Compound/PW C000047 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0015108
type: UnificationXref
id: HMDB0015108
db: HMDB

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/GENE ONTOLOGY GO 0030139
type: UnificationXref
id: GO:0030139
db: GENE ONTOLOGY

Reaction218598
type: BiochemicalReaction
participant stoichiometry: Compound/Generic635 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/Generic637 Lysosome/Stoichiometry/1.0
right: Cholesterol ester
spontaneous: false
left: Low density lipoproteins
name: Low density lipoproteins → Cholesterol ester
conversion direction: LEFT_TO_RIGHT

3.1.1.13
type: BiochemicalReaction
participant stoichiometry: Compound/Generic635 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000047 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Lysosome/Stoichiometry/1.0
participant stoichiometry: Compound/Generic25 Lysosome/Stoichiometry/1.0
right: Cholesterol
right: Fatty Acid
spontaneous: false
EC number: 3.1.1.13
left: Water
left: Cholesterol ester
name: Cholesterol ester + Water → Cholesterol + Fatty Acid
conversion direction: LEFT_TO_RIGHT

Reaction218596
type: BiochemicalReaction
participant stoichiometry: Compound/Generic636 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic635 Cytosol/Stoichiometry/1.0
right: Cholesterol ester
spontaneous: false
left: chylomicron remnant
name: chylomicron remnant → Cholesterol ester
conversion direction: LEFT_TO_RIGHT

NPC1-like intracellular cholesterol transporter 1
type: ProteinReference
xref: Reference/UniProt Q9UHC9
organism: BiologicalState75

direct_interaction
type: InteractionVocabulary

Reference/BioCyc CHOLESTEROL
type: UnificationXref
id: CHOLESTEROL
db: BioCyc

Clathrin light chain A
type: ProteinReference
xref: Reference/UniProt P09496
organism: BiologicalState75

Low-density lipoprotein receptor
type: Protein
cellular location: Endocytic Vesicle
entity reference: Low-density lipoprotein receptor

Fatty Acid
type: SmallMolecule
cellular location: Lysosome
entity reference: Fatty Acid

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/GENE ONTOLOGY GO 0070382
type: UnificationXref
id: GO:0070382
db: GENE ONTOLOGY

chylomicron remnant
type: SmallMolecule
cellular location: Extracellular Space
entity reference: chylomicron remnant

Fatty Acids
type: SmallMoleculeReference

Reference/UniProt P02655
type: UnificationXref
id: P02655
db: UniProt

Reference/UniProt P53680
type: UnificationXref
id: P53680
db: UniProt

Triglyceride
type: SmallMolecule
cellular location: Cytosol
entity reference: Triglyceride

NPC1-like intracellular cholesterol transporter 1
type: Protein
cellular location: Cell Membrane
entity reference: NPC1-like intracellular cholesterol transporter 1

Low-density lipoprotein receptor
type: Protein
cellular location: Cytosol
entity reference: Low-density lipoprotein receptor

chylomicron remnant
type: SmallMolecule
cellular location: Endocytic Vesicle
entity reference: chylomicron remnant

Reference/UniProt P63010
type: UnificationXref
id: P63010
db: UniProt

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/Generic635 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol ester
stoichiometric coefficient: 1.0

Reference/UniProt Q9UHC9
type: UnificationXref
id: Q9UHC9
db: UniProt

Ezetimibe
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 49040
xref: Reference/HMDB HMDB0015108
xref: Reference/PubChem-compound 150311
xref: Reference/ChemSpider 132493
xref: Reference/CAS 163222-33-1
chemical formula: C24H21F2NO3
molecular weight: 409.14896
structure: ChemicalStructure/PW C009412

Apolipoprotein C-II
type: ProteinReference
xref: Reference/UniProt P02655
organism: Homo sapiens

AP-2 complex subunit beta
type: ProteinReference
xref: Reference/UniProt P63010
organism: BiologicalState75

