Reference/HMDB HMDB0014018
type: UnificationXref
id: HMDB0014018
db: HMDB

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

ChemicalStructure/PW C040980
type: ChemicalStructure
structure format: SMILES

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PathWhiz PW126624
type: UnificationXref
id: PW126624
db: PathWhiz

Reference/UniProt O60656
type: UnificationXref
id: O60656
db: UniProt

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Unknown
type: ProteinReference
organism: BiologicalState973

4-Hydroxypropofol
type: SmallMolecule
entity reference: 4-Hydroxypropofol
name: SubPathwayInput

ChemicalStructure/PW C008695
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)C1=CC(O)=CC(C(C)C)=C1O

Compound/PW C112976 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-Quinol glucuronide
stoichiometric coefficient: 1.0

Reference/CAS 2616-64-0
type: UnificationXref
id: 2616-64-0
db: CAS

Cytochrome P450 2B6
type: ProteinReference
xref: Reference/UniProt P20813
organism: BiologicalState973

Reference/ChEBI CHEBI 58223
type: UnificationXref
id: CHEBI:58223
db: ChEBI

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADPH

Compound/PW C112976/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-Quinol glucuronide
stoichiometric coefficient: 1.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/HMDB HMDB0000935
type: UnificationXref
id: HMDB0000935
db: HMDB

Reference/KEGG Compound C00167
type: UnificationXref
id: C00167
db: KEGG Compound

Canalicular multispecific organic anion transporter 2
type: ProteinReference
xref: Reference/UniProt O15438

Reference/UniProt O15438
type: UnificationXref
id: O15438
db: UniProt

Uridine diphosphate glucuronic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine diphosphate glucuronic acid

Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/PathWhiz PW126631
type: UnificationXref
id: PW126631
db: PathWhiz

1-Quinol glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 1-Quinol glucuronide

UDP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP

UDP
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58223
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C040980

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/HMDB HMDB0014956
type: UnificationXref
id: HMDB0014956
db: HMDB

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/SMPDB SMP0125095
type: UnificationXref
id: SMP0125095
db: SMPDB

Reference/PubChem-compound 4943
type: UnificationXref
id: 4943
db: PubChem-compound

Reference/ChemSpider 4774
type: UnificationXref
id: 4774
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 17200
type: UnificationXref
id: CHEBI:17200
db: ChEBI

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ChemicalStructure/PW C112977
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)C1=CC(OS(O)(=O)=O)=CC(C(C)C)=C1O

ChemicalStructure/PW C112976
type: ChemicalStructure
structure format: SMILES

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C112975
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C07523
type: UnificationXref
id: C07523
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Compound/PW C009281/Stoichiometry/1.0
type: Stoichiometry
physical entity: Propofol
stoichiometric coefficient: 1.0

Compound/PW C112977 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Quinol Sulfate
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Renal excretion
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117560
pathway component: SubPathwayInteraction117560
name: SubPathway

Reference/ChemSpider 16522
type: UnificationXref
id: 16522
db: ChemSpider

Reference/SMPDB SMP0125089
type: UnificationXref
id: SMP0125089
db: SMPDB

Reference/ChEBI CHEBI 44915
type: UnificationXref
id: CHEBI:44915
db: ChEBI

Reference/BioCyc UDP-GLUCURONATE
type: UnificationXref
id: UDP-GLUCURONATE
db: BioCyc

4-Quinol Sulfate
type: SmallMolecule
entity reference: 4-Quinol Sulfate
name: SubPathwayInput

1-Quinol glucuronide
type: SmallMolecule
entity reference: 1-Quinol glucuronide
name: SubPathwayInput

BiologicalState973
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

UDP-glucuronosyltransferase 1-8
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP-glucuronosyltransferase 1-8

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/ChemSpider 32696723
type: UnificationXref
id: 32696723
db: ChemSpider

Compound/PW C008695/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxypropofol
stoichiometric coefficient: 1.0

Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucuronic acid
stoichiometric coefficient: 1.0

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Reference/ChemSpider 2282600
type: UnificationXref
id: 2282600
db: ChemSpider

Reference/HMDB HMDB0060933
type: UnificationXref
id: HMDB0060933
db: HMDB

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

4-Hydroxypropofol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 4-Hydroxypropofol

UDP-glucuronosyltransferase 1-9
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP-glucuronosyltransferase 1-9

Reference/UniProt P20813
type: UnificationXref
id: P20813
db: UniProt

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Solute carrier family 22 member 1
type: ProteinReference
xref: Reference/UniProt O15245

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Uridine diphosphate glucuronic acid
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCURONATE
xref: Reference/CAS 2616-64-0
xref: Reference/PubChem-compound 17473
xref: Reference/HMDB HMDB0000935
xref: Reference/ChEBI CHEBI 17200
xref: Reference/ChemSpider 16522
xref: Reference/KEGG Compound C00167
chemical formula: C15H22N2O18P2
molecular weight: 580.0343
structure: ChemicalStructure/PW C000746

