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5,10- Methylene-THF transporter 5-- Methyltetrahydrofolic acid transporter 10- Formyltetrahydrofolate transporter Folate receptor beta Folate receptor beta Folate receptor beta Proton-coupled folate transporter Uridine phosphorylase 2 Thymidine kinase, cytosolic Thymidylate synthase Dihydrofolate reductase Dihydrofolate reductase Serine hydroxymethyltransferase, cytosolic S- adenosylmethionine synthase isoform type-2 Methionine adenosyltransferase 2 subunit beta DNA (cytosine-5)- methyltransferase 3A DNA (cytosine-5)- methyltransferase 3-like Adenosylhomocysteinase Methionine synthase Methylenetetrahydrofolate reductase C-1- tetrahydrofolate synthase, cytoplasmic Thymidylate kinase Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylformylglycinamidine synthase Multifunctional protein ADE2 Multifunctional protein ADE2 Adenylosuccinate lyase Bifunctional purine biosynthesis protein PURH Bifunctional purine biosynthesis protein PURH Inosine-5'- monophosphate dehydrogenase 1 Trifunctional purine biosynthetic protein adenosine-3 GMP synthase [glutamine- hydrolyzing] Guanylate kinase Adenylate kinase 9 Ribonucleoside- diphosphate reductase large subunit Ribonucleoside- diphosphate reductase subunit M2 Adenylate kinase 9 Adenylosuccinate synthetase isozyme 1 Adenylosuccinate lyase Adenylate kinase isoenzyme 1 Ribonucleoside- diphosphate reductase large subunit Ribonucleoside- diphosphate reductase subunit M2 Adenylate kinase 9 Adenylate kinase 9 Adenylate kinase 9 S- Adenosylmethionine GTP dGTP ATP Deoxyadenosine triphosphate dTTP 5,10- Methylene-THF 5,10- Methylene-THF 5- Methyltetrahydrofolic acid 5- Methyltetrahydrofolic acid 10- Formyltetrahydrofolate 10- Formyltetrahydrofolate 5,10-Methylene-THF 5-Methyltetrahydrofolic acid 10-Formyltetrahydrofolate Folic acid Folic acid Uracil Ribose 1-phosphate Deoxyuridine Pi ATP dUMP ADP 5-Thymidylic acid Dihydrofolic acid Dihydrofolic acid NADP NADPH NADPH Tetrahydrofolic acid NADP L-Serine Glycine H2O L-Methionine H2O ATP Diphosphoric acid Pi S- Adenosylhomocysteine H2O Homocysteine Adenosine Tetrahydrofolic acid NADPH H+ NADP Formic acid ATP ADP Pi ATP dTDP ADP Glycineamideribotide Tetrahydrofolic acid 5'- Phosphoribosyl- N- formylglycinamide ATP L-Glutamine H2O ADP Phosphoric acid Phosphoribosylformylglycineamidine L-Glutamic acid 5-amino-1-(5- phospho-D- ribosyl)imidazole- 4-carboxylate 5- Aminoimidazole ribonucleotide CO2 ATP L-Aspartic acid ADP Phosphoric acid SAICAR Fumaric acid AICAR 10-Formyltetrahydrofolate Tetrahydrofolic acid Phosphoribosyl formamidocarboxamide Inosinic acid H2O H2O NAD Xanthylic acid H+ NADH ATP ADP Pi ATP H2O L-Glutamine AMP PPi L-Glutamic acid Guanosine monophosphate ATP ADP GDP ATP ADP dGDP H2O ATP ADP GTP L-Aspartic acid