Olivetol is a compound involved in the biosynthesis of tetrahydrocannabinol (THC). The pathway starts with Hexanoyl-CoA and adds 2 hydrogen ions and 2 malonyl-CoA which is catalyzed by the enzyme 3,5,7-trioxododecanoyl-CoA synthase or olivetol synthase to produce 3,5-dioxodecanoyl-CoA as well as 2 coenzyme A and 2 carbon dioxide as a byproduct. The 3,5-dioxodecanoyl-CoA then is catalyzed in two reactions, one making triketide pyrone by way of the enzyme triketide pyrone synthase, and the other making 3,5,7-trioxododecanoyl-CoA with the enzyme olivetol synthase along with a hydrogen ion and malonyl-CoA, 3,5,7-trioxododecanoyl-CoA then is also catalyzed in two reactions. With the ensyme olivetol synthase in one reaction it makes olivetol.. In the other reaction with the same enzyme it makes tetraketide pyrone.

Olivetol Biosynthesis MetaCyc References