TransportCatalysis4995
type: Catalysis
controller: Canalicular multispecific organic anion transporter 2
controlled: Transport14018
control type: ACTIVATION

Propofol
type: SmallMoleculeReference
xref: Reference/CAS 2078-54-8
xref: Reference/ChEBI CHEBI 44915
xref: Reference/HMDB HMDB0014956
xref: Reference/PubChem-compound 4943
xref: Reference/ChemSpider 4774
xref: Reference/KEGG Compound C07523
chemical formula: C12H18O
molecular weight: 178.13577
structure: ChemicalStructure/PW C009281

TransportCatalysis4993
type: Catalysis
controller: Canalicular multispecific organic anion transporter 2
controlled: Transport14016
control type: ACTIVATION

TransportCatalysis4994
type: Catalysis
controller: Canalicular multispecific organic anion transporter 2
controlled: Transport14017
control type: ACTIVATION

4-Quinol Sulfate
type: SmallMoleculeReference
xref: Reference/ChemSpider 8621450
chemical formula: C12H18O5S
molecular weight: 274.0875
structure: ChemicalStructure/PW C112977

1-Quinol glucuronide
type: SmallMoleculeReference
xref: Reference/ChemSpider 32696723
chemical formula: C18H26O8
molecular weight: 370.16278
structure: ChemicalStructure/PW C112976

Propofol glucuronide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 168560
xref: Reference/ChemSpider 26324521
xref: Reference/HMDB HMDB0060933
chemical formula: C18H26O7
molecular weight: 354.16785
structure: ChemicalStructure/PW C112975

Reference/UniProt O15245
type: UnificationXref
id: O15245
db: UniProt

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

UDP-glucuronosyltransferase 1-8
type: ProteinReference
xref: Reference/UniProt Q9HAW9
organism: BiologicalState973

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

UDP-glucuronosyltransferase 1-9
type: ProteinReference
xref: Reference/UniProt O60656
organism: BiologicalState973

Propofol Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/2510631
pathway order: PathwayTransport/2510637
pathway order: PathwayEnzymeReaction/2510632
pathway order: PathwayTransport/2510638
pathway order: PathwayEnzymeReaction/2510633
pathway order: PathwayTransport/2510636
pathway order: PathwaySubPathway/117560
pathway order: PathwayEnzymeReaction/2510635
pathway order: PathwayTransport/2510634
pathway order: PathwayEnzymeReaction/2505849
pathway order: PathwaySubPathway/117556
pathway component: ReactionCatalysis207709
pathway component: TransportCatalysis4995
pathway component: TransportCatalysis4993
pathway component: TransportCatalysis4994
pathway component: 1.14.13.-
pathway component: Propofol Pathway
pathway component: ReactionCatalysis207712
pathway component: ReactionCatalysis207700
pathway component: 2.4.1.17
pathway component: ReactionCatalysis207711
pathway component: Transport14018
pathway component: Reaction218338
pathway component: ReactionCatalysis207699
pathway component: Transport14017
pathway component: Transport14016
pathway component: Transport14015
pathway component: Reaction218340
pathway component: TransportCatalysis4992
pathway component: Renal excretion
xref: Reference/PathWhiz PW126631
xref: Reference/SMPDB SMP0125095
organism: Homo sapiens

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/UniProt Q9HAW9
type: UnificationXref
id: Q9HAW9
db: UniProt

Unknown
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Unknown

Canalicular multispecific organic anion transporter 2
type: Protein
entity reference: Canalicular multispecific organic anion transporter 2

Compound/PW C112975 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Propofol glucuronide
stoichiometric coefficient: 1.0

Compound/PW C008695 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxypropofol
stoichiometric coefficient: 1.0

TransportCatalysis4992
type: Catalysis
controller: Solute carrier family 22 member 1
controlled: Transport14015
control type: ACTIVATION

Reference/ChemSpider 8621450
type: UnificationXref
id: 8621450
db: ChemSpider

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/PW C040980 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Propofol glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Propofol glucuronide

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/ChemSpider 26324521
type: UnificationXref
id: 26324521
db: ChemSpider

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/PubChem-compound 3014064
type: UnificationXref
id: 3014064
db: PubChem-compound

ReactionCatalysis207699
type: Catalysis
controller: Cytochrome P450 2B6
controlled: 1.14.13.-
control type: ACTIVATION

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Compound/PW C009281 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Propofol
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 17473
type: UnificationXref
id: 17473
db: PubChem-compound

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

ChemicalStructure/PW C009281
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)C1=CC=CC(C(C)C)=C1O

ReactionCatalysis207709
type: Catalysis
controller: Unknown
controlled: Reaction218338
control type: ACTIVATION

