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Myosin light chain kinase, smooth muscle Inositol 1,4,5- trisphosphate receptor type 1 Protein kinase C alpha type Protein phosphatase 1 regulatory subunit 14A Serine/threonine- protein phosphatase PP1-beta catalytic subunit Alpha-1A adrenergic receptor Actin, cytoplasmic 1 Myosin LC-P Myosin light chain 3 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Calmodulin-1 Calmodulin-1 Inositol 1,4,5- trisphosphate Phenylephrine Ca+ Ca+ Phosphatidylinositol 4,5- bisphosphate Magnesium Calcium Manganese Ca+ Diacylglycerol Contraction Relaxation Gq signaling cascade Calcium 1. Phenylephrine activates alpha1 adrenergic receptor on the smooth muscle of the blood vessel 6.Myosin LC-P interacts with actin to produce smooth muscle contraction. Since there are low levels of myosin LC-P, contraction is inhibited 2. The Gq signaling cascade is activated, leading to the production of IP3 and DAG 3. IP3 activates IP3 receptor on the sarcoplasmic reticulum leading to influx of calcium into the cytosol 4. Calcium binds to calmodulin and activates myosin light chain kinase Cytosol Sarcoplasmic Reticulum 5. Diacylglycerol activates PKC leading to inhibition of myosin light chain phosphatase
MYLK ITPR1 PRKCA PPP1R14A PPP1CB ADRA1A ACTB MYL3 MYL3 PLCB1 CALM1 CALM1 Inositol 1,4,5- trisphosphate Phenylephrine Calcium Calcium Phosphatidylinositol 4,5- bisphosphate Calcium Diacylglycerol Contraction Relaxation Gq signaling cascade
MYLK ITPR1 PRKCA PPP1R14A PPP1CB ADRA1A ACTB MYL3 MYL3 PLCB1 CALM1 CALM1 Inotp Doktors Ca+ Ca+ P45P Mg2+ Ca2+ Mn2+ Ca+ Diacylg Contr Relax Gq si c Ca2+ 1. Phenylephrine activates alpha1 adrenergic receptor on the smooth muscle of the blood vessel 6.Myosin LC-P interacts with actin to produce smooth muscle contraction. Since there are low levels of myosin LC-P, contraction is inhibited 2. The Gq signaling cascade is activated, leading to the production of IP3 and DAG 3. IP3 activates IP3 receptor on the sarcoplasmic reticulum leading to influx of calcium into the cytosol 4. Calcium binds to calmodulin and activates myosin light chain kinase Cytosol Sarcoplasmic Reticulum 5. Diacylglycerol activates PKC leading to inhibition of myosin light chain phosphatase
MYLK ITPR1 PRKCA PPP1R14A PPP1CB ADRA1A ACTB MYL3 MYL3 PLCB1 CALM1 CALM1 Inotp Doktors Ca2+ Ca2+ P45P Ca2+ Diacylg Contr Relax Gq si c