Transport14196
type: Transport
participant stoichiometry: BoundComplex/580 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: BoundComplex/580 Endocytic Vesicle/Stoichiometry/1.0
right: Low-density lipoprotein receptor (Homo sapiens)_Low density lipoproteins
spontaneous: false
left: Low-density lipoprotein receptor (Homo sapiens)_Low density lipoproteins
name: Low-density lipoprotein receptor (Homo sapiens) + Low density lipoproteins (→) Transport: Homo sapiens, Liver, Hepatocyte, Cell Membrane to Homo sapiens, Liver, Hepatocyte, Endocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Ezetimibe
type: SmallMolecule
entity reference: Ezetimibe

Transport14199
type: Transport
participant stoichiometry: Compound/Generic636 Endocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/Generic636/Stoichiometry/1.0
right: chylomicron remnant
spontaneous: false
left: chylomicron remnant
name: chylomicron remnant (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Endocytic Vesicle
conversion direction: LEFT_TO_RIGHT

Transport14198
type: Transport
participant stoichiometry: Protein/1764 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1764 Cell Membrane/Stoichiometry/1.0
right: Low-density lipoprotein receptor
spontaneous: false
left: Low-density lipoprotein receptor
name: Low-density lipoprotein receptor (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Cell Membrane
conversion direction: LEFT_TO_RIGHT

Cholesterol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000067
xref: Reference/ChEBI CHEBI 16113
xref: Reference/BioCyc CHOLESTEROL
xref: Reference/KEGG Compound C00187
xref: Reference/ChemSpider 5775
xref: Reference/PubChem-compound 5997
xref: Reference/CAS 57-88-5
chemical formula: C27H46O
molecular weight: 386.35486
structure: ChemicalStructure/PW C000047

AP-2 complex subunit mu
type: ProteinReference
xref: Reference/UniProt Q96CW1
organism: BiologicalState75

Transport14193
type: Transport
participant stoichiometry: Compound/Generic392 Exocytic Vesicle/Stoichiometry/1.0
participant stoichiometry: Compound/Generic392/Stoichiometry/1.0
right: Chylomicron
spontaneous: false
left: Chylomicron
name: Chylomicron (→) Transport: Homo sapiens, Intestine, Epithelial Cell, Exocytic Vesicle to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Clathrin heavy chain 2
type: ProteinReference
xref: Reference/UniProt P53675
organism: BiologicalState75

Transport14192
type: Transport
participant stoichiometry: Compound/Generic392 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic392 Exocytic Vesicle/Stoichiometry/1.0
right: Chylomicron
spontaneous: false
left: Chylomicron
name: Chylomicron (→) Transport: Homo sapiens, Intestine, Epithelial Cell, Cytosol to Homo sapiens, Intestine, Epithelial Cell, Exocytic Vesicle
conversion direction: LEFT_TO_RIGHT

AP-2 complex subunit alpha-1
type: ProteinReference
xref: Reference/UniProt O95782
organism: BiologicalState75

AP-2 complex subunit sigma
type: ProteinReference
xref: Reference/UniProt P53680
organism: BiologicalState75

Transport14194
type: Transport
participant stoichiometry: Compound/Generic636 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic636/Stoichiometry/1.0
right: chylomicron remnant
spontaneous: false
left: chylomicron remnant
name: chylomicron remnant (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Lipoprotein lipase
type: Protein
cellular location: Cell Membrane
entity reference: Lipoprotein lipase

Protein/24048 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NPC1-like intracellular cholesterol transporter 1
stoichiometric coefficient: 1.0

Transport14191
type: Transport
participant stoichiometry: Protein/24048 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/24048 Cytosol/Stoichiometry/1.0
right: NPC1-like intracellular cholesterol transporter 1
spontaneous: false
left: NPC1-like intracellular cholesterol transporter 1
name: Niemann-Pick C1-Like 1 (→) Transport: Homo sapiens, Intestine, Epithelial Cell, Cytosol to Homo sapiens, Intestine, Epithelial Cell, Cell Membrane
conversion direction: LEFT_TO_RIGHT

chylomicron remnant
type: SmallMolecule
entity reference: chylomicron remnant

chylomicron remnant
type: SmallMolecule
cellular location: Cytosol
entity reference: chylomicron remnant

