Ergosterol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16933
xref: Reference/HMDB HMDB0000878
xref: Reference/KEGG Compound C01694
xref: Reference/BioCyc ERGOSTEROL
xref: Reference/PubChem-compound 21775588
xref: Reference/ChemSpider 10477914
xref: Reference/CAS 57-87-4
chemical formula: C28H44O
molecular weight: 396.3392
structure: ChemicalStructure/PW C000701

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/ChEBI CHEBI 16933
type: UnificationXref
id: CHEBI:16933
db: ChEBI

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

direct_interaction
type: InteractionVocabulary

4,4-Dimethylcholesta-8,14,24-trienol
type: SmallMolecule
cellular location: Cell Membrane
entity reference: 4,4-Dimethylcholesta-8,14,24-trienol
name: SubPathwayInput

SubPathwayInteraction117588
type: Interaction
name: SubPathwayReaction
name: SubPathway117588Reaction
participant: 4,4-Dimethylcholesta-8,14,24-trienol
participant: Ergosterol

Reference/PathWhiz PW126623
type: UnificationXref
id: PW126623
db: PathWhiz

Insulin Signalling
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117642
pathway component: SubPathwayInteraction117642
xref: Reference/SMPDB SMP0000391
xref: Reference/PathWhiz PW000454
name: SubPathway

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Lanosterol
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Lanosterol

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

1.14.14.154
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000966 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cell Membrane/Stoichiometry/3.0
participant stoichiometry: Compound/PW C040034 Cell Membrane/Stoichiometry/4.0
participant stoichiometry: Compound/PW C000092 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cell Membrane/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000809 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cell Membrane/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/4.0
right: 4,4-Dimethylcholesta-8,14,24-trienol
right: NADP
right: Hydrogen Ion
right: Formic acid
right: Water
spontaneous: false
EC number: 1.14.14.154
left: Oxygen
left: Lanosterol
left: NADPH
name: Lanosterol + 3 NADPH + 3 Oxygen → 4,4-Dimethylcholesta-8,14,24-trienol + Formic acid + 4 Hydrogen Ion + 3 NADP + 4 Water
conversion direction: LEFT_TO_RIGHT

Transport14072
type: Transport
participant stoichiometry: ProteinComplex/15539/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/15539 Cytoplasm/Stoichiometry/1.0
right: Adiponectin Trimer
spontaneous: false
left: Adiponectin Trimer
name: Adiponectin Trimer (→) Transport: Homo sapiens, Adipose, Cell, Cytoplasm to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/KEGG Compound C11455
type: UnificationXref
id: C11455
db: KEGG Compound

Reference/UniProt P10613
type: UnificationXref
id: P10613
db: UniProt

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

ReactionCatalysis207749
type: Catalysis
controller: Lanosterol 14-alpha demethylase
controlled: 1.14.14.154
control type: ACTIVATION

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

4,4-Dimethylcholesta-8,14,24-trienol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17813
xref: Reference/ChemSpider 391478
xref: Reference/BioCyc 44-DIMETHYL-CHOLESTA-812-24-TRIENOL
xref: Reference/CAS 64284-64-6
xref: Reference/PubChem-compound 443212
xref: Reference/HMDB HMDB0001023
xref: Reference/KEGG Compound C11455
chemical formula: C29H46O
molecular weight: 410.35486
structure: ChemicalStructure/PW C000809

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/CAS 79-63-0
type: UnificationXref
id: 79-63-0
db: CAS

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Lipolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117603
pathway component: SubPathwayInteraction117603
name: SubPathway

Reference/ChemSpider 278
type: UnificationXref
id: 278
db: ChemSpider

Compound/PW C000041 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Adiponectin Trimer
type: Complex
component stoichiometry: Protein/1969/Stoichiometry/3.0
component: Adiponectin
name: SubPathwayInput