4-Quinol Sulfate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 4-Quinol Sulfate

1.14.13.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008695 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009281 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 4-Hydroxypropofol
right: Hydrogen Ion
right: NADP
spontaneous: false
EC number: 1.14.13.-
left: Oxygen
left: Propofol
left: NADPH
name: NADPH + Oxygen + Propofol → 4-Hydroxypropofol + Hydrogen Ion + NADP + Water
conversion direction: LEFT_TO_RIGHT

Propofol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Propofol

ReactionCatalysis207700
type: Catalysis
controller: UDP-glucuronosyltransferase 1-8
controlled: 2.4.1.17
control type: ACTIVATION

2.4.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C112976 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008695 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040980 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: 1-Quinol glucuronide
right: UDP
right: Hydrogen Ion
spontaneous: false
EC number: 2.4.1.17
left: Uridine diphosphate glucuronic acid
left: 4-Hydroxypropofol
name: 4-Hydroxypropofol + Uridine diphosphate glucuronic acid → 1-Quinol glucuronide + Hydrogen Ion + UDP
conversion direction: LEFT_TO_RIGHT

Reaction218338
type: BiochemicalReaction
participant stoichiometry: Compound/PW C112976 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C112975 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: 1-Quinol glucuronide
spontaneous: false
left: Propofol glucuronide
name: Propofol glucuronide → 1-Quinol glucuronide
conversion direction: LEFT_TO_RIGHT

2.4.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C112975 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040980 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009281 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Propofol glucuronide
right: UDP
right: Hydrogen Ion
spontaneous: false
EC number: 2.4.1.17
left: Uridine diphosphate glucuronic acid
left: Propofol
name: Propofol + Uridine diphosphate glucuronic acid → Hydrogen Ion + Propofol glucuronide + UDP
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000746
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/ChEBI CHEBI 145211
type: UnificationXref
id: CHEBI:145211
db: ChEBI

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reaction218340
type: BiochemicalReaction
participant stoichiometry: Compound/PW C112977 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008695 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: 4-Quinol Sulfate
spontaneous: false
left: 4-Hydroxypropofol
name: 4-Hydroxypropofol → 4-Quinol Sulfate
conversion direction: LEFT_TO_RIGHT

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

4-Hydroxypropofol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 145211
xref: Reference/HMDB HMDB0014018
xref: Reference/ChemSpider 2282600
xref: Reference/PubChem-compound 3014064
chemical formula: C12H18O2
molecular weight: 194.13068
structure: ChemicalStructure/PW C008695

Cytochrome P450 2B6
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 2B6

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADP

Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Compound/PW C112977/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Quinol Sulfate
stoichiometric coefficient: 1.0

Propofol
type: SmallMolecule
entity reference: Propofol
name: SubPathwayInput

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

SubPathwayInteraction117560
type: Interaction
name: SubPathway117560Reaction
name: SubPathwayReaction
participant: 4-Hydroxypropofol
participant: 4-Quinol Sulfate
participant: 1-Quinol glucuronide

Propofol Pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117556
pathway component: SubPathwayInteraction117556
xref: Reference/SMPDB SMP0125089
xref: Reference/PathWhiz PW126624
name: SubPathway

ReactionCatalysis207712
type: Catalysis
controller: Unknown
controlled: Reaction218340
control type: ACTIVATION

ReactionCatalysis207711
type: Catalysis
controller: UDP-glucuronosyltransferase 1-9
controlled: 2.4.1.17
control type: ACTIVATION

Transport14018
type: Transport
participant stoichiometry: Compound/PW C008695/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008695 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: 4-Hydroxypropofol
spontaneous: false
left: 4-Hydroxypropofol
name: 4-Hydroxypropofol (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Solute carrier family 22 member 1
type: Protein
entity reference: Solute carrier family 22 member 1

Transport14017
type: Transport
participant stoichiometry: Compound/PW C112977 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C112977/Stoichiometry/1.0
right: 4-Quinol Sulfate
spontaneous: false
left: 4-Quinol Sulfate
name: 4-Quinol Sulfate (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Transport14016
type: Transport
participant stoichiometry: Compound/PW C112976 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C112976/Stoichiometry/1.0
right: 1-Quinol glucuronide
spontaneous: false
left: 1-Quinol glucuronide
name: 1-Quinol glucuronide (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Reference/CAS 2078-54-8
type: UnificationXref
id: 2078-54-8
db: CAS

Transport14015
type: Transport
participant stoichiometry: Compound/PW C009281/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009281 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Propofol
spontaneous: false
left: Propofol
name: Propofol (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane
conversion direction: LEFT_TO_RIGHT

SubPathwayInteraction117556
type: Interaction
name: SubPathwayReaction
name: SubPathway117556Reaction
participant: Propofol

Reference/ChEBI CHEBI 168560
type: UnificationXref
id: CHEBI:168560
db: ChEBI