Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

L-Glutamic acid
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: L-Glutamic acid

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/HMDB HMDB0014375
type: UnificationXref
id: HMDB0014375
db: HMDB

direct_interaction
type: InteractionVocabulary

Glutamate [NMDA] receptor subunit epsilon-3
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-3

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

TransportCatalysis5019
type: Catalysis
controller: NMDA Receptor
controlled: Transport14050
control type: ACTIVATION

TransportCatalysis5017
type: Catalysis
controller: Excitatory amino acid transporter 2
controlled: Transport14048
control type: ACTIVATION

TransportCatalysis5018
type: Catalysis
controller: AMPA
controlled: Transport14049
control type: ACTIVATION

Brain
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000142

TransportCatalysis5015
type: Catalysis
controller: Vesicular glutamate transporter 1
controlled: Transport14045
control type: ACTIVATION

TransportCatalysis5016
type: Catalysis
controller: L-type calcium channel
controlled: Transport14047
control type: ACTIVATION

Interaction3971
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium activates L-Glutamic acid
participant: Calcium
participant: L-Glutamic acid

Interaction3972
type: MolecularInteraction
interaction type: direct_interaction
name: L-Glutamic acid activates AMPA
participant: AMPA
participant: L-Glutamic acid

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium
name: SubPathwayInput

Interaction3974
type: MolecularInteraction
interaction type: direct_interaction
name: Pregabalin inhibits L-type calcium channel
participant: Pregabalin
participant: L-type calcium channel

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Glutamate [NMDA] receptor subunit 3A
type: ProteinReference
xref: Reference/UniProt Q8TCU5
organism: BiologicalState1044

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Extracellular Space
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Glutamate receptor 1
type: Protein
entity reference: Glutamate receptor 1

Reference/UniProt Q12879
type: UnificationXref
id: Q12879
db: UniProt

Reference/UniProt Q8TCU5
type: UnificationXref
id: Q8TCU5
db: UniProt

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reference/CAS 148553-50-8
type: UnificationXref
id: 148553-50-8
db: CAS

3.5.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C022608 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
right: L-Glutamic acid
right: Ammonium
spontaneous: false
EC number: 3.5.1.2
left: L-Glutamine
left: Water
name: L-Glutamine + Water ↔ Ammonium + L-Glutamic acid
conversion direction: REVERSIBLE

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Glutamate [NMDA] receptor subunit epsilon-4
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-4

Depolarization
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway117606
pathway component: SubPathwayInteraction117606
name: SubPathway

Reference/UniProt O60391
type: UnificationXref
id: O60391
db: UniProt

Reference/UniProt Q13936
type: UnificationXref
id: Q13936
db: UniProt

Pregabalin
type: SmallMoleculeReference
xref: Reference/ChemSpider 4589156
xref: Reference/CAS 148553-50-8
xref: Reference/HMDB HMDB0014375
xref: Reference/PubChem-compound 25271887
xref: Reference/ChEBI CHEBI 64356
chemical formula: C8H17NO2
molecular weight: 159.12593
structure: ChemicalStructure/PW C008772

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Glutamic acid

ReactionCatalysis207755
type: Catalysis
controller: Glutaminase kidney isoform, mitochondrial
controlled: 3.5.1.2
control type: ACTIVATION

Reference/UniProt Q9P2U7
type: UnificationXref
id: Q9P2U7
db: UniProt

Reference/UniProt O94925
type: UnificationXref
id: O94925
db: UniProt

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Glutaminase kidney isoform, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Glutaminase kidney isoform, mitochondrial

Glutamate [NMDA] receptor subunit 3B
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit 3B

Transport14050
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

L-type calcium channel
type: Complex
component: Voltage-dependent calcium channel subunit alpha-2/delta-1
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit beta-1

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Reference/ChEBI CHEBI 64356
type: UnificationXref
id: CHEBI:64356
db: ChEBI

Glutamate receptor 2
type: Protein
entity reference: Glutamate receptor 2

Reference/SMPDB SMP0125115
type: UnificationXref
id: SMP0125115
db: SMPDB

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: Protein
cellular location: Extracellular Space
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-1