N(6)-(1,2- dicarboxyethyl)AMP GDP Pi AMP Fumaric acid ATP ADP dADP H2O ATP ADP ATP ADP ATP ADP Pyridoxal 5'-phosphate Potassium NAD Zinc (II) ion Methylcobalamin FAD Potassium Fe3+ Magnesium Fe3+ Thioredoxin Thioredoxin disulfide Thioredoxin Thioredoxin disulfide DNA DNA 5- methylcytosine DNA Methylation RNA synthesis DNA synthesis RNA synthesis DNA synthesis DNA synthesis Magnesium Magnesium Magnesium Folic acid and its derivatives is transported across cells by receptor-mediated endocytosis Erythroblast Thymidylate nucleic acid synthesis is required to be incorporated in DNA during DNA synthesis Hepatocyte Cytosol Folate is need to produce s-Adenosylmethionine for DNA synthesis that is essential for cell survival Cytosol 10-Formyltetrahydrofolate is involved in production of purine nucleosides needed for DNA and RNA synthesis
Unknown Unknown Unknown FOLR2 FOLR2 FOLR2 SLC46A1 UPP2 TK1 TYMS DHFR DHFR SHMT1 MAT2A MAT2B DNMT3A DNMT3L AHCY MTR MTHFR MTHFD1 DTYMK GART PFAS PAICS PAICS ADSL ATIC ATIC IMPDH1 GART GMPS GUK1 AK9 RRM1 RRM2 AK9 ADSSL1 ADSL AK1 RRM1 RRM2 AK9 AK9 AK9 S- Adenosylmethionine Guanosine triphosphate dGTP Adenosine triphosphate Deoxyadenosine triphosphate dTTP 5,10- Methylene-THF 5,10- Methylene-THF 5- Methyltetrahydrofolic acid 5- Methyltetrahydrofolic acid 10- Formyltetrahydrofolate 10- Formyltetrahydrofolate 5,10- Methylene-THF 5- Methyltetrahydrofolic acid 10- Formyltetrahydrofolate Folic acid Folic acid Uracil Ribose 1-phosphate Deoxyuridine Phosphate Adenosine triphosphate dUMP Adenosine diphosphate 5-Thymidylic acid Dihydrofolic acid Dihydrofolic acid NADP NADPH NADPH Tetrahydrofolic acid NADP L-Serine Glycine Water L-Methionine Water Adenosine triphosphate Diphosphoric acid Phosphate S- Adenosylhomocysteine Water Homocysteine Adenosine Tetrahydrofolic acid NADPH Hydrogen Ion NADP Formic acid Adenosine triphosphate Adenosine diphosphate Phosphate Adenosine triphosphate dTDP Adenosine diphosphate Glycineamideribotide Tetrahydrofolic acid 5'- Phosphoribosyl- N- formylglycinamide Adenosine triphosphate L-Glutamine Water Adenosine diphosphate Phosphoric acid Phosphoribosylformylglycineamidine L-Glutamic acid 5-amino-1-(5- phospho-D- ribosyl)imidazole- 4-carboxylate 5- Aminoimidazole ribonucleotide Carbon dioxide Adenosine triphosphate L-Aspartic acid Adenosine diphosphate Phosphoric acid SAICAR Fumaric acid AICAR 10- Formyltetrahydrofolate Tetrahydrofolic acid Phosphoribosyl formamidocarboxamide Inosinic acid Water Water NAD Xanthylic acid Hydrogen Ion NADH Adenosine triphosphate Adenosine diphosphate Phosphate Adenosine triphosphate Water L-Glutamine Adenosine monophosphate Pyrophosphate L-Glutamic acid Guanosine monophosphate Adenosine triphosphate Adenosine diphosphate Guanosine diphosphate Adenosine triphosphate Adenosine diphosphate dGDP Water