Pseudoephedrine is a drug taken orally in cold and sinus medication or allergy medication. It is swallowed as a pill where it is digested then absorbed through the epithelial cells of the intestine without a transporter. Pseudoephedrine is a BSC class 1 compound, and therefore has high permiability and is able to pass through the membranes of the intestine and liver. It travels through the blood stream where only a small portion of Pseudoephedrine is metabolized in the liver. It is N-demethylated by Cytochrome P450 1A2 into the inactive metabolite Norpseudoephedrine. Both Pseudoephedrine and Norpseudoephedrine travel to the kidney where 55%-75% of the dose are excreted in the urine as unchanged Pseudoephedrine.

Pseudoephedrine Metabolism References