Transport14047
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Brain, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14046
type: Transport
participant stoichiometry: Compound/PW C000095 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Synapse/Stoichiometry/1.0
right: L-Glutamic acid
spontaneous: false
left: L-Glutamic acid
name: L-Glutamic acid (→) Transport: Homo sapiens, Brain, Neuron, Exocytic Vesicle to Homo sapiens, Brain, Neuron, Synapse
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Transport14049
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Brain, Extracellular Space to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14048
type: Transport
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Synapse/Stoichiometry/1.0
right: L-Glutamic acid
spontaneous: false
left: L-Glutamic acid
name: L-Glutamic acid (→) Transport: Homo sapiens, Brain, Neuron, Synapse to Homo sapiens, Brain, Neuron, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14045
type: Transport
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Exocytic Vesicle/Stoichiometry/1.0
right: L-Glutamic acid
spontaneous: false
left: L-Glutamic acid
name: L-Glutamic acid (→) Transport: Homo sapiens, Brain, Neuron, Cytosol to Homo sapiens, Brain, Neuron, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C008772
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)C[C@H](CN)CC(O)=O

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-1

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

NMDA Receptor
type: Complex
component: Glutamate [NMDA] receptor subunit 3B
component: Glutamate [NMDA] receptor subunit 3A
component: Glutamate [NMDA] receptor subunit epsilon-1
component: Glutamate [NMDA] receptor subunit epsilon-3
component: Glutamate [NMDA] receptor subunit epsilon-2
component: Glutamate [NMDA] receptor subunit epsilon-4
component: Glutamate [NMDA] receptor subunit zeta-1

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/UniProt Q05586
type: UnificationXref
id: Q05586
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/ChemSpider 4589156
type: UnificationXref
id: 4589156
db: ChemSpider

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Glutamate [NMDA] receptor subunit 3A
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit 3A

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

BiologicalState84
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain
tissue: Brain

Reference/CELL TYPE ONTOLOGY CL 0000540
type: UnificationXref
id: CL:0000540
db: CELL TYPE ONTOLOGY

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: Reference/UniProt Q13936

Glutamate receptor 1
type: ProteinReference
xref: Reference/UniProt P42261
organism: BiologicalState1044

Neuron
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000540

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

Excitatory amino acid transporter 2
type: ProteinReference
xref: Reference/UniProt P43004

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

Glutaminase kidney isoform, mitochondrial
type: ProteinReference
xref: Reference/UniProt O94925
organism: BiologicalState1044

Vesicular glutamate transporter 1
type: ProteinReference
xref: Reference/UniProt Q9P2U7

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Glutamate [NMDA] receptor subunit 3B
type: Protein
entity reference: Glutamate [NMDA] receptor subunit 3B

Reference/UniProt P54289
type: UnificationXref
id: P54289
db: UniProt

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

post-synaptic membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045211

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit zeta-1

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/PathWhiz PW126653
type: UnificationXref
id: PW126653
db: PathWhiz

Reference/UniProt Q14957
type: UnificationXref
id: Q14957
db: UniProt

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Glutamate [NMDA] receptor subunit epsilon-3
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-3

L-Glutamic acid
type: SmallMolecule
cellular location: post-synaptic membrane
entity reference: L-Glutamic acid

Glutamate [NMDA] receptor subunit epsilon-2
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-2

Glutamate [NMDA] receptor subunit epsilon-4
type: Protein
entity reference: Glutamate [NMDA] receptor subunit epsilon-4

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Reference/BRENDA TISSUE ONTOLOGY BTO 0000142
type: UnificationXref
id: BTO:0000142
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt P43004
type: UnificationXref
id: P43004
db: UniProt

NMDA Receptor
type: Complex
cellular location: post-synaptic membrane
component: Glutamate [NMDA] receptor subunit epsilon-2
component: Glutamate [NMDA] receptor subunit epsilon-3
component: Glutamate [NMDA] receptor subunit epsilon-4
component: Glutamate [NMDA] receptor subunit 3B
component: Glutamate [NMDA] receptor subunit 3A
component: Glutamate [NMDA] receptor subunit zeta-1
component: Glutamate [NMDA] receptor subunit epsilon-1

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/UniProt O15399
type: UnificationXref
id: O15399
db: UniProt

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

Reference/GENE ONTOLOGY GO 0045211
type: UnificationXref
id: GO:0045211
db: GENE ONTOLOGY

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

BiologicalState1044
type: BioSource
cell type: Neuron
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Brain, Neuron
tissue: Brain

L-type calcium channel
type: Complex
cellular location: Extracellular Space
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent calcium channel subunit alpha-2/delta-1

Glutamate [NMDA] receptor subunit epsilon-1
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-1

Glutamate receptor 2
type: ProteinReference
xref: Reference/UniProt P42262
organism: BiologicalState1044