Hydroxycarboxylic acid receptor 2
type: Protein
cellular location: Cell Membrane
entity reference: Hydroxycarboxylic acid receptor 2

TransportCatalysis5037
type: Catalysis
controller: Hydroxycarboxylic acid receptor 2
controlled: Transport14072
control type: ACTIVATION

Protein/1969 Cytoplasm/Stoichiometry/3.0
type: Stoichiometry
physical entity: Adiponectin
stoichiometric coefficient: 3.0

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/SMPDB SMP0125088
type: UnificationXref
id: SMP0125088
db: SMPDB

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/CAS 57-87-4
type: UnificationXref
id: 57-87-4
db: CAS

Adiponectin
type: Protein
entity reference: Adiponectin

Compound/PW C001065 Cell Membrane/Stoichiometry/3.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 3.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

ChemicalStructure/PW C000809
type: ChemicalStructure
structure format: SMILES

Hydrogen Ion
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Hydrogen Ion

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Ergosterol
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Ergosterol

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/CAS 23593-75-1
type: UnificationXref
id: 23593-75-1
db: CAS

Clotrimazole
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001922
xref: Reference/PubChem-compound 2812
xref: Reference/ChemSpider 2710
xref: Reference/ChEBI CHEBI 3764
xref: Reference/CAS 23593-75-1
xref: Reference/KEGG Compound C06922
chemical formula: C22H17ClN2
molecular weight: 344.10803
structure: ChemicalStructure/PW C001281

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Compound/PW C040034 Cell Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 4.0

Compound/PW C000092 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/SMPDB SMP0125104
type: UnificationXref
id: SMP0125104
db: SMPDB

NADP
type: SmallMolecule
cellular location: Cell Membrane
entity reference: NADP

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C01694
type: UnificationXref
id: C01694
db: KEGG Compound

Reference/BioCyc ERGOSTEROL
type: UnificationXref
id: ERGOSTEROL
db: BioCyc

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Lanosterol 14-alpha demethylase
type: ProteinReference
xref: Reference/UniProt P10613
organism: BiologicalState1027

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChemSpider 10477914
type: UnificationXref
id: 10477914
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q8TDS4
type: UnificationXref
id: Q8TDS4
db: UniProt

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Lanosterol
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16521
xref: Reference/KEGG Compound C01724
xref: Reference/PubChem-compound 246983
xref: Reference/BioCyc LANOSTEROL
xref: Reference/HMDB HMDB0001251
xref: Reference/ChemSpider 216175
xref: Reference/CAS 79-63-0
chemical formula: C30H50O
molecular weight: 426.38617
structure: ChemicalStructure/PW C000966

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/ChemSpider 2710
type: UnificationXref
id: 2710
db: ChemSpider

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Adenylate cyclase type 9
type: ProteinReference
xref: Reference/UniProt O60503
organism: BiologicalState1041

Hydroxycarboxylic acid receptor 2
type: ProteinReference
xref: Reference/UniProt Q8TDS4
organism: BiologicalState1041

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/PathWhiz PW126641
type: UnificationXref
id: PW126641
db: PathWhiz

BiologicalState51
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

Adiponectin Trimer
type: Complex
component stoichiometry: Protein/1969 Cytoplasm/Stoichiometry/3.0
cellular location: Cytoplasm
component: Adiponectin

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChEBI CHEBI 17813
type: UnificationXref
id: CHEBI:17813
db: ChEBI

Steroid Biosynthesis (Not This One)
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117588
pathway component: SubPathwayInteraction117588
xref: Reference/PathWhiz PW126623
xref: Reference/SMPDB SMP0125088
name: SubPathway

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/PubChem-compound 443212
type: UnificationXref
id: 443212
db: PubChem-compound

Reference/KEGG Compound C06922
type: UnificationXref
id: C06922
db: KEGG Compound

Protein/1969/Stoichiometry/3.0
type: Stoichiometry
physical entity: Adiponectin
stoichiometric coefficient: 3.0

