Fenofibryl Glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Fenofibryl Glucuronide

BiologicalState26
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

ChemicalStructure/PW C000687
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)O

Compound/PW C113132 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenofibric acid
stoichiometric coefficient: 1.0

Fenofibryl Glucuronide
type: SmallMolecule
cellular location: Cytosol
entity reference: Fenofibryl Glucuronide

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Reduced Fenofibric Acid Glucuronide
type: SmallMolecule
entity reference: Reduced Fenofibric Acid Glucuronide
name: SubPathwayInput

Fenofibryl Glucuronide
type: SmallMolecule
entity reference: Fenofibryl Glucuronide
name: SubPathwayInput

Reference/PathWhiz PW126865
type: UnificationXref
id: PW126865
db: PathWhiz

Reference/UniProt O60656
type: UnificationXref
id: O60656
db: UniProt

Fenofibric acid
type: SmallMolecule
entity reference: Fenofibric acid
name: SubPathwayInput

Unknown
type: Protein
entity reference: Unknown

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/SMPDB SMP0125319
type: UnificationXref
id: SMP0125319
db: SMPDB

Reference/CAS 67-63-0
type: UnificationXref
id: 67-63-0
db: CAS

Unknown
type: ProteinReference

Liver carboxylesterase 1
type: Protein
cellular location: Cytosol
entity reference: Liver carboxylesterase 1

TransportCatalysis5139
type: Catalysis
controller: Unknown
controlled: Transport14254
control type: ACTIVATION

Reference/CAS 2616-64-0
type: UnificationXref
id: 2616-64-0
db: CAS

Carbonyl reductase [NADPH] 1
type: ProteinReference
xref: Reference/UniProt P16152
organism: BiologicalState26

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000935
type: UnificationXref
id: HMDB0000935
db: HMDB

Compound/PW C113134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenofibryl Glucuronide
stoichiometric coefficient: 1.0

Liver carboxylesterase 1
type: ProteinReference
xref: Reference/UniProt P23141
organism: BiologicalState26

Reference/KEGG Compound C00167
type: UnificationXref
id: C00167
db: KEGG Compound

Uridine diphosphate glucuronic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine diphosphate glucuronic acid

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

SubPathwayInteraction118063
type: Interaction
name: SubPathway118063Reaction
name: SubPathwayReaction
participant: Reduced Fenofibric Acid Glucuronide
participant: Fenofibryl Glucuronide
participant: Fenofibric acid

Fenofibrate Metabolism Pathway (New)
type: Pathway
pathway order: PathwayTransport/2509012
pathway order: PathwayTransport/2509013
pathway order: PathwayTransport/2509014
pathway order: PathwayTransport/2509016
pathway order: PathwayTransport/2509006
pathway order: PathwayTransport/2509017
pathway order: PathwayTransport/2509018
pathway order: PathwayTransport/2509019
pathway order: PathwaySubPathway/118063
pathway order: PathwayEnzymeReaction/2509009
pathway order: PathwayEnzymeReaction/2509007
pathway order: PathwayEnzymeReaction/2509011
pathway order: PathwayEnzymeReaction/2509010
pathway component: Excretion
pathway component: TransportCatalysis5139
pathway component: 3.1.1.1
pathway component: Reaction218624
pathway component: Transport14259
pathway component: Reaction218623
pathway component: Reaction218622
pathway component: ReactionCatalysis208048
pathway component: ReactionCatalysis208047
pathway component: Transport14255
pathway component: ReactionCatalysis208046
pathway component: Transport14258
pathway component: ReactionCatalysis208045
pathway component: Transport14257
pathway component: Transport14252
pathway component: Transport14254
pathway component: Transport14253
pathway component: TransportCatalysis5143
pathway component: Transport14260
pathway component: TransportCatalysis5144
pathway component: TransportCatalysis5142
pathway component: TransportCatalysis5140
xref: Reference/PathWhiz PW126865
xref: Reference/SMPDB SMP0125319
organism: Homo sapiens

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 17200
type: UnificationXref
id: CHEBI:17200
db: ChEBI

Compound/PW C113132 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenofibric acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

Reduced Fenofibric Acid Glucuronide
type: SmallMoleculeReference
xref: Reference/ChemSpider 58995113

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/PubChem-compound 3339
type: UnificationXref
id: 3339
db: PubChem-compound

Fenofibric acid
type: SmallMoleculeReference

Fenirofibrate
type: SmallMoleculeReference
xref: Reference/ChemSpider 61966

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Fenofibryl Glucuronide
type: SmallMoleculeReference
xref: Reference/ChemSpider 58994234

Compound/PW C009470/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenofibrate
stoichiometric coefficient: 1.0

TransportCatalysis5143
type: Catalysis
controller: Unknown
controlled: Transport14259
control type: ACTIVATION

Compound/PW C113135 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced Fenofibric Acid Glucuronide
stoichiometric coefficient: 1.0

TransportCatalysis5144
type: Catalysis
controller: Unknown
controlled: Transport14260
control type: ACTIVATION