Reference/ChEBI CHEBI 16113
type: UnificationXref
id: CHEBI:16113
db: ChEBI

Cholesterol
type: SmallMolecule
cellular location: Lysosome
entity reference: Cholesterol

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

AP-2 complex subunit mu
type: Protein
cellular location: Cytosol
entity reference: AP-2 complex subunit mu

Lysosome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005764

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Endocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0030139

Reference/CELL TYPE ONTOLOGY CL 0000066
type: UnificationXref
id: CL:0000066
db: CELL TYPE ONTOLOGY

Reference/PubChem-compound 5997
type: UnificationXref
id: 5997
db: PubChem-compound

Compound/Generic25 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fatty Acid
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Compound/Generic392 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chylomicron
stoichiometric coefficient: 1.0

Low-density lipoprotein receptor (Homo sapiens)_Low density lipoproteins
type: Complex
component stoichiometry: Protein/1764 Endocytic Vesicle/Stoichiometry/1.0
component stoichiometry: Compound/Generic637 Endocytic Vesicle/Stoichiometry/1.0
cellular location: Endocytic Vesicle
component: Low-density lipoprotein receptor
component: Low density lipoproteins

Compound/Generic369 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diacylglycerol
stoichiometric coefficient: 1.0

Low density lipoproteins
type: SmallMolecule
cellular location: Endocytic Vesicle
entity reference: Low density lipoproteins

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Reference/BRENDA TISSUE ONTOLOGY BTO 0000648
type: UnificationXref
id: BTO:0000648
db: BRENDA TISSUE ONTOLOGY

Compound/Generic392 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chylomicron
stoichiometric coefficient: 1.0

Reference/UniProt P53675
type: UnificationXref
id: P53675
db: UniProt

Triglyceride
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00422

AP-2 complex subunit beta
type: Protein
cellular location: Cytosol
entity reference: AP-2 complex subunit beta

Epithelial Cell
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000066

Clathrin heavy chain 2
type: Protein
cellular location: Cytosol
entity reference: Clathrin heavy chain 2

Compound/Generic636 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: chylomicron remnant
stoichiometric coefficient: 1.0

Low density lipoproteins
type: SmallMolecule
cellular location: Lysosome
entity reference: Low density lipoproteins

Apolipoprotein C-II
type: Protein
cellular location: Extracellular Space
entity reference: Apolipoprotein C-II

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Triglyceride
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Triglyceride

Lysosomal acid lipase/cholesteryl ester hydrolase
type: ProteinReference
xref: Reference/UniProt P38571
organism: BiologicalState53

Fatty Acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Fatty Acid

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

BiologicalState75
type: BioSource
cell type: Epithelial Cell
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Intestine, Epithelial Cell
tissue: Intestine

Reference/GENE ONTOLOGY GO 0005764
type: UnificationXref
id: GO:0005764
db: GENE ONTOLOGY

Cholesterol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cholesterol

Compound/Generic637 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low density lipoproteins
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/UniProt P09496
type: UnificationXref
id: P09496
db: UniProt

Reference/ChEBI CHEBI 35366
type: UnificationXref
id: CHEBI:35366
db: ChEBI

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Compound/Generic635 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol ester
stoichiometric coefficient: 1.0

Intestine
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000648

Protein/24048 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NPC1-like intracellular cholesterol transporter 1
stoichiometric coefficient: 1.0

AP-2 complex subunit alpha-1
type: Protein
cellular location: Cytosol
entity reference: AP-2 complex subunit alpha-1

BiologicalState1123
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Muscle
tissue: Muscle

Reference/CAS 57-88-5
type: UnificationXref
id: 57-88-5
db: CAS

Compound/Generic410 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fatty Acids
stoichiometric coefficient: 1.0