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Voltage-dependent calcium channel subunit alpha-2/delta-1
type: ProteinReference
xref: Reference/UniProt P54289

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Glutamate receptor 1
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate receptor 1

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C022608 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

AMPA
type: Complex
component: Glutamate receptor 2
component: Glutamate receptor 1

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

AMPA
type: Complex
cellular location: post-synaptic membrane
component: Glutamate receptor 1
component: Glutamate receptor 2

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Interaction3357
type: MolecularInteraction
interaction type: direct_interaction
name: L-Glutamic acid activates NMDA Receptor
participant: NMDA Receptor
participant: L-Glutamic acid

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/UniProt P42262
type: UnificationXref
id: P42262
db: UniProt

Reference/UniProt P42261
type: UnificationXref
id: P42261
db: UniProt

Glutamate [NMDA] receptor subunit epsilon-2
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit epsilon-2

Compound/PW C000500 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Glutamate [NMDA] receptor subunit zeta-1
type: ProteinReference
xref: Reference/UniProt Q05586
organism: BiologicalState1044

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium
name: SubPathwayInput

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Glutamate [NMDA] receptor subunit 3A
type: Protein
entity reference: Glutamate [NMDA] receptor subunit 3A

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Glutamate [NMDA] receptor subunit 3B
type: ProteinReference
xref: Reference/UniProt O60391
organism: BiologicalState1044

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

L-Glutamine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Glutamine

Glutamate [NMDA] receptor subunit epsilon-3
type: ProteinReference
xref: Reference/UniProt Q14957
organism: BiologicalState1044

Glutamate [NMDA] receptor subunit epsilon-2
type: ProteinReference
xref: Reference/UniProt Q13224
organism: BiologicalState1044

Glutamate [NMDA] receptor subunit epsilon-4
type: ProteinReference
xref: Reference/UniProt O15399
organism: BiologicalState1044

Compound/PW C000095 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Glutamate [NMDA] receptor subunit epsilon-1
type: ProteinReference
xref: Reference/UniProt Q12879
organism: BiologicalState1044

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Glutamate receptor 2
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate receptor 2

Reference/PubChem-compound 25271887
type: UnificationXref
id: 25271887
db: PubChem-compound

Compound/PW C000095 Synapse/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

Glutamate [NMDA] receptor subunit zeta-1
type: Protein
cellular location: post-synaptic membrane
entity reference: Glutamate [NMDA] receptor subunit zeta-1

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Pregabalin Action Pathway (New)
type: Pathway
pathway order: PathwaySubPathway/117606
pathway order: PathwayInteraction/3974
pathway order: PathwayTransport/2506086
pathway order: PathwayInteraction/3357
pathway order: PathwayTransport/2506097
pathway order: PathwayTransport/2506085
pathway order: PathwayInteraction/3972
pathway order: PathwayTransport/2506096
pathway order: PathwayInteraction/3971
pathway order: PathwayEnzymeReaction/2506084
pathway order: PathwayTransport/2506092
pathway order: PathwayTransport/2506090
pathway component: TransportCatalysis5019
pathway component: TransportCatalysis5017
pathway component: TransportCatalysis5018
pathway component: TransportCatalysis5015
pathway component: TransportCatalysis5016
pathway component: 3.5.1.2
pathway component: Interaction3971
pathway component: Interaction3972
pathway component: Interaction3357
pathway component: Interaction3974
pathway component: ReactionCatalysis207755
pathway component: Transport14047
pathway component: Transport14046
pathway component: Transport14049
pathway component: Transport14048
pathway component: Transport14045
pathway component: Depolarization
pathway component: Transport14050
xref: Reference/SMPDB SMP0125115
xref: Reference/PathWhiz PW126653
organism: Homo sapiens

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

SubPathwayInteraction117606
type: Interaction
name: SubPathway117606Reaction
name: SubPathwayReaction
participant: Calcium
participant: Sodium

Compound/PW C000095 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0045202
type: UnificationXref
id: GO:0045202
db: GENE ONTOLOGY

Reference/UniProt Q13224
type: UnificationXref
id: Q13224
db: UniProt

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
cellular location: Extracellular Space
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Vesicular glutamate transporter 1
type: Protein
entity reference: Vesicular glutamate transporter 1

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Pregabalin
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Pregabalin

Ammonium
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Ammonium

Excitatory amino acid transporter 2
type: Protein
entity reference: Excitatory amino acid transporter 2

L-Glutamic acid
type: SmallMolecule
cellular location: Synapse
entity reference: L-Glutamic acid

Synapse
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0045202