Reference/ChemSpider 16522
type: UnificationXref
id: 16522
db: ChemSpider

TransportCatalysis5142
type: Catalysis
controller: Unknown
controlled: Transport14258
control type: ACTIVATION

Reference/UniProt P16152
type: UnificationXref
id: P16152
db: UniProt

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

TransportCatalysis5140
type: Catalysis
controller: Unknown
controlled: Transport14255
control type: ACTIVATION

Reference/BioCyc UDP-GLUCURONATE
type: UnificationXref
id: UDP-GLUCURONATE
db: BioCyc

Compound/PW C113135/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced Fenofibric Acid Glucuronide
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Compound/PW C000687 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Isopropyl alcohol
stoichiometric coefficient: 1.0

Reference/CAS 49562-28-9
type: UnificationXref
id: 49562-28-9
db: CAS

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ReactionCatalysis208048
type: Catalysis
controller: UDP-glucuronosyltransferase 1-9
controlled: Reaction218624
control type: ACTIVATION

ReactionCatalysis208047
type: Catalysis
controller: UDP-glucuronosyltransferase 1-9
controlled: Reaction218623
control type: ACTIVATION

ReactionCatalysis208046
type: Catalysis
controller: Carbonyl reductase [NADPH] 1
controlled: Reaction218622
control type: ACTIVATION

ReactionCatalysis208045
type: Catalysis
controller: Liver carboxylesterase 1
controlled: 3.1.1.1
control type: ACTIVATION

Reference/ChemSpider 58994234
type: UnificationXref
id: 58994234
db: ChemSpider

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucuronic acid
stoichiometric coefficient: 1.0

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Fenofibrate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C07586
xref: Reference/ChEBI CHEBI 5001
xref: Reference/PubChem-compound 3339
xref: Reference/HMDB HMDB0015173
xref: Reference/ChemSpider 3222
xref: Reference/CAS 49562-28-9
chemical formula: C20H21ClO4
molecular weight: 360.11282
structure: ChemicalStructure/PW C009470

Fenofibrate
type: SmallMolecule
entity reference: Fenofibrate

UDP-glucuronosyltransferase 1-9
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP-glucuronosyltransferase 1-9

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/KEGG Compound C01845
type: UnificationXref
id: C01845
db: KEGG Compound

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Uridine diphosphate glucuronic acid
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCURONATE
xref: Reference/CAS 2616-64-0
xref: Reference/PubChem-compound 17473
xref: Reference/HMDB HMDB0000935
xref: Reference/ChEBI CHEBI 17200
xref: Reference/ChemSpider 16522
xref: Reference/KEGG Compound C00167
chemical formula: C15H22N2O18P2
molecular weight: 580.0343
structure: ChemicalStructure/PW C000746

Reference/ChEBI CHEBI 17824
type: UnificationXref
id: CHEBI:17824
db: ChEBI

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Reference/ChemSpider 3222
type: UnificationXref
id: 3222
db: ChemSpider

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 5001
type: UnificationXref
id: CHEBI:5001
db: ChEBI

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

UDP-glucuronosyltransferase 1-9
type: ProteinReference
xref: Reference/UniProt O60656
organism: BiologicalState26

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

ChemicalStructure/PW C009470
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Unknown
type: Protein
entity reference: Unknown

Compound/PW C113132/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenofibric acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Fenofibric acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Fenofibric acid

Compound/PW C009470 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenofibrate
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Compound/PW C113135 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced Fenofibric Acid Glucuronide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Unknown
type: ProteinReference

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/UniProt P23141
type: UnificationXref
id: P23141
db: UniProt

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/ChemSpider 61966
type: UnificationXref
id: 61966
db: ChemSpider

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/HMDB HMDB0000863
type: UnificationXref
id: HMDB0000863
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Fenirofibrate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fenirofibrate

Reference/PubChem-compound 17473
type: UnificationXref
id: 17473
db: PubChem-compound

Compound/PW C113133 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenirofibrate
stoichiometric coefficient: 1.0

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Excretion
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway118063
pathway component: SubPathwayInteraction118063
name: SubPathway

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Isopropyl alcohol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01845
xref: Reference/ChEBI CHEBI 17824
xref: Reference/HMDB HMDB0000863
xref: Reference/ChemSpider 3644
xref: Reference/CAS 67-63-0
xref: Reference/PubChem-compound 3776
chemical formula: C3H8O
molecular weight: 60.057514
structure: ChemicalStructure/PW C000687

Reference/ChemSpider 3644
type: UnificationXref
id: 3644
db: ChemSpider

Compound/PW C113133 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenirofibrate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 3776
type: UnificationXref
id: 3776
db: PubChem-compound

Reduced Fenofibric Acid Glucuronide
type: SmallMolecule
cellular location: Cytosol
entity reference: Reduced Fenofibric Acid Glucuronide

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

ChemicalStructure/PW C000746
type: ChemicalStructure
structure format: SMILES

Compound/PW C113134/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenofibryl Glucuronide
stoichiometric coefficient: 1.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Fenirofibrate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Fenirofibrate