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Cholesterol ester
type: SmallMoleculeReference

chylomicron remnant
type: SmallMoleculeReference

Low density lipoproteins
type: SmallMoleculeReference

Lysosomal acid lipase/cholesteryl ester hydrolase
type: Protein
cellular location: Lysosome
entity reference: Lysosomal acid lipase/cholesteryl ester hydrolase

Compound/Generic636/Stoichiometry/1.0
type: Stoichiometry
physical entity: chylomicron remnant
stoichiometric coefficient: 1.0

Chylomicron
type: SmallMolecule
cellular location: Cytosol
entity reference: Chylomicron

Compound/PW C000047 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

BoundComplex/580 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low-density lipoprotein receptor (Homo sapiens)_Low density lipoproteins
stoichiometric coefficient: 1.0

Clathrin
type: Complex
cellular location: Cytosol
component: Clathrin heavy chain 2
component: Clathrin light chain A

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Compound/Generic637 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low density lipoproteins
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 49040
type: UnificationXref
id: CHEBI:49040
db: ChEBI

Sterol O-acyltransferase 1
type: ProteinReference
xref: Reference/UniProt P35610
organism: BiologicalState75

BiologicalState53
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

ProteinComplex/15661 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: AP-2 complex
stoichiometric coefficient: 1.0

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Compound/Generic309 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Triglyceride
stoichiometric coefficient: 1.0

Cholesterol
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Cholesterol

Compound/Generic636 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: chylomicron remnant
stoichiometric coefficient: 1.0

Low density lipoproteins
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Low density lipoproteins

Reaction218588
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/15660 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/15661 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/579 Cytosol/Stoichiometry/1.0
right: Cholesterol_Niemann-Pick C1-Like 1 (Homo sapiens)
spontaneous: false
left: Cholesterol_Niemann-Pick C1-Like 1 (Homo sapiens)
left: AP-2 complex
left: Clathrin
name: AP-2 complex + Cholesterol + Niemann-Pick C1-Like 1 (Homo sapiens) + Clathrin → Cholesterol + Niemann-Pick C1-Like 1 (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Reaction218587
type: BiochemicalReaction
participant stoichiometry: BoundComplex/579 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000047 Cell Membrane/Stoichiometry/1.0
right: Cholesterol_Niemann-Pick C1-Like 1 (Homo sapiens)
spontaneous: false
left: Cholesterol
name: Cholesterol → Cholesterol + Niemann-Pick C1-Like 1 (Homo sapiens)
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 5775
type: UnificationXref
id: 5775
db: ChemSpider

ProteinComplex/15660 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Clathrin
stoichiometric coefficient: 1.0

Compound/Generic392/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chylomicron
stoichiometric coefficient: 1.0

Reaction218589
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000047 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/579 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/24048 Cytosol/Stoichiometry/1.0
right: NPC1-like intracellular cholesterol transporter 1
right: Cholesterol
spontaneous: false
left: Cholesterol_Niemann-Pick C1-Like 1 (Homo sapiens)
name: Cholesterol + Niemann-Pick C1-Like 1 (Homo sapiens) → Cholesterol + Niemann-Pick C1-Like 1
conversion direction: LEFT_TO_RIGHT

Reaction218591
type: BiochemicalReaction
participant stoichiometry: Compound/Generic635 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic392 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic309 Cytosol/Stoichiometry/1.0
right: Chylomicron
spontaneous: false
left: Triglyceride
left: Cholesterol ester
name: Cholesterol ester + Triglyceride → Chylomicron
conversion direction: LEFT_TO_RIGHT

Compound/Generic635 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol ester
stoichiometric coefficient: 1.0

Reaction218590
type: BiochemicalReaction
participant stoichiometry: Compound/Generic635 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000047 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic410 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Cholesterol ester
spontaneous: false
left: Fatty Acids
left: Cholesterol
name: Cholesterol + Fatty Acids ↔ Cholesterol ester + Water
conversion direction: REVERSIBLE

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reaction218595
type: BiochemicalReaction
participant stoichiometry: Compound/Generic637 Cytosol/Stoichiometry/1.0
participant stoichiometry: BoundComplex/580 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/1764 Cytosol/Stoichiometry/1.0
right: Low-density lipoprotein receptor
right: Low density lipoproteins
spontaneous: false
left: Low-density lipoprotein receptor (Homo sapiens)_Low density lipoproteins
name: Low-density lipoprotein receptor (Homo sapiens) + Low density lipoproteins → Low density lipoproteins + Low-density lipoprotein receptor
conversion direction: LEFT_TO_RIGHT

Reaction218594
type: BiochemicalReaction
participant stoichiometry: Compound/Generic637 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: BoundComplex/580 Cell Membrane/Stoichiometry/1.0
right: Low-density lipoprotein receptor (Homo sapiens)_Low density lipoproteins
spontaneous: false
left: Low density lipoproteins
name: Low density lipoproteins → Low-density lipoprotein receptor (Homo sapiens) + Low density lipoproteins
conversion direction: LEFT_TO_RIGHT

Reaction218593
type: BiochemicalReaction
participant stoichiometry: Compound/Generic369 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic25 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/Generic309 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Fatty Acid
right: Diacylglycerol
spontaneous: false
left: Triglyceride
left: Water
name: Triglyceride + Water → Diacylglycerol + Fatty Acid
conversion direction: LEFT_TO_RIGHT

Reaction218592
type: BiochemicalReaction
participant stoichiometry: Compound/Generic392 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic636 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic309 Extracellular Space/Stoichiometry/1.0
right: chylomicron remnant
right: Triglyceride
spontaneous: false
left: Chylomicron
name: Chylomicron → Triglyceride + chylomicron remnant
conversion direction: LEFT_TO_RIGHT

Interaction4090
type: MolecularInteraction
interaction type: direct_interaction
name: Ezetimibe inhibits Niemann-Pick C1-Like 1
participant: Ezetimibe
participant: NPC1-like intracellular cholesterol transporter 1

BiologicalState60
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Intestine
tissue: Intestine

Cholesterol ester
type: SmallMolecule
cellular location: Cytosol
entity reference: Cholesterol ester

Reference/UniProt P35610
type: UnificationXref
id: P35610
db: UniProt

AP-2 complex
type: Complex
cellular location: Cytosol
component: AP-2 complex subunit mu
component: AP-2 complex subunit beta
component: AP-2 complex subunit alpha-1
component: AP-2 complex subunit sigma

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Lipoprotein lipase
type: ProteinReference
xref: Reference/UniProt P06858
organism: Homo sapiens

Cholesterol_Niemann-Pick C1-Like 1 (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000047 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/24048 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: NPC1-like intracellular cholesterol transporter 1
component: Cholesterol

Compound/Generic637 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low density lipoproteins
stoichiometric coefficient: 1.0

Reference/UniProt P06858
type: UnificationXref
id: P06858
db: UniProt

Reference/ChemSpider 132493
type: UnificationXref
id: 132493
db: ChemSpider

Diacylglycerol
type: SmallMoleculeReference

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Compound/PW C000047 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

Chylomicron
type: SmallMolecule
entity reference: Chylomicron

Protein/1764 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low-density lipoprotein receptor
stoichiometric coefficient: 1.0

Compound/Generic309 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Triglyceride
stoichiometric coefficient: 1.0

Compound/Generic25 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fatty Acid
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0125259
type: UnificationXref
id: SMP0125259
db: SMPDB

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Protein/1764 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low-density lipoprotein receptor
stoichiometric coefficient: 1.0

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

BoundComplex/579 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol_Niemann-Pick C1-Like 1 (Homo sapiens)
stoichiometric coefficient: 1.0

Compound/Generic636 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: chylomicron remnant
stoichiometric coefficient: 1.0

Exocytic Vesicle
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070382

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Low-density lipoprotein receptor (Homo sapiens)_Low density lipoproteins
type: Complex
component stoichiometry: Compound/Generic637 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1764 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Low-density lipoprotein receptor
component: Low density lipoproteins

Chylomicron
type: SmallMoleculeReference

Triglyceride
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Triglyceride

Water
type: SmallMolecule
cellular location: Lysosome
entity reference: Water

Reference/KEGG Compound C00187
type: UnificationXref
id: C00187
db: KEGG Compound

Compound/Generic392 Exocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chylomicron
stoichiometric coefficient: 1.0

Cholesterol_Niemann-Pick C1-Like 1 (Homo sapiens)
type: Complex
component stoichiometry: Compound/PW C000047 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/24048 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: NPC1-like intracellular cholesterol transporter 1
component: Cholesterol

Diacylglycerol
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Diacylglycerol

ChemicalStructure/PW C000047
type: ChemicalStructure
structure format: SMILES

Compound/PW C000047 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

ChemicalStructure/PW C009412
type: ChemicalStructure
structure format: SMILES

Clathrin light chain A
type: Protein
cellular location: Cytosol
entity reference: Clathrin light chain A

BoundComplex/580 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low-density lipoprotein receptor (Homo sapiens)_Low density lipoproteins
stoichiometric coefficient: 1.0

Reference/UniProt P38571
type: UnificationXref
id: P38571
db: UniProt

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Ezetimibe Action Pathway (New)
type: Pathway
pathway order: PathwayTransport/2508291
pathway order: PathwayTransport/2508270
pathway order: PathwayTransport/2508271
pathway order: PathwayTransport/2508282
pathway order: PathwayTransport/2508293
pathway order: PathwayTransport/2508285
pathway order: PathwayInteraction/4090
pathway order: PathwayTransport/2508265
pathway order: PathwayEnzymeReaction/2508506
pathway order: PathwayTransport/2508278
pathway order: PathwayTransport/2508289
pathway order: PathwayEnzymeReaction/2508268
pathway order: PathwayEnzymeReaction/2508279
pathway order: PathwayEnzymeReaction/2508276
pathway order: PathwayEnzymeReaction/2508269
pathway order: PathwayEnzymeReaction/2508281
pathway order: PathwayEnzymeReaction/2508290
pathway order: PathwayEnzymeReaction/2508263
pathway order: PathwayEnzymeReaction/2508264
pathway order: PathwayEnzymeReaction/2508275
pathway order: PathwayEnzymeReaction/2508262
pathway order: PathwayEnzymeReaction/2508284
pathway order: PathwayEnzymeReaction/2508295
pathway component: Reaction218598
pathway component: 3.1.1.13
pathway component: Reaction218596
pathway component: ReactionCatalysis208016
pathway component: ReactionCatalysis208015
pathway component: Transport14201
pathway component: ReactionCatalysis208014
pathway component: Transport14200
pathway component: ReactionCatalysis208011
pathway component: ReactionCatalysis208010
pathway component: Reaction218588
pathway component: Reaction218587
pathway component: Reaction218589
pathway component: Reaction218591
pathway component: Reaction218590
pathway component: Reaction218595
pathway component: Reaction218594
pathway component: Transport14196
pathway component: Reaction218593
pathway component: Transport14199
pathway component: Reaction218592
pathway component: Transport14198
pathway component: Transport14193
pathway component: Transport14192
pathway component: Interaction4090
pathway component: Transport14194
pathway component: Transport14191
xref: Reference/PathWhiz PW126803
xref: Reference/SMPDB SMP0125259
organism: Homo sapiens

Fatty Acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 35366

Low density lipoproteins
type: SmallMolecule
cellular location: Cytosol
entity reference: Low density lipoproteins

Cholesterol
type: SmallMolecule
cellular location: Cytosol
entity reference: Cholesterol

ReactionCatalysis208016
type: Catalysis
controller: Lysosomal acid lipase/cholesteryl ester hydrolase
controlled: 3.1.1.13
control type: ACTIVATION

ReactionCatalysis208015
type: Catalysis
controller: Lipoprotein lipase
controlled: Reaction218593
control type: ACTIVATION

Transport14201
type: Transport
participant stoichiometry: Compound/Generic637 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic637 Lysosome/Stoichiometry/1.0
right: Low density lipoproteins
spontaneous: false
left: Low density lipoproteins
name: Low density lipoproteins (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Lysosome
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis208014
type: Catalysis
controller: Apolipoprotein C-II
controlled: Reaction218592
control type: ACTIVATION

Transport14200
type: Transport
participant stoichiometry: Compound/Generic635 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic635 Lysosome/Stoichiometry/1.0
right: Cholesterol ester
spontaneous: false
left: Cholesterol ester
name: Cholesterol ester (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Lysosome
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis208011
type: Catalysis
controller: Lipoprotein lipase
controlled: Reaction218592
control type: ACTIVATION

ReactionCatalysis208010
type: Catalysis
controller: Sterol O-acyltransferase 1
controlled: Reaction218590
control type: ACTIVATION

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt Q96CW1
type: UnificationXref
id: Q96CW1
db: UniProt

Fatty Acids
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Fatty Acids

Reference/UniProt P01130
type: UnificationXref
id: P01130
db: UniProt

Lipoprotein lipase
type: Protein
cellular location: Extracellular Space
entity reference: Lipoprotein lipase

Low-density lipoprotein receptor
type: ProteinReference
xref: Reference/UniProt P01130
organism: BiologicalState53

Compound/Generic309 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Triglyceride
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000067
type: UnificationXref
id: HMDB0000067
db: HMDB

NPC1-like intracellular cholesterol transporter 1
type: Protein
cellular location: Cytosol
entity reference: NPC1-like intracellular cholesterol transporter 1

NPC1-like intracellular cholesterol transporter 1
type: Protein
entity reference: NPC1-like intracellular cholesterol transporter 1

Chylomicron
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Chylomicron

Low-density lipoprotein receptor
type: Protein
cellular location: Cell Membrane
entity reference: Low-density lipoprotein receptor

Reference/CAS 163222-33-1
type: UnificationXref
id: 163222-33-1
db: CAS

Reference/PathWhiz PW126803
type: UnificationXref
id: PW126803
db: PathWhiz

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Cholesterol ester
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cholesterol ester

Reference/PubChem-compound 150311
type: UnificationXref
id: 150311
db: PubChem-compound

Protein/1764 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low-density lipoprotein receptor
stoichiometric coefficient: 1.0

Reference/UniProt O95782
type: UnificationXref
id: O95782
db: UniProt

Low-density lipoprotein receptor (Homo sapiens)_Low density lipoproteins
type: Complex
component stoichiometry: Compound/Generic637 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1764 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Low-density lipoprotein receptor
component: Low density lipoproteins

Cholesterol ester
type: SmallMolecule
cellular location: Lysosome
entity reference: Cholesterol ester

Sterol O-acyltransferase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Sterol O-acyltransferase 1

BoundComplex/579 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cholesterol_Niemann-Pick C1-Like 1 (Homo sapiens)
stoichiometric coefficient: 1.0

BoundComplex/580 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low-density lipoprotein receptor (Homo sapiens)_Low density lipoproteins
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00422
type: UnificationXref
id: C00422
db: KEGG Compound

Compound/Generic637 Endocytic Vesicle/Stoichiometry/1.0
type: Stoichiometry
physical entity: Low density lipoproteins
stoichiometric coefficient: 1.0

Compound/PW C001420 Lysosome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Chylomicron
type: SmallMolecule
cellular location: Exocytic Vesicle
entity reference: Chylomicron

AP-2 complex subunit sigma
type: Protein
cellular location: Cytosol
entity reference: AP-2 complex subunit sigma