Reference/UniProt O60503
type: UnificationXref
id: O60503
db: UniProt

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/BioCyc 44-DIMETHYL-CHOLESTA-812-24-TRIENOL
type: UnificationXref
id: 44-DIMETHYL-CHOLESTA-812-24-TRIENOL
db: BioCyc

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

ProteinComplex/15539 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adiponectin Trimer
stoichiometric coefficient: 1.0

BiologicalState1027
type: BioSource
xref: Reference/TAXONOMY 5476
name: Candida albicans

cAMP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cAMP
name: SubPathwayInput

Lanosterol 14-alpha demethylase
type: Protein
cellular location: Cell Membrane
entity reference: Lanosterol 14-alpha demethylase

Oxygen
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Oxygen

BiologicalState1041
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Adipose
tissue: Adipose

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Compound/PW C000143 Cell Membrane/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 3.0

ChemicalStructure/PW C000966
type: ChemicalStructure
structure format: SMILES

Adenylate cyclase type 9
type: Protein
cellular location: Cell Membrane
entity reference: Adenylate cyclase type 9

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

Reference/PathWhiz PW000454
type: UnificationXref
id: PW000454
db: PathWhiz

Reference/BioCyc LANOSTEROL
type: UnificationXref
id: LANOSTEROL
db: BioCyc

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Clotrimazole Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/2506033
pathway order: PathwayInteraction/3966
pathway order: PathwayInteraction/3963
pathway order: PathwayTransport/2506509
pathway order: PathwayEnzymeReaction/2506514
pathway order: PathwaySubPathway/117642
pathway order: PathwayInteraction/3961
pathway order: PathwaySubPathway/117588
pathway order: PathwayInteraction/3960
pathway order: PathwaySubPathway/117603
pathway component: TransportCatalysis5037
pathway component: ReactionCatalysis207749
pathway component: ReactionCatalysis203357
pathway component: Interaction3960
pathway component: Steroid Biosynthesis (Not This One)
pathway component: Interaction3961
pathway component: Interaction3963
pathway component: Reaction213772
pathway component: Lipolysis
pathway component: 1.14.14.154
pathway component: Interaction3966
pathway component: Insulin Signalling
pathway component: Transport14072
xref: Reference/SMPDB SMP0125104
xref: Reference/PathWhiz PW126641
organism: Homo sapiens

Reference/ChemSpider 216175
type: UnificationXref
id: 216175
db: ChemSpider

Compound/PW C000966 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lanosterol
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Reference/PubChem-compound 18971002
type: UnificationXref
id: 18971002
db: PubChem-compound

Formic acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Formic acid

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C000809 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4,4-Dimethylcholesta-8,14,24-trienol
stoichiometric coefficient: 1.0

Adiponectin
type: ProteinReference
xref: Reference/UniProt Q15848
organism: BiologicalState1041

Reference/HMDB HMDB0000142
type: UnificationXref
id: HMDB0000142
db: HMDB

cAMP
type: SmallMolecule
cellular location: Cell Membrane
entity reference: cAMP

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000701
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C00058
type: UnificationXref
id: C00058
db: KEGG Compound

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Formic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30751
xref: Reference/ChemSpider 278
xref: Reference/PubChem-compound 18971002
xref: Reference/BioCyc FORMATE
xref: Reference/CAS 64-18-6
xref: Reference/KEGG Compound C00058
xref: Reference/HMDB HMDB0000142
chemical formula: CH2O2
molecular weight: 46.005478
structure: ChemicalStructure/PW C000092

Reference/HMDB HMDB0001922
type: UnificationXref
id: HMDB0001922
db: HMDB

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 3764
type: UnificationXref
id: CHEBI:3764
db: ChEBI

Reference/BioCyc FORMATE
type: UnificationXref
id: FORMATE
db: BioCyc

Reference/ChEBI CHEBI 16521
type: UnificationXref
id: CHEBI:16521
db: ChEBI

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChemSpider 391478
type: UnificationXref
id: 391478
db: ChemSpider