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/ChemSpider 58995113
type: UnificationXref
id: 58995113
db: ChemSpider

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine 5'-diphosphate

Transport14260
type: Transport
participant stoichiometry: Compound/PW C009470/Stoichiometry/1.0
right: Fenofibrate
spontaneous: false
left: Fenofibrate
name: Fenofibrate (→) Transport: Homo sapiens, Intestine to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Compound/PW C113134 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fenofibryl Glucuronide
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

3.1.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009470 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000687 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113132 Cytosol/Stoichiometry/1.0
right: Isopropyl alcohol
right: Fenofibric acid
right: Hydrogen Ion
spontaneous: false
EC number: 3.1.1.1
left: Fenofibrate
left: Water
name: Fenofibrate + Water ↔ Fenofibric acid + Hydrogen Ion + Isopropyl alcohol
conversion direction: REVERSIBLE

Reference/HMDB HMDB0015173
type: UnificationXref
id: HMDB0015173
db: HMDB

Fenofibrate
type: SmallMolecule
cellular location: Cytosol
entity reference: Fenofibrate

Reaction218624
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113133 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113135 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Reduced Fenofibric Acid Glucuronide
right: Uridine 5'-diphosphate
right: Hydrogen Ion
spontaneous: false
left: Uridine diphosphate glucuronic acid
left: Fenirofibrate
name: Fenirofibrate + Uridine diphosphate glucuronic acid ↔ Reduced Fenofibric Acid Glucuronide + Hydrogen Ion + Uridine 5'-diphosphate
conversion direction: REVERSIBLE

Transport14259
type: Transport
participant stoichiometry: Compound/PW C009470 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009470/Stoichiometry/1.0
right: Fenofibrate
spontaneous: false
left: Fenofibrate
name: Fenofibrate (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Reaction218623
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113132 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113134 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Fenofibryl Glucuronide
right: Uridine 5'-diphosphate
right: Hydrogen Ion
spontaneous: false
left: Uridine diphosphate glucuronic acid
left: Fenofibric acid
name: Fenofibric acid + Uridine diphosphate glucuronic acid ↔ Fenofibryl Glucuronide + Hydrogen Ion + Uridine 5'-diphosphate
conversion direction: REVERSIBLE

Reaction218622
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113132 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113133 Cytosol/Stoichiometry/1.0
right: Fenirofibrate
right: NADP
spontaneous: false
left: Fenofibric acid
left: Hydrogen Ion
left: NADPH
name: Fenofibric acid + Hydrogen Ion + NADPH ↔ Fenirofibrate + NADP
conversion direction: REVERSIBLE

Reference/KEGG Compound C07586
type: UnificationXref
id: C07586
db: KEGG Compound

Reduced Fenofibric Acid Glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Reduced Fenofibric Acid Glucuronide

Transport14255
type: Transport
participant stoichiometry: Compound/PW C113132/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113132 Cytosol/Stoichiometry/1.0
right: Fenofibric acid
spontaneous: false
left: Fenofibric acid
name: Fenofibric acid (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Isopropyl alcohol
type: SmallMolecule
cellular location: Cytosol
entity reference: Isopropyl alcohol

Transport14258
type: Transport
participant stoichiometry: Compound/PW C113135/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113135 Cytosol/Stoichiometry/1.0
right: Reduced Fenofibric Acid Glucuronide
spontaneous: false
left: Reduced Fenofibric Acid Glucuronide
name: Reduced Fenofibric Acid Glucuronide (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Fenofibric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Fenofibric acid

Transport14257
type: Transport
participant stoichiometry: Compound/PW C113135 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113135 Cytosol/Stoichiometry/1.0
right: Reduced Fenofibric Acid Glucuronide
spontaneous: false
left: Reduced Fenofibric Acid Glucuronide
name: Reduced Fenofibric Acid Glucuronide (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport14252
type: Transport
participant stoichiometry: Compound/PW C009470/Stoichiometry/1.0
right: Fenofibrate
spontaneous: false
left: Fenofibrate
name: Fenofibrate (→) Transport: Homo sapiens to Homo sapiens, Intestine
conversion direction: LEFT_TO_RIGHT

Transport14254
type: Transport
participant stoichiometry: Compound/PW C113134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113134/Stoichiometry/1.0
right: Fenofibryl Glucuronide
spontaneous: false
left: Fenofibryl Glucuronide
name: Fenofibryl Glucuronide (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

Carbonyl reductase [NADPH] 1
type: Protein
cellular location: Cytosol
entity reference: Carbonyl reductase [NADPH] 1

Transport14253
type: Transport
participant stoichiometry: Compound/PW C113134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C113134 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Fenofibryl Glucuronide
spontaneous: false
left: Fenofibryl Glucuronide
name: Fenofibryl Glucuronide (→) Transport: Homo sapiens, Liver, Hepatocyte, Endoplasmic Reticulum Membrane to Homo sapiens, Liver, Hepatocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP