenylate cyclase type 1
type: ProteinReference
xref: Reference/UniProt Q08828
organism: BiologicalState787

Protein/1864 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit gamma-2
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Protein/1864 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit gamma-2
stoichiometric coefficient: 1.0

Glutamate decarboxylase 1
type: Protein
cellular location: Cell Membrane
entity reference: Glutamate decarboxylase 1

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Compound/PW C008733 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lorazepam
stoichiometric coefficient: 1.0

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Endocytic Vesicle
entity reference: γ-Aminobutyric acid

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Compound/PW C000071 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Compound/PW C001316 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/UniProt Q9H598
type: UnificationXref
id: Q9H598
db: UniProt

Gamma-aminobutyric acid receptor subunit gamma-2
type: ProteinReference
xref: Reference/UniProt P18507
organism: BiologicalState787

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: Reference/UniProt O00555

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/UniProt P18507
type: UnificationXref
id: P18507
db: UniProt

Reference/ChemSpider 306
type: UnificationXref
id: 306
db: ChemSpider

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Lorazepam
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Lorazepam

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Compound/PW C000071 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reaction217622
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000374 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Cell Membrane/Stoichiometry/1.0
right: Chloride ion
spontaneous: false
left: Chloride ion
left: γ-Aminobutyric acid
name: Chloride ion + γ-Aminobutyric acid → Chloride ion
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0014332
type: UnificationXref
id: HMDB0014332
db: HMDB

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway119964
pathway component: SubPathwayInteraction119964
xref: Reference/SMPDB SMP0000072
xref: Reference/PathWhiz PW000003
name: SubPathway

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt O00555
type: UnificationXref
id: O00555
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

GABAA receptor
type: Complex
component stoichiometry: Protein/3425 Synapse/Stoichiometry/1.0
component stoichiometry: Protein/3418 Synapse/Stoichiometry/1.0
component stoichiometry: Protein/1864 Synapse/Stoichiometry/1.0
cellular location: Synapse
component: Gamma-aminobutyric acid receptor subunit beta-2
component: Gamma-aminobutyric acid receptor subunit gamma-2
component: Gamma-aminobutyric acid receptor subunit alpha-1

Compound/PW C000374 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Chloride ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Chloride ion
name: SubPathwayInput

Gamma-aminobutyric acid receptor subunit beta-2
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid receptor subunit beta-2

ReactionCatalysis2224
type: Catalysis
controller: Glutamate decarboxylase 1
controlled: 4.1.1.15
control type: ACTIVATION

Reference/BioCyc CPD-4521
type: UnificationXref
id: CPD-4521
db: BioCyc

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Gamma-aminobutyric acid receptor subunit beta-2
type: Protein
cellular location: Synapse
entity reference: Gamma-aminobutyric acid receptor subunit beta-2

Reference/CAS 56-12-2
type: UnificationXref
id: 56-12-2
db: CAS

Reference/PathWhiz PW000003
type: UnificationXref
id: PW000003
db: PathWhiz

Reference/SMPDB SMP0125053
type: UnificationXref
id: SMP0125053
db: SMPDB

Lorazepam
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 116959
xref: Reference/PubChem-compound 3958
xref: Reference/ChemSpider 3821
xref: Reference/CAS 846-49-1
xref: Reference/HMDB HMDB0014332
chemical formula: C15H10Cl2N2O2
molecular weight: 320.01193
structure: ChemicalStructure/PW C008733

Protein/3425 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit beta-2
stoichiometric coefficient: 1.0

Reference/BioCyc 4-AMINO-BUTYRATE
type: UnificationXref
id: 4-AMINO-BUTYRATE
db: BioCyc

TransportCatalysis2352
type: Catalysis
controller: Vesicular inhibitory amino acid transporter
controlled: Transport11219
control type: ACTIVATION

L-Glutamic acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: L-Glutamic acid

ChemicalStructure/PW C000071
type: ChemicalStructure
structure format: SMILES
structure data: NCCCC(O)=O

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Interaction3395
type: MolecularInteraction
interaction type: direct_interaction
name: γ-Aminobutyric acid activates Gamma-aminobutyric acid type B receptor
participant: γ-Aminobutyric acid
participant: Gamma-aminobutyric acid type B receptor

Protein/3418 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: Gamma-aminobutyric acid receptor subunit alpha-1
stoichiometric coefficient: 1.0

4.1.1.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cell Membrane/Stoichiometry/1.0
right: γ-Aminobutyric acid
right: Carbon dioxide
spontaneous: false
EC number: 4.1.1.15
left: L-Glutamic acid
name: L-Glutamic acid → Carbon dioxide + γ-Aminobutyric acid
conversion direction: LEFT_TO_RIGHT

Gamma-aminobutyric acid type B receptor subunit 2
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-aminobutyric acid type B receptor subunit 2

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202