Compound/PW C001420 Cell Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 4.0

Reaction213772
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000041 Cell Membrane/Stoichiometry/1.0
right: cAMP
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate → cAMP
conversion direction: LEFT_TO_RIGHT

SubPathwayInteraction117642
type: Interaction
name: SubPathway117642Reaction
name: SubPathwayReaction
participant: Adiponectin Trimer

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/SMPDB SMP0000391
type: UnificationXref
id: SMP0000391
db: SMPDB

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 246983
type: UnificationXref
id: 246983
db: PubChem-compound

Reference/UniProt Q15848
type: UnificationXref
id: Q15848
db: UniProt

Reference/PubChem-compound 21775588
type: UnificationXref
id: 21775588
db: PubChem-compound

Reference/HMDB HMDB0001251
type: UnificationXref
id: HMDB0001251
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/KEGG Compound C01724
type: UnificationXref
id: C01724
db: KEGG Compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Reference/ChEBI CHEBI 30751
type: UnificationXref
id: CHEBI:30751
db: ChEBI

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0001023
type: UnificationXref
id: HMDB0001023
db: HMDB

ChemicalStructure/PW C000092
type: ChemicalStructure
structure format: SMILES
structure data: OC=O

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

ProteinComplex/15539/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adiponectin Trimer
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

NADPH
type: SmallMolecule
cellular location: Cell Membrane
entity reference: NADPH

Reference/TAXONOMY 5476
type: UnificationXref
id: 5476
db: TAXONOMY

Adiponectin
type: Protein
cellular location: Cytoplasm
entity reference: Adiponectin

Reference/PubChem-compound 2812
type: UnificationXref
id: 2812
db: PubChem-compound

Clotrimazole
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Clotrimazole

Ergosterol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Ergosterol
name: SubPathwayOutput

Interaction3960
type: MolecularInteraction
interaction type: direct_interaction
name: Clotrimazole inhibits Lanosterol 14-alpha demethylase
participant: Lanosterol 14-alpha demethylase
participant: Clotrimazole

Interaction3961
type: MolecularInteraction
interaction type: direct_interaction
name: Clotrimazole inhibits Ergosterol
participant: Ergosterol
participant: Clotrimazole

Interaction3963
type: MolecularInteraction
interaction type: direct_interaction
name: Clotrimazole inhibits Hydroxycarboxylic acid receptor 2
participant: Hydroxycarboxylic acid receptor 2
participant: Clotrimazole

Reference/CAS 64-18-6
type: UnificationXref
id: 64-18-6
db: CAS

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BRENDA TISSUE ONTOLOGY BTO 0000441
type: UnificationXref
id: BTO:0000441
db: BRENDA TISSUE ONTOLOGY

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Interaction3966
type: MolecularInteraction
interaction type: direct_interaction
name: Hydroxycarboxylic acid receptor 2 inhibits Adenylyl Cyclase
participant: Hydroxycarboxylic acid receptor 2
participant: Adenylate cyclase type 9

SubPathwayInteraction117603
type: Interaction
name: SubPathway117603Reaction
name: SubPathwayReaction
participant: cAMP

ChemicalStructure/PW C001281
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Adipose
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000441

ReactionCatalysis203357
type: Catalysis
controller: Adenylate cyclase type 9
controlled: Reaction213772
control type: ACTIVATION

Reference/HMDB HMDB0000878
type: UnificationXref
id: HMDB0000878
db: HMDB

Reference/CAS 64284-64-6
type: UnificationXref
id: 64284-64-6
db: CAS

Compound/PW C000146 Cell Membrane/Stoichiometry/3.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 3.0

Hydroxycarboxylic acid receptor 2
type: Protein
entity reference: Hydroxycarboxylic acid receptor 2