Adenosine triphosphate Adenosine diphosphate Guanosine triphosphate L-Aspartic acid N(6)-(1,2- dicarboxyethyl)AMP Guanosine diphosphate Phosphate Adenosine monophosphate Fumaric acid Adenosine triphosphate Adenosine diphosphate dADP Water Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate Thioredoxin Thioredoxin disulfide Thioredoxin Thioredoxin disulfide DNA DNA 5- methylcytosine DNA Methylation RNA synthesis DNA synthesis RNA synthesis DNA synthesis DNA synthesis
FOLR2 FOLR2 FOLR2 SLC46A1 UPP2 TK1 TYMS DHFR DHFR SHMT1 MAT2A MAT2B DNMT3A DNMT3L AHCY MTR MTHFR MTHFD1 DTYMK GART PFAS PAICS PAICS ADSL ATIC ATIC IMPDH1 GART GMPS GUK1 AK9 RRM1 RRM2 AK9 ADSSL1 ADSL AK1 RRM1 RRM2 AK9 AK9 AK9 SAMe GTP dGTP ATP doATP dTTP 5XM-THF 5XM-THF 5-MTHFa 5-MTHFa 10-FTHF 10-FTHF 5XM-THF 5-MTHFa 10-FTHF Folate Folate Uracil Rib-1P Du Pi ATP dUMP ADP 5TMA FAH2 FAH2 NADP NADPH NADPH THFA NADP Ser Gly H2O Met H2O ATP Dip aci Pi SAH H2O Hcys Adenosi THFA NADPH H+ NADP Formate ATP ADP Pi ATP dTDP ADP Glyadbt THFA 5PPNFG ATP Gln H2O ADP PhosfrA FGAM Glu CR 5-AnRbn CO2 ATP Asp ADP PhosfrA SAICAR Fumarat AICAR 10-FTHF THFA FosbFca Imp H2O H2O NAD XntylcA H+ NADH ATP ADP Pi ATP H2O Gln AMP PPi Glu GSMP ATP ADP GDP ATP ADP dGDP H2O ATP ADP GTP Asp N6AMP GDP Pi AMP Fumarat ATP ADP dADP H2O ATP ADP ATP ADP ATP ADP Pyr-5'P K+ NAD Zinc Mecbl FAD K+ Fe3+ Mg2+ Fe3+ Thiored TD Thiored TD DNA DN 5-me DNA Met RNA syn DNA syn RNA syn DNA syn DNA syn Mg2+ Mg2+ Mg2+ Folic acid and its derivatives is transported across cells by receptor-mediated endocytosis Erythroblast Thymidylate nucleic acid synthesis is required to be incorporated in DNA during DNA synthesis Hepatocyte Cytosol Folate is need to produce s-Adenosylmethionine for DNA synthesis that is essential for cell survival Cytosol 10-Formyltetrahydrofolate is involved in production of purine nucleosides needed for DNA and RNA synthesis
FOLR2 FOLR2 FOLR2 SLC46A1 UPP2 TK1 TYMS DHFR DHFR SHMT1 MAT2A MAT2B DNMT3A DNMT3L AHCY MTR MTHFR MTHFD1 DTYMK GART PFAS PAICS PAICS ADSL ATIC ATIC IMPDH1 GART GMPS GUK1 AK9 RRM1 RRM2 AK9 ADSSL1 ADSL AK1 RRM1 RRM2 AK9 AK9 AK9 SAMe GTP dGTP ATP doATP dTTP 5XM-THF 5XM-THF 5-MTHFa 5-MTHFa 10-FTHF 10-FTHF 5XM-THF 5-MTHFa 10-FTHF Folate Folate Uracil Rib-1P Du Pi ATP dUMP ADP 5TMA FAH2 FAH2 NADP NADPH NADPH THFA NADP Ser Gly H2O Met H2O ATP Dip aci Pi SAH H2O Hcys Adenosi THFA NADPH H+ NADP Formate ATP ADP Pi ATP dTDP ADP Glyadbt THFA 5PPNFG ATP Gln H2O ADP PhosfrA FGAM Glu CR 5-AnRbn CO2 ATP Asp ADP PhosfrA SAICAR Fumarat AICAR 10-FTHF THFA FosbFca Imp H2O H2O NAD XntylcA H+ NADH ATP ADP Pi ATP H2O Gln AMP Ppi Glu GSMP ATP ADP GDP ATP ADP dGDP H2O ATP ADP GTP Asp N6AMP GDP Pi AMP Fumarat ATP ADP dADP H2O ATP ADP ATP ADP ATP ADP Thiored TD Thiored TD DNA DN 5-me DNA Met RNA syn DNA syn RNA syn DNA syn DNA syn